Best Healthcare IT Companies in Illinois, United States
The 338 best Healthcare IT companies in Illinois, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: VillageMD.
Our analysis of 90 Healthcare IT companies
$11.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Healthcare IT companies in Illinois
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | VillageMD Provider of value-based primary care management tools for providers | $1.2B | 72 mo ago | Acquired | 3,107 3,107 → 1,684 (-46%) · sector median +46% | Tim Barry Co-Founder & CEO | — | — |
| 2 | Tempus 🦄 Developer of genomic testing and artificial intelligence tools for medicine | $1.1B | 43 mo ago | Public | 772 | Eric Lefkofsky Founder & CEO | 594 patents AI-powered medical diagnostics: imaging biomarkers, liquid biopsy genomics, and cardiac ECG analysis | — |
| 3 | RLDatix GRC software solutions for the healthcare industry | $736M | 53 mo ago | Late Stage | 1,400 | Dan Michelson CEO | — | — |
| 4 | Outcome Health 🦄 Online patient engagement tool for providers | $533M | 107 mo ago | Acqui-Hired | 221 | — | — | — |
| 5 | Endotronix Provider of device for Measurement of Hemodynamic parameters for heart failure maangement | $155M | 80 mo ago | Acquired | 104 | Michael Nagy Engineer & product development | 234 patents Implantable wireless physiological monitoring using MEMS sensors and multi-frequency excitation | — |
| 6 | Upfront Healthcare Provider of data analytics platform to help clinics schedule and allocate resources | $96M | 36 mo ago | Acquired | 45 45 → 26 (-42%) · sector median +46% | Carrie Kozlowski COO & Co-Founder | — | — |
| 7 | Higi Gamified app for personal health management | $95M | 71 mo ago | Acquired | 53 53 → 75 (+42%) · sector median +46% | — | 17 patents Automated cuff blood pressure/arm circumference measurement devices and ocular biomolecule detection systems. | 1 partnership |
| 8 | Blue Health Intelligence Healthcare data analytics empowering better outcomes, equity, and value-based care | $71M | 106 mo ago | Series C | 179 | — | — | — |
| 9 | Nucle AI AI-assisted platform for image analysis | $60M | 26 mo ago | Series B | 9 | Lotan Chorev Co-Founder and VP R&D | — | — |
| 10 | TimeDoc Provider of the chronic care management solution for healthcare professionals | $57M | 50 mo ago | Series B | 156 | William Boeglin Co-Founder & CEO | — | — |
| 11 | Janus AI AI and SaaS-based revenue cycle management tool for healthcare providers | $56M | 20 mo ago | Series B | 94 94 → 110 (+17%) · sector median +46% | Brendan Downing Co-Founder & CEO | 28 patents Hardware security and access control solutions for computing devices and network interfaces | 3 job openings · 2 partnerships |
| 12 | Visibly Online vision test technology for providers | $50M | 38 mo ago | Series B | 29 29 → 62 (+114%) · sector median +46% | — | 19 patents Camera‑based ophthalmic diagnostics for refraction, astigmatism, and visual‑field assessment | — |
| 13 | Sibel Health Developer of wireless medical monitoring devices for clinical and remote use 32Funding top 25%Moat top 31%Talent bottom 49%Growth bottom 42% All 8 signals ▾Fundingtop 25% Moattop 31% Talentbottom 49% Growthbottom 42% Techbottom 41% Marketbottom 38% Globalbottom 36% Newsbottom 17% Funding: Raised $50.0M across 6 rounds · 6 rounds over 6 yrs (1.0/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 32/100 | $50M | 14 mo ago | Series C | 47 | Steve Xu Co-Founder & CEO | — | 1 award |
| 14 | AVIA Digital business management and networking platform for the healthcare industry | $50M | 89 mo ago | Series B | 177 | Linda Finkel CEO & President | — | 2 awards |
