Best Sustainability Tech Companies in Irvine, United States
The 47 best Sustainability Tech companies in Irvine, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: BlueFire Renewables.
Our analysis of 84 Sustainability Tech companies
$19.4b in tracked funding; 85% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Sustainability Tech companies in Irvine
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | BlueFire Renewables Provider of solutions to convert cellulosic waste into ethanol | $270M | 141 mo ago | Funding Raised | Arnold Klann CEO & President | 2006 | — | — | — |
| 2 | Greenwave Systems Developer of software-defined network platform enabling virtual network operator capabilities | $86M | 127 mo ago | Series C | — | 2008 | — | — | — |
| 3 | CombiMatrix Diagnostic solutions for female reproductive health and pediatrics | $54M | 138 mo ago | Acqui-Hired | — | 1995 | — | 92 patents Electrochemical synthesis and detection on high‑density oligonucleotide electrode microarrays | — |
| 4 | Ecotrak Provider of SaaS-driven CMMS software for commercial spaces | $32M | 28 mo ago | Acquired | David Bennett Co-Founder | 2015 | StoryblokApple iCloud MailNode.js+26 | — | — |
| 5 | Ener-Core Transforming waste gases into clean energy solutions for various industries | $20M | 98 mo ago | Public | — | 2008 | — | — | — |
| 6 | Phoenix Energy Technologies AI-powered facilities intelligence for smarter, sustainable building performance | $17M | 87 mo ago | Acquired | — | 2004 | HubSpot CMS HubSalesforceAmazon Web Services+17 | — | — |
| 7 | Genea Provider of cloud-based software for access control, HVAC, and submeter billing | $11M | 98 mo ago | Series C | Michael Wong CEO | 2006 | WordPressApple iCloud MailMicrosoft 365+29 | — | — |
| 8 | EndoCyclic Therapeutics Developer of therapeutics for women health treatment | $5M | 71 mo ago | Funding Raised | Tanya Petrossian CEO | 2017 | Wix eCommerceWixSentry+11 | — | — |
| 9 | Nanotech Engineering Developer of nanotechnology-based PV systems | $4M | 90 mo ago | Deadpooled | — | 2018 | — | — | — |
| 10 | IntelliFlux Controls Process automation software for water treatment facilities | $3M | 40 mo ago | Series A | Subir Bhattacharjee Founder and CEO | 2017 | — | — | — |
| 11 | Material Methods Manufacturer of electrodes and energy storage devices using nanostructured materials | $2M | 191 mo ago | Deadpooled | Stephen Jaffe CEO | 1998 | — | — | — |
| 12 | AiResource Manufacturer and design of combustion engine system | $2M | 59 mo ago | Early Stage | Randy Chapman Founder & CEO | 1996 | — | — | — |
| 13 | ECO Integrated Technologies Offering thermolysis solution for solid waste processing | $2M | 42 mo ago | Series A | — | 2013 | — | — | — |
| 14 | Aggios Software defined Power Management for micro devices | $2M | 140 mo ago | Seed | — | 2010 | — | 7 patents Patents concentrated in computing, sensing & instrumentation | — |
| 15 | Celestial Therapeutics Developer of mRNA-based vaccines and therapies for multiple diseases | $1M | 15 mo ago | Seed | Leontis Teryazos Co-Founder | 2019 | — | — | — |
| 16 | TinyKicks Fetal sensor to detect baby movement | $1M | 115 mo ago | Seed | Michelle Khine Co-Founder | 2014 | — | — | — |
| 17 | AJK Biopharmaceutical Developer of peptide-based drugs for infectious diseases | $597K | 47 mo ago | Funding Raised | Jeremy Middleton CEO | 2018 | — | — | — |
| 18 | Nouslogic Smart home access and automation solutions for enhanced security | $300K | 86 mo ago | Seed | Hoang Nhu Founder & CEO | 2013 | — | — | — |
Top 12 Sustainability Tech companies in Irvine
#1
Seed · Irvine, California · founded 2019$1.4Mraised▾
Developer of mRNA-based vaccines and therapies for multiple diseases. It offers pipeline drug candidates CT-03 and CT-04 based on the company's Stellar mRNA platform for the treatment of infectious diseases, rare diseases, and cancers.
