74 indexable Artificial Intelligence companies headquartered in Chicago, United States, ranked by total equity funding and recent funding momentum. Combined disclosed equity funding of $2B across 29 funded companies, including 3 unicorns.
| # | Company | Funding | Valuation | Stage | Latest round | Employees | Founded | Momentum |
|---|---|---|---|---|---|---|---|---|
| 1 |
Loop
Provider of a logistics data platform offering freight audit and visibility |
$65M | — | Series C | Series C Apr 2026 | 47 | 2021 | ↑ Active |
| 2 |
K1x
Provider of AI-powered automation software for K-1, K-3, and 990 tax reporting |
$35M | — | Series B | PE Apr 2026 | 61 | 2022 | ↑ Active |
| 3 |
Thoughtful
AI-powered healthcare administration platform to automate tasks |
$20M | — | Series A | PE Apr 2025 | 16 | 2020 | ↑ Active |
| 4 |
Vermill
Provider of AI rights management platform protecting and licensing digital content |
$16M | — | Series A | Series A Mar 2025 | 21 | 2021 | ↑ Active |
| 5 |
Tempus
Unicorn Developer of genomic testing and artificial intelligence tools for medicine |
$1.1B | $8.1B as of 2020 |
Public | Conventional Debt Oct 2022 | 772 | 2015 | — |
| 6 |
ModelOp
Platform offering machine learning model deployment and management |
$16M | — | Series B | Series B Aug 2024 | 36 | 2016 | ↑ Active |
| 7 |
Arvist
Provider of AI-powered solutions for warehouse quality control and compliance |
$1.1M | — | Series A | Series A Jul 2025 | 7 | 2021 | ↑ Active |
| 8 |
FourKites
Unicorn Developer of AI and web-based visibility solutions for the supply chain |
$243.3M | — | Series D | Series D Sep 2022 | 24 | 2014 | — |
| 9 |
iAsk AI
Developer of an AI search engine providing detailed, accurate responses |
$4.2M | — | Seed | Seed Oct 2024 | — | 2022 | ↑ Active |
| 10 |
Pando
Provider of AI-powered solutions for freight management and supply chain |
$45M | $73.4M as of 2021 |
Series B | Series B May 2023 | 250 | 2018 | — |
| 11 |
Altris
AI-based diagnostic solution for ophthalmologists |
$1M | — | Seed | Seed Jan 2025 | 15 | 2018 | ↑ Active |
| 12 |
Uptake
Unicorn Cloud-based platform for predictive analytics and asset performance management |
$282.3M | $2.3B as of 2017 |
Series D | Series D 2018 | 102 | 2014 | — |
| 13 |
ProvenAir
Provider of AI-powered platform for aircraft records management and compliance |
$1.8M | — | Series A | Series A Jul 2024 | 13 | 2015 | ↑ Active |
| 14 |
eSpark Learning
Personalized learning on the iPad for schools |
$30.7M | — | Series C | Series C Jan 2022 | 41 | 2010 | — |
| 15 |
Narrative Science
Provider of an AI-based content creation solution |
$47.5M | — | Acquired | Series D Apr 2017 | 64 | 2010 | — |
| 16 |
Market Logic
Provider of AI-powered market and competitive intelligence platform for businesses |
$50.3M | — | Series C | Series C May 2017 | 321 | 2005 | — |
| 17 |
Ascent
Cloud-based platform to track and automate financial regulatory compliance |
$26.7M | — | Acquired | Series B Nov 2019 | 47 | 2015 | — |
| 18 |
Tagado
Provider of SaaS-based ML and NLP technology for data collection and analytics platform for marketing |
$4M | — | Seed | Seed Nov 2022 | 10 | 2021 | — |
| 19 |
Neurensic
Regulatory compliance using Artificial Intelligence |
$9M | — | Acqui-Hired | Seed Mar 2017 | 186 | 2015 | — |
| 20 |
Samya.ai
AI-based SaaS platform for consumer packaged goods companies |
$6M | — | Acqui-Hired | Seed Jan 2020 | 61 | 2019 | — |
| 21 |
Clockwork
AI & cloud-based cash flow management solutions for small businesses |
$2M | — | Seed | Seed Apr 2022 | 11 | 2018 | — |
| 22 |
Rippleshot