| 15 | Kalderos Online platform to coordinate and manage drug discount programs | $50M | 17 mo ago | Series C | 110 | James William Schuyler Co-Founder | 2 patents Healthcare marketplace financial transaction platforms for patient payments and secondary trades | 1 partnership |
| 16 | Valence Health Provider of clinical integration and health plan services. | $45M | 138 mo ago | Acquired | 503 | — | — | — |
| 17 | Apervita Analytics platform for for reducing readmission, disease risks and improving compliance | $44M | 80 mo ago | Series B | 13 | — | 2 patents Integrated electronic health record storage platform and graph transitive‑closure computation algorithms. | — |
| 18 | Sittercity Marketplace platform for caregivers | $43M | 150 mo ago | Acquired | 38 | — | — | — |
| 19 | Annexus Health Patient access and patient engagement solutions | $43M | 46 mo ago | Series B | 156 156 → 128 (-18%) · sector median +46% | Brad Frazier Co-Founder | — | — |
| 20 | Artisight Provider of IoT solutions for the healthcare industry | $42M | 12 mo ago | Series B | 63 63 → 139 (+121%) · sector median +46% | Garrett Larance Co-Founder | 3 patents Remote monitoring and communication systems for IoT devices | 2 partnerships · 1 award |
| 21 | Healthsense Remote monitoring, emergency call, and wellness management solutions | $34M | 123 mo ago | Acqui-Hired | 40 | — | 36 patents Wearable and remote personal activity monitoring systems for health tracking | — |
| 22 | Blueprint Provider of AI-powered documentation and insights for mental health therapists | $32M | 14 mo ago | Series B | 4 | Danny Freed Founder & CEO | — | — |
| 23 | KeyCare Digital teleconsultation tool for providers and patients 45Funding top 25%News top 36%Moat top 39%Growth top 45% All 8 signals ▾Fundingtop 25% Newstop 36% Moattop 39% Growthtop 45% Techtop 45% Talentbottom 49% Marketbottom 40% Globalbottom 37% Funding: Raised $29.5M across 4 rounds · 4 rounds over 4 yrs (1.0/yr) News: 2 BI events in 12 mo (of 4 tracked, 2 types) · Top themes: Funding, Capital raise rank vs industry peers · Fliar Intelligence Index 45/100 | $29M | 3 mo ago | Series A | 21 | Lyle Berkowitz Founder & CEO | — | — |
| 24 | PhysIQ Provider of AI-based personalized physiology data analytics platform. | $26M | 76 mo ago | Series B | 84 | — | 23 patents AI-driven wearable monitoring for activity recognition and cardiovascular health analytics | — |
| 25 | PatientIQ Research and analytics platform for clinical data and PROs | $26M | 49 mo ago | Series B | 29 | — | — | 1 award |
| 26 | Third Eye Health Provider of virtual care and coordination software for hospitals | $25M | 33 mo ago | Series A | 50 | Lucas Baran Co-Founder & CTO | — | 1 job opening · 1 partnership |
| 27 | CancerIQ Cloud-based platform to doctors, for identifying cancer risk patients and delivering care plans | $24M | 21 mo ago | Series B | 78 | Feyi Olopade CEO | — | 1 launch |
| 28 | Inteneural AI-based central nervous system imaging and diagnosis for healthcare professionals | $21M | 53 mo ago | Series B | — | Kris Siemionow Co-Founder | — | — |
| 29 | Prenosis AI-based precision diagnostic platform for acute care | $20M | 4 mo ago | Series A | 29 | Rashid Bashir Co-Founder | 21 patents AI-driven clinical risk prediction, dataset normalization, and personalized therapy dashboards | — |
| 30 | Thoughtful AI-powered healthcare administration platform to automate tasks | $20M | 14 mo ago | Series A | 16 | Alex Zekoff Co-Founder & CEO | — | — |
| 31 | Praia Health Provider of a platform as a service technology for patient engagement | $20M | 19 mo ago | Series A | — | Justin Dearborn Founder & CEO | — | — |
