Best Blockchain Technology Companies in San Diego, United States
The 40 best Blockchain Technology companies in San Diego, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: GreenBox POS.
Our analysis of 81 Blockchain Technology companies
$9.2b in tracked funding; 100% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Blockchain Technology companies in San Diego
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | GreenBox POS Software and hardware PoS solutions to businesses for accepting crypto payments | $83M | 58 mo ago | Public | — | 2016 | — | — | — |
| 2 | Onramp Invest Cryptoasset management solution for financial advisors | $13M | 51 mo ago | Acquired | — | 2018 | — | — | — |
| 3 | XYO Network Blockchain network focused on XYO technology | $12M | 99 mo ago | Funding Raised | — | 2012 | Node.jsNextAuth.jsReact+18 | — | 3 launchs · 1 partnership |
| 4 | Cubist Online platform for cross-chain development tools and security audits | $7M | 41 mo ago | Seed | Riad Wahby Co-Founder & CEO | 2022 | — | 3 patents Secure credential storage and management for network authentication devices | — |
| 5 | Ink Finance Blockchain-based platform for multi-chain financial governance | $5M | 26 mo ago | Series A | Tony Tang Founder | 2021 | WebflowQuilljQuery+10 | — | — |
| 6 | Crypthulhu Online platform that develops the NFT gaming ecosystem | $3M | 49 mo ago | Seed | Mark Smith Co-Founder & CTO | 2021 | — | — | — |
| 7 | XY Labs Platform offering self-sovereign data gathering, storage, and processing solutions | $1M | 92 mo ago | Series B | Arie Trouw Founder & CEO | 2012 | Facebook LoginMUIReact Router+11 | — | — |
| 8 | Altcoin Decentralized cryptocurrency exchange | $1M | 96 mo ago | Acqui-Hired | — | 2017 | — | — | — |
| 9 | S-3 Provider of research as a service using data-driven solutions | $796K | 11 mo ago | Funding Raised | — | 2018 | — | — | — |
| 10 | Edge App Blockchain-based security platform and mobile wallet for crypto storage | $780K | 51 mo ago | Series A | — | 2014 | WordPressApple iCloud MailGoogle Workspace+34 | — | 1 partnership |
| 11 | DragonGlass Hardware for cryptocurrency mining | $700K | 89 mo ago | Seed | Alex Kamergorodsky Founder & CEO | 2018 | — | — | — |
| 12 | Ciphrex Solana Compass: Guiding you through the Solana ecosystem with insights and tools | $500K | 137 mo ago | Series A | Eric Lombrozo Co-Founder | 2013 | — | — | — |
Top 12 Blockchain Technology companies in San Diego
#1
Funding Raised · San Diego, California · founded 2018 · 9 employees$795.7Kraised▾
Provider of research as a service using data-driven solutions. The company offers data collection, advanced data analysis, and custom data visualization. It delivers interdisciplinary research solutions, including digital health application development. The company uses machine learning, deep learning, and statistical analysis.
- Sep 2025Grant (prize money)$499.8K
- May 2025Grant (prize money)$295.9K
#2
Series A · San Diego, California · founded 2021 · 5 employees$5Mraised▾
Blockchain-based platform for multi-chain financial governance. It builds financial institutions of the Web3 era, with comprehensive tools enabling DAOs to carry out fiscal duties. It allows a DAO to govern from its native blockchain, and carry out its finance.
- Jun 2024Series A$5M
#3
Public · San Diego, California · founded 2016 · 110 employees$83.3Mraised▾
Software and hardware PoS solutions to businesses for accepting crypto payments. It features QuickCard Kiosk for depositing funds via cash, card, or ACH. It also provides merchants with tools for business management including payroll processing and sales auditing. The POS offers tracking, reporting, and sales integration with the QuickCard system for payment processing.
- Nov 2021Post IPO$80.3M
- Dec 2020Series A$2.7M
- Aug 2018Seed$306K
- Aug 2018Conventional Debt—
#4
Seed · San Diego, California · founded 2022 · 7 employees$7Mraised▾
Online platform for cross-chain development tools and security audits. The platform offers web3 development, testing, deployment and upgrade workflows in custom, security-focused CI/CD pipelines. The platform also provides multi-chain and cross-chain SDKs.
- Mar 2023Seed$7M
- 2022Seed$250K
#5
Acquired · San Diego, California · founded 2018 · 27 employees$13Mraised▾
Cryptoasset management solution for financial advisors. It features advisor workflow and data integration. It provides the tools for financial advisors to learn about, model, invest and manage the clients' crypto assets. It also provides access to crypto asset custodians offering trading, rebalancing, reporting, and billing.
