Best Native AI Companies in Colorado, United States
The 74 best Native AI companies in Colorado, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Crusoe.
Our analysis of 100 Native AI companies
$80.0b in tracked funding; 98% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Native AI companies in Colorado
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Crusoe 🦄 Operator of cloud platform providing infrastructure for artificial intelligence workloads 91Funding top 11%Partners top 23%Tech top 24%Moat top 26% All 10 signals ▾Fundingtop 11% Partnerstop 23% Techtop 24% Moattop 26% Markettop 27% AItop 30% Newstop 33% Growthtop 35% Talenttop 36% Globalbottom 39% Funding: Raised $577M across 14 rounds · 14 rounds over 7 yrs (2.0/yr) Partners: 1 partnership announcement in 12 mo (4 in 24 mo) · 8 contract events in 12 mo rank vs industry peers · Fliar Intelligence Index 91/100 | $577M | 4 mo ago | 242 | Cully Cavness Co-Founder | Amazon WebstoreWebflowSentry+36 | Top 100k | — | — |
| 2 | Cleerly Provider of an AI-driven platform for coronary artery disease assessment | $472M | 19 mo ago | 145 | James Min Founder & CEO | HubSpot CMS HubMaterial Design LiteStripe+14 | Top 5M | 215 patents AI-driven cardiovascular imaging analysis for plaque assessment and risk stratification | 1 job opening |
| 3 | Welltok Provider of cloud-based employee wellness platform | $312M | 62 mo ago | 305 | Scott Rotermund Co-Founder | — | — | 9 patents AI-driven personalized wellness program generation and adaptive nudging using synthetic health data | — |
| 4 | Outrider Provider of autonomous systems for automating yard operations at logistics hubs 64Funding top 18%AI top 20%Moat top 28%Patents top 37% All 12 signals ▾Fundingtop 18% AItop 20% Moattop 28% Patentstop 37% Growthtop 38% Producttop 41% Innovationtop 48% Techtop 50% Talentbottom 49% Marketbottom 46% Globalbottom 40% Newsbottom 21% Funding: Raised $262M across 7 rounds · 7 rounds over 9 yrs (0.8/yr) AI: Classified as an AI company rank vs industry peers · Fliar Intelligence Index 64/100 | $262M | 2 mo ago | 123 123 → 166 (+35%) | Andrew Smith Founder & CEO | WordPressMarkerZendesk+24 | Top 10M | 22 patents Autonomous heavy‑truck and trailer control, articulation sensing, and interchange zone management. | — |
| 5 | Quantum Metric 🦄 Provides product design analytics software | $250M | 65 mo ago | 187 187 → 464 (+148%) | Mario Ciabarra CEO | Founder | SanitySentryApple iCloud Mail+30 | Top 5M | 111 patents Digital experience monitoring and privacy-preserving session replay for web applications. | 1 award |
| 6 | AMP AI-based waste sorting robot developer | $178M | 37 mo ago | 90 | — | — | — | — | 1 partnership · 1 award |
| 7 | Unsupervised AI powered text data analytics platform for enterprises | $57M | 62 mo ago | 57 | Noah Horton Co-Founder & CEO | TurbopackApple iCloud MailGoogle Workspace+12 | Top 50M | 8 patents Advanced data subset comparison and DAG-based dataset decomposition for analytics | — |
| 8 | Slingshot Aerospace Provider of AI-based satellite tracking, space traffic coordination, and space modeling and simulation… 69AI top 22%Innovation top 27%Talent top 28%Patents top 32% All 11 signals ▾AItop 22% Innovationtop 27% Talenttop 28% Patentstop 32% Moattop 32% Fundingtop 35% Growthtop 35% Techtop 48% Globalbottom 38% Marketbottom 36% Newsbottom 21% AI: Classified as an AI company · Holds AI/ML patents (G06N-family CPC) Innovation: 30 patents (top 42% of patent-holders) · 24 filings since 2022 vs 6 in 2017-21 rank vs industry peers · Fliar Intelligence Index 69/100 | $35M | 17 mo ago | — | David Godwin Co-Founder | WebflowVimeoMicrosoft Advertising+15 | Top 5M | 30 patents Patents concentrated in computing, sensing & instrumentation | — |
| 9 | Josh.ai Developer of an artificial intelligence platform for smart home automation | $22M | 73 mo ago | 37 | Tim Gill Founder and CTO AI development projects | ZohoAnimate.cssYouTube+17 | Top 5M | — | 1 launch · 1 award |
