Best High Tech Companies in Durham, United States
The 44 best High Tech companies in Durham, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Restor3D.
Our analysis of 306 High Tech companies
$95.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best High Tech companies in Durham
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Restor3D Developer of 3D printing technology to reconstruct human bodies | $114M | 12 mo ago | 146 | Andrew Miller Co-Founder & COO | WordPressApple iCloud MailMySQL+24 | Top 5M | 32 patents Patents concentrated in health & consumer products | — |
| 2 | Asensus Developer of robotic laparoscopic system | $91M | 115 mo ago | 418 418 → 299 (-28%) | Anthony Fernando CEO | DrupalPHPAcquia Cloud Platform+23 | Top 10M | — | — |
| 3 | ndustrial Provider of energy management solutions for industrial and cold chain operations | $26M | 19 mo ago | 40 | Jason Massey Co-Founder & CEO | — | — | 15 patents IoT sensor provisioning and onboarding for wireless communication networks | — |
| 4 | TransLoc Platform offering end-to-end software solutions for micro transit operators | $8M | 124 mo ago | 82 82 → 128 (+56%) | — | WordPressApple iCloud MailMicrosoft 365+31 | Top 5M | 4 patents Real-time public transit route information display and delivery systems | 2 launchs |
| 5 | Alievio Developer of a glaucoma drainage device | $6M | 100 mo ago | — | Ray Krauss CEO | — | — | 2 patents Glaucoma treatment devices for lowering intraocular pressure | — |
| 6 | Alleviate Health Provider of AI-powered platform for clinical research participant recruitment workflows | $4M | 10 mo ago | — | Saathvik Boompelli Co-Founder | — | — | — | — |
| 7 | Fathom Provides sensor technology for athlete injury recovery & performance analysis | $3M | 101 mo ago | 4 | Gabrielle Levac Co-Founder | — | — | 9 patents Additive manufacturing platforms for custom 3D objects and on‑demand injection mold fabrication with automated pricing. | — |
| 8 | PranaQ Provider of AI-based wearable tracking device for sleep apnea | $3M | 44 mo ago | 17 | Jerry Chen Co-Founder & Ceo | WordPressMySQLPHP+30 | Top 10M | — | — |
| 9 | Wolfspeed Provider of radio frequency-based ICs | $2M | 28 mo ago | 4,802 | John Palmour Co-Founder & CTO | HashnodeSalesforceYouTube+23 | Top 5M | 1,178 patents Silicon carbide power electronics, RF device packaging, and advanced semiconductor manufacturing processes. | 1 launch · 1 partnership · 1 award |
| 10 | Protect3d Provider of 3D-printed products for sports applications | $2M | 19 mo ago | 10 | Clark Bulleit Co-Founder | WordPressApple iCloud MailMySQL+26 | Top 10M | 18 patents Customizable orthopedic braces and protective devices, including adjustable and 3D‑printed orthoses. | — |
| 11 | MGT Capital Investments Cryptocurrency mining firm | $2M | 4 mo ago | 2 | Robert Ladd President and CEO | — | — | — | — |
| 12 | Polaris Quantum Biotech Developer of a AI and quantum computing-based drug discovery platform | $2M | 60 mo ago | 13 13 → 9 (-31%) | Bill Shipman Co-Founder | — | — | — | — |
| 13 | BioMedomics Point of care diagnostic systems for blood-based disorders | $1M | 109 mo ago | 14 14 → 12 (-14%) | — | WordPressMySQLPHP+17 | Top 50M | 16 patents Nanotube-enhanced lateral flow immunoassays for rapid hemoglobin variant detection | — |
| 14 | FarmShots Analytics suite for precision agricutlure based on satellite imagery | $1M | 119 mo ago | 12 | — | — | — | — | — |
| 15 | NeuroPlus Game-based application for training attention skills | $999K | 99 mo ago | 17 | — | — | — | — | — |
| 16 | PRSONAS AI digital workforce solutions providing scalable, multilingual, and accessible support | $524K | 122 mo ago | 22 | Charles Rinker Chief Executive Officer | — | — | — | — |
| 17 | Purillume Provider of smart LED bed light | $250K | 120 mo ago | 2 | Neeraj Lal Founder & President | — | — | 12 patents LED luminaire fixtures and lighting harp mounting hardware for energy-efficient lighting | — |
| 18 | Foresite.ai AI-based predictive analytics platform for commercial real estate properties | $120K | 91 mo ago | — | Victor Franco ex-Co-Founder | — | — | 22 patents Computational drug discovery platforms and Raman-based nucleic acid sequencing technologies. | — |
| 19 | BreeziPro Provider of predictive maintenance technology for HVAC systems | $100K | 107 mo ago | 4 | Tim Seaton Co-Founder & CEO | — | — | — | — |
Top 12 High Tech companies in Durham
#1
Series B · Durham, North Carolina · founded 2017 · 146 employees$114Mraised▾
Developer of 3D printing technology to reconstruct human bodies
- Aug 2025Series B$104M
- Jan 2025Conventional Debt$38M
- Jun 2024Venture Debt$15M
- Jan 2024Series A$55M
#2
Public · Durham, North Carolina · founded 1977 · 2 employees$2Mraised▾
MGT is a cryptocurrency mining firm. The company operates & manages Bitcoin mining farms. Investors can buy stocks of the company via a licensed stockbroker or an online trading account.
