Best Sleep Medicine Companies in United States
The 131 best Sleep Medicine companies in United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: ResMed.
Ranked by disclosed equity funding and recent momentum, the 131 Sleep Medicine companies we're tracking across the United States have collectively pulled in $1.8 billion, a figure that tells you this field is past the proof-of-concept stage. The sector's projected CAGR sits at roughly 5.51%, driven by compounding demand from sleep deprivation, high stress, and extended screen time grinding against an under-resourced clinical infrastructure. Apnimed leads our directory at $208 million raised, with XII Medical and Nanit each at $75 million. So what separates the funded from the forgotten? Mostly clinical conviction and investor patience.
The funding mix here is telling. HHS and the National Science Foundation anchor the investor list alongside Aperture Venture Partners and Cleveland Clinic, which means a meaningful share of capital is grant-backed rather than purely venture-driven. No unicorns yet, and I'd argue that's honest, not a failure: this is a field where brotizolam-era pharmacological innovation and machine learning drug discovery are still earning their clinical credibility. Regulatory scrutiny, particularly the EU's tightening framework, adds friction for any company moving across markets. The revenue opportunity is real. But the path to it runs straight through evidence.
- NutraIngredients-USA
Ranked: Best Sleep Medicine companies in United States
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | ResMed Therapeutic devices to treat sleep apnea and respiratory disorders | $500M | 83 mo ago | 10,140 10,140 → 9,071 (-11%) | 1989 | Michael Farrell Chief Executive Officer | Amazon WebstoreWordPressApple iCloud Mail+34 | 346 patents Advanced CPAP/BiPAP devices with smart humidification, mask fit analytics, and cloud data management | 1 internship · 1 launch · 1 award |
| 2 | Apnimed Developer of small molecule based therapeutics for the treatment of obstructive sleep apnea 37Funding top 14%Growth top 28%Talent top 28%Moat top 35% All 12 signals ▾Fundingtop 14% Growthtop 28% Talenttop 28% Moattop 35% Producttop 40% Techbottom 49% Globalbottom 37% Patentsbottom 34% Marketbottom 32% Innovationbottom 21% Newsbottom 18% Customersbottom 3% Funding: Raised $208M across 9 rounds · 9 rounds over 7 yrs (1.3/yr) Growth: Web rank 10,000,000 → 5,000,000 YoY · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 37/100 | $208M | 2 mo ago | 13 | 2017 | Andrew Wellman Co-Founder | WordPressApple iCloud MailMySQL+21 | 2 patents Pharmaceutical solid‑form optimization and repurposed drug therapy for sleep‑apnea treatment | 1 job opening · 1 award |
| 3 | Respicardia Manufacturing implantable stimulation device to improve cardiovascular health by restoring natural breathing… | $157M | 102 mo ago | 68 68 → 96 (+41%) | 2006 | — | — | 47 patents Implantable neurostimulation leads for respiratory control and sleep‑apnea therapy | 1 job opening |
| 4 | Inspire Medical Developer of neurostimulation device to treat sleep apnea | $109M | 115 mo ago | 452 | 2007 | — | ContentfulApple iCloud MailMicrosoft 365+34 | 463 patents Implantable neurostimulation systems for diagnosing and treating sleep‑disordered breathing | — |
| 5 | Nanit Provider of smart baby monitoring systems with sleep and breathing analysis 74Funding top 19%Tech top 20%Moat top 24%Talent top 28% All 10 signals ▾Fundingtop 19% Techtop 20% Moattop 24% Talenttop 28% Producttop 30% Markettop 36% Customerstop 37% Growthbottom 47% Globalbottom 43% Newsbottom 33% Funding: Raised $75.0M across 5 rounds · 5 rounds over 10 yrs (0.5/yr) Tech: 73 technologies across 6/8 capability areas · Cloud: Amazon Cloudfront, Amazon Web Services rank vs industry peers · Fliar Intelligence Index 74/100 | $75M | 6 mo ago | 111 | 2014 | Andrew Berman Co-Founder | Cart FunctionalityShopifySentry+42 | — | 3 launchs · 1 award |
