Best Healthcare IT Companies in Tennessee, United States
The 204 best Healthcare IT companies in Tennessee, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Main Street.
Our analysis of 90 Healthcare IT companies
$11.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Healthcare IT companies in Tennessee
| # | Company | Disclosed funding | Last round | Employees | Founded | Stage | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Main Street 🦄 Value-based healthcare company focused on serving rural areas | $505M | 32 mo ago | 5 | 2021 | Series D | WordPressMySQLPHP+28 | 21 patents Patents concentrated in electrical & electronics | — |
| 2 | MedSolutions Medical Cost Management Solutions | $300M | 187 mo ago | 1,000 | 1992 | Late Stage | — | — | — |
| 3 | Passport Health Communication Provider of revenue cycle management solution for healthcare organizations | $236M | 214 mo ago | 343 | 1996 | Acquired | — | — | — |
| 4 | Thyme Care 🦄 Provider of home nursing care services | $178M | 14 mo ago | 123 | 2020 | Series D | HubSpot CMS HubApple iCloud MailGoogle Workspace+26 | — | 3 job openings |
| 5 | Digital Reasoning AI-based consumer behavior analysis for banks and financial institutions | $128M | 76 mo ago | 97 | 2000 | Acqui-Hired | — | 57 patents AI-driven risk analytics and compliance monitoring for multilingual financial communications | — |
| 6 | Specialty Networks Radiology imaging solution | $95M | 100 mo ago | 136 | 2004 | Series C | — | — | — |
| 7 | MModal Provider of speech based documentation and transcription solution | $81M | 99 mo ago | 3,028 | 1998 | Acquired | — | 192 patents Automated clinical documentation, coding, and workflow tools for medical speech dictation and data reconciliation. | — |
| 8 | XSOLIS AI-based platform for physicians and payers to analyze denial management | $75M | 59 mo ago | 166 166 → 244 (+47%) · sector median +34% | 2013 | Series C | WordPressSentryApple iCloud Mail+26 | — | — |
| 9 | Lirio Provider of an AI-based patient engagement and health management software for payers and doctors 62Funding top 22%AI top 30%Moat top 36%Growth top 40% All 9 signals ▾Fundingtop 22% AItop 30% Moattop 36% Growthtop 40% Techtop 44% Newsbottom 47% Marketbottom 46% Talentbottom 41% Globalbottom 37% Funding: Raised $54.4M across 10 rounds · 10 rounds over 7 yrs (1.4/yr) AI: Classified as an AI company · Product described with: ai-based rank vs industry peers · Fliar Intelligence Index 62/100 | $54M | 1 mo ago | 94 94 → 113 (+20%) · sector median +34% | 2017 | Series C | WordPressApple iCloud MailMicrosoft 365+33 | — | — |
| 10 | axialHealthcare Cloud-based risk and pain management tool for healthcare professionals | $45M | 75 mo ago | 85 | 2012 | Series C | — | — | 2 job openings · 2 awards |
| 11 | I-O Urology Remote patient monitoring system for urology | $35M | 26 mo ago | — | 2020 | Series A | — | — | — |
| 12 | myNEXUS Provider of patient health benefit management and remote monitoring platform for healthcare providers | $32M | 68 mo ago | 222 | 2014 | Acquired | — | — | — |
| 13 | Stratasan Providing SaaS platform for healthcare market intelligence. | $28M | 83 mo ago | 87 | 2010 | Acquired | — | — | — |
| 14 | MindCare Solutions Tele-behavioral health solution for the providers | $28M | 59 mo ago | 75 75 → 123 (+64%) · sector median +34% | 2013 | Series A | WordPressMySQLPHP+23 | — | 1 job opening |
| 15 | Reimagine Care Provider of in-home cancer care and nursing services | $25M | 7 mo ago | 23 | 2020 | Series A | — | — | 1 job opening · 2 partnerships · 1 expansion |
| 16 | Shareable Ink Cloud-based platform for digitization of clinical documentation | $25M | 132 mo ago | — | 2009 | Deadpooled | — | — | — |
| 17 | Optura AI orchestration platform built for the healthcare industry 32Funding top 24%Talent top 38%Tech bottom 44%Global bottom 33% All 5 signals ▾Fundingtop 24% Talenttop 38% Techbottom 44% Globalbottom 33% Marketbottom 31% Funding: Raised $24.0M across 2 rounds · 2 rounds over 1 yrs (2.0/yr) Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 32/100 | $24M | 2 mo ago | — | 2024 | Series A | WordPress Block EditorWordPressApple iCloud Mail+18 | — | — |