- Apr 2026Post IPO$25K
#3
Seed · Durham, North Carolina · founded 2023$4.3Mraised▾
Provider of AI-powered platform for clinical research participant recruitment workflows. The platform offers conversational engagement at scale, responding to participants quickly. It uses a library of conversations to maximize response rates. The platform adapts to different study requirements and indications. It facilitates pre-screening conversations via SMS and AI voice calls.
- Oct 2025Seed$4.3M
#4
Series B · Durham, North Carolina · founded 2015 · 40 employees$25.9Mraised▾
Provider of energy management solutions for industrial and cold chain operations. The company offers an energy intensity platform designed for production-first energy management. It provides solutions for load control, temperature monitoring, and shore power. The company aims to decrease costs and increase sustainable industrial operations through its platform and services.
- Jan 2025Series B—
- Aug 2024Grant (prize money)—
- Apr 2024Series B$20.1M
- May 2021Series A$6M
#5
Series A · Durham, North Carolina · founded 2021 · 10 employees$2.1Mraised▾
Provider of 3D-printed products for sports applications. It offers software for scanning. It allows users to collaborate with designers to create customized splints using 3D printing technology. It offers devices for the protection of collarbones, shoulders, sternums, ribs, fingers, thumbs, hands, wrists, legs, and feet.
- Jan 2025Grant (prize money)$1.3M
- Jul 2024Series A$1.7M
- May 2021Grant (prize money)$50K
- May 2021Seed$350K
#6
Acquired · Durham, North Carolina · founded 2006 · 418 employees$91.2Mraised▾
Developer of robotic laparoscopic system. It offers a minimally invasive digital laparoscopic platform that helps in the interaction between the surgeon and the patient. This system is used for general surgical procedures and laparoscopic gynecological surgery.
- Jan 2017Post IPO$5.2M
- Sep 2016Post IPO$115.7K
- Aug 2013Conventional Debt$2M
- Feb 2012Series B$15.2M
#7
Public · Durham, North Carolina · founded 2015 · 4802 employees$2.5Mraised▾
Provider of radio frequency-based ICs. It designs and develops GaN on silicon carbide technology. Its technology is deployed in the communication industry for RF communication and space exploration. It is also a manufacturer and distributor of silicon carbide diodes and MOSFETs for power conversion.
- Apr 2024Post IPO—
- Oct 2015Grant (prize money)$1M
- Jun 2015Grant (prize money)$1.5M
#8
Seed · Durham, North Carolina · founded 2021 · 17 employees$3Mraised▾
Provider of AI-based wearable tracking device for sleep apnea
- Dec 2022Seed$3M
#9
Series A · Durham, North Carolina · founded 2010$5.7Mraised▾
Alevio has developed a device for treating glaucoma to target intraocular pressure (IOP). The company has developed a small noninvasive device used to remove the intraocular pressure by draining the aqueous humor and enables the physicians to maintain the IOP by adjusting the pressure. The company claims that the outlet tube is as soft as a contact lens.
- Apr 2018Series A$5.7M
- Dec 2017Series A$2M
- Nov 2017Series A$3M
- Nov 2016Grant (prize money)$65K
#10
Acquired · Durham, North Carolina · founded 2004 · 82 employees$8Mraised▾
Platform offering end-to-end software solutions for micro transit operators. It provides software solutions for demand-responsive micro transit operators. It offers a suite of applications (includes management dashboards and mobile apps for passengers/rides & drivers) covering on-demand dispatching, passenger management, route planning and optimization, predictive modeling and big data analytics for simulations, GTFS data management (a tool to convert schedules to a standardized GTFS format).
- Mar 2016Series A$8M
#11
Seed · Durham, North Carolina · founded 2019 · 13 employees$2Mraised▾
Developer of an AI and quantum computing-based drug discovery platform. The platform utilizes the combination of quantum computing, machine learning, hybrid quantum mechanics, and molecular mechanics simulation. It provides information on human proteins, disease pathways, genetic mutations, and pathogens.
- Aug 2021Seed$2M
- Feb 2020Seed$485K
#12
Seed · Durham, North Carolina · founded 2015 · 4 employees$3Mraised▾
Provides sensor technology for athlete injury recovery & performance analysis. The sensor uses artificial intelligence technology and measures internal stress accumulated on tissues, recognizes fatigue, strain, and tissue tear conditions, and evaluates injury risk by analyzing workload ratios. It captures highlights and prioritizes areas of strength and weakness to plan rest, drills, and training sessions.
- Mar 2018Seed$3M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of High Tech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Semiconductors is moving in the United States
A read on the academic research around Semiconductors — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,739 United States-affiliated papers.
- Georgia Institute of Technology489
- IMEC343
- Intel325
- Purdue University West Lafayette218
- Industrial Technology Research Institute177
- Photonics56→121
- Photonic integrated circuit49→81
- Artificial neural network3→29
- Detector25→48
- Scalability53→73
- Photonics45→59
- Artificial neural network2→14
- Rapid single flux quantum2→12
- Detector20→29
- Image sensor2→11
- Photonics10→28
- Hardware security module6→13
- Thermal10→16
- Automotive industry2→8
- Photonic integrated circuit9→14
Where semiconductors is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing semiconductors patents in the United States
United States semiconductors patent filing is cooling — 112,775 filings from 8,000 assignees (2016–2025), led by IBM, Applied Materials, Intel; annual filings 11572→7675.
- IBM19691
- Applied Materials13119
- Intel11689
- Micron Technology10011
- Texas Instruments4804
- LAM RES4667
- Sandisk Technologies3051
- Qualcomm2897
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.