Best Healthcare IT Companies in Chicago, United States
The 210 best Healthcare IT companies in Chicago, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Tempus.
Our analysis of 90 Healthcare IT companies
$11.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Healthcare IT companies in Chicago
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Tempus 🦄 Developer of genomic testing and artificial intelligence tools for medicine | $1.1B | 44 mo ago | Public | 772 | Eric Lefkofsky Founder & CEO | Cart FunctionalityWordPressApple iCloud Mail+33 | 594 patents AI-powered medical diagnostics: imaging biomarkers, liquid biopsy genomics, and cardiac ECG analysis | — |
| 2 | RLDatix GRC software solutions for the healthcare industry | $736M | 53 mo ago | Late Stage | 1,400 | Dan Michelson CEO | WordPressApple iCloud MailMySQL+33 | — | — |
| 3 | Outcome Health 🦄 Online patient engagement tool for providers | $533M | 107 mo ago | Acqui-Hired | 221 | — | — | — | — |
| 4 | Upfront Healthcare Provider of data analytics platform to help clinics schedule and allocate resources | $96M | 36 mo ago | Acquired | 45 45 → 26 (-42%) · sector median +46% | Carrie Kozlowski COO & Co-Founder | Froala EditorSalesforceMicrosoft ASP.NET+10 | — | — |
| 5 | Higi Gamified app for personal health management | $95M | 71 mo ago | Acquired | 53 53 → 75 (+42%) · sector median +46% | — | Cart FunctionalitySquarespace CommerceSquarespace+25 | 17 patents Automated cuff blood pressure/arm circumference measurement devices and ocular biomolecule detection systems. | 1 partnership |
| 6 | Blue Health Intelligence Healthcare data analytics empowering better outcomes, equity, and value-based care | $71M | 106 mo ago | Series C | 179 | — | — | — | — |
| 7 | Nucle AI AI-assisted platform for image analysis | $60M | 26 mo ago | Series B | 9 | Lotan Chorev Co-Founder and VP R&D | — | — | — |
| 8 | TimeDoc Provider of the chronic care management solution for healthcare professionals | $57M | 51 mo ago | Series B | 156 | William Boeglin Co-Founder & CEO | WordPressMySQLPHP+32 | — | — |
| 9 | Janus AI AI and SaaS-based revenue cycle management tool for healthcare providers | $56M | 20 mo ago | Series B | 94 94 → 110 (+17%) · sector median +46% | Brendan Downing Co-Founder & CEO | — | 28 patents Hardware security and access control solutions for computing devices and network interfaces | 3 job openings · 2 partnerships |
| 10 | Visibly Online vision test technology for providers | $50M | 38 mo ago | Series B | 29 29 → 62 (+114%) · sector median +46% | — | Apple iCloud MailGoogle WorkspaceNode.js+15 | 19 patents Camera‑based ophthalmic diagnostics for refraction, astigmatism, and visual‑field assessment | — |
| 11 | AVIA Digital business management and networking platform for the healthcare industry | $50M | 89 mo ago | Series B | 177 | Linda Finkel CEO & President | Node.jsNextAuth.jsGoogle Sign-in+29 | — | 2 awards |
| 12 | Kalderos Online platform to coordinate and manage drug discount programs | $50M | 17 mo ago | Series C | 110 | James William Schuyler Co-Founder | WebflowSentryZendesk+21 | 2 patents Healthcare marketplace financial transaction platforms for patient payments and secondary trades | 1 partnership |
| 13 | Valence Health Provider of clinical integration and health plan services. | $45M | 139 mo ago | Acquired | 503 | — | — | — | — |
| 14 | Apervita Analytics platform for for reducing readmission, disease risks and improving compliance | $44M | 80 mo ago | Series B | 13 | — | — | 2 patents Integrated electronic health record storage platform and graph transitive‑closure computation algorithms. | — |
