Best Blockchain Infrastructure Companies in San Francisco, United States
The 244 best Blockchain Infrastructure companies in San Francisco, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Forte.
Ranked: Best Blockchain Infrastructure companies in San Francisco
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Forte 🦄 Provider of Web3 infrastructure and compliance platform for blockchain projects 53Talent top 23%Moat top 28%Funding top 29%Innovation top 38% All 8 signals ▾Talenttop 23% Moattop 28% Fundingtop 29% Innovationtop 38% Patentstop 44% Techtop 49% Globalbottom 39% Marketbottom 34% Talent: 5 named leaders on record · 5 C-suite/founder profiles curated Moat: Editorial + unicorn rating 9/10 · IP moat: 16 patents rank vs industry peers · Fliar Intelligence Index 53/100 | $910M | 55 mo ago | Series B | 3 | Brett Seyler Co-Founder | WordPressMySQLPHP+24 | 16 patents Blockchain infrastructure for digital asset custody, transaction authorization, and DeFi exchanges | — |
| 2 | Alchemy 🦄 Provider of complete blockchain developer platform | $564M | 52 mo ago | Series C | 27 | Joe Lau Co-Founder & CTO | DatoCMSSentryZendesk+24 | 5 patents Patents concentrated in computing, sensing & instrumentation | 3 launchs · 2 partnerships |
| 3 | Tempo Developer of a layer 1 blockchain designed for payment solutions 48Funding top 18%Tech top 37%Talent top 38%Global bottom 46% All 7 signals ▾Fundingtop 18% Techtop 37% Talenttop 38% Globalbottom 46% Innovationbottom 42% Marketbottom 37% Patentsbottom 37% Funding: Raised $500M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) Tech: 27 technologies across 5/8 capability areas · Cloud: Cloudflare, Vercel rank vs industry peers · Fliar Intelligence Index 48/100 | $500M | 8 mo ago | Series A | — | Matt Huang CEO | ContentfulApple iCloud MailGoogle Workspace+14 | 8 patents HVAC ventilation control systems and collaborative team scheduling software | 2 launchs |
| 4 | SCRT Labs Blockchain-based solutions for cloud computing, data privacy, and encrypted data | $401M | 52 mo ago | Series D | 22 | — | — | — | — |
| 5 | Solana Blockchain-based infrastructure for transactions and counting | $374M | 60 mo ago | Series C | 71 | Raj Gokal Co-Founder | SentryNode.jsRadix UI+18 | 8 patents Patents concentrated in computing, sensing & instrumentation | 2 internships |
| 6 | Helium 🦄 Hardware mining solutions for cryptocurrency 69Tech top 11%News top 26%Moat top 26%Talent top 28% All 10 signals ▾Techtop 11% Newstop 26% Moattop 26% Talenttop 28% Producttop 30% Fundingtop 36% Growthtop 38% Markettop 49% Globalbottom 39% Customersbottom 39% Tech: 75 technologies across 7/8 capability areas · Cloud: Amazon Cloudfront, Amazon Web Services News: 6 BI events in 12 mo (of 19 tracked, 5 types) · +50% YoY rank vs industry peers · Fliar Intelligence Index 69/100 | $370M | 51 mo ago | Series D | 61 61 → 129 (+111%) | — | SalesforceBootstrapAmazon Web Services+21 | — | 2 launchs · 2 partnerships · 1 expansion |
| 7 | World 🦄 Provider of proof-of-humanity network | $240M | 37 mo ago | Series C | — | Alex Blania Co-Founder | PrismicApple iCloud MailGoogle Workspace+28 | — | — |
| 8 | Worldcoin 🦄 Provider of a digital currency focused on general purpose | $240M | 37 mo ago | Series C | 9 | Max Novendstern Co-Founder | Apple iCloud MailGoogle WorkspaceNode.js+16 | — | — |