| 32 | Regroup Therapy Provider of telemental health and telepsychiatry services | $20M | 79 mo ago | Series A | 35 | — | — | — |
| 33 | Dina Provider of an AI-based senior care coordination software for healthcare organizations | $18M | 28 mo ago | Acquired | 38 38 → 68 (+79%) · sector median +46% | Ashish Shah Co-Founder & CEO | — | — |
| 34 | BrightOutcome Improving patient health outcomes with patient-centered web applications and electronic PRO | $17M | 5 mo ago | Funding Raised | 6 | DerShung Yang Founder | — | — |
| 35 | Cardiosense Developer of wearable sensor and AI platform for cardiac monitoring | $15M | 42 mo ago | Series A | 15 | Amit Gupta Co-Founder & CEO | 2 patents Wearable and implantable physiological monitoring devices with data analysis and presentation. | 1 launch |
| 36 | SimBioSys Provider of AI-based decision-making and cancer diagnosis tool for healthcare professionals | $15M | 17 mo ago | Series A | 46 | Joseph Peterson Founder and CTO | 12 patents Patient-specific 3D tumor modeling and perfusion MRI-based cancer prognostics | — |
| 37 | SonarMD Cloud-based care management solutions for chronic conditions 48Funding top 32%Growth top 35%Talent top 38%Tech top 39% All 7 signals ▾Fundingtop 32% Growthtop 35% Talenttop 38% Techtop 39% Producttop 46% Marketbottom 30% Globalbottom 29% Funding: Raised $14.3M across 5 rounds · 5 rounds over 8 yrs (0.6/yr) Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $14M | 3 mo ago | Series B | 25 | Lawrence Kosinski Founder at SonarMD | — | — |
| 38 | Cardio Diagnostics AI based platform offering cardiovascular medicine | $14M | 28 mo ago | Public | — | Robert Philibert Co-Founder | — | — |
| 39 | Blueprint Provider of patient assessment tool for behavioural medical practices | $14M | 35 mo ago | Series A | 18 | Danny Freed Founder & CEO | — | 3 launchs |
| 40 | Rhaeos Developer of a noninvasive device to monitor CSF and manage hydrocephalus 35Talent top 28%Funding top 32%Patents top 32%Innovation top 34% All 9 signals ▾Talenttop 28% Fundingtop 32% Patentstop 32% Innovationtop 34% Moattop 38% Globalbottom 40% Marketbottom 24% Techbottom 23% Newsbottom 18% Talent: 4 named leaders on record · 4 C-suite/founder profiles curated Funding: Raised $12.8M across 13 rounds · 13 rounds over 6 yrs (2.2/yr) rank vs industry peers · Fliar Intelligence Index 35/100 | $13M | 14 mo ago | Series A | 10 10 → 20 (+100%) · sector median +46% | Amit Ayer Co-Founder | 16 patents Medical wearable thermal sensing and non‑invasive fluid flow monitoring devices | — |
| 41 | Vodori Cloud based marketing solutions for life sciences companies | $12M | 56 mo ago | Series A | 38 38 → 57 (+50%) · sector median +46% | — | — | 1 job opening |
| 42 | Carallel Digital health care planning and coordination tool for providers and employees | $8M | 17 mo ago | Series A | 26 | Hillary Ebach Co-Founder | — | — |
| 43 | Adaptive Testing Technologies Provider of software for mental health assessment for patients | $5M | 16 mo ago | Funding Raised | 5 | David Weiss Founder | — | — |
| 44 | Beacon Developer of intelligent disinfection technology for air and surfaces | $4M | 13 mo ago | Series A | — | Andrea Clark Founder & Head of Product and Research | — | 1 launch |
| 45 | Planbase Scheduling and workforce management software for healthcare providers | $3M | 7 mo ago | Seed | — | Joe S Co-Founder | — | 1 launch |
| 46 | Hucu.ai AI and cloud-based person-centered secure messaging tool | $3M | 31 mo ago | Seed | 23 | Syed Kazmi Co-founder & Tech Lead | — | — |
