Best Healthcare IT Companies in South Carolina, United States
The 57 best Healthcare IT companies in South Carolina, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: AccessOne.
Our analysis of 90 Healthcare IT companies
$11.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Healthcare IT companies in South Carolina
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | AccessOne Patient healthcare payment processing solutions for businesses | $375M | 79 mo ago | Acquired | Russell Salton Founder & Owner | 2002 | WordPressMySQLMariaDB+28 | — | — |
| 2 | Glytec Systems Cloud-based Insulin and glucose dosing software solution | $44M | 62 mo ago | Series B | Bob Leonard Ex-CEO & President | 2005 | — | — | — |
| 3 | ChartSpan Mobile app for Patient health records | $37M | 85 mo ago | Series A | — | 2012 | WordPressApple iCloud MailGoogle Workspace+28 | — | — |
| 4 | Verge Health SaaS based solution to manage hospital processes, personnel and asses physician performance | $16M | 94 mo ago | Acquired | — | 2001 | WordPressMySQLPHP+20 | — | — |
| 5 | Sync.MD App for personal health record management | $14M | 57 mo ago | Series B | Jacob Grinberg Co-Founder | 2015 | ZohoFacebook LoginTailwind CSS+11 | — | 1 launch |
| 6 | Rymedi Cloud-based precision health platform enabling secure data sharing and patient-centered solutions | $9M | 32 mo ago | Series A | Jason Cross Co-Founder & Chief Strategy Officer | 2018 | WordPressMySQLPHP+19 | 8 patents Secure health data exchange via blockchain, cryptographic ciphers, and zero‑knowledge compliance proofs | — |
| 7 | PaceMate Provider of cloud-based cardiac health remote monitoring platform | $8M | 35 mo ago | Series B | — | 2015 | HubSpot CMS HubApple iCloud MailSalesforce+23 | — | — |
| 8 | ThoroughCare Care coordination software and clinical guidance to optimize patient care management | $8M | 2 mo ago | Series A | — | 2013 | HubSpot CMS HubApple iCloud MailGoogle Workspace+22 | — | 1 partnership |
| 9 | Blinktbi Innovating neurological disease management with non-invasive blink reflex technology | $7M | 36 mo ago | Series A | Ryan Fiorini Co-Founder & COO | 2017 | — | 14 patents Wearable ocular blink detection and monitoring for neurological and headache disorder diagnostics | — |
| 10 | Hank Cognitive engine providing medical coding automation solution | $3M | 40 mo ago | Seed | Sam Hartzog Co-Founder and Chief Data Officer | 2018 | WordPressMySQLPHP+18 | — | — |
| 11 | Encite Healthcare software solutions provider specializing in EHR, PM, and RCM services | $3M | 203 mo ago | Funding Raised | — | 2001 | — | 161 patents Micro‑scale MEMS fluidic and pressure devices for respiratory and gas‑handling applications | — |
| 12 | Formly.ai AI and cloud-based medical device management tool | $2M | 9 mo ago | Seed | — | 2021 | Webflow EcommerceWebflowZoho+12 | — | — |
| 13 | RingMD Provider of healthcare teleconsultation marketplace for patients and providers | $500K | 60 mo ago | Seed | — | 2012 | Node.jsVue.jsNuxt.js+11 | — | — |
| 14 | Recovr Creates therapy tools that enhance physical rehabilitation in skilled nursing facilities | $425K | 71 mo ago | Seed | — | 2013 | — | — | — |
| 15 | Nursenav Oncology Patient navigation software streamlining oncology care with digital onboarding and workflow automation | $373K | 198 mo ago | Seed | — | 2007 | — | — | — |
| 16 | ItRunsInMyFamily Mobile-based application to analyze risk for hereditary cancer | $286K | 81 mo ago | Funding Raised | Brandon M Welch Founder and Creator | 2015 | — | — | — |
| 17 | Rhinogram Provider of patient engagement platform for professionals | $14K | 48 mo ago | Seed | — | 2015 | Apple iCloud MailGoogle WorkspaceFacebook Login+10 | 20 patents Secure messaging integration with automated consent and autoreply management for telecom communications | — |
Top 12 Healthcare IT companies in South Carolina
#1
Series A · Spartanburg, South Carolina · founded 2013 · 10 employees$8Mraised▾
Care coordination software and clinical guidance to optimize patient care management. The company empowers healthcare providers with purpose-built software solutions and expert clinical guidance to enhance patient care management. It offers a comprehensive platform designed to streamline care coordination, improve patient engagement, and maximize efficiency. The software supports various care models, including chronic care management, remote patient monitoring, and behavioral health integration. It provides tools for advance care planning, AI analytics, and annual wellness visits. The platform is NCQA Prevalidated, ensuring alignment with evidence-based quality standards and HIPAA compliance. The company supports accountable care organizations, health plans, home health agencies, pharmacies, and physician groups, offering integration and interoperability solutions, clinical advisory services, and training. It leverages AI to analyze patient calls, automate care plans, and enhance engagement through secure messaging and educational resources. The goal is to enable integrated, coordinated care, improve patient outcomes, and drive value-based reimbursement in the healthcare ecosystem.