| 18 | CareHarmony Provider of the patient-centric chronic care management platform | $17M | 46 mo ago | 64 | 2015 | Series A | WordPressApple iCloud MailMicrosoft 365+28 | — | — |
| 19 | Echo Therapeutics SDY prediction platform offering insights for lottery enthusiasts | $17M | 121 mo ago | 17 | 1989 | Series B | — | — | — |
| 20 | RemitDATA Providing reimbursement, utilization, and productivity solutions to healthcare providers | $16M | 130 mo ago | 56 | 2000 | Acqui-Hired | — | 2 patents Automated analysis of electronic remittance notices for payment processing. | — |
| 21 | Psych Hub Online platform offering video-based content for mental health management | $16M | 45 mo ago | 10 | 2018 | Series A | Builder.ioZohoPHP+30 | — | 1 partnership |
| 22 | Spiras Health Home-based polychronic care improving health outcomes and reducing costs | $14M | 59 mo ago | 37 37 → 65 (+76%) · sector median +34% | 2015 | Series B | WordPress Block EditorWordPressApple iCloud Mail+22 | — | — |
| 23 | ingagepatient RegisterPatient received venture funding and hired an executive management team with Healthcare IT expertise… 7Funding top 38%Global bottom 30%Tech bottom 23%Market bottom 14% All 4 signals ▾Fundingtop 38% Globalbottom 30% Techbottom 23% Marketbottom 14% Funding: Raised $13.5M · 5 rounds over 16 yrs (0.3/yr) Global: Single-market focus (United States) rank vs industry peers · Fliar Intelligence Index 7/100 | $14M | 118 mo ago | 11 | 2009 | Deadpooled | — | — | — |
| 24 | emids Provider of digital transformation solutions across the healthcare and life science ecosystem | $13M | 75 mo ago | 347 | 1999 | Acquired | WordPress Block EditorWordPressApple iCloud Mail+31 | — | — |
| 25 | Trilliant Health Provider of healthcare analytics platform for the healthcare industry | $13M | 58 mo ago | 113 113 → 110 (-3%) · sector median +34% | 2015 | Series A | HubSpot CMS HubSentryEnvoy+23 | — | — |
| 26 | MedCenterDisplay Patient engagement solutions for healthcare facilities | $12M | 131 mo ago | 26 | 2008 | Acqui-Hired | — | — | — |
| 27 | Censis Provider of a SaaS-based surgical instrument tracking and workflow solutions for healthcare providers | $12M | 91 mo ago | 128 128 → 156 (+22%) · sector median +34% | 2001 | Acquired | HubSpot CMS HubSentryZendesk+36 | — | — |
| 28 | Lincor Developer of solutions for patient engagement | $12M | 72 mo ago | 26 | 2003 | Series A | — | — | — |
| 29 | Hashed Health Consortium of healthcare companies leveraging blockchain | $11M | 55 mo ago | 5 | 2016 | Series A | — | — | — |
| 30 | Evermind Plugs for monitoring the elderly | $11M | 128 mo ago | 5 | 2012 | Deadpooled | — | 5 patents Digital mental‑health treatment devices and passive physiological monitoring systems | — |
| 31 | Contessa Health Care coordination solutions for home-based recovery & bundled payments | $10M | 98 mo ago | 160 160 → 112 (-30%) · sector median +34% | 2014 | Acquired | WordPress Block EditorBeaver BuilderWordPress+35 | — | 1 partnership |
| 32 | Bridge Connector iPaaS for streamlined data integration and management for Healthcare organizations | $10M | 70 mo ago | 88 | 2017 | Series B | — | — | — |
| 33 | EvidenceCare Digital clinical workflow management tool | $9M | 15 mo ago | 38 | 2014 | Series B | WordPress Block EditorwpBakeryWordPress+32 | — | 1 partnership |
| 34 | Concert Provider of payment accuracy solutions for laboratory diagnostics and therapies | $9M | 101 mo ago | 25 25 → 50 (+100%) · sector median +34% | 2010 | Series B | — | 139 patents Dermatological topical formulations and digital media content tagging/recommendation systems | — |
| 35 | Azra AI and machine learning to automate oncology workflows | $8M | 12 mo ago | 26 | 2022 | Series A | HubSpot CMS HubEnvoyBootstrap+18 | — | 1 launch |
| 36 | Agilum Healthcare Revenue integrity and 340B management solutions for healthcare financial performance | $8M | 132 mo ago | 14 | 2005 | Acquired | — | — | — |
| 37 | Medaxion Mobile-based EHR for anesthesiologists | $8M | 96 mo ago | 28 | 2008 | Seed | HubSpot CMS HubApple iCloud MailMicrosoft 365+18 | 11 patents Patents concentrated in computing, sensing & instrumentation | — |
