Best SaaS Companies in Missouri, United States
The 56 best SaaS companies in Missouri, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals.
Our analysis of 50 SaaS companies
$3.4b in tracked funding; 88% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2020.
Ranked: Best SaaS companies in Missouri
| # | Company | Disclosed funding | Employees | Founded | Stage | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | bernstein-rein advertising Bernstein-Rein Advertising is an independent agency that connects brands with people. | — | 650 | 1964 | — | WebflowApple iCloud MailSharpSpring Ads+9 | Top 50M | — | — |
| 2 | solarity Solarity provides the healthcare industry with an automated medical record indexing solution. | — | 543 | 1995 | Acquired | — | — | 17 patents Nano-imprint lithography for advanced multi-junction photovoltaic structures and carrier collection | — |
| 3 | gfi digital GFI Digital is a computer hardware company. | — | 375 | 1999 | Private | Wix eCommerceWixSentry+18 | Top 10M | — | — |
| 4 | avala marketing group AVALA Marketing Group helps brands selling high consideration goods and services. | — | 97 | 1997 | Acquired | — | — | — | 1 partnership |
| 5 | gsi hosting GSI Hosting is a managed hosting service provider. | — | 75 | 1996 | Acquired | — | — | — | — |
| 6 | redcard RedCard is an information technology company providing data management and BPO services | — | 57 | 2006 | Acquired | — | — | — | — |
| 7 | motofuze MotoFuze powered by FuzeCast is revolutionizing the way automotive dealers ignite, engage, and influence… | — | 53 | 2013 | Acquired | — | — | — | — |
| 8 | guarded exchange Guarded Exchange is supplies fusion centers, corrections facilities with investigative software tools… | — | 51 | 2003 | Acquired | — | — | — | — |
Top 1 SaaS companies in Missouri
#1
Seed · St. Louis, Missouri · founded 2016—raised▾
Developer of a healthcare software designed to facilitate communication between care providers. The company's software facilitates secured and encrypted in-hospital, real-time communication for sensitive PHI and integrates seamlessly with the hospital's electronic medical records, enabling medical practitioners to significantly reduce the turnover time that would translate to more cases completed per day and make substantial cost-savings due to minimizing turnover inefficiency.
Funding & investor landscape
Market landscape — 10 sub-themes by coverage
Share of SaaS coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Cloud Computing in Missouri is moving
A read on the academic research around Cloud Computing in Missouri — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 85 papers.
University of Central Missouri, Missouri S&T, and UMKC lead optimistic (mean 0.59) cloud-computing research dominated by resource management and IoT/edge computing, with breakthroughs outpacing concerns 45-to-11.
- University of Central Missouri23
- Missouri University of Science and Technology18
- University of Missouri–Kansas City17
- Northwest Missouri State University10
- University of Missouri7
- Distributed computing1→7
- Scalability1→6
- Computer security1→3
- Software deployment6
- Analytics6
- Scalability6
- Microservices5
- Legacy system5
- Key (lock)1→4
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.