Disease Self Management · United States, India

Best Disease Self Management Companies in United States

Updated 2026-06-16 · Ranked by funding & momentum

2899 indexable Disease Self Management companies headquartered in United States, ranked by total equity funding and recent funding momentum. Combined disclosed equity funding of $18.5B across 1025 funded companies, including 9 unicorns.

2,899
Companies
$18.5B
Total Funding
1,025
Funded
9
Unicorns
8
Rounds (90d)

Ranked: Best Disease Self Management companies in United States

#CompanyFundingValuationStage Latest roundEmployeesFoundedMomentum
1 Cala Health
Developer of a wearable non-invasive neuromodulation device
$157.1M Series D Conventional Debt Apr 2026 50 2013 ↑ Active
2 BigHealth
CBT therapy for insomnia patients
$129.3M Series C Series C Feb 2026 251 2010 ↑ Active
3 Join Midi Unicorn
Provider of a virtual care platform focused on female midlife health
$104M Series D Series D Feb 2026 52 2021 ↑ Active
4 Signos
Provider of a wearable device for blood glucose pattern monitoring
$37M Series B Series B May 2026 30 2020 ↑ Active
5 MedRhythms
Provider of wearable devices to combat neurological injuries and recover walking functions
$57.1M Series B Series B Feb 2026 41 2013 ↑ Active
6 Nanit
Provider of smart baby monitoring systems with sleep and breathing analysis
$75M Series D Series D Dec 2025 111 2014 ↑ Active
7 Sword Health Unicorn
Provider of AI-powered digital physical therapy and pelvic health solutions
$340M $3B
as of 2024
Series E Series E Jun 2025 1 2015 ↑ Active
8 Lumia Health
Developer of wearable ear devices tracking blood flow to head
$29.1M Series B Series B Mar 2026 2020 ↑ Active
9 BioIntelliSense
Developer of medical-grade wearable devices and data services for patient monitoring
$82M Series C Series C Dec 2025 26 2018 ↑ Active
10 9amHealth
Provider of whole-body approach to healthcare delivering multiple services
$29.8M Series B Series B Mar 2026 35 2021 ↑ Active
11 Huxley Medical
Provider of wearable devices to monitor body chemistry
$12.6M Series A Series A Apr 2026 16 2019 ↑ Active
12 Axion
Developer of medical device depression treatment support program for patients
$62M Series B Series B Dec 2025 2021 ↑ Active
13 Jana Care
Provider of mobile-based healthcare diagnostics for diabetes prevention
$17.7M Series C Series C Mar 2026 60 2011 ↑ Active
14 Ubie
Developer of an AI-powered system providing symptom check and medical information
$110.5M Series C Series C Jun 2025 250 2017 ↑ Active
15 Patientory
Provider of a digital health passport wallet and related healthcare services
$6.9M Series A Series A Apr 2026 8 2015 ↑ Active
16 Neuros Medical
Neurostimulation therapy for chronic neuropathic pain
$89.2M Series D Series D Jul 2025 28 2008 ↑ Active
17 Eko
Provider of AI-based remote patient monitoring platform for cardiac health
$167M Series D Grant (prize money) Apr 2025 95 2012 ↑ Active
18 Malama Health
Provider of an app for women to manage gestational diabetes
$9.3M Seed Seed Mar 2026 52 2022 ↑ Active
19 Biolinq
Provider of a wearable biosensor platform for diabetes monitoring
$175.1M Series C Series C Mar 2025 91 2012 ↑ Active
20 LifeLens
Developer of wireless ECG monitor for personal health monitoring use
$24.6M Series B Series B Nov 2025 45 2014 ↑ Active
21 SafeinHome
A home monitoring system for the elderly
$25M Series D Series D Dec 2025 110 2012 ↑ Active
22 Inito
Provider of test devices to track fertility hormones at home
$15M $1.5M
as of 2023
Series B Series B Dec 2025 175 2012 ↑ Active
23 LibAirty
Provider of airway clearance system synchronizing controlled breathing with chest compressions
$9.3M Series A Series A Feb 2026 2016 ↑ Active
24 SOBR Safe
Manufacturer of medical devices
$12.7M Public Post IPO Dec 2025 15 2007 ↑ Active
