Best High Tech Companies in Missouri, United States
The 153 best High Tech companies in Missouri, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Aclara Technologies.
Our analysis of 306 High Tech companies
$95.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best High Tech companies in Missouri
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Aclara Technologies Connective platform for smart grid | $450M | 108 mo ago | 1,700 | — | — | — | 26 patents Smart grid communication, metrology, and security technologies for power distribution networks | — |
| 2 | The Climate Digital farming solutions to maximize results and empower farmers | $109M | 168 mo ago | 154 | — | Adobe Experience ManagerApple iCloud MailGoogle Workspace+22 | Top 1M | 1,778 patents Precision agriculture via satellite remote sensing for soil, water, and crop management | — |
| 3 | Capacity AI based information and data integration management solution | $86M | 10 mo ago | 102 | David Karandish Founder and CEO | WordPressApple iCloud MailGoogle Workspace+40 | Top 5M | 8 patents Agricultural tractor seating systems and refractory mortar/coating compositions for construction. | — |
| 4 | Balto AI-based real-time guidance tool for contact centers on cloud | $52M | 58 mo ago | 80 | Marc Bernstein Co-Founder & CEO | WordPress Block EditorWordPressApple iCloud Mail+48 | Top 5M | — | — |
| 5 | Stereotaxis Surgical robotics company advancing minimally invasive endovascular intervention for improved patient care | $52M | 72 mo ago | 122 122 → 193 (+58%) | — | DrupalPHPSalesforce+29 | Top 10M | 257 patents Magnetically guided robotic catheters for cardiac electrophysiology and remote interventional navigation | 1 launch |
| 6 | Kereos Provides biopharma developing nanotechnology therapeutics to target tumors | $27M | 176 mo ago | 2 | Gregory M. Lanza Co-Founder and Chief Scientific Officer | — | — | 26 patents Targeted cancer therapeutics using novel linker chemistries for drug conjugates | — |
| 7 | SentiAR Provider of a 3D visualization platform for interventional cardiac procedures 35Funding top 23%Moat top 25%Talent top 28%Patents top 34% All 9 signals ▾Fundingtop 23% Moattop 25% Talenttop 28% Patentstop 34% Innovationtop 37% Globalbottom 39% Marketbottom 25% Techbottom 22% Newsbottom 22% Funding: Raised $23.3M across 11 rounds · 11 rounds over 9 yrs (1.2/yr) Moat: Editorial + unicorn rating 7/10 · IP moat: 55 patents rank vs industry peers · Fliar Intelligence Index 35/100 | $23M | 1 mo ago | 8 | Michael Southworth Co-Founder | — | — | 55 patents AR-enabled intraoperative visualization and control for cardiac electrophysiology procedures | — |
| 8 | Site 1001 Mobile-first cloud based software for facility management tasks | $17M | 93 mo ago | 70 | — | — | — | — | — |
| 9 | SureCam Provider of fleet dash cameras and GPS vehicle tracking products | $12M | 29 mo ago | 67 | Max Hillman CEO | HubSpot CMS HubApple iCloud MailMicrosoft 365+26 | Top 1M | — | — |
| 10 | RF Controls Developer of RFID based identification systems for commercial applictions | $10M | 114 mo ago | 7 | Todd Spence Co-Founder & CAO | WordPressMySQLPHP+15 | Top 50M | 120 patents Patents concentrated in computing, sensing & instrumentation | — |
| 11 | Noonlight Provider of a personal safety mobile application | $10M | 78 mo ago | 16 16 → 33 (+106%) | Zach Winkler Co-Founder & CEO | WebflowApple iCloud MailZoho+19 | Top 5M | 14 patents Real-time emergency assistance platforms integrating alarm data processing and user safety communication. | 1 launch · 1 partnership |
| 12 | Aisle411 Provider of an AR-based indoor navigation solution for businesses | $9M | 149 mo ago | 11 | Matthew Kulig Co-Founder & CEO | — | — | 21 patents Indoor retail positioning and product location services using voice and mapping technologies | — |
| 13 | Brewer Science Manufacturer of the silicon based materials for the printed electronics devices | $8M | 198 mo ago | 404 404 → 452 (+12%) | — | WordPressApple iCloud MailMySQL+27 | Top 5M | 904 patents Patents concentrated in electrical & electronics | — |
| 14 | Acera Surgical Provider of synthetic electrospun scaffolds for regenerative medical applications | $6M | 92 mo ago | 98 | — | Apple iCloud MailMicrosoft 365Windows Server+12 | Top 10M | 55 patents Hybrid-scale fiber matrices for advanced tissue engineering and regenerative medical implants | 1 partnership |
| 15 | Nixtla AI based predictive analytics solutions for businesses | $6M | 6 mo ago | 10 | Federico Ramirez Co-Founder | Node.jsKaTeXRadix UI+22 | Top 5M | — | 1 launch |