| 9 | Aleo 🦄 Blockchain-based network for developers 69Funding top 22%Moat top 26%Growth top 35%Talent top 38% All 8 signals ▾Fundingtop 22% Moattop 26% Growthtop 35% Talenttop 38% Markettop 41% Techtop 43% Globalbottom 38% Newsbottom 32% Funding: Raised $228M across 3 rounds · 3 rounds over 5 yrs (0.6/yr) Moat: Editorial + unicorn rating 9/10 · Unicorn rank vs industry peers · Fliar Intelligence Index 69/100 | $228M | 15 mo ago | Series B | 55 | Michael Beller Co-Founder | ContentfulReactGatsby+12 | — | 1 partnership |
| 10 | Tools For Humanity Developer of tools for human identity verification in the age of AI. | $194M | 38 mo ago | Series C | 51 | Alex Blania Co-Founder & CEO | TurbopackApple iCloud MailNode.js+22 | — | — |
| 11 | TRM Labs 🦄 Provider of blockchain intelligence for detecting crypto-facilitated crime and compliance 64Funding top 18%News top 19%Moat top 26%Growth top 29% All 9 signals ▾Fundingtop 18% Newstop 19% Moattop 26% Growthtop 29% Techtop 31% Talenttop 43% Producttop 45% Marketbottom 40% Globalbottom 39% Funding: Raised $150M across 6 rounds · 6 rounds over 7 yrs (0.9/yr) News: 6 BI events in 12 mo (of 35 tracked, 6 types) · 4 high-value events (IPO/M&A/funding/contracts) in 12 mo rank vs industry peers · Fliar Intelligence Index 64/100 | $150M | 4 mo ago | Series C | 11 | Rahul Raina Co-Founder | WebflowMemberStackApple iCloud Mail+28 | — | 1 launch |
| 12 | Phantom 🦄 App-based digital wallet for cryptocurrency and NFT | $118M | 52 mo ago | Series B | 70 | Brandon Millman Co-Founder & CEO | SentryApple iCloud MailGoogle Workspace+11 | 73 patents Autonomous driving perception: lane reconstruction, trajectory prediction, and simulated data augmentation. | — |
| 13 | Sentient Non-profit organization advancing open-source AGI research | $85M | 23 mo ago | Seed | — | Himanshu Tyagi Co-Founder & Co-CEO | NotionSuper BuilderNode.js+14 | 21 patents Patents concentrated in health & consumer products | 1 launch |
| 14 | Lightning Labs Blockchain-based sidechain network | $82M | 50 mo ago | Series B | 30 | Olaoluwa Osuntokun Co-Founder & CTO | Google CloudReactGatsby+14 | 19 patents Detecting malicious online ad behavior, data leakage, and consent violations in digital advertising. | — |
| 15 | Compound P2P lending platform based on the Ethereum blockchain | $79M | 43 mo ago | Series B | 18 | — | Google Cloudcore-jsHSTS+7 | 18 patents Patents concentrated in computing, sensing & instrumentation | — |
| 16 | Eclipse Online platform for building decentralized applications | $65M | 27 mo ago | Series A | — | Neel Somani Founder | GitBookNode.jsRadix UI+12 | 67 patents UV exposure monitoring devices and electric vehicle charging meter collar housings | — |
| 17 | Bridge Provider of stablecoin infrastructure and APIs for developers and businesses | $58M | 21 mo ago | Acquired | 13 | Sean Yu Co-Founder | Node.jsKaTeXRadix UI+24 | — | 3 launchs · 3 partnerships |
| 18 | Iron Fish Developer of a zero-knowledge layer-1 blockchain providing optional privacy to assets | $57M | 37 mo ago | Acqui-Hired | 19 | Elena Nadolinski Founder & CEO | Node.jsChakra UIReact+9 | — | — |
| 19 | Conduit Provider of optimistic rollup for scaling | $44M | 24 mo ago | Series A | 5 | Andrew Huang Founder | Apple iCloud MailGoogle WorkspaceNode.js+14 | 6 patents Point‑of‑care saliva viral diagnostics and AI‑driven health documentation/linking tools | 1 launch |
| 20 | Portal P2P and decentralized platform for financial services | $42M | 28 mo ago | Funding Raised | 27 | — | Node.jsErlangtoastr+12 | 21 patents AI multi-agent orchestration platform for verification, ranking, and context-aware request processing | — |
| 21 | Movement Labs Provider of technology and experimental methods to build power for marginalized communities | $41M | 25 mo ago | Series A | — | — | ContentfulNode.jsTailwind CSS+14 | — | — |