25 Neopenda
Provider of wearable neonatal signs monitor
$2.7M Seed Conventional Debt Apr 2026 14 2015 ↑ Active
26 AngelEye Health
Provider of video, data, and analysis solutions for pediatric patient care
$12.2M Series C Series C Dec 2025 48 2013 ↑ Active
27 Vital Connect
Developer of biosensor patch for body vitals monitoring
$139.9M Series G Series G Feb 2025 184 2011 ↑ Active
28 Cloud
Provider of cloud-based remote cardiology vital signs monitoring devices and platforms
$3.1M Public Post IPO Mar 2026 55 2014 ↑ Active
29 K Health Unicorn
AI-based platform providing access to clinicians
$438.5M $900M
as of 2024
Series F Series F Jul 2024 19 2016 ↑ Active
30 Somatix
Provider of an AI-based remote health monitoring tool
$17.3M Acquired Series A Sep 2025 27 2015 ↑ Active
31 NightWare
Developer of a prescription digital therapeutic system for nightmare disorder
$3.5M Seed Seed Feb 2026 16 2015 ↑ Active
32 IBS
Developer of fingerprint drug testing and sweat drug monitoring solutions
$10M Public Post IPO Dec 2025 26 2016 ↑ Active
33 Glooko
Glucose meter and mobile app for diabetes management
$201M Series F Series F Oct 2024 121 2010 ↑ Active
34 NextSense
Developer of wireless earbuds that monitor brain activity and enhance sleep
$12.7M Series A Series A Nov 2025 20 2020 ↑ Active
35 Youth Health Tech
Platform offering health screening solutions
$4.5M Series A Series A Feb 2026 2023 ↑ Active
36 Avertix
Provider of an implantable heart attack warning system
$13.8M Series B Series B Sep 2025 31 2001 ↑ Active
37 Adaptyx Biosciences
Platform offering microneedle sensor patch
$14.2M Seed Seed Oct 2025 2022 ↑ Active
38 Spark Biomedical
Developer of wearable neurostimulation technology for drug-free opioid withdrawal treatment
$16.2M Series A Grant (prize money) Aug 2025 18 2018 ↑ Active
39 AventuSoft
Cloud connected wearable to detect heart related abnormalities
$13.7M Funding Raised Grant (prize money) Sep 2025 4 2013 ↑ Active
40 K4Connect
Integrated technology solutions enhancing senior living community experiences and operational efficiency
$51.3M Series C Series C Mar 2025 48 2013 ↑ Active
41 Sibel Health
Developer of wireless medical monitoring devices for clinical and remote use
$50M Series C Series C Mar 2025 47 2018 ↑ Active
42 BrainCo
Provider of a prosthetic hand and EEG headband for brain signal
$5.5M Series A Series A Jan 2026 40 2015 ↑ Active
43 SafelyYou
Provider of AI-based solutions for senior care and fall management
$59.5M Series C Series C Jan 2025 85 2014 ↑ Active
44 CoachCare
Provider of remote patient monitoring and virtual health support services
$48.2M Series C Series C Feb 2025 45 2013 ↑ Active
45 PhotoPharmics
Developer of non-invasive phototherapy for Parkinson's disease
$29.7M Series B Series B Apr 2025 7 2011 ↑ Active
46 Redi
Mobile-based application of medication adherence management
$17.7M Series B Series B Aug 2025 20 2021 ↑ Active
47 Wellinks
Provider of virtual pulmonary rehabilitation and personalized chronic obstructive pulmonary disease management
$26.1M Series A Series A May 2025 41 2013 ↑ Active
48 BrainHQ
Online brain training platform for cognitive improvement and brain health
$11.8M Series A Grant (prize money) Jul 2025 31 2002 ↑ Active
49 VerAvanti
Innovating intravascular imaging with advanced single-use endoscopes for enhanced patient care
$5.5M Series B Series B Oct 2025 13 2012 ↑ Active
50 DUSQ
Developer of sleep science studying recovery regulation under modern conditions
$2.6M Seed Seed Feb 2026 2024 ↑ Active

Top 12 Disease Self Management companies in United States

#1
Cala Health Series D
$157.1M Raised
expand_more
#1

Cala Health Series D

location_onStanford, California
Founded
2013
Employees
50
Funding raised
$157.1M
Stage
Series D