| 38 | SimplifyASC Platform for practice reputation management | $8M | 76 mo ago | 32 | 2004 | Acquired | — | — | — |
| 39 | Thrive Health Tech Provider of patient and benefit management solutions for providers and employees | $7M | 10 mo ago | — | 2022 | Seed | SanityTurbopackNode.js+10 | — | — |
| 40 | Medalogix Provider of predictive modeling toolset for the post-acute health care agencies | $5M | 61 mo ago | 20 20 → 30 (+50%) · sector median +34% | 2009 | Series A | WordPressApple iCloud MailMicrosoft 365+25 | — | 1 launch |
| 41 | Flexwise Health Online staffing platform connecting nurses and other healthcare professionals | $5M | 40 mo ago | 14 | 2017 | Acquired | — | — | — |
| 42 | Clariture Digital marketing platform for healthcare organizations | $5M | 15 mo ago | 16 | 2013 | Series B | — | — | — |
| 43 | Infusense Provider of biosensor technology for measuring drug levels in patients | $4M | 13 mo ago | 7 | 2009 | Seed | — | 6 patents Molecular detection biosensors and assay chemistries for identifying target compounds | — |
| 44 | UnityAI Developer of AI solutions for streamlining healthcare operations and workflows | $4M | 3 mo ago | — | 2023 | Series A | WebflowApple iCloud MailGSAP+10 | — | — |
| 45 | ClarisHealth Provider of AI-enabled payment integrity platform | $4M | 29 mo ago | 138 138 → 135 (-2%) · sector median +34% | 2013 | Seed | WordPressMySQLPHP+26 | — | 1 job opening |
| 46 | CareEco Provider of AI-powered revenue cycle management solutions for healthcare | $4M | 14 mo ago | — | 2019 | Seed | Cart FunctionalitySquarespace CommerceSquarespace+14 | — | — |
| 47 | Ursa Health Provider of healthcare analytics platform for clinics data management | $2M | 49 mo ago | 17 | 2015 | Series A | HubSpot CMS HubBootstrapAmazon Web Services+21 | — | 1 job opening |
| 48 | MiCare Path Cloud-based health management tool for payers and providers | $1M | 6 mo ago | 25 | 2019 | Series A | WordPressMySQLPHP+19 | — | 1 internship |
| 49 | Ludi Provider compensation and contract management software for healthcare organizations | $1M | 30 mo ago | 8 | 2012 | Series A | WordPressMySQLPHP+37 | 7 patents Provides a semantically‑rich data model and APIs for contextual web application development. | — |
| 50 | MSKai AI-powered spinal imaging platform for surgical outcomes | $375K | 13 mo ago | — | 2021 | Seed | — | — | — |
Top 12 Healthcare IT companies in Tennessee
#1
Series C · Knoxville, Tennessee · founded 2017 · 94 employees$54.4Mraised▾
Provider of an AI-based patient engagement and health management software for payers and doctors. The platform adapts to clinical history and social context, automating personalized communications. It facilitates engagement and navigation, aiming to close care gaps. The platform supports individualized healthcare experiences through dynamic communications. It helps individuals enroll, engage, and navigate the healthcare journeys.
- Apr 2026Series C$1.6M
- Sep 2023Series C$27M
- Jul 2022Series B$3M
- May 2022Series B$14.4M
#2
Series A · Nashville, Tennessee · founded 2024$24Mraised▾
AI orchestration platform built for the healthcare industry. It is targeting payers such as health plans, pharmacy benefit managers, and tech-enabled service organizations to scale enterprise productivity and deliver rapid, measurable ROI.
- Mar 2026Series A$17.5M
- May 2025Seed$6.5M
#3
Series D · Nashville, Tennessee · founded 2020 · 123 employees$178Mraised▾
Provider of home nursing care services
- Apr 2025Series D$97M
- Jul 2024Conventional Debt$40M
- Jul 2024Series C$55M
- May 2024Series B—
#4
Series A · Nashville, Tennessee · founded 2020 · 23 employees$25Mraised▾
Provider of in-home cancer care and nursing services
- Nov 2025Series A$2.4M
- Jan 2024Series A—
- Oct 2023Series A—
- Dec 2021Series A$25M
#5
Series A · Nashville, Tennessee · founded 2023$4Mraised▾
Developer of AI solutions for streamlining healthcare operations and workflows. The company’s integrated AI simplifies core workflows to coordinate actions and advance patient care. It improves efficiency, quality, satisfaction, and patient experience by enabling organizations to work as one team. The AI optimizes staffing and scheduling, improves revenue capture, and manages capacity across facilities.