| 47 | HumanImage Developer of three-dimensional imaging device for skin lesion and cancer tracking | $2M | 2 mo ago | Seed | — | David Teplica Founder & CEO & CMO | 5 patents Three‑dimensional body surface imaging for medical and fitness avatar creation | — |
| 48 | Altris AI-based diagnostic solution for ophthalmologists | $1M | 16 mo ago | Seed | 15 | Andrey Kuropyatnyk Founder & CEO | — | 1 launch |
| 49 | Third Coast Dynamics Developer of cloud-based solution delivering hemodynamic assessments from CT and MR angiography images | $657K | 21 mo ago | Funding Raised | — | Bradley Allen Co-Founder | — | — |
| 50 | Kompass Diagnostics Provider of a portable fertility monitor for breaking barriers to fertility care | $305K | 13 mo ago | Funding Raised | — | Hyun-June Jang Co-Founder | — | — |
Top 12 Healthcare IT companies in Illinois
#1
Series A · Chicago, Illinois · founded 2020 · 21 employees$29.5Mraised▾
Digital teleconsultation tool for providers and patients. It offers Epic-based virtual care platform which offer virtual care network, patients can book appointments through the MyChart portal or call center.
- Mar 2026Series A$27.4M
- Apr 2025Series A$27.7M
- Jan 2023Series A$27M
- Mar 2022Seed$2.5M
#2
Series A · Chicago, Illinois · founded 2014 · 29 employees$20Mraised▾
AI-based precision diagnostic platform for acute care. It offers Immunix precision diagnostics and evidence generation platform that leverages machine learning algorithms, clinical data, deep biological data, and biobanked sample to identify and treat patient with sepsis.
- Jan 2026Series A$20M
- Sep 2024Grant (prize money)$700K
- Jul 2023Grant (prize money)$4.8M
- Jun 2023Grant (prize money)$4.9M
#3
Series B · Chicago, Illinois · founded 2009 · 25 employees$14.3Mraised▾
Cloud-based care management solutions for chronic conditions. It offers a care coordination program that proactively connects patients with care teams in real time and provides wrap-around services to help patients manage their individual health needs. Their platform collects patient health data through surveys and analyzes it to track the status of improvement. They generate scores from the survey and send alerts to doctors.
- Feb 2026Series B$3M
- Dec 2024Series A$2.2M
- Jul 2024Conventional Debt$1M
- May 2023Series A$4.3M
#4
Funding Raised · Buffalo Grove, Illinois · founded 2003 · 6 employees$16.8Mraised▾
Improving patient health outcomes with patient-centered web applications and electronic PRO. The company focuses on enhancing patient care across the continuum through technology. They provide patient-centered web applications designed to engage, inform, and empower individuals in their healthcare journey. The company is dedicated to leading the shift toward electronic Patient-Reported Outcomes (PRO) to improve healthcare delivery. They partner with health researchers, care providers, and IT system vendors. The company offers software solutions to improve patient engagement and data-driven insights for better healthcare management. They are a B2B company offering SaaS based solutions.
- Dec 2025Grant (prize money)$399.8K
- Sep 2023Grant (prize money)$1.9M
- Sep 2022Grant (prize money)$1.7M
- Jul 2020Grant (prize money)$350.4K
#5
Series B · Glenview, Illinois · founded 2017 · 63 employees$42Mraised▾
Provider of IoT solutions for the healthcare industry. Its offerings include connected cameras and an IoT-based sensor network that facilitates inpatient monitoring, fall prevention, and bed management. Its features include multi-screen monitoring in real-time, ML-based movement detection, automated alarms, and pre-recorded patient alerts, two-way audio communication, and customization.