| 6 | XII Medical Developer of a device for the treatment of obstructive sleep apnea | $75M | 22 mo ago | 19 | 2021 | Garrett Schwab CEO | — | — | — |
| 7 | Invicta Medical Developer of a non-invasive device for sleep apnea and snoring | $73M | 38 mo ago | 6 | 2012 | Rick O'connor Chief Executive Officer | — | — | — |
| 8 | ApniCure Home use device for the treatment of sleep apnea | $71M | 123 mo ago | 22 | 2007 | — | — | 79 patents Patents concentrated in health & consumer products | — |
| 9 | Onera Developer of a wearable sleep monitoring system | $60M | 29 mo ago | 50 | 2018 | Pieter Ermers VP Research and Development & Founder | WebflowApple iCloud MailMicrosoft 365+14 | — | 1 partnership |
| 10 | Signifier Medical Technologies Provider of device and app for snoring and sleep-disordered breathing | $58M | 47 mo ago | 10 | 2015 | Akhil Tripathi Co-Founder & CEO | WordPressApple iCloud MailMicrosoft 365+28 | — | — |
| 11 | watermark medical Watermark Medical provides home sleep testing solutions to enhance ongoing patient care and sleep disorder… | $55M | 158 mo ago | 39 | 2008 | — | WebflowAmazon Web ServicesTypekit+15 | — | — |
| 12 | NovaSom Home sleep testing | $55M | 84 mo ago | 167 | 1992 | John Spitznagel CEO | — | — | — |
| 13 | Ebb Therapeutics Provider of IoT-enabled wearables for sleep monitoring | $45M | 113 mo ago | 13 | 2008 | Don Spence Member Board Of Directors | — | — | — |
| 14 | Sommetrics Innovative sleep health solutions using proprietary technology to treat sleep apnea | $37M | 110 mo ago | 16 | 2007 | — | — | 75 patents Airway management devices for pressure-controlled respiratory support and airway opening. | — |
| 15 | Sleepme Provider of sleep management systems | $37M | 52 mo ago | 21 21 → 23 (+10%) | 2007 | — | ShopifySentryZendesk+43 | 31 patents Adjustable thermal/acoustic bed zones for stress reduction, sleep enhancement, and weight loss | 1 expansion |
| 16 | Cryosa Provider of a therapeutic medical device for treating sleep disorders | $30M | 11 mo ago | 16 16 → 13 (-19%) | 2014 | — | Node.jsNextAuth.jsReact+10 | 50 patents Cryogenic adipose tissue ablation devices for obstructive sleep apnea treatment | — |
| 17 | ImThera Medical Implantable neurostimulation device for obstructive sleep apnea | $22M | 116 mo ago | 19 | 2008 | — | — | — | — |
| 18 | CleveMed Range of sleep testing devices and services | $19M | 118 mo ago | 33 | 1990 | — | WordPressMySQLPHP+25 | — | 1 partnership |
| 19 | SomnoMed Manufacturer of oral appliances for sleep apnea and related conditions | $17M | 52 mo ago | 43 | 2004 | — | Cart FunctionalityMagentoApple iCloud Mail+21 | — | — |
| 20 | Sana Developer of a wearable sleep inducer for individuals | $14M | 70 mo ago | 23 | 2015 | Richard Hanbury Chief Executive Officer | Cart FunctionalitySquarespace CommerceSquarespace+17 | — | — |
| 21 | ProSomnus Lower Jaw Advancement for Obstructive Sleep Apnea | $13M | 4 mo ago | 125 | 2016 | — | WordPressApple iCloud MailMicrosoft 365+28 | — | — |
| 22 | BioSpeech Biomedical applications of speech technology for better hearing and communication | $9M | 81 mo ago | 9 | 2004 | Jan Santen Founder | — | — | — |
| 23 | LinguaFlex Tongue retractor device for sleep apnea | $8M | 124 mo ago | 6 | 2005 | — | — | 67 patents Oral airway and tongue‑retraction devices for obstructive sleep apnea therapy | — |
| 24 | Brain Electrophysiology Laboratory Provider of neuroscience technologies for sleep management | $5M | 45 mo ago | 18 | 1980 | — | — | 13 patents Patents concentrated in health & consumer products | — |