| 10 | CodeBaby Developer of interactive avatars for business, education, and healthcare uses | $19M | 121 mo ago | 23 23 → 18 (-22%) | — | Cart FunctionalityWordPressNode.js+37 | Top 5M | 3 patents Preprocessing pipelines for generating natural‑language driven avatar representations | 1 partnership |
| 11 | Valyant AI Provider of digital tools for calculating income tax and superannuation | $17M | 38 mo ago | 20 | — | — | — | 10 patents AI-powered order processing, speech-to-text, and holographic interfaces for automated ordering | — |
| 12 | Payman AI Developer of an AI platform for banking transaction automation | $14M | 19 mo ago | — | Prashanth Reddy Co-Founder & Chief Technology Officer | WebflowApple iCloud MailRive+18 | Top 5M | — | — |
| 13 | Quadratic Visual data analytics platform | $11M | 9 mo ago | — | Peter Mills Co-founder & COO | SentryMonaco EditorRadix UI+22 | Top 1M | 78 patents Volumetric light‑sheet 3D printing using specialized photoinitiators and photohardenable resins | 1 launch |
| 14 | Exer Provider of AI-based app for tracking fitness activities | $11M | 43 mo ago | 11 | Sean Cook Co-Founder & CTO | WebflowAmazon Web ServicesHubSpot+21 | Top 5M | 5 patents AI-powered motion analysis and adaptive audio feedback for exercise/rehabilitation systems | — |
| 15 | RAIsonance AI-based medical diagnostic device and suite solution for the organization | $8M | 21 mo ago | 24 | Kitty Kolding Co-Founder & CEO | — | — | — | — |
| 16 | iLLUME Ai AI and cloud-based decision support and workflow management tool | $5M | 58 mo ago | 18 | — | — | — | 15 patents Advanced automotive lighting components: projector lamps, taillight modules, and heat‑resistant bulb shields. | — |
| 17 | Liminal Horizontal security for Generative AI | $5M | 7 mo ago | — | Steven Walchek Co-Founder & CEO | WebflowApple iCloud MailGoogle Workspace+24 | Top 5M | — | — |
| 18 | Luxonis Provider of AI and camera-enabled video analytics systems for multiple applications 50Tech top 25%Talent top 28%AI top 30%Growth top 35% All 12 signals ▾Techtop 25% Talenttop 28% AItop 30% Growthtop 35% Fundingbottom 49% Productbottom 45% Moatbottom 42% Innovationbottom 36% Globalbottom 32% Patentsbottom 29% Marketbottom 25% Newsbottom 21% Tech: 54 technologies across 5/8 capability areas · Cloud: Amazon S3, Amazon Ses Talent: 3 named leaders on record · 3 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 50/100 | $5M | 4 mo ago | 9 | Vlad Vyskocil Co-Founder | Cart FunctionalityShopifySentry+30 | Top 5M | 2 patents Automotive collision avoidance and safety systems for reducing vehicle crash probability. | 2 launchs · 1 partnership |
| 19 | Rippey AI Provider of AI & web-based document management solutions | $4M | 33 mo ago | 58 | Matt Motsick CEO | TypeScriptThree.jsZone.js+12 | Top 50M | — | — |
| 20 | Orion Provider of real-time risk intelligence for physical assets and locations | $4M | 7 mo ago | — | Rahul Thayil Founder & CEO | — | — | 158 patents Secure AI‑enhanced group communication platforms with encrypted, low‑energy audio streaming | — |
| 21 | Boulder Imaging Developer of machine vision inspection systems with artificial intelligence capabilities 40AI top 30%News top 38%Growth top 47%Tech top 47% All 8 signals ▾AItop 30% Newstop 38% Growthtop 47% Techtop 47% Talentbottom 49% Fundingbottom 45% Marketbottom 33% Globalbottom 32% AI: Classified as an AI company · Product described with: artificial intelligence News: 3 BI events in 12 mo (of 6 tracked, 2 types) · +200% YoY rank vs industry peers · Fliar Intelligence Index 40/100 | $2M | 2 mo ago | 40 40 → 85 (+112%) | Carlos Jorquera Founder & CEO | Cart FunctionalitySquarespace CommerceSquarespace+16 | Top 50M | — | — |
| 22 | AlchemyAPI Provider of API platform to analyze text, images, and, facial recognition | $2M | 145 mo ago | 18 | — | — | — | — | — |