| 16 | Nanova Biomaterials Developer of products based on nanofiber reinforced restorative composites | $6M | 168 mo ago | 27 | Hao Li CEO & President | — | — | 9 patents Anti‑migration surgical ligation clips and tissue anchoring devices for secure tissue fixation | — |
| 17 | Atomation Provider of software and hardware platform for IoT applications | $6M | 13 mo ago | 13 | Eran Keshet Co-Founder & CTO | — | — | — | — |
| 18 | Ezurio Provider of wireless modules, system-on-modules, single board computers, and antennas | $6M | 259 mo ago | 114 | Chris Shannon CEO | Cart FunctionalityApple iCloud MailMicrosoft 365+19 | Top 1M | — | — |
| 19 | Aker Smart farming calculators and tools for efficient land, resource, and profit management | $6M | 51 mo ago | 6 | — | — | — | 131 patents Patents concentrated in construction | — |
| 20 | Kenzen Developer of a smart patch for health monitoring | $5M | 64 mo ago | 24 | Sonia Sousa Co-Founder | WordPress Block EditorWordPressMySQL+13 | Top 50M | 6 patents Patents concentrated in health & consumer products | — |
| 21 | Textel Provider of a text and cloud-based customer support chatbot for enterprises | $5M | 69 mo ago | 85 | — | — | — | — | — |
| 22 | Prattle Analytics Watch live soccer matches today with HD quality for free | $4M | 112 mo ago | 30 | — | — | — | — | — |
| 23 | Bellwethr Developer of no-code AI platforms | $3M | 66 mo ago | 7 | — | — | — | — | — |
| 24 | NeuroLutions Developer of robotic glove controlled by brain | $2M | 16 mo ago | 9 | Eric Leuthardt Co-Founder | WordPressApple iCloud MailGoogle Workspace+27 | Top 5M | 70 patents BCI-driven neurorehabilitation and assistive orthotic devices for motor control and pain relief | — |
| 25 | Disruptel Provider of a search engine for products and video content | $2M | 64 mo ago | 9 | Alex Quinn Founder & CEO | — | — | 6 patents Advanced control systems for high‑speed printing and output device management | — |
| 26 | Innervo Technology Intraoral device for improving posture | $1M | 80 mo ago | 4 | — | — | — | 4 patents Palatal stimulation devices for intra‑oral balance therapy | — |
| 27 | OxyBand Advanced transdermal oxygen therapy for wound healing and tissue regeneration | $700K | 194 mo ago | 4 | Amie Franklin President & CEO | — | — | 44 patents Advanced wound care technologies: diffusion dressings, gas delivery, and infrared monitoring. | — |
| 28 | Applied Particle Technology Developer of environmental sensors for measuring aerosols in the air | $534K | 69 mo ago | 6 | — | WebflowApple iCloud MailMicrosoft 365+10 | Top 50M | — | — |
| 29 | Epigraph Provider of visualization solution for AR/VR applications | $500K | 67 mo ago | 17 | Bruno Guerreiro Co-Founder | WebflowThree.jsAmazon Web Services+27 | Top 50M | — | — |
| 30 | AppsCo Unified identity access management solutions software | $500K | 108 mo ago | 1 | Marko Jevtovic Co-Founder & COO | WordPressMySQLPHP+24 | Top 10M | — | — |
| 31 | SmartCare Consultant SmartCare is cloud-based technology which uses Sensor Fusion to aggregate data discretely collected through… | $350K | 141 mo ago | 11 | Bryan Jefferson CEO | — | — | — | — |
| 32 | redlyst Provider of facial biometrics system for access control and threat detection | $250K | 86 mo ago | — | Patrick Doherty Founder | — | — | — | — |
| 33 | Aware Vehicles Provider of an AI-based autonomous drone application | $225K | 96 mo ago | 3 | — | Google Font APICloudflareOpen Graph+1 | Top 50M | — | — |
| 34 | Dura Seal Coating Nanotechnology-based anti-corrosion coatings | $175K | 195 mo ago | — | Joe Johnston Founder | — | — | — | — |
| 35 | Simerse Provider of synthetic data solutions for AI models | $150K | 56 mo ago | 5 | — | — | — | — | — |
| 36 | Keybot Provides solution for visitor management | $120K | 99 mo ago | — | Daniel Dawson Co-Founder | — | — | — | — |
| 37 | Strayos Provider of cloud-based data analytics software for drone images | $100K | 55 mo ago | 18 | Ravi Sahu Founder & CEO | SentryZohoUbuntu+16 | Top 10M | — | — |
| 38 | Stratodyne Provider of aerial crop scouting platforms | $100K | 61 mo ago | 4 | Amit Pinnamaneni Co-Founder & CTO | — | — | — | — |
Top 12 High Tech companies in Missouri
#1
Series B · St. Louis, Missouri · founded 2017 · 8 employees$23.3Mraised▾
Provider of a 3D visualization platform for interventional cardiac procedures. Using a head-up display, it enables a clinician to see the anatomic model and allows for accurate and safe procedures.