| 25 | ReVENT Medical Implant for treatment of Obstructive Sleep Apnea | $4M | 173 mo ago | 10 | 2008 | Ed Gillis Founder & CTO | — | — | — |
| 26 | Zelegent Physician tools to treat sleep disorders | $3M | 80 mo ago | 6 | 2015 | — | — | 9 patents Implants and devices for minimally invasive soft‑palate suspension to treat obstructive sleep apnea | — |
| 27 | PranaQ Provider of AI-based wearable tracking device for sleep apnea | $3M | 42 mo ago | 17 | 2021 | Jerry Chen Co-Founder & Ceo | WordPressMySQLPHP+30 | — | — |
| 28 | RealSleep Developer of plant-based sleep medicine | $2M | 59 mo ago | 3 | 2019 | — | — | — | — |
| 29 | Dymedix Innovative sleep diagnostic sensors and sleep disorder testing equipment manufacturer | $2M | 172 mo ago | 11 | 1998 | James Moore President / CEO | — | 75 patents Wearable respiratory and physiological sensor systems for sleep and health monitoring | — |
| 30 | SilentAlert Monitor Home sensors which monitors activities of elderly people and alerts for emergency situation | $2M | 161 mo ago | 1 | 2011 | William Kaigler Founder & CEO | — | — | — |
| 31 | Siesta Medical Provider of minimally invasive sleep apnea treatment systems. | $2M | 170 mo ago | 6 | 2009 | Michael Kolber Co-Founder | Cart FunctionalityWixSentry+15 | — | — |
| 32 | Airing Revolutionary micro-CPAP device offering maskless, hoseless, cordless sleep apnea solution | $2M | 101 mo ago | 2 | 2015 | Stephen Marsh Founder | Squarespace CommerceSquarespaceVimeo+15 | — | — |
| 33 | NuCalm Neuroscience-backed app for stress relief, sleep, focus, and recovery | $2M | 102 mo ago | 12 | 2010 | — | Cart FunctionalityShopifyZURB Foundation+30 | — | — |
| 34 | Circadiance Remote patient monitoring and PAP products improving health and quality of life | $1M | 80 mo ago | 14 14 → 13 (-7%) | 2006 | David Groll Founder & CEO | Cart FunctionalityWordPressMySQL+29 | 14 patents Disposable cloth respiratory masks and airtight seal technologies for personal protection | — |
| 35 | Advanced Brain Monitoring Provider of neuro-diagnostics devices for researchers and clinical trials | $1M | 9 mo ago | 41 | 1997 | — | WebflowjQuery-pjaxMicrosoft Advertising+12 | 104 patents Neurodegenerative diagnostics, brain‑targeted personalized therapy, and precise positioning systems for neurosurgery | — |
| 36 | AeroCare Holdings Provider of medical devices for obstructive respiratory diseases and sleep apnea | $1M | 80 mo ago | 2,731 | 2002 | Steve Griggs CEO | — | — | — |
| 37 | InnoMed Technologies Products for respiratory disorders | $564K | 95 mo ago | 20 | 2001 | — | — | 38 patents Patents concentrated in health & consumer products | — |
| 38 | SomniFix Developer of non-invasive sleep aids for enabling breathing | $548K | 81 mo ago | 3 | 2014 | Nicholas Michalak Co-Founder & CEO | Shogun Page BuilderCart FunctionalityShopify+57 | — | — |
| 39 | Awarables Wearable and mobile app for sleep disorder identification & management via coaching and behavior modification | $500K | 117 mo ago | 3 | 2013 | Madhvi Upender Co-Founder & CEO | — | 6 patents Wearable sensor-based sleep stage detection and hypnogram visualization/analysis | — |
| 40 | NuSomnea Urinary biomarker for the diagnosis & management of OSA | $500K | 157 mo ago | — | 2012 | Michael Thomas Co-Founder & CEO | — | — | — |
| 41 | WhisperSom Provider of a sleep tracking and adaptive neuromodulation therapy devices | $430K | 65 mo ago | 8 | 2014 | Kevin Goldstein Co Founder | — | 13 patents Patents concentrated in health & consumer products | — |
| 42 | Anhelo Products for respiratory disease and sleep apnea | $410K | 150 mo ago | — | 2011 | — | — | — | — |
| 43 | Somnarus Diagnostic patch for sleep disorders | $347K | 56 mo ago | — | 2012 | Maria Merchant Founder | — | 13 patents Sleep apnea and respiratory effort monitoring devices for patient health tracking | — |