- Apr 2025Grant (prize money)$1.3M
- Apr 2025Seed$625K
- Sep 2024Seed$800K
- Apr 2023Grant (prize money)$290.1K
#2
Acquired · Irvine, California · founded 2015 · 25 employees$32.1Mraised▾
Provider of SaaS-driven CMMS software for commercial spaces. It facilitates restaurants, healthcare, the automotive industry, convenience stores, retail, and more. Offerings include service request management, repair, and replacement management, asset life cycle tracking, actionable data management, repair, and maintenance reporting, analytics, cost management, and more.
- Apr 2024Series A$30M
- Jul 2023Seed$85K
- Feb 2023Seed—
- Mar 2020Seed$2M
#3
Funding Raised · Irvine, California · founded 2006 · 3 employees$270Mraised▾
Provider of solutions to convert cellulosic waste into ethanol. The company uses a concentrated acid hydrolysis technology process for the conversion of cellulosic waste materials to ethanol and other viable alternatives to petroleum-derived fuels. It produces ethanol and other petroleum displacing fuels from urban trash, rice and wheat straws, wood waste, and other agricultural residues.
- Oct 2014Conventional Debt$270M
- Dec 2009Grant (prize money)$89.2M
- Sep 2009Grant (prize money)$3.7M
- Sep 2009Grant (prize money)—
#4
Series C · Irvine, California · founded 2008 · 13 employees$86.3Mraised▾
Developer of software-defined network platform enabling virtual network operator capabilities. The platform allows customers to offer connected services without infrastructure ownership. It enables device manufacturers to deploy devices with connectivity services, customer support, and worldwide coverage. The platform also allows control of data services.
- Jan 2016Series C$45.1M
- Jan 2016Conventional Debt$15M
- Sep 2013Series B$19M
- Jun 2010Series A$11M
#5
Acqui-Hired · Irvine, California · founded 1995 · 55 employees$53.5Mraised▾
CombiMatrix develops diagnostic solutions for female reproductive health and pediatrics. The company has five main diagnostic products. CombiPGS identifies pre-implantation genetic abnormalities in embryos developed during IVF, followed by CombiPGD to identify single gene and chromosomal abnormalities. The company also has three CombiSNP products: one for non-invasive prenatal testing of chromosomal abnormalities in the developing fetus, one for determination of cause of miscarriage, stillbirths and/or recurrent pregnancy loss, and another one for diagnosis of cause of pediatric developmental delays. While CombiPGS uses next-generation sequencing, all other products use custom microarrays. CombiMatrix maintains a proprietary database of genomic variants for analysis of assay results, and also provides traditional diagnostic testing services for reproductive health.
- Feb 2015Post IPO—
- Jun 2014Post IPO$52.1K
- May 2013Post IPO$1.2M
- Oct 2012Post IPO$1.1M
#6
Series A · Irvine, California · founded 2017 · 15 employees$3.2Mraised▾
Process automation software for water treatment facilities. The software optimizes membrane cleaning protocols and notifies about abnormal changes in operating characteristics. It uses cloud-based monitoring for real-time performance reports generation & provides analytical reports generated through data analytics and AI algorithms. Claims that the software solution optimizes the filtration process autonomously for difficult-to-treat water conditions. Also enables the protection of filtration membranes against irreversible fouling and optimizes operating expenditures.