Developer of a wearable non-invasive neuromodulation device. The company has developed a neuromodulation device that aims to provide relief of hand tremors in adults with essential tremors. It combines a watch-like device with an implantable sensor that externally stimulates peripheral nerves to reduce the same. The company has also developed a portable medical device with sensors to monitor the physical movement of

Funding rounds (7 disclosed of 9)
Round Date Amount
Conventional Debt Apr 2026 $50M
Series D Oct 2025 $50M
Series D Dec 2024 $50M
Series D May 2022 Undisclosed
Series D Nov 2021 $77M
Series C May 2019 $50.1M
3 earlier rounds — sign up free
Tech stack
accessibeamplitudeapple icloud mailcdnjschoicescloudflare+14
#2
BigHealth Series C
$129.3M Raised
expand_more
#2

BigHealth Series C

location_onSan Francisco, California
Founded
2010
Employees
251
Funding raised
$129.3M
Stage
Series C

CBT therapy for insomnia patients. Its flagship product Sleepio is a digital sleep improvement program, clinically proven to help users overcome poor sleep. Its virtual sleep expert "The Prof" teaches users proven Cognitive Behavioral Therapy (CBT) techniques, personalized to their problems and monitors their progress. Sleepio has been validated in the world’s first placebo-controlled RCT for a digital sleep interv

Funding rounds (5 disclosed of 5)
Round Date Amount
Series C Feb 2026 $23.7M
Series C Jan 2022 $75M
Series B Jun 2020 $39M
Series B Jul 2016 $12M
Series A Apr 2014 $3.3M
Tech stack
amazon cloudfrontamazon s3amazon sesamazon web servicesapolloapple icloud mail+14
#3
Join Midi Unicorn Series D
$104M Raised
expand_more
#3

Join Midi Unicorn Series D

location_onLos Altos Hills, California
Founded
2021
Employees
52
Funding raised
$104M
Stage
Series D

Provider of a virtual care platform focused on female midlife health

Funding rounds (6 disclosed of 6)
Round Date Amount
Series D Feb 2026 $100M
Series C Oct 2025 $50M
Series B Sep 2024 $5M
Series B Apr 2024 $60M
Series A Sep 2023 $25M
Seed Oct 2022 $14M
Founders & key people
Tech stack
amazon cloudfrontamazon web servicesapple paycart functionalitycloudflarecore-js+14
#4
Signos Series B
$37M Raised
expand_more
#4

Signos Series B

location_onSan Francisco, California
Founded
2020
Employees
30
Funding raised
$37M
Stage
Series B

Provider of a wearable device for blood glucose pattern monitoring. The company has developed an app-based platform that recommends meals and exercises for users based on the glucose pattern detected through the connected device. The app provides real-time glucose monitoring and glucose spike levels for different foods. Based on this, personalized fitness and nutrition plan can be developed.

Funding rounds (3 disclosed of 3)
Round Date Amount
Series B Oct 2023 $20M
Series A Nov 2021 $13M
Seed Jan 2021 $4M
Tech stack
addshoppersamazon cloudfrontamazon web servicescloudflarecloudflare bot managementcore-js+14
#5
MedRhythms Series B
$57.1M Raised
expand_more
#5

MedRhythms Series B

location_onBoston, Massachusetts
Founded
2013
Employees
41
Funding raised
$57.1M
Stage
Series B

Provider of wearable devices to combat neurological injuries and recover walking functions. The company has developed inertial measurement unit (IMU) sensors to measure gait parameters and run proprietary algorithms on them to make changes to the music accordingly. It uses artificial intelligence to personalize and improve the algorithm over time, as well as make predictive insights about the user population.