| 22 | Fabric Developer of hardware-accelerated cryptography solutions for real-time, high-performance systems | $39M | 21 mo ago | Series A | 23 | Tina Ju Co-Founder | WebflowApple iCloud MailGoogle Workspace+10 | — | — |
| 23 | 0G Labs AI-based programmable layer for dApps development | $35M | 19 mo ago | Seed | — | Ming Wu Co-Founder & CTO | Turbopackstyled-componentsSentry+18 | — | 2 launchs · 1 award |
| 24 | Sei Online platform offering blockchain infrastructure solutions | $35M | 23 mo ago | Series B | 41 | — | GhostNode.jsKaTeX+15 | 24 patents Mobile content delivery, device activation, near‑field power, and secure element transaction management | — |
| 25 | Nexus Provider of Layer 1 blockchain platform optimized for high-frequency cryptocurrency trading and decentralized… | $27M | 24 mo ago | Series A | — | Daniel Marin Founder & CEO | GhostNode.jsMathJax+17 | 121 patents Microfluidic diagnostic platforms and thin‑film centrifuge devices for biomedical analysis | — |
| 26 | ZetaChain Blockchain-based public network for omnichain interoperability | $27M | 28 mo ago | Series B | 32 | Richard Brown Co-Founder | ContentfulApple iCloud MailGoogle Workspace+23 | — | 3 launchs |
| 27 | Kresus Web3 app intended to let users create mint, manage, and store digital assets 40Funding top 26%Customers top 32%Tech top 42%Growth top 45% All 9 signals ▾Fundingtop 26% Customerstop 32% Techtop 42% Growthtop 45% Moattop 48% Talentbottom 49% Productbottom 48% Globalbottom 36% Marketbottom 25% Funding: Raised $25.0M across 2 rounds · 2 rounds over 3 yrs (0.7/yr) Customers: Play-Store rating 4.60★ across 283 ratings (1 apps) rank vs industry peers · Fliar Intelligence Index 40/100 | $25M | 3 mo ago | Series A | 6 | Trevor Traina Founder & Chairman | WordPress Block EditorWordPressMySQL+32 | — | 1 partnership |
| 28 | Caldera Developer of infrastructure for building and scaling custom blockchain networks | $25M | 22 mo ago | Series A | 7 | Matthew Katz Co-Founder & CEO | Node.jsNextAuth.jsRadix UI+17 | 6 patents Patents concentrated in chemistry & materials | — |
| 29 | Irreducible Blockchain-based zero knowledge proofs platform | $24M | 16 mo ago | Series A | — | Jim Posen Co-Founder & CTO | Framer SitesKaTeXVimeo+12 | — | — |
| 30 | Provenance Public & distributed stakeholder blockchain for the financial services industry | $20M | 19 mo ago | Series B | 18 | Alana Aldag Ackerson Co-Founder | Apple iCloud MailGoogle WorkspaceECharts+16 | — | 1 launch |
| 31 | MegaETH Provider of Layer 2 solution designed to enhance the Ethereum blockchain | $20M | 23 mo ago | Seed | — | Yilong Li Co-Founder | — | — | — |
| 32 | Kite Developer of a blockchain infrastructure for autonomous agents and AI systems 78Funding top 28%Tech top 28%AI top 30%Market top 35% All 10 signals ▾Fundingtop 28% Techtop 28% AItop 30% Markettop 35% Innovationtop 36% Talenttop 38% Patentstop 39% Moattop 41% Globaltop 50% Growthbottom 48% Funding: Raised $18.0M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) Tech: 39 technologies across 4/8 capability areas · Cloud: Amazon Alb, Amazon S3 rank vs industry peers · Fliar Intelligence Index 78/100 | $18M | 7 mo ago | Series A | — | Chi Zhang Co-Founder & CEO | Node.jsThree.jsRadix UI+15 | 11 patents Patents concentrated in transport & manufacturing processes | 2 launchs · 3 partnerships |