- May 2022Series A$7M
- Aug 2021Seed$6M
#6
Seed · San Diego, California · founded 2021 · 8 employees$3Mraised▾
Online platform that develops the NFT gaming ecosystem. The platform offers various play-to-earn games to its users and enables them to play, and interact with other players in the ecosystem. It allows users to trade in in-game assets with other players.
- Jul 2022Seed$3M
#7
Funding Raised · San Diego, California · founded 2012 · 1 employees$12Mraised▾
Blockchain network focused on XYO technology. It is a network that enables layered location verification across multiple devices and protocols. The network is powered via XYO token. It provides a fully decentralized network capable of combining cryptographic security with real-world data
- May 2018ICO$12M
#8
Series A · San Diego, California · founded 2014 · 26 employees$779.7Kraised▾
Blockchain-based security platform and mobile wallet for crypto storage. It allows users to buy, sell, store & trade crypto. It support cryptocurrency including Bitcoin, Ethereum, Litecoin, Monero, Dodecoin, and more. The app is available for iOS and Android platforms.
- Jun 2022Series A—
- Aug 2019Seed—
- Dec 2016Seed$304.7K
- Jul 2015Seed$450K
#9
Series B · San Diego, California · founded 2012 · 20 employees$1.3Mraised▾
Platform offering self-sovereign data gathering, storage, and processing solutions. Its product portfolio includes XYO which is a self-sovereign data platform that allows people to make dApps, Coin which is a mobile app enabling users to earn digital assets for validating geospatial location data when traveling, commuting, jogging, or more, and XY4 Bluetooth item finder that lets users use the phone to find the things that get misplaced.
- Dec 2018Series B$2.2M
- Mar 2018Series B$674.8K
- Mar 2018Series B$15M
- Oct 2017Seed$1.3M
#10
Acqui-Hired · San Diego, California · founded 2017 · 5 employees$1Mraised▾
Decentralized cryptocurrency exchange. Allows the users to buy, sell and exchange cryptocurrencies. It has integrated an atomic swap wallet, that enables trading between different blockchain networks. Transactions are secured via smart contracts.
- Sep 2018Seed$1M
#11
Seed · San Diego, California · founded 2018$700Kraised▾
Developer of adaptive hardware designed to serve the blockchain and cloud computing space. The company's hardware ecosystem consists of data centers, server racks, shards, power supplies and components and enterprise-level software, enabling clients to monetize their infrastructure through diversification of hardware services.
#12
Series A · San Diego, California · founded 2013 · 2 employees$500Kraised▾
Solana Compass: Guiding you through the Solana ecosystem with insights and tools. It offers resources for navigating the Solana blockchain, focusing on staking, DeFi, and NFTs. The platform provides information on Solana projects, infrastructure, developer tools, and various applications like asset management, trading, and gaming. It also covers topics such as DAOs, governance, security, and blockchain analytics. The site aims to educate users with tutorials and news, while also offering tools for validator performance monitoring and staking statistics. It serves as a community-run resource, helping users explore and understand the Solana ecosystem, including wallets, staking pools, and decentralized finance opportunities. The platform supports blockchain technology, decentralized applications, and the growing Web3 space.
- Mar 2015Series A$500K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Blockchain Technology coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Blockchain is moving in the United States
A read on the academic research around Blockchain — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 5,117 United States-affiliated papers.
- Community Partners293
- Northeastern University125
- University of the Cumberlands81
- Old Dominion University75
- The University of Texas at San Antonio66
- Computer security17→846
- Scalability3→216
- Smart contract2→160
- Database transaction2→160
- Distributed computing2→159
- Computer security7→633
- Supply chain1→196
- Transparency (behavior)2→158
- Database transaction4→132
- Cryptocurrency5→118
- Computer security18→380
- Cryptocurrency12→133
- Distributed ledger4→69
- Data science1→59
- Key (lock)3→52
Where blockchain is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing blockchain patents in the United States
United States blockchain patent filing is accelerating — 11,538 filings from 2,143 assignees (2016–2025), led by IBM, Mastercard International, BANK Of America; annual filings 32→1298.
- IBM1155
- Mastercard International594
- BANK Of America350
- State FARM Mutual Automobile Ins228
- Capital One Services216
- Paypal200
- Jpmorgan Chase BANK NA183
- VISA INT Service ASS174
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.