- Mar 2026Series A$8.5M
- Feb 2024Seed$4M
#6
Seed · Nashville, Tennessee · founded 2022$7Mraised▾
Provider of patient and benefit management solutions for providers and employees. The solutions provided by the company include patient engagement software for doctors, benefits, and perks management for employees.
- Aug 2025Seed$5M
- May 2023Seed$7M
#7
Series A · Franklin, Tennessee · founded 2022 · 26 employees$7.9Mraised▾
AI and machine learning to automate oncology workflows. It offers an AI powered oncology solution that automatically identifies, classifies, and abstracts cancer diagnoses and incidental findings from pathology and radiology reports. It manages oncology operations clinically, financially, and operationally. The features include cancer patient identification, generate, and manage radiology reports, populate data, compliance management, and more.
- Jun 2025Series A$1.9M
- Dec 2024Series A$6M
#8
Series B · Nashville, Tennessee · founded 2014 · 38 employees$9.2Mraised▾
Digital clinical workflow management tool. Their patent-pending technology works independently or can be integrated with the EMR to enhance the workflow of the Providers, allowing them to risk-stratify their patients and obtain treatment recommendations that are specific to their patient’s condition. In addition, they present data in a graphical format that is easy to share with patients and allows them to understand their treatment course. Their Enterprise solution allows hospitals to leverage their content base and provides them with the resources to easily create custom content unique to their organization. In addition, they offer multiple ways to integrate documentation with the EMR.
- Mar 2025Series B$15.4M
- Sep 2023Series A$640K
- May 2020Series A$579.6K
- May 2019Series A—
#9
Series D · Nashville, Tennessee · founded 2021 · 5 employees$504.9Mraised▾
Value-based healthcare company focused on serving rural areas. It assists clinic providers with care coordination activities including preventive screenings, scheduling patients for primary care visits and providing the clinic with the data and opportunities they need to succeed in value-based care solutions in rural America.
- Oct 2023Series D$315M
- May 2023Series D$189.9M
#10
Seed · Nashville, Tennessee · founded 2009 · 7 employees$4.4Mraised▾
Provider of biosensor technology for measuring drug levels in patients. The company offers "HemaSense" a first-in-class, hand-held device that can be used by physicians to measure drug levels directly from a drop of blood or saliva, without sample processing.
- May 2025Seed$1.4M
- Mar 2025Grant (prize money)$1.2M
- Jun 2023Grant (prize money)$1M
- Aug 2021Grant (prize money)$253.6K
#11
Series A · Memphis, Tennessee · founded 2019 · 25 employees$1.3Mraised▾
Cloud-based health management tool for payers and providers. The software assists with concierge care and management. It has features for patient education, feedback, a billing dashboard, and more for providers. Payers can use the platform for doctor viss, hospital cost management, treatment analysis, and more.
- Nov 2025Series A—
- Mar 2021Seed$1.3M
#12
Seed · Brentwood, Tennessee · founded 2019$3.7Mraised▾
Provider of AI-powered revenue cycle management solutions for healthcare. It offers tools to identify and recover missed revenue, improve coding accuracy, manage denials, and analyze underpayments. The platform uses a proprietary AI engine to analyze claims across clinical, coding, billing, and contractual contexts, ensuring accurate and timely payments. It also provides tools for billing error correction, modifier management, and level of service optimization. Further capabilities include payor contract analysis and identification of new revenue opportunities. The system aims to improve healthcare revenue operations and increase operational efficiency.
- Apr 2025Seed$2.5M
- Sep 2024Seed$345K
- Feb 2024Seed$654.4K
- Sep 2020Seed$240K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare IT coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Tennessee is moving
A read on the academic research around Digital Health in Tennessee — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 41 papers.
Tennessee's UTHSC, UT Knoxville, and ETSU predominantly research AI/ML integration and EHR systems in healthcare, with cautiously optimistic advancement findings dominating recent post-2020 output.
- University of Tennessee Health Science Center15
- University of Tennessee at Knoxville14
- East Tennessee State University4
- Tennessee Department of Health3
- VA Tennessee Valley Healthcare System3
- Public health2
- Memphis1
- Pandemic1
- Health informatics1
- Public health informatics1
- Health informatics5
- Health care5
- Telemedicine4
- Public health3
- Data science3
- Health informatics3
- Health care3
- Public health3
- Health administration2
- Nursing research2
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.