| 15 | Sittercity Marketplace platform for caregivers | $43M | 150 mo ago | Acquired | 38 | — | ContentfulTailwind CSSEnvoy+12 | — | — |
| 16 | Annexus Health Patient access and patient engagement solutions | $43M | 46 mo ago | Series B | 156 156 → 128 (-18%) · sector median +46% | Brad Frazier Co-Founder | WordPress Site EditorWordPressApple iCloud Mail+28 | — | — |
| 17 | Blueprint Provider of AI-powered documentation and insights for mental health therapists | $32M | 14 mo ago | Series B | 4 | Danny Freed Founder & CEO | WebflowSentryQuill+33 | — | — |
| 18 | KeyCare Digital teleconsultation tool for providers and patients 45Funding top 25%News top 36%Moat top 39%Growth top 45% All 8 signals ▾Fundingtop 25% Newstop 36% Moattop 39% Growthtop 45% Techtop 45% Talentbottom 49% Marketbottom 40% Globalbottom 37% Funding: Raised $29.5M across 4 rounds · 4 rounds over 4 yrs (1.0/yr) News: 2 BI events in 12 mo (of 4 tracked, 2 types) · Top themes: Funding, Capital raise rank vs industry peers · Fliar Intelligence Index 45/100 | $29M | 3 mo ago | Series A | 21 | Lyle Berkowitz Founder & CEO | WebflowSalesforceHubSpot+18 | — | — |
| 19 | PatientIQ Research and analytics platform for clinical data and PROs | $26M | 49 mo ago | Series B | 29 | — | HubSpot CMS HubMaterial Design LiteZURB Foundation+17 | — | 1 award |
| 20 | Third Eye Health Provider of virtual care and coordination software for hospitals | $25M | 33 mo ago | Series A | 50 | Lucas Baran Co-Founder & CTO | WordPressApple iCloud MailMicrosoft 365+20 | — | 1 job opening · 1 partnership |
| 21 | CancerIQ Cloud-based platform to doctors, for identifying cancer risk patients and delivering care plans | $24M | 21 mo ago | Series B | 78 | Feyi Olopade CEO | SkolengoSentryZendesk+17 | — | 1 launch |
| 22 | Retrofit An online weight management program | $23M | 121 mo ago | Deadpooled | 84 | — | — | — | — |
| 23 | Inteneural AI-based central nervous system imaging and diagnosis for healthcare professionals | $21M | 53 mo ago | Series B | — | Kris Siemionow Co-Founder | — | — | — |
| 24 | Lumere Provider of supply chain management and formulary management for pharmacies and healthcare organizations | $20M | 88 mo ago | Acquired | 212 | Will Danford CTO | SentryAtlassian StatuspagePython+21 | — | — |
| 25 | Prenosis AI-based precision diagnostic platform for acute care | $20M | 4 mo ago | Series A | 29 | Rashid Bashir Co-Founder | WordPressApple iCloud MailMicrosoft 365+27 | 21 patents AI-driven clinical risk prediction, dataset normalization, and personalized therapy dashboards | — |
| 26 | Thoughtful AI-powered healthcare administration platform to automate tasks | $20M | 14 mo ago | Series A | 16 | Alex Zekoff Co-Founder & CEO | WebflowZohoYouTube+29 | — | — |
| 27 | Praia Health Provider of a platform as a service technology for patient engagement | $20M | 19 mo ago | Series A | — | Justin Dearborn Founder & CEO | — | — | — |
| 28 | Regroup Therapy Provider of telemental health and telepsychiatry services | $20M | 79 mo ago | Series A | 35 | — | — | — | — |
| 29 | Dina Provider of an AI-based senior care coordination software for healthcare organizations | $18M | 28 mo ago | Acquired | 38 38 → 68 (+79%) · sector median +46% | Ashish Shah Co-Founder & CEO | — | — | — |
| 30 | Level Ex Developer of medical video games for physicians | $17M | 82 mo ago | Acquired | 105 | Sam Glassenberg Founder & CEO | Apache HTTP ServerAmazon Web ServicesGoogle Font API+2 | 25 patents Biometric health monitoring with secure imaging and authentication sensor technologies | — |
| 31 | SIM Partners Provider of a location-based marketing automation solution | $16M | 112 mo ago | Acqui-Hired | 65 | — | — | — | — |