Funding rounds (7 disclosed of 7)
Round Date Amount
Series B Feb 2026 $3.3M
Series B Mar 2025 $2.9M
Series B Nov 2023 $19.8M
Series B Feb 2023 $5.8M
Series B Jul 2021 $25M
Seed Aug 2019 $1.5M
1 earlier round — sign up free
Tech stack
wordpressmysqlmariadbphphello elementorvarnish+14
#6
Nanit Series D
$75M Raised
expand_more
#6

Nanit Series D

location_onNew York City, New York
Founded
2014
Employees
111
Funding raised
$75M
Stage
Series D

Provider of smart baby monitoring systems with sleep and breathing analysis. The systems offer real-time safety notifications, video history, and personalized sleep coaching. Features include breathing motion monitoring without sensors and advanced sleep insights. The company provides a range of compatible accessories, including breathing wear and display screens. It also offers membership plans for expanded data and

Funding rounds (5 disclosed of 5)
Round Date Amount
Series D Dec 2025 $50M
Series C Feb 2021 $25M
Series C May 2020 $21M
Series B May 2018 $14M
Series A Apr 2016 $6.6M
Tech stack
ab tastyamazon cloudfrontamazon payamazon web servicesapple payattentive+14
#7
Sword Health Unicorn Series E
$340M Raised
expand_more
#7

Sword Health Unicorn Series E

location_onNew York, New York
Founded
2015
Employees
1
Funding raised
$340M
Valuation
$3B · 2024
Stage
Series E

Provider of AI-powered digital physical therapy and pelvic health solutions. It offers personalized therapy programs combining artificial intelligence with human clinical expertise. These programs address muscle and joint pain, pelvic health conditions, and movement health issues. The company also provides on-demand access to clinical pain specialists and educational resources. Its solutions are designed to improve p

Funding rounds (11 disclosed of 11)
Round Date Amount
Series E Jun 2025 $40M
Series D Jun 2024 $30M
Series D Nov 2021 $163M
Series C Jun 2021 $85M
Series B Jan 2021 $25M
Series A Feb 2020 $9M
5 earlier rounds — sign up free
Tech stack
amazon s3amazon web servicesapple icloud mailbootstrapcloudflarecloudflare bot management+14
#8
Lumia Health Series B
$29.1M Raised
expand_more
#8

Lumia Health Series B

location_onBoston, Massachusetts
Founded
2020
Funding raised
$29.1M
Stage
Series B

Developer of wearable ear devices tracking blood flow to head. These devices monitor physiological metrics to assist individuals in understanding how daily activities and physical positioning influence blood circulation. The hardware integrates with mobile software to record and analyze data regarding heart rate and blood flow patterns. Users can tag specific events or behaviors to identify factors that affect their

Funding rounds (3 disclosed of 3)
Round Date Amount
Series B Mar 2026 $17M
Series A Nov 2025 $7M
Grant (prize money) Nov 2025 $5.1M
Tech stack
amazon cloudfrontamazon web servicesclickbankcloudflarecore-jsfacebook pixel+14
#9
BioIntelliSense Series C
$82M Raised
expand_more
#9

BioIntelliSense Series C

location_onDenver, Colorado
Founded
2018
Employees
26
Funding raised
$82M
Stage
Series C

Developer of medical-grade wearable devices and data services for patient monitoring. it provides BioButton a rechargeable, multi-parameter wearable that captures vital signssuch as heart rate, respiratory rate, and skin temperature. It is integrated with data platforms BioCloud that provides advanced analytics and algorithmic notifications to support actionable triage and workflow efficiency and BioDashboard that En

Funding rounds (4 disclosed of 4)
Round Date Amount
Series C Dec 2025 $58.1M
Series B Jul 2021 $45M
Series B Aug 2020 $12M
Series B Dec 2018 $25M
#10
9amHealth Series B
$29.8M Raised
expand_more
#10

9amHealth Series B

location_onEncinitas, California
Founded
2021
Employees
35
Funding raised
$29.8M
Stage
Series B

Provider of whole-body approach to healthcare delivering multiple services. The company's services include personalized care plans, prescription medication, at-home lab tests, virtual medical care, devices & supplies.

Funding rounds (2 disclosed of 4)
Round Date Amount
Series B Mar 2026 $26M
Series A Feb 2024 $9.5M
Series A Apr 2022 Undisclosed
Seed 2021 Undisclosed
Tech stack
amazon cloudfrontamazon s3amazon web servicesapple icloud mailcloudflarecloudflare bot management+14
#11
Huxley Medical Series A
$12.6M Raised
expand_more
#11

Huxley Medical Series A

location_onAtlanta, Georgia
Founded
2019
Employees
16
Funding raised
$12.6M
Stage
Series A

Provider of wearable devices to monitor body chemistry. It is offering an ultrathin biosensor patch to monitor and communicate various details of body chemistry and composition.

