Best Cardiac and Vascular Disorders Companies in Israel

Magenta Medical is focussed on developing a temporary venous catheter-based therapy for hospital-admitted patients with Acute Decompensated Heart Failure (ADHF). It is developing its device for renal venous congestion and its deleterious effects on renal and cardiac function.

VVT Medical has developed a medical technology for the treatment of varicose veins. Its procedure called V-Block includes a percutaneous delivery of vascular embolic device (called v-block device) into the proximal great saphenous vein (GSV) and induce a concomitant liquid sclerotherapy using its proprietary dual procedure syringe system by the simultaneous aspiration of the blood and the discharging of the sclerosing agent. Claims that the procedure requires no anesthesia and requires minimal post procedure care.

Restore Medical is an early stage company focussed on developing a catheter-delivered implant for treatment of congestive heart failure (CHF). It is developing its flagship product called ContraBand which claims to provide improved quality of life for patients with left ventricle heart failure. As of December 2016, the company is operating as a portfolio of Incentive & the hasn't disclosed the device development details.

Developer of transcatheter solutions for patients with heart diseases. The company's percutaneous device Trillium is designed to provide treatment of tricuspid regurgitation.

Funding rounds

• Oct 2024Series B$28.5M
• Jun 2022Grant (prize money)$2.7M
• Nov 2021Grant (prize money)$2.9M
• Nov 2021Series A$13.3M

Founders & team

Rafi BenaryFounder

Investors

EIC Fund, RA Capital Management, BRM, JG Investment, Europa, Mivtach Shamir Holdings

Biobeat offers a non-invasive body vitals monitoring wearable solution. It uses reflective Pulse Oximetry technology with their algorithm to allow for constant measurements of related body vitals. Sensor delivers a range of body vitals measurement including consciousness, saturation, pulse, temperature and perspiration. The devices are connected to a mobile app or a central monitoring system where the user's data is stored. Data is then compared against a person's normal levels to identify life-threatening situations. It also allows data sharing with doctors and caregivers. They have released their products for athletes and Hospitals. Founded by Arik Ben Ishai Director of startups in the Rocket and Space Department of the Ministry of Defense, Israel.

Manufacturer of endovascular suture-like device for cardiovascular treatment. It uses a smart stapling mechanism that enables multiple staples to simultaneously penetrate the stent graft and the aortic wall. With a small profile delivery system, the device, Aortoseal is quickly deployed via a single release action. It enables the implementation of endograft procedures in almost all types of anatomies and can dramatically reduce complications and reinterventions.

Funding rounds

• Jul 2024Series A$10M
• Feb 2023Grant (prize money)$2.7M
• 2022Grant (prize money)$2.8M
• Dec 2021Seed$5M

Founders & team

Ron KarmeliCo-Founder & CMO

Investors

Sofinnova Partners, EIC Fund, MD Start, MedTech Innovator

CathWorks is developing FFRAngio, a novel technology for angiogram-based physiology measurement that does not require pressure wires or hyperemic stimulus. It is based on the processing of visual information and automatic multi-layered algorithms. Its technology is focused on improving the utilization of coronary angiography data to validate measurement-based medicine in the cath lab.

Funding rounds

• Jul 2022Series E$75M
• Jan 2021Series D$30M
• Feb 2019Series C$30M
• Oct 2017Series B$15.8M

Founders & team

Ifat LaviFounder & CTO

Investors

Medtronic, Deerfield, Quark Venture, Planven Investments, Pontifax, Corundum Open Innovation

Tech stack

Animate.CssCloudflareCloudflare Bot ManagementComplianzCore-JsGodaddy

Developer of denervation catheter for the treatment of pulmonary hypertension. It has developed a therapeutic catheter called TIVUS (Therapeutic Intra-Vascular Ultrasound) which can be inserted into the pulmonary artery and then selectively damages nerves associated with disease activity without touching the vessel walls or damaging the adjacent tissues.

Funding rounds

• Jan 2023Series C$60M
• Nov 2015Series A$2.5M

Founders & team

Tomaso ZambelliCEO

Investors

Andera Partners, Supernova Invest, Omega Funds, TechWald Holding, Accelmed, Arkin Holdings

V-Wave develops percutaneous implantable devices for treating patients with chronic Heart Failure. The compnay offers products like human implantable an inter-atrial shunt aimed at relieving symptoms and treating heart failure by controlling the left atrial pressure. The product is FDA approved.

MValve Technologies is an Israeli-Americal company focused on developing solutions for Mitral Regurgitation (MR). MR is an abnormal reversal of blood flow from the heart's left ventricle into the left atrium. The company's product is a docking system for transcatheter mitral valve repair which works in conjunction with Boston Scientific's Lotus Valve. MValve has been backed by Boston Scientific since 2012. The $15 M deal with Boston Scientific in 2014 included a $200 M buyout option. In Oct 2015, the company announced the first human implantation of its device in a patient in Germany. Lotus Valve System has not received FDA approval as of Oct, 2015. It is CE marked.

Manufacturer of medical devices specializing in carotid stenting. The company's product is a percutaneous transcarotid stenting system to provide a safer method for carotid artery access, which aims to reduce complications associated with traditional approaches.

Funding rounds

• Jul 2024Seed$1.2M

Founders & team

Or ZigelboimFounder & CEO

Investors

MEDX Xelerator

Developer of a device for the left atrial appendage closure system. The system is used to prevent the blood clot leakage from the Left Atrial Appendage through LAA complete closure.