Best Dental Disorders Companies in United States
The 353 best Dental Disorders companies in United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: SmileDirectClub.
Tracking the best-funded companies working on Dental Disorders in the United States, this directory covers 353 ventures with $2.2B in total disclosed funding behind them. No unicorns yet, but the capital concentration is real. Sonendo leads at $285M raised, Neocis follows at $179M, and the gap to the next tier is steep. Perceptive IO sits at $45M, Lighthouse Pharma at $15M, and the rest of the pack thins out fast. According to Future Market Insights, the global dental disorders market was roughly $10.5B in 2023 and is forecast to reach $18.2B by 2034, a 5.2% CAGR driven by an aging population, rising disposable income, and steady technology adoption.
So what does that mean for you as an investor or founder sizing up this space? The demand fundamentals are durable. HHS, Keiretsu Forum, Ally Bridge Group, and Domain Associates have all been active backers here, which tells you institutional and strategic money is watching. I'd note the funding distribution is lopsided, two companies hold roughly 21% of all disclosed capital between them, which leaves a lot of the 353-company field undercapitalized relative to the market opportunity ahead.
Ranked: Best Dental Disorders companies in United States
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SmileDirectClub Developer of customized dental aligners | $440M | 64 mo ago | 1,360 | Jordan Katzman Co-Founder | — | — | 132 patents AI-driven 3D imaging and treatment planning for orthodontic tooth movement | — |
| 2 | Sonendo Developer of therapy device to treat tooth decay | $285M | 13 mo ago | 216 | Bjarne Bergheim President & CEO | DrupalApple iCloud MailPHP+14 | Top 50M | 221 patents Dental treatment and cleaning devices, especially liquid‑jet endodontic instrumentation. | — |
| 3 | Neocis Provider of robotic guidance system for dental surgeries 74Innovation top 16%Patents top 17%Funding top 25%Moat top 26% All 10 signals ▾Innovationtop 16% Patentstop 17% Fundingtop 25% Moattop 26% Growthtop 33% Techtop 40% Markettop 48% Talentbottom 49% Globalbottom 42% Newsbottom 22% Innovation: 198 patents (top 8% of patent-holders) · 117 filings since 2022 vs 64 in 2017-21 Patents: 198 patents matched (strict assignee match) · 117 filings since 2022 vs 64 in 2017-21 rank vs industry peers · Fliar Intelligence Index 74/100 | $179M | 29 mo ago | 118 118 → 113 (-4%) | Alon Mozes Co-Founder & CEO | Cart FunctionalityWooCommerceWordPress+44 | Top 5M | 198 patents Robotic-guided dental and cranio‑maxillofacial surgery systems and planning tools | 1 launch · 1 award |
| 4 | InBrace Provider of behind-the-teeth, teeth straightening | $173M | 47 mo ago | 156 | Hongsheng Tong Co-Founder | Apple iCloud MailMicrosoft 365Node.js+32 | Top 10M | — | — |
| 5 | Candid Developer of dental aligners | $148M | 66 mo ago | 501 | Bobby Ghoshal Co-founder (was CXO) | WebflowSentryZendesk+49 | Top 5M | 2 patents Automated deployment and management of cloud infrastructure services | — |
| 6 | OraMetrix Straighter teeth and healthier smiles through aligners, braces, and retainers | $135M | 157 mo ago | 95 | — | — | — | 122 patents Digital orthodontic treatment planning and custom archwire shaping using 3D craniofacial modeling | — |
| 7 | Convergent Dental Dental laser technology company revolutionizing dental practices with innovative solutions | $116M | 37 mo ago | 89 89 → 111 (+25%) | — | HubSpot CMS HubSalesforceWistia+24 | Top 10M | 180 patents Laser-based dental tissue treatment and periodontal therapy devices | — |