| 44 | NeuroLight Developer of neuromodulation devices for improved sleep and cognitive function | $256K | 45 mo ago | 5 | 2017 | Alexander Poltorak President and Founder | — | 5 patents Auditory neuromodulation devices for sleep induction and emotional response enhancement. | — |
| 45 | Smart Human Dynamics Developer of smart sensor devices for sleep quality monitoring | $252K | 35 mo ago | — | 2014 | Steve Dugan Founder & CEO | — | — | — |
| 46 | Zyppah Anti-snoring mouthguard solutions for better sleep and healthier relationships | $185K | 21 mo ago | 5 | 2012 | Jonathan Greenburg Founder & CEO | Cart FunctionalityShopifySentry+37 | — | — |
| 47 | FullEight Provider of products for sleep and restless leg relief | $115K | 24 mo ago | — | 2020 | Patrick Redmond Founder & CEO | — | — | — |
Top 12 Sleep Medicine companies in United States
#1
Series C · Cambridge, Massachusetts · founded 2017 · 13 employees$207.8Mraised▾
Developer of small molecule-based therapeutics for the treatment of obstructive sleep apnea. The company has developed a combination of Atomoxetine and Oxybutynin which reduces the obstructive sleep apnea severity. It targets the neurological control and activation of upper airway dilator muscles which improve respiration and oxygenation during sleep.
- Apr 2026Conventional Debt$50M
- Mar 2026Series C$25M
- Sep 2025Conventional Debt$35M
- Apr 2025Series C$16.5M
#2
Series D · New York City, New York · founded 2014 · 111 employees$75Mraised▾
Provider of smart baby monitoring systems with sleep and breathing analysis. The systems offer real-time safety notifications, video history, and personalized sleep coaching. Features include breathing motion monitoring without sensors and advanced sleep insights. The company provides a range of compatible accessories, including breathing wear and display screens. It also offers membership plans for expanded data and video history.
- Dec 2025Series D$50M
- Feb 2021Series C$25M
- May 2020Series C$21M
- May 2018Series B$14M
#3
Public · Dublin, California · founded 2016 · 125 employees$12.7Mraised▾
ProSomnus develops technologies for sleep and snore in the dental care setting. The company develops MicrO2, a device that alleviates snoring and symptoms of Obstructive Sleep Apnea. For individuals who snore during sleep, the device performs lower jaw advancement. The device offers tongue space with the ability to open and close during wear. The MicrO2 device holds the lower jaw in a slightly forward position, thus moves the throat tissues away from the back of the throat.
- Feb 2026Post IPO$38M
- Sep 2023Post IPO$10.1M
- Aug 2019Conventional Debt$50K
- May 2019Series A$3.5M
#4
Series B · Roseville, Minnesota · founded 2014 · 16 employees$29.8Mraised▾
Provider of a therapeutic medical device for treating sleep disorders. The company offers a minimally invasive medical device for the diagnosis and treatment of Obstructive Sleep Apnea (OSA).
- Jun 2025Series B$15M
- Sep 2021Series B$21.5M
- Jun 2020Series A$8.2M
#5
Series B · Ohio · founded 2021 · 19 employees$75Mraised▾
Developer of a device for the treatment of obstructive sleep apnea. The company's technology develops a minimally invasive neurostimulation device to alleviate sleep apnea and increases oropharyngeal airflow.
- Aug 2024Series B$45M
- Apr 2022Series A$30M
#6
Early Stage · San Diego, California · founded 1997 · 41 employees$1.2Mraised▾
Advanced Brain Monitoring develops mobile EEG hardware and software, integrating, analyzing and reporting multi-sensor data. The company offers B-Alert EEG Software, X-Series EEG Headsets, Sleep Profiler (to detect sleep-disordered breathing in the home), InsomniCare (web-based solution for diagnosis & treatment of chronic insomnia). The company received FDA clearance for its X-Series System.