- Apr 2023Series A$350K
- Dec 2021Series A$2M
- May 2018Seed$873.4K
#7
Public · Irvine, California · founded 2008 · 10 employees$19.6Mraised▾
Transforming waste gases into clean energy solutions for various industries. The company designs and manufactures innovative systems that convert ultra-low quality gas into useful heat and power, minimizing emissions. Their patented Power Oxidizer technology, when paired with gas turbines, enables this conversion. This provides industries with an opportunity to generate or sell energy profitably while complying with environmental standards. They operate in the waste gas to energy market, offering a groundbreaking technology with a focus on sustainability and environmental impact. The company provides solutions for industries looking to leverage waste gases for energy production.
- Jun 2018Post IPO$395.5K
- Apr 2018Post IPO$2.2M
- Dec 2016Post IPO$3.2M
- Sep 2016Post IPO$1.2M
#8
Series A · Irvine, California · founded 2013 · 11 employees$2.1Mraised▾
Offering thermolysis solution for solid waste processing. The solution can process plastic, tires, wood, railroad ties, poultry litter, and food waste and produces activated carbon and synthetic gas. Can capture hazardous materials such as halogens, sulfur & mercury. Also has developed a well-produced water evaporation unit.
- Feb 2023Series A—
- Nov 2017Seed$778.1K
- Aug 2015Seed$295K
- Oct 2014Seed$1M
#9
Acquired · Irvine, California · founded 2004 · 85 employees$17Mraised▾
AI-powered facilities intelligence for smarter, sustainable building performance. The company provides a software platform that integrates IoT devices and data sources for proactive building management. They offer solutions for optimizing HVAC, refrigeration, and lighting systems, leveraging AI and data analytics to improve equipment efficiency, reduce energy costs, and extend asset life. Their services include predictive analytics, building monitoring, and building intelligence, catering to industries like grocery, retail, healthcare, and the public sector. They offer a suite of products including EnterpriseDX® Platform, Building View™, Command Manager®, Alarm Manager®, Demand Manager™, Schedule Manager®, HVAC IQ™, Refrigeration IQ™, and Carbon Manager®. The company focuses on sustainability and operational excellence, enabling facilities to achieve peak performance while minimizing energy consumption. They provide data-driven insights and personalized service for efficient and sustainable building operations. This is a B2B, SaaS, software, AI-driven solution.
- Apr 2019PE—
- Oct 2017PE$12M
- Apr 2012PE$5M
#10
Series C · Irvine, California · founded 2006 · 73 employees$10.5Mraised▾
Provider of cloud-based software for access control, HVAC, and submeter billing. The platform offers tools for security, tenant satisfaction, and energy management. It provides features such as mobile access, visitor management, and automated billing. The software integrates with existing building management systems and non-proprietary hardware.
- Jun 2018Series C$3M
- Jan 2016Series C—
- Nov 2009Series B$3.9M
- Oct 2008Series A$650K
#11
Early Stage · Irvine, California · founded 1996$2.2Mraised▾
Developer of an integrated diesel combustion efficiency system designed and engineered to generate more complete combustion of the fuel. The company's holistic approach to efficient combustion design aims to reduce harmful emissions, extend fuel-range, and boost operational sustained-power efficiency and longevity, enabling economic drivers to maximize existing resources and make combustion cleaner, cost-efficient, and beneficial for global transportation and fuel infrastructure energy challenges.
- Aug 2021Unattributed$1.5M
- Apr 2019Conventional Debt$962K
- Mar 2019Conventional Debt$266K
- Feb 2013Unattributed$690K
#12
Funding Raised · Irvine, California · founded 2017 · 2 employees$5.4Mraised▾
Developer of therapeutics for women health treatment. It offers ENDO-205 which is an investigational non-hormonal, disease-modifying therapeutic for endometriosis and endometrial cancer and ENDO-995 is a disease-modifying therapeutic for colon cancer.
- Sep 2020Grant (prize money)$5.4M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Sustainability Tech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
What Irvine researches in climate adaptation
- University of California, Irvine14
- Irvine University9
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.