Best Native AI Companies in Tennessee, United States
The 36 best Native AI companies in Tennessee, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Digital Reasoning.
Our analysis of 100 Native AI companies
$80.0b in tracked funding; 98% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Native AI companies in Tennessee
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Digital Reasoning AI-based consumer behavior analysis for banks and financial institutions | $128M | 79 mo ago | Acqui-Hired | — | 2000 | — | 57 patents AI-driven risk analytics and compliance monitoring for multilingual financial communications | — |
| 2 | Lirio Provider of an AI-based patient engagement and health management software for payers and doctors 62Funding top 22%AI top 30%Moat top 36%Growth top 40% All 9 signals ▾Fundingtop 22% AItop 30% Moattop 36% Growthtop 40% Techtop 44% Newsbottom 47% Marketbottom 46% Talentbottom 41% Globalbottom 37% Funding: Raised $54.4M across 10 rounds · 10 rounds over 7 yrs (1.4/yr) AI: Classified as an AI company · Product described with: ai-based rank vs industry peers · Fliar Intelligence Index 62/100 | $54M | 4 mo ago | Series C | Michael West Chairman and CEO | 2017 | WordPressApple iCloud MailMicrosoft 365+33 | — | — |
| 3 | Azra AI and machine learning to automate oncology workflows | $8M | 15 mo ago | Series A | Chris Cashwell Founder & CEO | 2022 | HubSpot CMS HubEnvoyBootstrap+18 | — | — |
| 4 | IP Copilot AI-assisted platform to share ideas and create disclosures | $6M | 24 mo ago | Series A | Austin Walters Founder | 2023 | — | 4 patents Patents concentrated in electrical & electronics | — |
| 5 | Superwise Developer of a platform for AI governance and operations management | $4M | 78 mo ago | Acquired | John Leschorn Co-Founder & Chief Product Officer | 2017 | WordPressMySQLPHP+30 | — | — |
| 6 | UnityAI Developer of AI solutions for streamlining healthcare operations and workflows | $4M | 6 mo ago | Series A | Edmund Jackson Chief Executive Officer | 2023 | WebflowApple iCloud MailGSAP+10 | — | — |
| 7 | CareEco Provider of AI-powered revenue cycle management solutions for healthcare | $4M | 17 mo ago | Seed | Corey Johnson Co-Founder & CEO | 2019 | Cart FunctionalitySquarespace CommerceSquarespace+14 | — | — |
| 8 | Starseer Provider of AI exposure management platform securing AI model deployments | $3M | 13 mo ago | Seed | Carl Hurd Co-Founder & CTO | 2025 | HubSpot CMS HubApple iCloud MailGoogle Workspace+8 | — | — |
| 9 | Teaming Team leadership and coaching software provider | $2M | 69 mo ago | Seed | Stephen Franklin Co-Founder | 2019 | — | — | — |
| 10 | Tryharmony Developer of a GTM intelligence platform providing data-driven sales insights | $2M | 14 mo ago | Seed | Guillermo Sequeira Co-Founder | 2025 | VercelCloudflarecore-js+12 | — | — |
Top 12 Native AI companies in Tennessee
#1
Series C · Knoxville, Tennessee · founded 2017 · 94 employees$54.4Mraised▾
Provider of an AI-based patient engagement and health management software for payers and doctors. The platform adapts to clinical history and social context, automating personalized communications. It facilitates engagement and navigation, aiming to close care gaps. The platform supports individualized healthcare experiences through dynamic communications. It helps individuals enroll, engage, and navigate the healthcare journeys.
- Apr 2026Series C$1.6M
- Sep 2023Series C$27M
- Jul 2022Series B$3M
- May 2022Series B$14.4M
#2
Series A · Nashville, Tennessee · founded 2023$4Mraised▾
Developer of AI solutions for streamlining healthcare operations and workflows. The company’s integrated AI simplifies core workflows to coordinate actions and advance patient care. It improves efficiency, quality, satisfaction, and patient experience by enabling organizations to work as one team. The AI optimizes staffing and scheduling, improves revenue capture, and manages capacity across facilities.
- Mar 2026Series A$8.5M
- Feb 2024Seed$4M
#3
Series A · Franklin, Tennessee · founded 2022 · 26 employees$7.9Mraised▾
AI and machine learning to automate oncology workflows. It offers an AI powered oncology solution that automatically identifies, classifies, and abstracts cancer diagnoses and incidental findings from pathology and radiology reports. It manages oncology operations clinically, financially, and operationally. The features include cancer patient identification, generate, and manage radiology reports, populate data, compliance management, and more.