Provider of AI-driven banking fraud analytics and detection platform solutions |
$4.8M | — | Series A | Series A Aug 2018 | 10 | 2013 | — |
| 23 |
QuillBot
Provider of an AI-based paraphrasing tool |
$4.3M | — | Acquired | Seed Apr 2020 | 171 | 2017 | — |
| 24 |
Semantify
Knowledge based Data Discovery and Analytics Platform |
$3.2M | — | Series A | Series A May 2016 | 25 | 2008 | — |
| 25 |
Blinkfire Analytics
Sports media analytics |
$2.6M | — | Seed | Seed Jun 2017 | 27 | 2013 | — |
| 26 |
Telnyx
Provider of voice AI platform with global telecommunications infrastructure |
$2.2M | — | Seed | Seed Nov 2014 | 106 | 2009 | — |
| 27 |
Rhetora
Cloud and AI based cold calling sales enablement solutions for sales teams |
$120K | — | Deadpooled | Seed Sep 2023 | 6 | 2022 | — |
| 28 |
Brain.fm
Developer of music designed to enhance focus and cognitive performance |
$225K | — | Funding Raised | Grant (prize money) Mar 2018 | 13 | 2014 | — |
| 29 |
Parkster
AI-enabled platform offering parking space detection and management solutions |
$20K | — | Seed | Seed Sep 2022 | — | 2021 | — |
| 30 |
Chaos
Offering secure communication solutions |
— | — | Deadpooled | Seed Apr 2021 | 5 | 2021 | — |
| 31 |
3pm Ai
Cloud based platform offering safety management compliance solutions |
— | — | Acquired | — | 33 | 2013 | — |
| 32 |
AIDO
Provider of an AI platform for international student enrollment management |
— | — | Unfunded | — | — | 2024 | — |
| 33 |
Aktiver
Developer of a platform automating ontology and taxonomy development using AI |
— | — | Unfunded | — | — | 2020 | — |
| 34 |
anthro innovations
Anthro Innovations is an information technology & services company. |
— | — | Private | — | 4 | 2016 | — |
| 35 |
askwhai
We choose to build the moon. |
— | — | Private | — | 2 | 2018 | — |
| 36 |
athreon
Athreon provides prompt and reliable insurance transcription for all facets of the insurance industry. |
— | — | — | — | 20 | 1988 | — |
| 37 |
bob.tv
Explorer of industries. Passionate sharer of content. Creator of communities. Go-to guy for all things relevant. |
— | — | Acquired | — | 8 | 2012 | — |
| 38 |
Botenders
Provider of AI-powered assistant for developers |
— | — | Unfunded | — | — | 2024 | — |
| 39 |
cardio diagnostics
Cardio Diagnostics makes heart disease prevention and early detection more accessible, personalized, and precise. |
— | — | Public | — | 8 | 2017 | — |
| 40 |
Channel Group
Channel Group Inc is a computer software company based out of 3851 N Bell Ave, Chicago, Illinois, United States. |
— | — | — | — | 12 | — | — |
| 41 |
Chirpz
Developer of an AI agent for academic paper discovery and citation |
— | — | Unfunded | — | — | 2025 | — |
| 42 |
content carnivores
Content Carnivores is dedicated to delivering the highest standards of ideas and writing. |
— | — | Private | — | 6 | 2011 | — |
| 43 |
Context Analytcs
Big data analytics and decision support software for finance industry |
— | — | Acquired | — | 14 | 2012 | — |
| 44 |
DIME
Developer of an industrial intelligence platform with integrated AI capabilities |
— | — | Unfunded | — | — | 2025 | — |
| 45 |
Drift Net Securities
At Drift Net Securities, our mission is to create and provide the most innovative technical solutions to keep communities safe— disrupting not only the world security but also of artificial intelligence based technology. |
— | — | — | — | 74 | — | — |
| 46 |
eContext
Semantic text classification API structures unstructured data for AI and machine learning |
— | — | Unfunded | — | 10 | 1999 | — |
| 47 |
enviropedia inc.