Funding rounds (9 disclosed of 9)
Round Date Amount
Series A Apr 2026 $2.8M
Series A Nov 2025 $10M
Series A May 2025 $1.7M
Series A Nov 2024 $4.6M
Series A Feb 2024 $5.4M
Series A Jun 2023 $7.2M
3 earlier rounds — sign up free
Tech stack
cdnjscloudflarecloudflare turnstilegoogle analyticsgoogle font apigoogle hosted libraries+11
#12
Axion Series B
$62M Raised
expand_more
#12

Axion Series B

location_onBrooklyn, New York
Founded
2021
Funding raised
$62M
Stage
Series B

Developer of medical device depression treatment support program for patients. The program aims to provide support for individuals undergoing depression treatment. The company focuses on research, development, and sales in the medical device field. It is actively seeking partners for further research, development, and sales efforts.

Funding rounds (3 disclosed of 3)
Round Date Amount
Series B Dec 2025 $37M
Series A Mar 2024 $17.5M
Seed Feb 2023 $7.5M
Tech stack
cloudflarecloudflare bot managementframer sitesgoogle analyticsgoogle font apihsts+10

Recent signals in United States Disease Self Management

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Funding & investor landscape

Total raised
$18.5B
across these companies
Companies funded
1,025
with disclosed funding
Highest-funded
$877M raised

Most active investors

H HHS 136 investments in Disease Self Management M MassChallenge 63 investments in Disease Self Management T Techstars 60 investments in Disease Self Management NF National Science Foundation 44 investments in Disease Self Management YC Y Combinator 44 investments in Disease Self Management SH StartUp Health 36 investments in Disease Self Management AF America’s Seed Fund 26 investments in Disease Self Management N NIH 26 investments in Disease Self Management SE Springboard Enterprises 25 investments in Disease Self Management H HAX 24 investments in Disease Self Management PC Plug and Play Tech Center 24 investments in Disease Self Management JF Jumpstart Foundry 22 investments in Disease Self Management

Notable founders in United States Disease Self Management

DH Deanna Harshbarger CEO Cala Health · $157.1M raised
KR Kate Rosenbluth Founder and Co-President Cala Health · $157.1M raised
CE Colin Espie Co-Founder BigHealth · $129.3M raised
YB Yael Berman CEO BigHealth · $129.3M raised
JS Joanna Strober Founder Join Midi · $104M raised
SF Sharam Fouladgar-Mercer Co-Founder & CEO Signos · $37M raised
BH Brian Harris Co-Founder & CEO MedRhythms · $57.1M raised
OM Owen Mccarthy Co-Founder MedRhythms · $57.1M raised
AB Andrew Berman Co-Founder Nanit · $75M raised
TI Tor Ivry Founder & Cto Nanit · $75M raised
AS Andre Santos Co-Founder Sword Health · $340M raised
IG Ivo Gabriel Co-Founder Sword Health · $340M raised

Frequently asked questions

How many Disease Self Management companies are there in United States?
Radar tracks 2899 indexable Disease Self Management companies headquartered in United States, India, that meet our profile-completeness bar.
What is the total funding raised by Disease Self Management companies in United States?
The Disease Self Management companies in United States on this list have raised a combined $18.5B in disclosed equity funding across 1025 funded companies.
Which is the highest-funded Disease Self Management company in United States?
Jawbone is the highest-funded Disease Self Management company in United States, with $877M in disclosed equity funding.
How many Disease Self Management companies in United States are funded?
1025 of the 2899 Disease Self Management companies in United States on this list have disclosed at least one equity funding round.
How many Disease Self Management unicorns are there in United States?
9 Disease Self Management companies in United States on this list are valued at $1B or more.
Who are the top investors in United States Disease Self Management companies?
The most active investors in United States Disease Self Management companies on this list include HHS, MassChallenge, Techstars, National Science Foundation, Y Combinator.

Rankings are computed by Radar (Fliar BI) from the Radar company master and are updated periodically. Funding and momentum scores use disclosed equity-funding data only. Figures may lag private rounds. Last updated 2026-06-16.

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