- Jun 2025Series A$1.9M
- Dec 2024Series A$6M
#4
Seed · Knoxville, Tennessee · founded 2025$3Mraised▾
Provider of AI exposure management platform securing AI model deployments. The platform empowers teams to secure AI deployments and generate audit-ready documentation. It supports various models, including open weights and internally developed ones. The platform offers features such as quick scans, visual comparisons, and dynamic probes to test for resiliency. It helps identify and fix risks, supporting forensics and detections throughout the AIOps lifecycle.
- Jul 2025Seed$2M
- Jul 2025Seed$1M
#5
Seed · Brentwood, Tennessee · founded 2019$3.7Mraised▾
Provider of AI-powered revenue cycle management solutions for healthcare. It offers tools to identify and recover missed revenue, improve coding accuracy, manage denials, and analyze underpayments. The platform uses a proprietary AI engine to analyze claims across clinical, coding, billing, and contractual contexts, ensuring accurate and timely payments. It also provides tools for billing error correction, modifier management, and level of service optimization. Further capabilities include payor contract analysis and identification of new revenue opportunities. The system aims to improve healthcare revenue operations and increase operational efficiency.
- Apr 2025Seed$2.5M
- Sep 2024Seed$345K
- Feb 2024Seed$654.4K
- Sep 2020Seed$240K
#6
Seed · Chattanooga, Tennessee · founded 2025$1.6Mraised▾
Developer of a GTM intelligence platform providing data-driven sales insights. The platform connects and analyzes sales and marketing data in real time. It offers dashboards, data synchronization, and answers to revenue-related questions. The platform provides tools to connect GTM stacks, enabling data management across teams.
- Jul 2025Seed$1.6M
#7
Acqui-Hired · Franklin, Tennessee · founded 2000 · 97 employees$128.2Mraised▾
AI-based consumer behavior analysis for banks and financial institutions. Its offering includes voice surveillance, employee communication analytics, healthcare automation for cancer detection, trading insight, and more.
- Jan 2020Series D$20M
- Sep 2019Series D—
- Feb 2019Series D$30M
- Mar 2018Series D$30M
#8
Series A · Columbia, Tennessee · founded 2023 · 1 employees$5.7Mraised▾
AI-assisted platform to share ideas and create disclosures. It leverages AI to summarize, classify, and tag disclosures. The platform also offers real-time prior art searches and prompts for idea submissions.
- Sep 2024Series A$5.7M
#9
Acquired · Nashville, Tennessee · founded 2017 · 29 employees$4.5Mraised▾
Developer of a platform for AI governance and operations management. The platform offers controls and runtimes for AI and agents. It provides support to accelerate AI deployment. The platform helps ensure governance, compliance, and ongoing enterprise support. It offers runtime safety to agentic applications.
- Mar 2020Seed$4.5M
#10
Seed · Nashville, Tennessee · founded 2019 · 6 employees$1.7Mraised▾
Cloud-based enterprise project management software provider. Provides solutions to build a better team with teaming's team operating system. It allows setting goals, host effective team meetings, work style coaching, feedback, and etc. Clients include Ambition, Beachy, Elastic, Olo, Planview, and Technology Advance.
- Dec 2020Seed$1.7M
#11
Seed · Memphis, Tennessee · founded 2023$50Kraised▾
Provider of AI-driven monitoring platform with automated response and action capabilities. The platform allows users to monitor messages, jobs, news, and other digital content. It responds with alarms or calls and can take automated actions. The platform uses a request, response, and action model. It enables users to receive alerts and automate tasks such as sending emails or applying for jobs.
- Seed$50K
#12
Deadpooled · Memphis, Tennessee · founded 2017—raised▾
Ajax Intel offers solutions for monitoring and analyzing client sentient in real-time and provides a sentiment score. It provides weekly snapshots of clients' mood and other emotional metrics and provides analytical insights. It product Emotion Variance Analyser(EVA) integrates with a CRM system and associates emails with a positive and negative score and uses natural language processing and machine learning for deriving insights. Its product is priced at $14.99 for a 6-month subscription.
- 2017Seed—
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Native AI coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Artificial Intelligence in Tennessee is moving
A read on the academic research around Artificial Intelligence in Tennessee — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 158 papers.
- University of Tennessee at Chattanooga139
- University of Tennessee at Knoxville12
- University of Tennessee Health Science Center2
- Middle Tennessee State University1
- Tennessee Cancer Specialists1
- Conformational isomerism1
- Prior probability1
- Dihedral angle1
- Dirichlet distribution1
- Context (archaeology)1
- Drone1
- Pollen1
- Pollination1
- Bee pollen1
- Categorization1
- Context (archaeology)2
- Class (philosophy)2
- Biomarker1
- Extracellular vesicles1
- Modalities1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.