- Oct 2025Series A$3M
- Sep 2024Series A$5M
- May 2022Series A$3M
- Feb 2014Seed—
#2
Seed · Mount Pleasant, South Carolina · founded 2021 · 4 employees$2Mraised▾
AI and cloud-based medical device management tool
- Sep 2025Seed$2M
#3
Acquired · Fort Mill, South Carolina · founded 2002 · 118 employees$375Mraised▾
Patient healthcare payment processing solutions for businesses
- Nov 2019Conventional Debt$225M
- Jun 2018Seed—
- May 2018Conventional Debt$150M
#4
Series A · Greenville, South Carolina · founded 2018 · 26 employees$9Mraised▾
Cloud-based precision health platform enabling secure data sharing and patient-centered solutions. The company has developed a software solution that assists treatment workflow management and anomalous testing solutions. The software has features for telehealth integration and smart heat passport generation. The platform has the ability to provide real-time patient data analysis for contact tracking and identification. Users are allowed to share clinical data and information with other team members.
- Oct 2023Series A$9M
#5
Series A · Charleston, South Carolina · founded 2017 · 8 employees$6.9Mraised▾
Innovating neurological disease management with non-invasive blink reflex technology. They are a biotech company pioneering blink reflex technology intended to improve the detection and management of neurological disease and conditions. Their FDA-cleared EyeStat device offers a rapid, objective assessment of neurological function through the blink reflex. This technology enables earlier detection, personalized care, and improved patient outcomes. The i-blink app extends its reach to clinical and telehealth settings, facilitating low-cost, objective blink capturing for enhanced neurological management. They collaborate with pharmaceutical and academic partners to improve diagnosis and clinical trials and empower patients with remote monitoring tools. Their technology provides researchers and doctors insights into neurological activity following a head injury. The company's cloud-based platform ensures secure data management and comprehensive reporting, supporting better decision-making in neurology.
- Jul 2023Series A$1.6M
- Feb 2021Series A$6M
- Nov 2018Conventional Debt$673.4K
- Oct 2017Seed$850K
#6
Series B · Greenville, South Carolina · founded 2005 · 124 employees$44.3Mraised▾
Developer of insulin management software designed to improve the quality of diabetic care. The company's titration software and proprietary algorithms power personalized diabetes treatment recommendations across the continuum of care, enabling hospitals to eliminate hypo and hyperglycemia events.
#7
Series B · Hilton Head Island, South Carolina · founded 2015 · 109 employees$8Mraised▾
PaceMate provides a cloud-based cardiac health remote monitoring platform. The platform provides digital tools with a live EHR integrated platform for remote monitoring of heart health and patient care. On-demand teleconsultations are provided for patients with integrated data management across the cardiology departments.