| 32 | SwervePay EMR integrated patient-centric payment solution using text messages | $16M | 87 mo ago | Acquired | 16 | — | Amazon Web ServicesSendgridMicrosoft 365+6 | — | — |
| 33 | PinpointCare Cloud based SaaS platform for personalized care cordination | $16M | 128 mo ago | Series A | 3 | Tracey Powell Founder | — | — | — |
| 34 | Cardiosense Developer of wearable sensor and AI platform for cardiac monitoring | $15M | 42 mo ago | Series A | 15 | Amit Gupta Co-Founder & CEO | — | 2 patents Wearable and implantable physiological monitoring devices with data analysis and presentation. | 1 launch |
| 35 | SimBioSys Provider of AI-based decision-making and cancer diagnosis tool for healthcare professionals | $15M | 17 mo ago | Series A | 46 | Joseph Peterson Founder and CTO | WordPressApple iCloud MailMicrosoft 365+27 | 12 patents Patient-specific 3D tumor modeling and perfusion MRI-based cancer prognostics | — |
| 36 | SonarMD Cloud-based care management solutions for chronic conditions 48Funding top 32%Growth top 35%Talent top 38%Tech top 39% All 7 signals ▾Fundingtop 32% Growthtop 35% Talenttop 38% Techtop 39% Producttop 46% Marketbottom 30% Globalbottom 29% Funding: Raised $14.3M across 5 rounds · 5 rounds over 8 yrs (0.6/yr) Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $14M | 4 mo ago | Series B | 25 | Lawrence Kosinski Founder at SonarMD | WordPressApple iCloud MailMicrosoft 365+21 | — | — |
| 37 | Cardio Diagnostics AI based platform offering cardiovascular medicine | $14M | 28 mo ago | Public | — | Robert Philibert Co-Founder | WordPress Block EditorCart FunctionalityBuilder.io+19 | — | — |
| 38 | Blueprint Provider of patient assessment tool for behavioural medical practices | $14M | 35 mo ago | Series A | 18 | Danny Freed Founder & CEO | SentryCannyApple iCloud Mail+34 | — | 3 launchs |
| 39 | Cured Digital marketing tool for healthcare professionals | $13M | 57 mo ago | Acquired | 25 25 → 54 (+116%) · sector median +46% | Rohit Narayan Co-Founder & Chief Customer Officer | WebflowApple iCloud MailGoogle Workspace+20 | — | — |
| 40 | Vodori Cloud based marketing solutions for life sciences companies | $12M | 56 mo ago | Series A | 38 38 → 57 (+50%) · sector median +46% | — | HubSpot CMS HubYouTubeEnvoy+14 | — | 1 job opening |
| 41 | Adaptive Testing Technologies Provider of software for mental health assessment for patients | $5M | 16 mo ago | Funding Raised | 5 | David Weiss Founder | — | — | — |
| 42 | Beacon Developer of intelligent disinfection technology for air and surfaces | $4M | 13 mo ago | Series A | — | Andrea Clark Founder & Head of Product and Research | Wix eCommerceWixSentry+19 | — | 1 launch |
| 43 | 4D Healthware Cloud based platform for chronic care management | $4M | 56 mo ago | Series A | 11 | — | — | — | — |
| 44 | Clinify Provider of cloud-based EHR management software for healthcare professionals | $3M | 39 mo ago | Seed | 15 | Nathan Pelzer Founder & CEO | WordPressMySQLPHP+19 | 3 patents Value-based healthcare decision optimization and analytics software | — |
| 45 | Planbase Scheduling and workforce management software for healthcare providers | $3M | 7 mo ago | Seed | — | Joe S Co-Founder | — | — | 1 launch |
| 46 | Hucu.ai AI and cloud-based person-centered secure messaging tool | $3M | 31 mo ago | Seed | 23 | Syed Kazmi Co-founder & Tech Lead | WordPressMySQLPHP+21 | — | — |
| 47 | HumanImage Developer of three-dimensional imaging device for skin lesion and cancer tracking | $2M | 2 mo ago | Seed | — | David Teplica Founder & CEO & CMO | — | 5 patents Three‑dimensional body surface imaging for medical and fitness avatar creation | — |