- Apr 2026Series B$1.5M
- Apr 2025Series B$2.5M
- Apr 2023Series B$8.5M
- Apr 2021Series A$5.1M
#2
Series D · St. Louis, Missouri · founded 2017 · 102 employees$86.5Mraised▾
AI-based information and data integration management solution. It allows users to handle the company knowledge, enterprise search, knowledge management, knowledge sharing, and data integration management solutions. It uses artificial intelligence, natural language processing, and machine learning technologies. It also handles process automation solutions. It caters to solutions to asset management, banking, credit unions, education, mortgage, and wealth management solutions.
- Aug 2025Conventional Debt$50M
- Jul 2025Series D$42.6M
- Sep 2023Series D$182.4M
- May 2020Series C$38.9M
#3
Series A · Mexico, Missouri · founded 2021 · 10 employees$6Mraised▾
AI-based predictive analytics solutions for businesses. It provides a forecasting platform that offers software for assisting data scientists to deploy predictive pipelines by using artificial intelligence and machine learning technology. It enables users to forecast based on statistical and econometric methods.
- Dec 2025Series A$21.9M
- Apr 2023Series A$6.2M
- Jul 2022Grant (prize money)$100K
- 2021Seed$20K
#4
Seed · St. Louis, Missouri · founded 2014 · 13 employees$5.6Mraised▾
Atomation is dedicated to forming an IoT platform, incorporating both cloud-based analytics and mobile SDK for developers. It aims to help easily create smart objects enabling interaction with these objects, analytics based on them and real time decisions based on the results. It has clients in agriculture, medical, electricity and logistics space where it partners with the organizations to make the objects easily connect with cloud and draw real time insights from it.
- May 2025Seed$2.3M
- Feb 2022Seed$825K
- Nov 2020Seed$200K
- Sep 2020Seed$16.4K
#5
Series A · St. Louis, Missouri · founded 2007 · 9 employees$2Mraised▾
NeuroLutions is developing devices based on brain-computer interface technology restoring functions in patients disabled due to neurological injury. It is developing a robotic glove that the user can wear it on their hand and a headset.
- Feb 2025Series A$26.5M
- Sep 2022Grant (prize money)$2M
- Jun 2015Seed$1.1M
- Nov 2008Seed$625K
#6
Acquired · Hazelwood, Missouri · founded 1972 · 1700 employees$450Mraised▾
Aclara Technologies(owned by an affiliate of Sun Capital Partners) is a supplier of smart infrastructure solutions (SIS) to water, gas, and electric utilities globally SIS magnifies the benefits of networks that perform automated metering reading by incorporating a range of sensors, communications, and analytic technologies that let utilities monitor their distribution networks, optimize operations, respond to issues quickly, and preempt problems. Aclara’s Synergize RF electric network offers two-way communications and provides a connective platform for the smart grid. It acquired GE Energy Management’s grid solutions electricity meter business from General Electric Company.
- Jun 2017Conventional Debt$105M
- Aug 2016Conventional Debt$345M
#7
Series B · St. Louis, Missouri · founded 2013 · 67 employees$11.5Mraised▾
Provider of fleet dash cameras and GPS vehicle tracking products. The company offers camera options, including multicamera systems, front-facing, dual-facing, front and rear, and waterproof dash cameras. Features include GPS tracking, cloud storage, live streaming, and driver coaching. The company provides solutions for industries such as construction, oil, gas, mining, utility services, and moving companies.
- Jan 2024Series B$12.5M
- Jan 2024Conventional Debt$23.5M
- May 2022Series B$11.5M
#8
Series B · St. Louis, Missouri · founded 2017 · 80 employees$52Mraised▾
Offers an AI-based real-time guidance tool for contact centers on the cloud. It offers two solutions real-time coaching for agents along with the smart checklist, dynamic prompts, notification, sticky note, and leader board, Real-time management for managers with features agent performance analysis, win rate analysis, and trend analysis.