| 23 | Picknik Ai Developer of robotics application platform and manipulation libraries for automation | $2M | 32 mo ago | 23 23 → 44 (+91%) | Dave Coleman Co-Founder & CPO | VarnishBootstrapGitHub Pages+22 | Top 1M | — | 1 launch |
| 24 | Merlin Mobility Provider of an ML-based automated driver safety system | $768K | 56 mo ago | 7 | — | — | — | — | — |
| 25 | OptTek Developer of simulation optimization software for government and commercial sectors | $746K | 194 mo ago | 20 | — | WordPressMySQLPHP+19 | Top 50M | — | — |
| 26 | EchoMind AI-based ultrasound diagnostic tool for providers | $270K | 46 mo ago | 5 | Casey Charlebois Co-Founder | — | — | — | 1 job opening · 1 launch |
| 27 | Inbuild Technologies Developer of AI-powered invoice processing software integrating with construction platforms | $125K | 36 mo ago | 10 | Ian Sharp Co-Founder & COO | — | — | — | — |
| 28 | Andia Provider of access management solutions for biometrics through blockchain | $120K | 84 mo ago | 6 | Jose Alberto Garcia Co-Founder | — | — | — | — |
Top 12 Native AI companies in Colorado
#1
Crusoe 🦄Series E · Denver, Colorado · founded 2018 · 242 employees$576.9Mraised▾
Operator of cloud platform providing infrastructure for artificial intelligence workloads. The company designs, builds, and operates infrastructure to power artificial intelligence. It offers managed inference, cluster management, and observability. The platform features high-performance compute, accelerated storage, and optimized networking. It provides support for open and open-source models. The company focuses on environmentally aligned power sources.
- Feb 2026Conventional Debt$300M
- Oct 2025Series E$1.4B
- Aug 2025Venture Debt$175M
- Jun 2025Venture Debt$750M
#2
Series D · Golden, Colorado · founded 2017 · 123 employees$262.2Mraised▾
Provider of autonomous systems for automating yard operations at logistics hubs. The integrated system includes management software, autonomous vehicles, and site infrastructure. It focuses on improving efficiency, safety, and sustainability within yard environments. The system aims to automate manual and repetitive tasks, reduce carbon footprint, and improve asset tracking.
- Apr 2026Series D$21.5M
- May 2024Series D$62.5M
- Jan 2023Series C$73M
- Oct 2020Series B$65M
#3
Series C · Denver, Colorado · founded 2016 · 145 employees$472.5Mraised▾
Provider of an AI-driven platform for coronary artery disease assessment. The platform quantifies atherosclerosis by measuring plaque volume, composition, length, and location. It evaluates stenosis severity and determines the likely presence or absence of ischemia. The software aims to reduce the need for additional testing and enhance diagnostic confidence.
- Nov 2024Series C$106M
- Aug 2022Series C$223M
- Mar 2022Series C$192M
- Jun 2021Series B$43M
#4
Early Stage · Louisville, Colorado · founded 1995 · 40 employees$2.4Mraised▾
Developer of machine vision inspection systems with artificial intelligence capabilities. The company’s software platform powers products to make intelligent decisions and adapt using artificial intelligence. The system can be trained as specialized needs evolve, avoiding development updates. The systems deliver detailed reports and high definition video records for forensics, comparison, and archiving. The company provides turnkey technology, project managers, trainers, and customer care.
- Apr 2026Unattributed—
- Oct 2016Unattributed$250K
- May 2014Conventional Debt$2M
- Oct 2013Conventional Debt$1.1M
#5
Series A · Littleton, Colorado · founded 2011 · 9 employees$4.8Mraised▾
Provider of AI and camera-enabled video analytics systems for multiple applications. Its product portfolio includes AI cameras, object detectors, modular cameras, chargers, motherboards, and accessories. Its offering includes 4k videos, thermal imaging, and motion detectors. It uses computer vision technology.