| 33 | Lagrange Cross-chain infrastructure for the creation of generalized state proofs across all blockchains | $17M | 25 mo ago | Seed | 10 | Ismael Hishon-Rezaizadeh Co-founder & CEO | Node.jsTailwind CSSReact+13 | 6 patents Secure cryptographic verification of database queries and searchable encryption protocols | 2 launchs |
| 34 | zbyte Blockchain-based platform for application development | $15M | 29 mo ago | Seed | 9 | Ankush Tiwari Co-Founder | Sentrystyled-componentsReact+10 | — | — |
| 35 | Alpen Labs Bitcoin platform with zero knowledge technology | $11M | 17 mo ago | Series B | 5 | Pramod Kandel Co-Founder & CTO | WebflowGSAPAmazon Web Services+19 | — | 1 launch · 1 partnership |
| 36 | Pieverse Developer of blockchain interoperability infrastructure to unify decentralized network connectivity 42Funding top 33%Talent top 38%Global top 45%Tech top 50% All 5 signals ▾Fundingtop 33% Talenttop 38% Globaltop 45% Techtop 50% Marketbottom 37% Funding: Raised $10.0M across 2 rounds · 2 rounds over 1 yrs (2.0/yr) Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 42/100 | $10M | 7 mo ago | Seed | — | Colin Ho Co-Founder & CEO | TurbopackNode.jsThree.js+14 | — | — |
| 37 | PumpBTC Platform that enables Bitcoin holders to stake their bitcoins and earn yield | $10M | 19 mo ago | Seed | — | Chef Jose CEO | — | — | — |
| 38 | Doppler Developer of tools for creating and launching tokenized assets and markets 62AI top 15%Growth top 28%Funding top 35%Innovation top 42% All 9 signals ▾AItop 15% Growthtop 28% Fundingtop 35% Innovationtop 42% Techtop 44% Patentstop 46% Talentbottom 49% Globalbottom 42% Marketbottom 31% AI: Holds AI/ML patents (G06N-family CPC) Growth: Web rank 50,000,000 → 10,000,000 YoY · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 62/100 | $9M | 4 mo ago | Seed | — | Austin Adams Founder | Turbopackstyled-componentsNode.js+13 | 55 patents AI-driven real-time audio processing and noise suppression for hearing assistance devices | — |
| 39 | Self Labs Provider of digital identity verification using zero-knowledge cryptography for Web2/Web3 42Talent top 28%Growth top 35%Tech top 41%Funding top 49% All 8 signals ▾Talenttop 28% Growthtop 35% Techtop 41% Fundingtop 49% Productbottom 40% Customersbottom 35% Globalbottom 33% Marketbottom 30% Talent: 3 named leaders on record · 3 C-suite/founder profiles curated Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 42/100 | $9M | 7 mo ago | Seed | — | Marek Olszewski Co-Founder | GitBookApple iCloud MailNode.js+11 | — | 4 launchs |
| 40 | Masa Developer of a layer-1 blockchain for AI-powered trading strategies | $9M | 18 mo ago | Series A | — | Brendan Playford Co-Founder | Node.jsReactNext.js+18 | — | — |
| 41 | Octane Security Vulnerability management solution | $7M | 14 mo ago | Seed | — | Giovanni Vignone Founder & CEO | WebflowGSAPMicrosoft Clarity+19 | — | — |
| 42 | Shinami Platform offering node as a service | $6M | 18 mo ago | Seed | 6 | — | WebflowAmazon Web ServicesjQuery+8 | — | — |
| 43 | Network3 Provider of decentralized AI infrastructure solutions | $6M | 22 mo ago | Seed | — | Rock Zhang Founder | Node.jsRadix UITailwind CSS+12 | — | — |
| 44 | Network3 Blockchain platform focused on developing an AI-based Layer2 network | $6M | 22 mo ago | Seed | — | — | — | — | — |
| 45 | Fun API for cross-chain decentralized wallets on the Odsy blockchain 50Growth top 35%Moat top 39%Funding top 40%Tech top 40% All 7 signals ▾Growthtop 35% Moattop 39% Fundingtop 40% Techtop 40% Talentbottom 49% Marketbottom 41% Globalbottom 36% Growth: Fresh capital in last 24 mo Moat: Editorial + unicorn rating 7/10 · 9 curated direct competitors tracked rank vs industry peers · Fliar Intelligence Index 50/100 | $4M | 1 mo ago | Series A | 22 | Alex Fine Co-Founder & CEO | Webflow EcommerceCart FunctionalityWebflow+14 | — | — |
