Best Artificial Intelligence Companies in Houston, United States
The 45 best Artificial Intelligence companies in Houston, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Mstack AI.
Our analysis of 101 Artificial Intelligence companies
$80.5b in tracked funding; 99% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Artificial Intelligence companies in Houston
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Mstack AI Developer of AI platform for chemical synthesis and manufacturing solutions | $40M | 22 mo ago | Series A | Shreyans Chopra Founder & CEO | 2022 | Tailwind CSSAmazon Web ServicesGoogle Workspace+5 | — | 1 launch |
| 2 | Tavus Developer of a conversational video interface and AI human models 62AI top 20%Tech top 24%Funding top 27%Talent top 38% All 10 signals ▾AItop 20% Techtop 24% Fundingtop 27% Talenttop 38% Growthtop 45% Moattop 48% Producttop 49% Newsbottom 45% Globalbottom 39% Marketbottom 30% AI: Classified as an AI company Tech: 60 technologies across 5/8 capability areas · Cloud: Amazon Cloudfront, Amazon S3 rank vs industry peers · Fliar Intelligence Index 62/100 | $24M | 9 mo ago | Series B | Quinn Favret Co-Founder & COO | 2020 | WebflowSentryBootstrap+29 | — | — |
| 3 | Bot Auto An autonomous truck fleet operators offering transportation as a service | $20M | 22 mo ago | Seed | Xiaodi Hou Founder & CEO | 2023 | Framer SitesReactAmazon Web Services+6 | — | — |
| 4 | ThoughtTrace AI-based document and contract analytics software | $10M | 75 mo ago | Acqui-Hired | — | 1990 | — | 10 patents AI-powered document analysis, ontology generation, and federated NLP for enterprise data | — |
| 5 | RETINA-AI Health AI-powered device for diabetic retinopathy screening | $8M | 44 mo ago | Series A | Stephen Odaibo Founder & CEO | 2017 | — | — | — |
| 6 | ThirdAI Platform offering large language models and AI technologies | $6M | 60 mo ago | Seed | Anshumali Shrivastava Co-Founder | 2021 | — | — | — |
| 7 | Ruths.ai Data analytics and visualization solution | $5M | 94 mo ago | Series A | — | 2013 | — | — | — |
| 8 | Osperity Provider of computer vision and sensor triggered industrial monitoring services | $4M | 92 mo ago | Series B | Lukasz Skalka Co-Founder & Director | 2012 | — | — | — |
| 9 | AI Innovatech Provider of an AI-enabled medical image processing platform for detecting diseases | $3M | 55 mo ago | Seed | Vinicio Vargas Co-Founder & CEO | 2019 | — | 88 patents Modular construction hardware (temporary braces, boom clamps, roofing systems) and electrosurgical electrodes | — |
| 10 | Melax Technologies Provider of development platform for healthcare organisations | $2M | 42 mo ago | Acquired | — | 2017 | — | — | — |
| 11 | Industrial Data Labs Platform for sales teams to generate sales quotes | $2M | 35 mo ago | Seed | Aaron deOliveira Co-Founder | 2019 | — | — | — |
| 12 | i2k Connect Provider of AI platform for unstructured data analysis and knowledge curation | $1M | 131 mo ago | Funding Raised | — | 2013 | — | — | — |
| 13 | NthDS Provider of AI-driven solutions for data management and document digitization | $428K | 66 mo ago | Seed | Johnathan Green Co-Founder & CTO | 2017 | — | — | — |
| 14 | inCONTEXT Domain marketplace facilitating secure transactions with buyer protection and flexible payments | $225K | 73 mo ago | Deadpooled | — | 2016 | — | 12 patents 3D virtual reality retail simulation and apparel digitization for online shopping | — |
| 15 | CellChorus Provider of single-cell analysis platform evaluating cell dynamics and interactions | $125K | 16 mo ago | Seed | Daniel Meyer CEO | 2017 | — | 2 patents Automated single-cell profiling platforms integrating AI-driven imaging and analysis | — |
Top 12 Artificial Intelligence companies in Houston
#1
Series B · Houston, Texas · founded 2020 · 10 employees$24.2Mraised▾
Developer of a conversational video interface and AI human models. The company offers tools for building AI humans that can interact in real time. It provides models for face-rendering, speech, and emotional intelligence. The company’s APIs allow product teams to own their brand experience. It offers models for generating lifelike digital replicas and analyzing conversational rhythm.
- Nov 2025Series B$40M
- Mar 2024Series A$18M
- Mar 2023Seed$6.1M
- Sep 2021Seed$125K
#2
Series A · Houston, Texas · founded 2022$40Mraised▾
Developer of AI platform for chemical synthesis and manufacturing solutions. The platform unifies chemical lifecycle stages, including IP analysis, synthesis design, lab optimization, and commercial cost modeling. It offers modules for literature intelligence, synthesis intelligence, experimentation assistance, and real-time cost modeling. The platform aims to accelerate research and development workflows.
- Oct 2024Series A$40M
- Oct 2024Conventional Debt—
- 2022Seed—
#3
Seed · Houston, Texas · founded 2023$20Mraised▾
An autonomous truck fleet operators offering transportation as a service. The company focuses on fleet operations, transforming autonomous trucking into a commercially profitable product. It integrates advancements in machine learning, data infrastructure, and hardware into its system. The company's technology creates new transportation capacity and integrates within today’s freight market.
- Sep 2024Seed$20M
#4
Seed · Houston, Texas · founded 2017 · 6 employees$125Kraised▾
Provider of single-cell analysis platform evaluating cell dynamics and interactions. The platform applies visual artificial intelligence to assess cell activation, movement, and cell-to-cell interactions over time. It integrates functional profiling with modalities like single-cell RNA sequencing and flow cytometry. The technology characterizes migration, contact dynamics, cytotoxicity, survival, and biomolecule secretion.
- Apr 2025Grant (prize money)$1.3M
- Mar 2025Grant (prize money)$2.3M
- Aug 2024Grant (prize money)$349.2K
- May 2024Grant (prize money)$350K
#5
Series A · Houston, Texas · founded 2017 · 4 employees$8.1Mraised▾
AI-powered device for diabetic retinopathy screening. The company offers AI systems such as the RETINA-AI Galaxy that uses robotic camera for the diagnoses of diseases such as diabetic retinopathy from pictures of the retina and other ophthalmic diseases include macular degeneration and glaucoma.
- Dec 2022Series A$2.6M
- Apr 2022Series A$2.5M
- Aug 2020Series A$5.2M
#6
Seed · Houston, Texas · founded 2019$1.5Mraised▾
Platform for sales teams to generate sales quotes. it helps sales representatives generate price quotes for the customers. It enables users to connect the platform with that of the distributor and manufacturer to understand the inventory and stocks while processing the quote.
- Aug 2023Seed$1.5M
#7
Acquired · Houston, Texas · founded 2017 · 19 employees$2.1Mraised▾
Melax Tech provides a development platform for healthcare organizations. The company develops machine learning and natural language processing technology based software platform CLAMP toolkit which helps in the analyzing and extraction of clinical health data from the patient medical reports. The platform also helps in managing clinical data collection, research purposes, billing, and coding solutions.
- Feb 2023Grant (prize money)$1.1M
- Apr 2020Grant (prize money)$1000K
#8
Acqui-Hired · Houston, Texas · founded 1990 · 68 employees$10Mraised▾
ThoughtTrace offers an AI-based document and contract analytics software. The company offers a cloud-based platform that delivers contextual insights for complex documents and contracts. The solution offers features such as enterprise search, deep commercial insights, intelligent document identification, contextual relationships, etc. The company offers its solution to industries such as oil & gas, telecommunication, real estate, IT, etc.
- May 2020PE$10M
- 2017PE—
#9
Seed · Houston, Texas · founded 2021 · 10 employees$6Mraised▾
Platform offering large language models and AI technologies. It offers an offline application for AI-assisted document management called Pocket LLM. It leverages Ray for parallel training of NN on AMD. Its solutions include text classification, question answering, product search and recommendation.
- Aug 2021Seed$6M
#10
Seed · Houston, Texas · founded 2019 · 10 employees$2.8Mraised▾
Provider of an AI-enabled medical image processing platform for detecting diseases. It enables users to do biomedical image analysis. Its offering includes image processing, medical AR, data processing, and data analytics. It uses cognitive computing and computer vision technologies to analyze medical images. It caters to healthcare industries.
- Jan 2022Seed$2.8M
#11
Series A · Houston, Texas · founded 2013 · 8 employees$5Mraised▾
Ruths Analytics provides data analytics and visualization solution for TIBCO Spotfire in the Oil and Gas industry to manage, analyze and visualize data from various sources. It offers modular apps for Spotfire - visualization, connectors, tools and templates. Applications are 3D subsurface visualization, basic type curve, SharePoint data source and well log visualization.
- Oct 2018Series A$5M
#12
Series B · Houston, Texas · founded 2012 · 7 employees$3.8Mraised▾
Provider of computer vision and sensor triggered industrial monitoring services. The company offers automated visual inspections for industrial operations. It provides visual alerts when industrial sensors are triggered. The company delivers terminal, thermal, fire, smoke, and PPE monitoring. It also offers field operations, facility management, and activity detection.
- Dec 2018Series B$2.8M
- Jun 2015Series A$964.6K
- Jan 2015Seed$2.2M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Artificial Intelligence coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
What Houston researches in artificial intelligence
- University of Houston10
- The University of Texas Health Science Center at Houston8
- Houston Independent School District2
- Sam Houston State University2
- Houston Methodist1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.