| 8 | Align Technology Developer of invisalign clear aligners and other dental products | $105M | 99 mo ago | 1,051 | Joe Hogan CEO | DrupalApple iCloud MailMicrosoft 365+28 | Top 1M | 4,569 patents Digital orthodontic devices, 3D‑printed aligners, and imaging software for tooth modeling and treatment planning. | 1 launch · 1 award |
| 9 | Keystone Dental Dental solutions provider: implants, biomaterials, prosthetics, instruments, and planning software | $86M | 132 mo ago | 107 107 → 204 (+91%) | — | Shogun Page BuilderCart FunctionalityShopify+21 | Top 5M | 47 patents Advanced internal connection systems and modular components for dental implants and prostheses. | 1 expansion |
| 10 | Acologix Therapeutics for the treatment of metabolic disorders of kidney and bone | $70M | 244 mo ago | 13 | — | — | — | 49 patents Peptide therapeutics for cartilage and bone regeneration with high‑temperature stability | — |
| 11 | OrthoAccel Technologies Micro-pulse based orthodontic device | $68M | 85 mo ago | 35 | — | — | — | 44 patents Vibratory orthodontic devices accelerating tooth movement and enhanced aligner aesthetics | — |
| 12 | OrthoAccel Technologies Orthodontic treatment for straightening teeth | $63M | 113 mo ago | 35 | — | — | — | 44 patents Accelerated orthodontic treatment via vibrating dental devices and enhanced clear aligners. | — |
| 13 | Young Innovations Portfolio of dental equipment | $58M | 159 mo ago | 557 557 → 500 (-10%) | — | — | — | — | 1 launch · 1 award |
| 14 | Perceptive IO AI-powered automated robotic surgery device for dentists | $45M | 10 mo ago | — | Chris Ciriello Co-Founder & CEO | Craft CMSPHPYii+9 | Top 50M | 22 patents Vehicle safety and autonomous perception sensors integrating IR seat‑belt detection and centralized object detection networks. | — |
| 15 | Mavrik Dental Modernizing dental therapies with innovative oral care automation for enhanced aesthetics | $30M | 78 mo ago | 24 | Daniel Sanders Co-Founder | — | — | — | — |
| 16 | Eon Aligner Provider of invisible and removable braces | $26M | 55 mo ago | 216 | Firas Shahrour Co-Founder | WebflowReactMicrosoft Clarity+13 | Top 5M | — | — |
| 17 | Portray Developer of intraoral 3D Tomosynthesis dental X-ray system | $25M | 35 mo ago | 19 | David Vance CEO | — | — | — | — |
| 18 | Boka Sciences Provider of saliva-based real time health monitoring devices | $18M | 72 mo ago | 5 | Porter Jones CEO | — | — | — | — |
| 19 | OraPharma Developer of treatment for oral health | $16M | 330 mo ago | 175 | — | SentryWistiaBootstrap+9 | Top 50M | 28 patents Patents concentrated in transport & manufacturing processes | — |
| 20 | Soocas Manufacturer of electric toothbrushes, water flossers, and related oral health products | $16M | 99 mo ago | — | Meng Fandi Founder & CEO | Amazon WebstoreCart FunctionalityShopify+34 | Top 5M | — | — |
| 21 | Lighthouse Pharma Developer of therapeutics for neurology and infectious diseases 11Funding top 46%Talent bottom 49%Tech bottom 45%Global bottom 25% All 5 signals ▾Fundingtop 46% Talentbottom 49% Techbottom 45% Globalbottom 25% Marketbottom 18% Funding: Raised $15.2M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) Talent: 1 named leader on record · 1 C-suite/founder profile curated rank vs industry peers · Fliar Intelligence Index 11/100 | $15M | 1 mo ago | 4 | Casey Lynch Chief Executive Officer | WixSentryBootstrap+10 | Top 50M | — | 1 job opening |
| 22 | Specialty Appliances Leading US orthodontic lab providing custom appliances and exceptional customer care | $15M | 77 mo ago | 115 115 → 110 (-4%) | Scott Huge CEO | Cart FunctionalityWooCommerceWordPress+30 | Top 5M | — | — |