| 46 | Unicity Developer of infrastructure for autonomous agent marketplaces and machine-speed commerce 13Talent bottom 49%Funding bottom 48%Tech bottom 40%Global bottom 35% All 7 signals ▾Talentbottom 49% Fundingbottom 48% Techbottom 40% Globalbottom 35% Innovationbottom 34% Patentsbottom 26% Marketbottom 25% Talent: 1 named leader on record · 1 C-suite/founder profile curated Funding: Raised $3.0M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) rank vs industry peers · Fliar Intelligence Index 13/100 | $3M | 4 mo ago | Seed | — | Mike Gault Founder & CEO | WebflowSwiperjQuery+9 | 3 patents Nutraceutical fiber matrices for metabolic regulation and controlled-release biologic delivery | — |
| 47 | Rakurai Developer of high-performance blockchain infrastructure solutions | $3M | 15 mo ago | Seed | — | Syed Ali Rizvi Founder | Node.jsRadix UITailwind CSS+7 | — | 3 launchs |
| 48 | Uniblock Web3 infrastructure to facilitate the development of decentralized applications 53Tech top 31%Growth top 35%Talent top 38%Innovation top 46% All 9 signals ▾Techtop 31% Growthtop 35% Talenttop 38% Innovationtop 46% Fundingtop 46% Moattop 47% Patentsbottom 49% Globalbottom 39% Marketbottom 33% Tech: 32 technologies across 5/8 capability areas · Cloud: Cloudflare, Vercel Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 53/100 | $2M | 2 mo ago | Seed | 14 | James Liu VP Engineering & Co-Founder | Node.jsMUIReact+12 | 3 patents Adaptive modulation metric selection for OFDM subcarrier transmission | 1 job opening · 3 launchs |
| 49 | Interstate Provider of decentralized and interoperable Ethereum L1 blockchain platform 24Global top 45%Talent bottom 49%Funding bottom 46%Tech bottom 36% All 4 signals ▾Globaltop 45% Talentbottom 49% Fundingbottom 46% Techbottom 36% Global: Investors from 3 countries beyond United States Talent: 1 named leader on record · 1 C-suite/founder profile curated rank vs industry peers · Fliar Intelligence Index 24/100 | $2M | 3 mo ago | Seed | — | Irfan Shaik Founder | WebflowjsDelivrGoogle Hosted Libraries+7 | — | — |
| 50 | MAP Protocol Bitcoin layer-2 solution for peer-to-peer cross-chain interoperability | $1M | 19 mo ago | Seed | — | James Cheng Co-Founder | Node.jsUbuntuReact+6 | — | — |
Top 12 Blockchain Infrastructure companies in San Francisco
#1
TRM Labs 🦄Series C · San Francisco, California · founded 2018 · 11 employees$149.9Mraised▾
Provider of blockchain intelligence for detecting crypto-facilitated crime and compliance. The platform offers tools for investigations, compliance, and supervision of digital assets. It facilitates transaction monitoring, wallet screening, and entity due diligence. The company provides resources such as training, reports, webinars, and guides.
- Feb 2026Series C$70M
- Nov 2022Series B$70M
- Feb 2022Series B—
- Dec 2021Series B$60M
#2
Series A · San Francisco, California · founded 2017$500Mraised▾
Developer of a layer 1 blockchain designed for payment solutions. The blockchain supports stablecoins, enabling high-throughput, low-cost global transactions for various business applications. It offers embedded payment features, including memo fields and batch transfers. The blockchain facilitates remittances, global payouts, embedded finance, microtransactions, agentic commerce, and tokenized deposits. Technical features include fee flexibility, dedicated payments lane, stablecoin interoperability, and compliance measures.