- Jul 2023Series B—
- Mar 2021Series A$8M
- Sep 2019Seed—
#8
Series A · Greenville, South Carolina · founded 2012 · 171 employees$37.1Mraised▾
ChartSpan, is a patient-facing personal health record tool, which can import records in various electronic formats, can convert paper records into structured data using machine learning and optical character recognition. Using the app patients can request records from providers and send records to others. ChartSpan provides patients, hospitals, clinics, insurers, pharma, public health agencies, researchers and big data companies access to real-time information and meaningful interpretation of healthcare data.
- Jun 2019Series A$15M
- Jun 2017Series A$16M
- Apr 2016Series A$3.2M
- Feb 2015Seed$1.7M
#9
Series B · Anderson, South Carolina · founded 2015 · 22 employees$13.6Mraised▾
App for personal health record management. Users can use their phone's camera to scan paper documents. It automatically crops, straightens and saves it into the health record. The app syncs with the device to access the record.
- Sep 2021Series B$10M
- Dec 2018Series A$3.6M
#10
Seed · Lexington, South Carolina · founded 2018 · 11 employees$3.3Mraised▾
Cognitive engine providing medical coding automation solution. The platform offers a cognitive computing-based medical coding automation platform for multiple industries including healthcare, insurance, and more. It Is used to predict applicable medical codes and identify documentation deficiencies relative to assigned codes to automate repetitive decision-making tasks. It uses natural language processing, machine learning, neural networks, and autonomous computer programming technologies to learn the cognitive reasoning or decision-making capabilities of human domain experts.
- Mar 2023Seed$300K
- Jul 2021Seed$1.8M
- Nov 2020Grant (prize money)$200K
- Aug 2020Seed$1.2M
#11
Acquired · Charleston, South Carolina · founded 2001 · 140 employees$15.7Mraised▾
Verge Health provides a web-based software solution to help healthcare organizations streamline their administrative processes. The company offers three different suite solutions; hospital, practitioner and employee. The solutions help healthcare facilities manage hospital processes, identify gaps, improve patient safety, maintain compliance, assess physician performance and manage hospital personnel and asses their capabilities. The company also offers hospitals an integrated credentialing and privileging solution.
- Aug 2018Series A$7M
- Dec 2010Series A$8.7M
- Apr 2008Seed—
#12
Funding Raised · Fort Mill, South Carolina · founded 2001 · 8 employees$2.5Mraised▾
Healthcare software solutions provider specializing in EHR, PM, and RCM services. The company delivers healthcare software solutions designed to enhance efficiency through automation. Its suite includes Electronic Health Records (EHR), E-Prescribing, Practice Management (PM), Patient Engagement, Patient Portal, and Revenue Cycle Management (RCM) services. The software is scalable and customizable, catering to both large and small healthcare organizations. It offers flexibility, enabling healthcare providers to tailor the application to their unique workflows. The company focuses on developing integrated healthcare information technology (HIT) solutions, designed with the collaboration of healthcare professionals. The goal is to provide intuitive, non-restrictive software that aligns with the thought processes of healthcare professionals, eliminating cumbersome templates and promoting workflow freedom. The company strives to advance healthcare software through new technologies, ultimately improving patient care.
- Jul 2009Grant (prize money)$2.5M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare IT coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health is moving in the United States
A read on the academic research around Digital Health — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,843 United States-affiliated papers.
- Design Intelligence421
- Harvard University383
- Johns Hopkins University295
- University of North Carolina at Chapel Hill206
- University of Washington173
- Health care9→240
- Wearable computer6→129
- Health informatics25→140
- Remote patient monitoring11→76
- Informatics10→60
- Health care36→766
- Health informatics113→495
- Psychological intervention20→320
- Public health34→290
- Intervention (counseling)5→193
- Health care98→1170
- Health informatics213→712
- Public health73→525
- Psychological intervention26→368
- Health administration110→363
Where digital health is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing digital health patents in the United States
United States digital health patent filing is accelerating — 2,575 filings from 1,291 assignees (2016–2025), led by Boeing, Honeywell INT, Advanced Neuromodulation Systems; annual filings 173→270.
- Boeing150
- Honeywell INT129
- Advanced Neuromodulation Systems96
- General Electric91
- Hamilton Sundstrand67
- IBM65
- OTIS Elevator50
- Sikorsky Aircraft49
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.