| 48 | Altris AI-based diagnostic solution for ophthalmologists | $1M | 16 mo ago | Seed | 15 | Andrey Kuropyatnyk Founder & CEO | WordPressMySQLPHP+26 | — | 1 launch |
| 49 | Third Coast Dynamics Developer of cloud-based solution delivering hemodynamic assessments from CT and MR angiography images | $657K | 21 mo ago | Funding Raised | — | Bradley Allen Co-Founder | — | — | — |
| 50 | Kompass Diagnostics Provider of a portable fertility monitor for breaking barriers to fertility care | $305K | 13 mo ago | Funding Raised | — | Hyun-June Jang Co-Founder | — | — | — |
Top 12 Healthcare IT companies in Chicago
#1
Series A · Chicago, Illinois · founded 2020 · 21 employees$29.5Mraised▾
Digital teleconsultation tool for providers and patients. It offers Epic-based virtual care platform which offer virtual care network, patients can book appointments through the MyChart portal or call center.
- Mar 2026Series A$27.4M
- Apr 2025Series A$27.7M
- Jan 2023Series A$27M
- Mar 2022Seed$2.5M
#2
Series A · Chicago, Illinois · founded 2014 · 29 employees$20Mraised▾
AI-based precision diagnostic platform for acute care. It offers Immunix precision diagnostics and evidence generation platform that leverages machine learning algorithms, clinical data, deep biological data, and biobanked sample to identify and treat patient with sepsis.
- Jan 2026Series A$20M
- Sep 2024Grant (prize money)$700K
- Jul 2023Grant (prize money)$4.8M
- Jun 2023Grant (prize money)$4.9M
#3
Series B · Chicago, Illinois · founded 2009 · 25 employees$14.3Mraised▾
Cloud-based care management solutions for chronic conditions. It offers a care coordination program that proactively connects patients with care teams in real time and provides wrap-around services to help patients manage their individual health needs. Their platform collects patient health data through surveys and analyzes it to track the status of improvement. They generate scores from the survey and send alerts to doctors.
- Feb 2026Series B$3M
- Dec 2024Series A$2.2M
- Jul 2024Conventional Debt$1M
- May 2023Series A$4.3M
#4
Seed · Chicago, Illinois · founded 2021$1.5Mraised▾
Developer of three-dimensional imaging device for skin lesion and cancer tracking. The company develops AnthroCam, a 3D imaging device that creates high-resolution, life-sized avatars of skin surfaces using non-invasive visible light technology. It enables tracking subtle changes for early skin cancer detection, rooted in decades of anatomic imaging research.
- Mar 2026Seed$1.5M
#5
Series B · Chicago, Illinois · founded 2019 · 4 employees$31.9Mraised▾
Provider of AI-powered documentation and insights for mental health therapists. It offers AI-assisted progress notes and treatment plans, generating these documents from session recordings. The platform provides real-time clinical assistance before, during, and after client sessions, including reminders, suggestions, and post-session resources. It integrates with existing electronic health record (EHR) systems and prioritizes data security and privacy, adhering to relevant compliance standards. The service aims to streamline workflows and improve the efficiency of mental health practices.
- Apr 2025Series B$15M
- Jun 2023Series A$6.6M
- Jun 2023Series A$9M
- Apr 2019Seed$1.3M
#6
Series C · Chicago, Illinois · founded 2016 · 110 employees$49.9Mraised▾
Provider of an online platform for managing drug discount programs. The platform tracks and records the validation tests of data and custom validation tests. it also offers features such as compliance issues verification, claims level visibility, transparency in the drug supply chain, and communication for dispute resolution among the affected parties.