- Jan 2026Series A$2.8M
- Jul 2022Seed$2.8M
- Jul 2021Seed$2M
#6
Seed · Boulder, Colorado · founded 2022$11.3Mraised▾
Visual data analytics platform. It is a spreadsheet-based platform that helps users in scripting and visualizing data in real-time. The platform integrates AI, Python, and SQL, allowing users to collaborate on data analysis in the web browser.
- Sep 2025Seed$5.4M
- Apr 2024Seed$5.6M
#7
Series A · Denver, Colorado · founded 2017$5Mraised▾
Horizontal security for Generative AI. The platform offers horizontal security solutions for enterprises to leverage generative AI in multiple applications. Its platform enables organizations to maintain control over data privacy and security while leveraging AI technology.
- Nov 2025Series A$4M
- Jun 2024Series A$5M
- May 2024Series A$8M
- Aug 2023Seed—
#8
Seed · Windsor, Colorado · founded 2017$35.2Mraised▾
Provider of AI-based satellite tracking, space traffic coordination, and space modeling and simulation solutions. It provides users with a company, leveraging advanced space object tracking, artificial intelligence, astrodynamics, and data fusion to enhance awareness, improve operational efficiency, and reduce risk for all space operators.
- Jan 2025Grant (prize money)$1.9M
- Sep 2024Venture Debt$30M
- Dec 2017Seed$3.3M
#9
Seed · Denver, Colorado · founded 2022$3.5Mraised▾
Provider of real-time risk intelligence for physical assets and locations. It offers tools to track physical exposure and predict volatility. The company provides solutions for countering crises and eliminating threats. It delivers risk scores using millions of data sources. The company automates reactions to volatility with a network of on-site operatives. It offers financial modeling and country risk scores. Asset tables and personalized newsletters are also available.
- Nov 2025Seed$3.5M
- Nov 2025Grant (prize money)—
#10
Series A · Durango, Colorado · founded 2024$13.8Mraised▾
Developer of an AI platform for banking transaction automation. The platform facilitates payments, transfers, and account analysis through voice or text. It integrates with existing banking systems and validates actions against defined policies. The platform provides audit trails, compliance readiness, and security controls for regulated institutions.
- Oct 2024Series A$9.6M
- Aug 2024Seed$3M
- May 2024Seed$1.2M
#11
Seed · Greenwood Village, Colorado · founded 2020 · 24 employees$8.2Mraised▾
AI-based medical diagnostic device and suite solution for the organization. It provides products such as AudibleHealth Dx, Biometric SoundPass and MyAdvocate Long Covid.The features include a cough vocalization analyzer, biometric self-check software, a symptoms tracker app, and more. It also provide TestHub which is a web-based, integrated testing solution and a SaMD approach for COVID-19 testing with no swabs and more.
- Sep 2024Seed$563.8K
- Sep 2023Seed$5.2M
- May 2023Seed$1.9M
- Jan 2023Seed$100K
#12
Series C · Louisville, Colorado · founded 2015 · 90 employees$178Mraised▾
AMP Robotics has developed an artificial intelligence-based waste sorting robot which picks recyclable materials off a conveyor belt in mixed waste, construction & demolition waste, and e-waste facilities. AI-technology is used to identify the waste material and machine learning platform keeps record of types of materials identified. The operational data is captured and is analyzed in a web-based platform through graphs. Has a capability to perform 60-picks per minute, can work 3-shifts per day with 1-year payback period.
- May 2023Series C$8M
- Nov 2022Series C$91.2M
- Dec 2020Series B$55M
- Nov 2019Series A$16M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Native AI coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Artificial Intelligence in Colorado is moving
A read on the academic research around Artificial Intelligence in Colorado — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 40 papers.
- University of Colorado Boulder19
- University of Colorado System11
- University of Colorado Denver8
- Colorado State University6
- Colorado School of Mines3
- Inference3
- Task (project management)3
- Set (abstract data type)3
- Generalization2
- Forgetting2
- Convolutional neural network2
- Artificial neural network2
- Hyperspectral imaging1
- Pattern recognition (psychology)1
- Classifier (UML)1
- Transformational leadership1
- Adaptation (eye)1
- Climate change1
- Vulnerability (computing)1
- Resource (disambiguation)1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.