- Aug 2021Series B$37.5M
- Oct 2020Series A$10M
- Sep 2019Seed$3M
- Oct 2018Seed$1.2M
#9
Public · St. Louis, Missouri · founded 1990 · 122 employees$52Mraised▾
Surgical robotics company advancing minimally invasive endovascular intervention for improved patient care. It pioneers and globally leads in surgical robotics for minimally invasive endovascular intervention. The mission centers on discovering, developing, and delivering robotic systems, instruments, and information solutions for the interventional laboratory. These innovations empower physicians to provide exceptional patient care with robotic precision and safety, expand access to minimally invasive therapy, and enhance productivity, connectivity, and intelligence in the operating room. They focus on robotic magnetic navigation, cardiac ablation, electrophysiology, and endovascular procedures. The company aims to revolutionize surgical practice through innovation and technology, improving outcomes for patients with heart rhythm disorders and other endovascular conditions.
- May 2020Post IPO$15M
- Aug 2019Post IPO$25M
- Oct 2016Post IPO$24M
- May 2012Post IPO$18.5M
#10
Acquired · St. Louis, Missouri · founded 2006 · 154 employees$108.5Mraised▾
Digital farming solutions to maximize results and empower farmers. They offer an all-in-one digital farming solution, empowering farmers with data-driven insights and innovative ag tech. The platform connects crop data, enables field scouting, builds prescriptions, and analyzes yield data in real-time. They provide hardware like FieldView Drive to empower farming missions. Resources include guides, a knowledge center, blog, videos, and podcasts. They focus on secure data, maximizing time, staying ahead, and boosting profits. The company aims to help farmers sustainably increase productivity and profitability with digital tools, enabling informed decisions from planning to harvest. They combine digital tools with physical products to enhance farming profitability and sustainability. They partner with other digital farming tools to make the technology more open, accessible and impactful for farmers.
- Jun 2012Series C$50M
- Feb 2011Series B$40.2M
- Oct 2007Series A$14.7M
- Jan 2007Series A$3.6M
#11
Deadpooled · Saint Louis, Missouri · founded 1999 · 2 employees$27.2Mraised▾
Kereos provides biopharma developing nanotechnology therapeutics to target tumors for delivery and activation of therapeutic payloads. Their proprietary Kereos nanodroplet technology is composed of a perfluorocarbon (PFC) core, and a lipid monolayer surrounding the core. It has developed KER-1001 lead cancer therapeutic incorporates paclitaxel, a major cancer therapeutic drug, into the targeted nanodroplet. Its targeted delivery of paclitaxel increases efficacy and reduce side effects. It also provides KER-1002 is cancer therapeutic that incorporates a natural product that has anti-tumor efficacy in preclinical studies.
- Sep 2011Series B$1.1M
- May 2010Series B$5.7M
- Jun 2009Series B$887.1K
- Sep 2005Series B$19.5M
#12
Acquired · St. Louis, Missouri · founded 2016 · 6 employees$5.5Mraised▾
Smart farming calculators and tools for efficient land, resource, and profit management. This platform provides farmers with essential calculators and tools to optimize their operations. It focuses on empowering farmers to make data-driven decisions regarding land measurement, cost management, water usage, and profitability analysis. The platform offers tools such as acres to square meters converter, fuel cost calculator, tank volume calculator, and ROI calculator. By integrating simple math with insights from remote sensing and crop diagnostics, farmers can improve efficiency, reduce waste, and enhance overall farm performance. This is a B2C platform that helps in smart farming through data and calculators.
- Mar 2022Seed$2.4M
- Aug 2019Seed$2.6M
- Jun 2018Seed$571K
- May 2017Grant (prize money)$400K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of High Tech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Semiconductors in Missouri is moving
A read on the academic research around Semiconductors in Missouri — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 91 papers.
Missouri University of Science and Technology and peers optimistically advance 3D IC, TSV, and semiconductor materials research, with breakthroughs and advancements dominating an older, largely pre-2020 publication record.
- Missouri University of Science and Technology59
- University of Missouri–Kansas City24
- University of Missouri5
- Southeast Missouri State University3
- Integrated circuit9
- Three-dimensional integrated circuit8
- CMOS8
- Capacitance8
- Electronic circuit7
- Electronic engineering20
- Integrated circuit16
- Three-dimensional integrated circuit11
- Through-silicon via10
- CMOS7
- Benchmarking1
- Rendering (computer graphics)1
- Footprint1
- Integrated circuit1
- Context (archaeology)1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.