- Sep 2025Grant (prize money)$325.7K
- Oct 2019Grant (prize money)$1.5M
- Sep 2018Grant (prize money)$410.6K
- Jul 2017Grant (prize money)$524.6K
#7
Series C · Palo Alto, California · founded 2018 · 50 employees$60.2Mraised▾
Developer of a wearable sleep monitoring system. The company offers a disposable patch device that consists of a wireless autonomous sensor and nanoelectronics to measure disturbances in sleep. The platform tracks the data from the device to analyze sleep patterns and diagnose sleep disorders.
- Jan 2024Series C$32.9M
- Oct 2022Grant (prize money)$49.8K
- Jul 2021Series B$12.4M
- Nov 2020Grant (prize money)$2.9M
#8
Series C · Portola Valley, California · founded 2012 · 6 employees$73.3Mraised▾
Developer of a non-invasive device for sleep apnea and snoring. The company's device controls the upper airway and allows self-calibrated therapy for each patient. An oral appliance is disclosed that provides electrical stimulation to a patient's tongue in a manner that prevents collapse of the tongue and/or soft palate during sleep.
- Apr 2023Series C$25M
- Oct 2022Series C$18.1M
- Nov 2021Series B$3.7M
- Jan 2018Series B$21M
#9
Public · San Diego, California · founded 1989 · 10140 employees$500Mraised▾
Therapeutic devices to treat sleep apnea and respiratory disorders. The roducts include Masks (Nasal pillows, Nasal masks, Full-face masks, Paediatric masks, and Non-vented masks), Devices (Range of CPAP, VPAP, Ventilators, etc), Humidifiers, and Accessories. It has also developed a non-contact sleep tracking system that helps users analyze and improve sleep. The system records the light, noise, and temperature conditions in the room, and syncs with smartphones to provide feedback and suggestions.
- Jul 2019Conventional Debt$500M
- Oct 2016Post IPO—
#10
Series D · Needham, Massachusetts · founded 2015 · 10 employees$58Mraised▾
Provider of device and app for snoring and sleep-disordered breathing. The company offers its proprietary product eXciteOSA which is non-invasive solutions for patients suffering form sleep-disordered breathing conditions and snoring. The company uses the genioglossal muscle-neurostimulation technology and electrical stimulation to target the oral muscle stimulation.
- Jun 2022Series D$21.3K
- Jul 2021Series D$35M
- May 2020Series C$16.2M
- Sep 2018Series C$1.3M
#11
Acquired · Minnetonka, Minnesota · founded 2006 · 68 employees$157.4Mraised▾
Respicardia is dedicated to improving the lives of heart failure patients by developing implantable therapies designed to improve respiratory rhythm management and cardiovascular health. The first product, the remedē System, is an implantable stimulation device that is designed to restore a more normal breathing pattern during sleep for patients with central sleep apnea. he remedē System includes wires for sensing and stimulation, a neurostimulation device, and a portable tablet programmer. Central Sleep Apnea and Heart Failure Heart failure patients have a 1 in 3 chance of having Central Sleep Apnea. Central Sleep Apnea (CSA) is often silent, with symptoms similar to heart failure such as fatigue, poor energy, and nocturia. CSA worsens heart failure progression, decreases quality of life, and increases mortality rates. Treatment of CSA has the potential to improve heart failure symptoms and outcome
- Dec 2017Series D$58.5M
- Jun 2017Series C$5.1M
- Oct 2014Series C$25.1M
- Aug 2014Series C$5M
#12
Public · Maple Grove, Minnesota · founded 2007 · 452 employees$109Mraised▾
Developer of neurostimulation device to treat sleep apnea. The company uses neurostimulation technologies and incorporates a proprietary algorithm that stimulates key airway muscles based on a patient’s unique breathing patterns to treat Obstructive Sleep Apnea.
- Nov 2016Series F$37.5M
- May 2014Series E$40M
- May 2012Series C$14.5M
- Jun 2009Series B$17M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Sleep Medicine coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.