- Dec 2024Series C$26.4M
- Sep 2022Series B$14.9M
- Jun 2020Series B$28M
- May 2019Series A$7M
#7
Seed · Chicago, Illinois · founded 2022$2.6Mraised▾
Scheduling and workforce management software for healthcare providers. Planbase is a comprehensive scheduling software with features such as appointment booking, scheduling dashboard, automated reminders, messaging, and waitlist management.
- Nov 2025Seed$2.1M
- 2024Seed$500K
#8
Series A · Chicago, Illinois · founded 2020 · 16 employees$20Mraised▾
AI-powered healthcare administration platform to automate tasks. The company offers solutions for automating revenue cycle management, streamlining company processes, and implementing robotic process automation (RPA).
- Apr 2025PE—
- Jul 2024Series A$20M
#9
Series B · Chicago, Illinois · founded 2020 · 94 employees$56Mraised▾
AI and SaaS-based revenue cycle management tool for healthcare providers. It provides an end-to-end revenue cycle platform to provide operational insights, patient access, collecting data, claims management, navigating payer portals, and more.
- Sep 2024Series B$10M
- Mar 2023Series B$45.1M
- Dec 2021Series A$8.9M
#10
Tempus 🦄Public · Chicago, Illinois · founded 2015 · 772 employees$1.1Braised▾
Developer of genomic testing and artificial intelligence tools for medicine. This organization provides molecular profiling, algorithmic diagnostic models, and digital pathology services to assist in clinical decision-making. The technology integrates clinical data with sequencing results to identify therapeutic options and potential clinical trial matches. These tools support oncology, neurology, psychiatry, cardiology, and radiology by analyzing biological data to assist in patient care and drug development. The platform facilitates the identification of biomarkers and provides insights into disease progression and treatment responses.
- Oct 2022Series G—
- Oct 2022Conventional Debt—
- Dec 2020Series G$200M
- Mar 2020Series G$100M
#11
Series B · Chicago, Illinois · founded 2013 · 78 employees$23.9Mraised▾
Cloud-based platform to doctors, for identifying cancer risk patients and delivering care plans. The company provides a cloud-based platform to doctors for identifying cancer-risk patients by lifestyle, clinical, and genetic assessment; improving patient adherence by engaging with them on the portal; and making decisions to improve patient's disease condition. Proposes to launch a patient-facing portal in future, which patients can access from their homes. Platform is offered in three parts to providers - genetic screening, risk assessment & prevention, digital communication.
- Aug 2024Series B—
- Nov 2023Series B$3.4M
- Mar 2022Series B$14M
- Aug 2020Series A$4.8M
#12
Series A · Chicago, Illinois · founded 2016 · 46 employees$15Mraised▾
Provider of AI-based decision-making and cancer diagnosis tool for healthcare professionals. The company has developed TumorScope a digital software that uses AI-based technology and supercomputing to model the behavior of cancer in humans for diagnosis. It has tools for tumor visual on from patients MRI, PET, or other radiology scans. TumorScope software provides predictions of the tumor pre-treatment for lung cancer, prostate cancer, and breast cancer.
- Dec 2024Series A$5.2M
- Oct 2021Series A$15M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare IT coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Chicago is moving
A read on the academic research around Digital Health in Chicago — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 127 papers.
University of Illinois Chicago, University of Chicago, and Loyola University Chicago predominantly research AI, digital mental health, and mobile health applications, with concern-leaning but cautiously optimistic recent output.
- University of Illinois Chicago68
- University of Chicago47
- Loyola University Chicago14
- Chicago Department of Public Health12
- Chicago State University2
- SNOMED CT3
- Interoperability3
- Unstructured data3
- Key (lock)3
- Wearable computer3
- Informatics1→5
- mHealth1→4
- Telemedicine1→3
- Data science1→3
- Health informatics2→12
- Health administration1→8
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.