A startup creating a game-changing way to see the world's information through context, augmented reality and VR |
— | — | Private | — | 1 | 2014 | — |
| 48 |
Fiesta Cantina
Fiesta Cantina is a computer software company based out of 3407 N Clark St, Chicago, Illinois, United States. |
— | — | — | — | 15 | — | — |
| 49 |
focused labs
Focused Labs is a software development firm that offers consultation, platform deployment, cloud migration and training services. |
— | — | Private | — | 52 | 2018 | — |
| 50 |
GreenKey
Provider of NLP solutions for producing insights from the news |
— | — | Acqui-Hired | — | 18 | 2013 | — |
Provider of a logistics data platform offering freight audit and visibility. The platform unifies shipment and tracking data, enabling logistics teams to operate efficiently. It offers features such as parcel contract intelligence and carrier payments. The platform provides tools for cost allocation, decision intelligence, and transportation network optimization.
Provider of AI-powered automation software for K-1, K-3, and 990 tax reporting. This software automates the receipt and production of K-1s, streamlining the process for both investors and advisors. It also offers automated 990 exempt reporting and filing, including e-filing capabilities. The platform integrates with various other software solutions and provides support, training, and onboarding services. The software
AI-powered healthcare administration platform to automate tasks. The company offers solutions for automating revenue cycle management, streamlining company processes, and implementing robotic process automation (RPA).
Provider of AI rights management platform protecting and licensing digital content. The platform offers tools to manage terms, conditions, and usage rights for content. It helps content owners protect against unauthorized use, deepfakes, and distribution. The platform also provides content monitoring and risk assessment services. It aims to enable content owners to capitalize on revenue streams from generative AI.
Developer of genomic testing and artificial intelligence tools for medicine. This organization provides molecular profiling, algorithmic diagnostic models, and digital pathology services to assist in clinical decision-making. The technology integrates clinical data with sequencing results to identify therapeutic options and potential clinical trial matches. These tools support oncology, neurology, psychiatry, cardiol
Platform offering machine learning model deployment and management. It enables data scientists, IT professionals, and business teams to deploy, monitor and govern artificial intelligence models. Has use case in credit scoring, bond trading, model risk management and trading applications.
Provider of AI-powered solutions for warehouse quality control and compliance. It automates inspections, detects hazards, enforces safety rules, and monitors restricted areas. The platform integrates with existing systems and equipment, providing real-time alerts and dashboards. It helps to standardize quality checks, reduce errors, and improve overall warehouse efficiency.
Developer of AI and web-based visibility solutions for the supply chain. It provides users with real-time visibility solutions for shippers, brokers, 3PLs, and carriers. It uses machine learning and AI to provide predictive insights and real-time supply chain information. It also enables users to calculate shipment arrival times and uses GPS or ELD devices for covering all modes including ocean, rail, parcel, and ove
Developer of an AI search engine providing detailed, accurate responses. The engine enables users to ask questions in natural language and receive answers. It offers features such as document analysis, image creation, and grammar checking. The platform also provides tools for summarizing web content and brainstorming content ideas.
Provider of AI-powered solutions for freight management and supply chain. The company offers AI agents for freight procurement, transportation, audit, and insights. It provides a platform for fulfillment, freight procurement, and freight audit and payment. Its technology integrates with enterprise systems and creates a supply chain knowledge graph.
AI-based diagnostic solution for ophthalmologists. The company provides software to detect eye diseases. The solution assists in the early detection of glaucoma, age-related macular degeneration, other retinal diseases, and more.
Cloud-based platform for predictive analytics and asset performance management. The company offerings include Asset Performance Management software and Uptake Fusion for OT data management on Microsoft Azure. These solutions predict failures, support ESG compliance, and reduce maintenance costs.
Plug and Play Tech Center
_1584095064231.png){kind=logo}
Techstars
Service Provider Capital
Valor Equity Partners
Baillie Gifford
Chicago Early Growth Ventures
DNS Capital
KDWC Ventures
KGC Capital
Lightbank
Method Capital
New Enterprise Associates
Rankings are computed by Radar (Fliar BI) from the Radar company master and are updated periodically. Funding and momentum scores use disclosed equity-funding data only. Figures may lag private rounds. Last updated 2026-06-23.
_1583293968662.png){kind=logo}
_1540538399559.png){kind=logo}
_1539760557480.png){kind=logo}