- May 2025Grant (prize money)$377.6K
- Jan 2024Series B$42M
- Jul 2022Grant (prize money)$377.6K
- Aug 2019Grant (prize money)$1.9M
#6
Series C · Niles, Illinois · founded 2018 · 47 employees$50Mraised▾
Developer of wireless medical monitoring devices for clinical and remote use. The company provides devices and data integration for healthcare delivery and patient outcomes. It focuses on vital signs monitoring for neonatal, maternal, and adult care. The company offers technology for clinical trials, research, and hospital settings.
- Mar 2025Series C$30M
- May 2024Grant (prize money)$17.5M
- Aug 2022Series B$33M
- Dec 2021Grant (prize money)$150K
#7
Seed · Chicago, Illinois · founded 2021$1.5Mraised▾
Developer of three-dimensional imaging device for skin lesion and cancer tracking. The company develops AnthroCam, a 3D imaging device that creates high-resolution, life-sized avatars of skin surfaces using non-invasive visible light technology. It enables tracking subtle changes for early skin cancer detection, rooted in decades of anatomic imaging research.
- Mar 2026Seed$1.5M
#8
Series B · Chicago, Illinois · founded 2019 · 4 employees$31.9Mraised▾
Provider of AI-powered documentation and insights for mental health therapists. It offers AI-assisted progress notes and treatment plans, generating these documents from session recordings. The platform provides real-time clinical assistance before, during, and after client sessions, including reminders, suggestions, and post-session resources. It integrates with existing electronic health record (EHR) systems and prioritizes data security and privacy, adhering to relevant compliance standards. The service aims to streamline workflows and improve the efficiency of mental health practices.
- Apr 2025Series B$15M
- Jun 2023Series A$6.6M
- Jun 2023Series A$9M
- Apr 2019Seed$1.3M
#9
Series C · Chicago, Illinois · founded 2016 · 110 employees$49.9Mraised▾
Provider of an online platform for managing drug discount programs. The platform tracks and records the validation tests of data and custom validation tests. it also offers features such as compliance issues verification, claims level visibility, transparency in the drug supply chain, and communication for dispute resolution among the affected parties.
- Dec 2024Series C$26.4M
- Sep 2022Series B$14.9M
- Jun 2020Series B$28M
- May 2019Series A$7M
#10
Series A · Evanston, Illinois · founded 2018 · 10 employees$12.8Mraised▾
Developer of a noninvasive device to monitor CSF and manage hydrocephalus. It offers a wireless non-invasive thermal flow sensor that is placed over the neck to monitor the ventricular shunt function and detect or measure CSF. Its data is transferred to an app to manage hydrocephalus.
- Apr 2025Grant (prize money)$298.8K
- Apr 2025Grant (prize money)$4.1M
- Mar 2025Grant (prize money)$1.9M
- Mar 2025Grant (prize money)$306.5K
#11
Seed · Chicago, Illinois · founded 2022$2.6Mraised▾
Scheduling and workforce management software for healthcare providers. Planbase is a comprehensive scheduling software with features such as appointment booking, scheduling dashboard, automated reminders, messaging, and waitlist management.
- Nov 2025Seed$2.1M
- 2024Seed$500K
#12
Series A · Chicago, Illinois · founded 2020 · 16 employees$20Mraised▾
AI-powered healthcare administration platform to automate tasks. The company offers solutions for automating revenue cycle management, streamlining company processes, and implementing robotic process automation (RPA).
- Apr 2025PE—
- Jul 2024Series A$20M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare IT coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Illinois is moving
A read on the academic research around Digital Health in Illinois — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 149 papers.
UIC and UIUC lead Illinois's cautiously contested digital-health research, focusing on EHR systems and telehealth implementation, with concern-dominant findings slightly outweighing breakthroughs.
- University of Illinois Chicago68
- University of Illinois Urbana-Champaign30
- Western Illinois University11
- Illinois College10
- Illinois Department of Public Health9
- Wearable computer6
- Health care5
- Wearable technology3
- Precision medicine3
- SNOMED CT3
- Wearable computer1→4
- Remote patient monitoring1→3
- Health care2→20
- Health informatics1→9