- Oct 2025Series A$500M
#3
Series A · San Francisco, California · founded 2022 · 6 employees$25Mraised▾
Web3 app intended to let users create mint, manage, and store digital assets. The application curates interesting web3 finds, teaches users how to mint NFT, offers ongoing education about the evolving landscape, and connects users with exciting communities.
- Feb 2026Series A$13M
- Mar 2023Series A$25M
#4
Aleo 🦄Series B · San Francisco, California · founded 2019 · 55 employees$228Mraised▾
Blockchain-based network for developers. Its features of the platform include a zero-knowledge IDE, package manager, etc. The platform features enable developers to build custom cross-platform mobile applications.
- Mar 2025Series B$480K
- Feb 2022Series B$200M
- Apr 2021Series A$28M
#5
Series A · San Francisco, California · founded 2022 · 22 employees$3.9Mraised▾
API for cross-chain decentralized wallets on the Odsy blockchain. It leverages blockchain technology, in partnership with the Odsy network, to build cross-chain wallet infrastructure. It provides components for wallet APIs & protocols, so developers can create experiences for their customers.
- May 2026Series A$72M
- Oct 2022Seed$3.9M
#6
Seed · San Francisco, California · founded 2018$9Mraised▾
Developer of tools for creating and launching tokenized assets and markets. It provides mechanisms for onchain price discovery and liquidity bootstrapping. The platform supports token creation, market pricing, and liquidity growth. It offers smart contracts and a TypeScript SDK for building applications. The system facilitates migration of liquidity to decentralized exchanges. It allows for the integration of governance and treasury tools.
- Jan 2026Seed$9M
#7
Series A · San Francisco, California · founded 2020$18Mraised▾
Developer of a blockchain infrastructure for autonomous agents and AI systems. It provides tools for building agents with verifiable identity, programmable governance, and native stablecoin transactions. The infrastructure includes a Layer 1 blockchain designed for artificial intelligence, utilizing Proof of Artificial Intelligence. It facilitates agent discovery, interaction, and payment for services within an autonomous economy.
- Oct 2025Series A—
- Sep 2025Series A$18M
#8
Seed · San Francisco, California · founded 2022 · 14 employees$2.3Mraised▾
Web3 infrastructure to facilitate the development of decentralized applications. It allows users to integrate NFTs into their apps and projects, and deploy pre-validated smart contracts. It provides APIs that work with prominent EVM-compatible chains such as ETH, BSC, MATIC, FTM, and AVAX.
- Mar 2026Seed$5.2M
- Nov 2023Seed$2.3M
#9
Seed · San Francisco, California · founded 2024$10Mraised▾
Developer of blockchain interoperability infrastructure to unify decentralized network connectivity. The platform provides bidding mechanisms for engagements and interaction workflows. It features an AI-integrated calendar system, fiat and cryptocurrency payment support, and smart-contracted time recognition. The platform enables Web3 and startup users to manage activities securely and engage with investor communities while maintaining privacy.
- Oct 2025Seed$3M
- Oct 2025Seed$7M
#10
Seed · San Francisco, California · founded 2024$9Mraised▾
Provider of digital identity verification using zero-knowledge cryptography for Web2/Web3. It offers tools for users to verify their identity attributes without exposing personal information. The company provides solutions for airdrop protection, social media, marketplaces, and sanction list checking. It supports biometric IDs and passports, enabling users to generate proofs.
- Nov 2025Seed$9M
#11
Seed · San Francisco, California · founded 2017$3Mraised▾
Developer of infrastructure for autonomous agent marketplaces and machine-speed commerce. The company focuses on enabling agents to discover services and connect directly. It aims to facilitate transactions at machine speed with validation at the edge. The infrastructure is designed to support cryptographic verification without intermediaries, addressing the limitations of traditional blockchains.
- Feb 2026Seed$3M
#12
Seed · San Francisco, California · founded 2022$1.5Mraised▾
Provider of decentralized and interoperable Ethereum L1 blockchain platform. Its designed to enable faster and more decentralized transactions.
- Mar 2026Seed$1.5M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Blockchain Infrastructure coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising