Best Artificial Intelligence Companies in Chicago, United States
The 74 best Artificial Intelligence companies in Chicago, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Tempus.
Our analysis of 101 Artificial Intelligence companies
$80.5b in tracked funding; 99% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Artificial Intelligence companies in Chicago
| # | Company | Disclosed funding | Last round | Stage | Employees | Founded | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Tempus 🦄 Developer of genomic testing and artificial intelligence tools for medicine | $1.1B | 44 mo ago | Public | 772 | 2015 | Eric Lefkofsky Founder & CEO | 594 patents AI-powered medical diagnostics: imaging biomarkers, liquid biopsy genomics, and cardiac ECG analysis | — |
| 2 | Uptake 🦄 Cloud-based platform for predictive analytics and asset performance management | $282M | 96 mo ago | Series D | 102 102 → 120 (+18%) | 2014 | Bradley Keywell Co-Founder & Executive Chairman | 35 patents Predictive maintenance analytics and optimization for industrial asset performance and failure prevention. | — |
| 3 | FourKites 🦄 Developer of AI and web-based visibility solutions for the supply chain | $243M | 44 mo ago | Series D | 24 | 2014 | Mathew Elenjickal co-Founder & CEO | 14 patents Patents concentrated in computing, sensing & instrumentation | — |
| 4 | Loop Provider of a logistics data platform offering freight audit and visibility 67AI top 18%Funding top 21%Growth top 35%Patents top 35% All 10 signals ▾AItop 18% Fundingtop 21% Growthtop 35% Patentstop 35% Moattop 38% Innovationtop 41% Techtop 43% Talentbottom 49% Globalbottom 40% Marketbottom 39% AI: Classified as an AI company · Holds AI/ML patents (G06N-family CPC) Funding: Raised $65.0M across 4 rounds · 4 rounds over 5 yrs (0.8/yr) rank vs industry peers · Fliar Intelligence Index 67/100 | $65M | 2 mo ago | Series C | 47 | 2021 | Matt McKinney Co-Founder & CEO | 75 patents Integrated EV charging payment, load management, and smart‑ledger commerce platforms | — |
| 5 | Market Logic Provider of AI-powered market and competitive intelligence platform for businesses | $50M | 108 mo ago | Series C | 321 321 → 171 (-47%) | 2005 | Olaf Lenzmann Co-Founder & CTO | — | 2 partnerships |
| 6 | Narrative Science Provider of an AI-based content creation solution | $48M | 110 mo ago | Acquired | 64 | 2010 | — | — | — |
| 7 | Pando Provider of AI-powered solutions for freight management and supply chain | $45M | 37 mo ago | Series B | 250 | 2018 | Abhijeet Manohar Co-Founder & CTO | 2 patents Coordination training devices for sports, therapy, and exercise | — |
| 8 | K1x Provider of AI-powered automation software for K-1, K-3, and 990 tax reporting 55Funding top 26%AI top 30%Growth top 35%Moat top 37% All 12 signals ▾Fundingtop 26% AItop 30% Growthtop 35% Moattop 37% Newstop 41% Patentstop 45% Producttop 49% Talentbottom 48% Innovationbottom 47% Techbottom 45% Marketbottom 40% Globalbottom 33% Funding: Raised $35.0M across 3 rounds · 3 rounds over 4 yrs (0.8/yr) AI: Classified as an AI company · Product described with: ai-powered rank vs industry peers · Fliar Intelligence Index 55/100 | $35M | 2 mo ago | Series B | 61 | 2022 | Neal Schneider Co-Founder | 6 patents Patents concentrated in computing, sensing & instrumentation | 1 award |
| 9 | eSpark Learning Personalized learning on the iPad for schools | $31M | 53 mo ago | Series C | 41 41 → 29 (-29%) | 2010 | Eric Dahlberg Chief Executive Officer | — | — |
| 10 | Ascent Cloud-based platform to track and automate financial regulatory compliance | $27M | 79 mo ago | Acquired | 47 | 2015 | Brian Clark Founder | 71 patents HVAC fan and housing systems plus ultrasonic transducer manufacturing technologies | 1 job opening · 1 award |
| 11 | Thoughtful AI-powered healthcare administration platform to automate tasks | $20M | 14 mo ago | Series A | 16 | 2020 | Alex Zekoff Co-Founder & CEO | — | — |
| 12 | Vermill Provider of AI rights management platform protecting and licensing digital content | $16M | 15 mo ago | Series A | 21 | 2021 | Dan Neely Co-Founder & CEO | — | — |
| 13 | ModelOp Platform offering machine learning model deployment and management | $16M | 22 mo ago | Series B | 36 | 2016 | Stu Bailey Co-Founder | 20 patents Containerized machine‑learning model execution platforms with performance instrumentation and diagnostics | 1 launch · 3 awards |
| 14 | Neurensic Regulatory compliance using Artificial Intelligence | $9M | 111 mo ago | Acqui-Hired | 186 | 2015 | — | — | — |
| 15 | Samya.ai AI-based SaaS platform for consumer packaged goods companies | $6M | 77 mo ago | Acqui-Hired | 61 | 2019 | — | 5 patents Patents concentrated in computing, sensing & instrumentation | — |
| 16 | Rippleshot Provider of AI-driven banking fraud analytics and detection platform solutions | $5M | 94 mo ago | Series A | 10 10 → 13 (+30%) | 2013 | Yueyu Fu Co-Founder | — | — |
| 17 | QuillBot Provider of an AI-based paraphrasing tool | $4M | 74 mo ago | Acquired | 171 171 → 358 (+109%) | 2017 | Anil Jason Co-Founder | — | — |
| 18 | iAsk AI Developer of an AI search engine providing detailed, accurate responses | $4M | 20 mo ago | Seed | — | 2022 | Dominik Mazur Co-Founder & CEO | — | — |
| 19 | Tagado Provider of SaaS-based ML and NLP technology for data collection and analytics platform for marketing | $4M | 43 mo ago | Seed | 10 | 2021 | — | — | — |
| 20 | Semantify Knowledge based Data Discovery and Analytics Platform | $3M | 121 mo ago | Series A | 25 | 2008 | — | — | — |
| 21 | Blinkfire Analytics Sports media analytics | $3M | 108 mo ago | Seed | 27 27 → 50 (+85%) | 2013 | Juan Luis Hortelano Co-founder and COO | 11 patents AI-powered image analysis and automated media content review/valuation systems | — |
| 22 | Telnyx Provider of voice AI platform with global telecommunications infrastructure | $2M | 139 mo ago | Seed | 106 | 2009 | — | 16 patents Cloud-based secure virtual private mobile and IP networking services | 1 launch |
| 23 | Clockwork AI & cloud-based cash flow management solutions for small businesses | $2M | 50 mo ago | Seed | 11 | 2018 | Fady Hawatmeh Founder and CEO | 2 patents Pricing algorithms and sales platforms for home repair and service commerce | 2 launchs |
| 24 | ProvenAir Provider of AI-powered platform for aircraft records management and compliance | $2M | 23 mo ago | Series A | 13 | 2015 | James Boccarossa CEO | — | — |
| 25 | Arvist Provider of AI-powered solutions for warehouse quality control and compliance | $1M | 10 mo ago | Series A | 7 | 2021 | Werner Stapela Co-Founder | — | — |
| 26 | Altris AI-based diagnostic solution for ophthalmologists | $1M | 17 mo ago | Seed | 15 | 2018 | Andrey Kuropyatnyk Founder & CEO | — | — |
| 27 | Brain.fm Developer of music designed to enhance focus and cognitive performance | $225K | 99 mo ago | Funding Raised | 13 | 2014 | Daniel Clark CEO | 576 patents Robotic mapping, sensor calibration, and feature detection for autonomous navigation systems. | — |
| 28 | Rhetora Cloud and AI based cold calling sales enablement solutions for sales teams | $120K | 33 mo ago | Deadpooled | 6 | 2022 | Luka Eric Co-Founder & CEO | — | — |
Top 12 Artificial Intelligence companies in Chicago
#1
Series C · Chicago, Illinois · founded 2021 · 47 employees$65Mraised▾
Provider of a logistics data platform offering freight audit and visibility. The platform unifies shipment and tracking data, enabling logistics teams to operate efficiently. It offers features such as parcel contract intelligence and carrier payments. The platform provides tools for cost allocation, decision intelligence, and transportation network optimization.
- Apr 2026Series C$95M
- Oct 2023Series B$35M
- Nov 2022Series A$24M
- 2021Seed$6M
#2
Series B · Chicago, Illinois · founded 2022 · 61 employees$35Mraised▾
Provider of AI-powered automation software for K-1, K-3, and 990 tax reporting. This software automates the receipt and production of K-1s, streamlining the process for both investors and advisors. It also offers automated 990 exempt reporting and filing, including e-filing capabilities. The platform integrates with various other software solutions and provides support, training, and onboarding services. The software aims to reduce manual effort, costs, and risks associated with alternative investment tax compliance.
- Apr 2026PE$175M
- Sep 2024PE$20M
- Dec 2022Series B$15M
#3
Series A · Chicago, Illinois · founded 2020 · 16 employees$20Mraised▾
AI-powered healthcare administration platform to automate tasks. The company offers solutions for automating revenue cycle management, streamlining company processes, and implementing robotic process automation (RPA).
- Apr 2025PE—
- Jul 2024Series A$20M
#4
Series A · Chicago, Illinois · founded 2021 · 21 employees$16Mraised▾
Provider of AI rights management platform protecting and licensing digital content. The platform offers tools to manage terms, conditions, and usage rights for content. It helps content owners protect against unauthorized use, deepfakes, and distribution. The platform also provides content monitoring and risk assessment services. It aims to enable content owners to capitalize on revenue streams from generative AI.