| 23 | St. Renatus Developer of needle-free nasal spray | $11M | 109 mo ago | — | Jim Mulvahill Co-Founder | — | — | 48 patents Dental intranasal anesthetic formulations and software for managing sales campaigns | — |
| 24 | Biolectrics Developer of a medical device for oral care solutions | $9M | 73 mo ago | 7 | Bill Leimkuehler Co-Founder | — | — | 81 patents Intraoral electrical stimulation and iontophoresis devices for oral disease treatment | — |
| 25 | Danville Materials Develops dental products and focused on producing clinical dental materials | $8M | 148 mo ago | 45 | Garrett Sato CEO | — | — | — | — |
| 26 | iDentical Provider of a developer of personalized, drill-free dental implants that offers a safer, faster, and more… | $8M | 50 mo ago | 10 | Iris Wedeking Co-Founder & CEO | WixSentryBootstrap+11 | Top 50M | 31 patents Custom root-analog and multi-root dental implants for personalized oral reconstruction | — |
| 27 | TriAgenics Developer of a minimally invasive wisdom tooth prevention treatment. | $8M | 14 mo ago | 2 | Leigh Colby CEO & President | WordPressMySQLPHP+16 | Top 50M | 91 patents Dental therapeutic ablation devices for targeted tooth‑bud removal and related medical probe systems. | — |
| 28 | Six Month Smiles Fast, affordable teeth straightening solutions with clear braces and aligners | $8M | 136 mo ago | 45 | Perry S. Lowe CEO | HubSpot CMS HubUnbounceReact+21 | Top 10M | 8 patents Orthodontic bracket systems and kits for dental alignment and treatment. | — |
| 29 | Onpharma Innovating local anesthetic buffering solutions for efficient and painless dentistry | $8M | 178 mo ago | 21 | Matt Stepovich President & Chief Executive Officer | Cart FunctionalityShopifyJava+24 | Top 10M | 86 patents Formulating and delivering buffered anesthetic solutions for improved stability and efficacy. | — |
| 30 | BioMers Medical device company for orthodontic treatment | $5M | 175 mo ago | — | — | — | — | — | — |
| 31 | CuRE Innovations Specialty company developing and marketing oral health products | $4M | 123 mo ago | 2 | — | — | — | — | — |
| 32 | Cagenix Titanium dental frameworks | $3M | 178 mo ago | 26 | Carl Schulter Founder | — | — | 33 patents Design and manufacturing of dental implant frameworks and prosthetic overdenture systems. | — |
| 33 | InPronto Custom engineered end-to-end surgical and prosthetic solution for Dentist | $3M | 175 mo ago | 11 | Issa Geroge Karkar Co-Founder & CEO | — | — | 5 patents Dental implant planning software and surgical kit systems for tooth replacement | — |
| 34 | Bristle Provider of dental treatment kits and dental health monitoring platform for individuals | $3M | 46 mo ago | 7 | Shivam Patel Co-Founder | Cart FunctionalityShopifySentry+36 | Top 5M | 2 patents Diagnostic analysis of oral microbiome composition for health outcome prediction | — |
| 35 | Brontes Technologies Developer of intraoral imaging technology solutions for dental | $3M | 248 mo ago | — | Michael Roman CEO | — | — | — | — |
| 36 | Balto Therapeutics Rapid oral dissolving formulations for patients with difficulty swallowing | $3M | 104 mo ago | 2 | Thomas Fernandez Co-Founder | — | — | — | — |
| 37 | PerioSciences Topically applied, antioxidant-based oral care products | $3M | 151 mo ago | 12 | Russell Moon Founder & CEO | Cart FunctionalityShopifyShop Pay+44 | Top 5M | — | 1 launch |
| 38 | Arcato Laboratories Develops products using sustained release of anaesthetics technology to serve oral healthcare practitioners | $2M | 93 mo ago | 2 | Michael Jay Founder | — | — | — | — |
| 39 | Nasseo Nanotechnology for Medical Devices | $2M | 119 mo ago | 4 | Garrett Cale Smith Co-Founder & CEO | — | — | 2 patents Nanotube-coated dental implants and abutments for enhanced osseointegration. | — |
| 40 | OraHealth Developer of products for oral care | $2M | 172 mo ago | 10 | — | — | — | 63 patents Mucoadhesive oral drug delivery systems for mucosal lesion treatment and saliva stimulation | — |
| 41 | BRIUS Developer of an invisible orthodontic treatment system. | $2M | 14 mo ago | 31 31 → 47 (+52%) | Mehdi Peikar Founder | — | — | 10 patents Orthodontic appliance design and teeth repositioning systems for dental alignment. | — |
| 42 | BioHorizons Developer of dental implant technologies and tissue regeneration products | $2M | 162 mo ago | 331 331 → 500 (+51%) | — | Apple iCloud MailSalesforceVimeo+18 | Top 1M | — | 4 launchs |
| 43 | The Restful Jaw Innovating dental solutions for stability, support, and safety during procedures | $1M | 78 mo ago | — | Eric Schiffman Co-Founder | — | — | 9 patents Oral jaw support devices for sleep apnea and orthodontic therapy | — |
| 44 | Versah Innovating osseodensification with specialized dental burs and comprehensive surgical solutions | $1M | 139 mo ago | — | Salah Huwais Founder & President | Cart FunctionalityBigCommerceAmazon Web Services+24 | Top 5M | 50 patents Surgical burr kit holders and keyless guided orthopedic surgery instrumentation | 1 launch · 1 award |
| 45 | Photomedics Developer of smart devices for oral hygiene care | $1M | 39 mo ago | — | Nikos Soukos Co-Founder & CEO | — | — | 2 patents Patents concentrated in health & consumer products | — |
| 46 | EPIEN Medical Developer of cleansing devices to treat infected tissue surfaces and remove biofilm | $900K | 57 mo ago | 14 | Roger Barrett Founder & VP Operations | WordPressMySQLPHP+16 | Top 50M | — | — |
| 47 | Snoasis Medical Biologic solutions for clinicians, delivering trusted results in regenerative dentistry | $660K | 54 mo ago | 20 | — | — | — | — | — |
| 48 | Quadric BioMed Developer of next-generation dental implants | $550K | 37 mo ago | 1 | Jim Grant Co-Founder | — | — | — | — |
| 49 | ClearClub Provider of an online platform for the purchase of customized dental guards | $480K | 36 mo ago | 9 | — | Cart FunctionalityShopifylit-html+21 | Top 5M | — | — |
| 50 | Standard Dental Labs Manufacturer of dental products, including implants, crowns, bridges, and dentures | $118K | 8 mo ago | — | James Brooks Chief Executive Officer | — | — | — | — |
Top 12 Dental Disorders companies in United States
#1
Series A · San Francisco, California · founded 2019 · 4 employees$15.2Mraised▾
Developer of therapeutics for neurology and infectious diseases. It offers a pipeline of drug candidates which include LHP588, is a next-generation gingipain inhibitor for gingivalis infection which causes Alzheimer's disease, Parkinson's disease, and oral dyslapsia. It also offers LHP852 for gingivalis infection and LHP803 for coronavirus infection.
- Apr 2026Series A$15.2M
#2
Public · Laguna Hills, California · founded 2006 · 216 employees$285.4Mraised▾
Developer of therapy device to treat tooth decay. The company develops GentleWave System, an innovative technology platform designed to treat tooth decay by cleaning and disinfecting the microscopic spaces within teeth without the need to remove tooth structure. Also, offers TDO Software integrates practice management, imaging, referral reporting, and CBCT imaging, and offers built-in communication with the GentleWave System.
- Apr 2025Post IPO$5M
- Sep 2022Post IPO$63M
- Dec 2019Series G$84.7M
- Jul 2019Series F$17M
#3
Series B · Madison, Wisconsin · founded 2018$45.1Mraised▾
AI-powered automated robotic surgery device for dentists. The company combines novel imaging technology with AI and surgical robotics to automate surgery in dental industry.
- Aug 2025Grant (prize money)$1.7M
- Jul 2025Series B—
- Jul 2024Series B$30M
- Sep 2023Grant (prize money)$1.7M
#4
Series A · Redmond, Oregon · founded 2016 · 2 employees$8Mraised▾
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- Apr 2025Series A$3M
- Jan 2025Series A$5M
#5
Series D · Miami, Florida · founded 2012 · 118 employees$179.4Mraised▾
Provider of robotic guidance system for dental surgeries. It is a computerized navigational system that assists both pre and intra-operative phases of dental implantation surgery. The device involves haptic robotic technology to provide physical guidance. It provides a haptic response to the dental surgeon’s hand for precise angulation during oral procedures.
- Jan 2024Series D$20M
- Oct 2022Series D$40M
- Oct 2020Series D$72M
- Jul 2019Series C$30M
#6
Series A · Addison, Texas · founded 2006 · 31 employees$1.7Mraised▾
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- Apr 2025Series A$19.5M
- Apr 2023Seed$1.7M
#7
Series C · Natick, Massachusetts · founded 2011 · 89 employees$116.1Mraised▾
Dental laser technology company revolutionizing dental practices with innovative solutions. They specialize in all-tissue laser systems, providing dentists with advanced tools for restorative, soft tissue, pediatric, implant, and cosmetic procedures. Their flagship product offers an anesthesia-free, blood-free, suture-free experience, enhancing patient comfort and practice efficiency. The company focuses on minimally invasive dentistry, enabling faster healing times and reliable outcomes. They empower dental professionals to elevate their practices through improved efficiency, patient experience, clinical effectiveness, and procedural expansion. The company provides training, education, and ongoing support to ensure successful adoption and utilization of their technology. They are committed to advancing dental care through innovation and a patient-centric approach.
- Apr 2023Venture Debt$40M
- Apr 2023Series C$10.1M
- Oct 2021Series C$43.7M
- Sep 2019Series B$8M
#8
Deadpooled · Nashville, Tennessee · founded 2014 · 1360 employees$439.5Mraised▾
Developer of customized dental aligners. The online platform can be used to order the aligners by taking teeth impressions and the company develops customized invisible aligners for the users.
- Feb 2021Post IPO$350M
- Oct 2018Series C$380M
- Jul 2017Series B$12.8M
- 2016Series B$46.7M
#9
Series D · Irvine, California · founded 2014 · 156 employees$172.6Mraised▾
Provider of behind-the-teeth, teeth straightening
- Jul 2022Venture Debt$45M
- Sep 2021Series D$102M
- Jul 2019Series C$45M
- Jan 2018Series B$20M
#10
Seed · Orlando, Florida · founded 1998$117.5Kraised▾
Manufacturer of dental products, including implants, crowns, bridges, and dentures. The company provides dental clinics with a range of restorative options. It focuses on collaborating with dental professionals to meet specific requirements. The manufacturer aims to deliver consistent and accurate results for patient care.
- Sep 2025Seed$117.5K
#11
Series B · New York City, New York · founded 2017 · 501 employees$147.8Mraised▾
Candid develops dental aligners. The company's product includes a 3D printed dental aligner which is used for the straightening of teeth. The company has developed a modeling kit that is used to create custom models. The company offers software and hardware orthodontics products used for the treatment plans and provides aligners based on custom measurements.
- Dec 2020Series B$54M
- Apr 2019Series B$63.4M
- Mar 2019Series A$13.4M
- Nov 2017Series A$15M
#12
Series B · Morrisville, North Carolina · founded 2015 · 19 employees$25.3Mraised▾
Developer of intraoral 3D Tomosynthesis dental X-ray system. It offers a Portray system and software that uses 3D Tomosynthesis to reconstruct X-rays taken from several angles into a 3D volume of images of the patient’s teeth. It provide information regarding caries, fractures, endodontic issues, periodontic conditions, and other oral pathologies.
- Jun 2023Series B$4.4M
- Apr 2019Series B$25.3M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Dental Disorders coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.