- Mar 2025Series A$16M
#5
Tempus 🦄Public · Chicago, Illinois · founded 2015 · 772 employees$1.1Braised▾
Developer of genomic testing and artificial intelligence tools for medicine. This organization provides molecular profiling, algorithmic diagnostic models, and digital pathology services to assist in clinical decision-making. The technology integrates clinical data with sequencing results to identify therapeutic options and potential clinical trial matches. These tools support oncology, neurology, psychiatry, cardiology, and radiology by analyzing biological data to assist in patient care and drug development. The platform facilitates the identification of biomarkers and provides insights into disease progression and treatment responses.
- Oct 2022Series G—
- Oct 2022Conventional Debt—
- Dec 2020Series G$200M
- Mar 2020Series G$100M
#6
Series B · Chicago, Illinois · founded 2016 · 36 employees$16Mraised▾
Platform offering machine learning model deployment and management. It enables data scientists, IT professionals, and business teams to deploy, monitor and govern artificial intelligence models. Has use case in credit scoring, bond trading, model risk management and trading applications.
- Aug 2024Series B$10M
- 2023Series A—
- Mar 2020Series A$6M
#7
Series A · Chicago, Illinois · founded 2021 · 7 employees$1.1Mraised▾
Provider of AI-powered solutions for warehouse quality control and compliance. It automates inspections, detects hazards, enforces safety rules, and monitors restricted areas. The platform integrates with existing systems and equipment, providing real-time alerts and dashboards. It helps to standardize quality checks, reduce errors, and improve overall warehouse efficiency.
- Jul 2025Series A$5.9M
- Nov 2023Seed$1.1M
- 2022Seed$20K
#8
Series D · Chicago, Illinois · founded 2014 · 24 employees$243.3Mraised▾
Developer of AI and web-based visibility solutions for the supply chain. It provides users with real-time visibility solutions for shippers, brokers, 3PLs, and carriers. It uses machine learning and AI to provide predictive insights and real-time supply chain information. It also enables users to calculate shipment arrival times and uses GPS or ELD devices for covering all modes including ocean, rail, parcel, and over-the-road. It provides end-to-end supply chain visibility platform using AI-driven technologies to provide comprehensive real-time tracking and predictive analytics for transportation and logistics management.
- Sep 2022Series D$10M
- Aug 2022Series D$30M
- Jun 2022Series D—
- Mar 2021Series D$100M
#9
Seed · Chicago, Illinois · founded 2022$4.2Mraised▾
Developer of an AI search engine providing detailed, accurate responses. The engine enables users to ask questions in natural language and receive answers. It offers features such as document analysis, image creation, and grammar checking. The platform also provides tools for summarizing web content and brainstorming content ideas.
- Oct 2024Seed$4.2M
#10
Series B · Chicago, Illinois · founded 2018 · 250 employees$45Mraised▾
Provider of AI-powered solutions for freight management and supply chain. The company offers AI agents for freight procurement, transportation, audit, and insights. It provides a platform for fulfillment, freight procurement, and freight audit and payment. Its technology integrates with enterprise systems and creates a supply chain knowledge graph.
- May 2023Series B$30M
- Sep 2021Series A$215.4K
- Jan 2020Series A$9M
- Sep 2019Angel$161.3K
#11
Seed · Chicago, Illinois · founded 2018 · 15 employees$1Mraised▾
AI-based diagnostic solution for ophthalmologists. The company provides software to detect eye diseases. The solution assists in the early detection of glaucoma, age-related macular degeneration, other retinal diseases, and more.
- Jan 2025Seed—
- Dec 2022Seed$1M
- May 2021Seed—
#12
Uptake 🦄Series D · Chicago, Illinois · founded 2014 · 102 employees$282.3Mraised▾
Cloud-based platform for predictive analytics and asset performance management. The company offerings include Asset Performance Management software and Uptake Fusion for OT data management on Microsoft Azure. These solutions predict failures, support ESG compliance, and reduce maintenance costs.
- 2018Series D—
- Nov 2017Series D$117M
- Apr 2017Series C$50M
- Feb 2017Series C$70.3M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Artificial Intelligence coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Artificial Intelligence in Chicago is moving
A read on the academic research around Artificial Intelligence in Chicago — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 67 papers.
- University of Chicago33
- University of Illinois Chicago22
- Toyota Technological Institute at Chicago9
- Loyola University Chicago6
- Concordia University Chicago1
- Set (abstract data type)1→4
- Conceptualization1
- Longitudinal data1
- Longitudinal study1
- External validity1
- Variance (accounting)1
- Sentiment analysis2
- Forum spam1
- Automatic summarization1
- Spamming1
- Spambot1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.