Best Healthcare IT Companies in Missouri, United States
The 107 best Healthcare IT companies in Missouri, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Lumeris.
Our analysis of 90 Healthcare IT companies
$11.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Healthcare IT companies in Missouri
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Stage | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Lumeris AI-powered solutions for value-based primary care transformation | $241M | 26 mo ago | 1,375 1,375 → 1,141 (-17%) | Michael Long Co-CEO | WordPressMySQLPHP+29 | Series D | 2 patents Data validation and integrity checking for enterprise data processing | — |
| 2 | Hicuity Health Provider of patient engagement services | $27M | 35 mo ago | 233 233 → 225 (-3%) | Lou Silverman CEO | WordPressMySQLPHP+27 | Series C | — | — |
| 3 | SentiAR Provider of a 3D visualization platform for interventional cardiac procedures 35Funding top 23%Moat top 25%Talent top 28%Patents top 34% All 9 signals ▾Fundingtop 23% Moattop 25% Talenttop 28% Patentstop 34% Innovationtop 37% Globalbottom 39% Marketbottom 25% Techbottom 22% Newsbottom 22% Funding: Raised $23.3M across 11 rounds · 11 rounds over 9 yrs (1.2/yr) Moat: Editorial + unicorn rating 7/10 · IP moat: 55 patents rank vs industry peers · Fliar Intelligence Index 35/100 | $23M | 1 mo ago | 8 | Michael Southworth Co-Founder | — | Series B | 55 patents AR-enabled intraoperative visualization and control for cardiac electrophysiology procedures | — |
| 4 | Astarte Medical Gut health monitoring informatics platform for preterm infants | $18M | 56 mo ago | 11 | — | WordPress Block EditorWordPressMySQL+10 | Series A | — | — |
| 5 | Quick Study Radiology Digital imaging solutions for radiology | $14M | 232 mo ago | — | Skip Sallee Founder | — | Acqui-Hired | — | — |
| 6 | Rezilient Provider of robotic telehealth device and cloud-based software for clinics and patients | $13M | 21 mo ago | 18 | Jeff Gamble Founder & COO | WebflowGSAPLenis+18 | Series A | — | 1 job opening · 2 awards |
| 7 | Radiologics Clinical trial software for imaging | $11M | 13 mo ago | 2 | Daniel Marcus Founder & President | — | Acquired | — | — |
| 8 | Foresite Healthcare Patient health monitoring solutions using AI technology | $4M | 60 mo ago | 2 | George Chronis Chief Executive Officer and Chief Technology Officer | — | Seed | 34 patents AI-driven patient monitoring and bed‑exit detection using sensor and optical technologies | — |
| 9 | Intuitive Medical Software EHR platform for Urology practices | $3M | 224 mo ago | — | Howard W Follis Founder & Chief Medical Officer | Windows ServerMicrosoft ASP.NETIIS+1 | Acquired | — | — |
| 10 | Gateway EDI Medical claims processing solutions for health care providers | $3M | 205 mo ago | 300 | — | — | Acqui-Hired | — | — |
| 11 | VedaPointe Digital data exchange and business intelligence platform for healthcare providers | $3M | 23 mo ago | 27 | Glen Schuster CEO | — | Seed | — | 1 partnership |
| 12 | MedAware Solutions Platform enhances clinical collaboration by exchanging real-time information within secure, patient-centric… | $2M | 123 mo ago | 14 | — | — | Deadpooled | — | — |
| 13 | Healthy Bytes Fitness and wellness center | $2M | 70 mo ago | 21 | Amy Roberts Founder & CEO | — | Seed | — | — |
| 14 | NeuroLutions Developer of robotic glove controlled by brain | $2M | 16 mo ago | 9 | Eric Leuthardt Co-Founder | WordPressApple iCloud MailGoogle Workspace+27 | Series A | 70 patents BCI-driven neurorehabilitation and assistive orthotic devices for motor control and pain relief | — |
| 15 | Blue Strata Healthcare technology company providing software and services for care continuum | $2M | 130 mo ago | 11 | — | — | Seed | — | — |
| 16 | PatientsVoices AI-based platform for analyzing patient feedback | $1M | 93 mo ago | 10 | Mary Kay OConnor Founder & CEO | — | Seed | — | — |
| 17 | FIRMM Provider of software to measure data quality for MRI | $1M | 78 mo ago | 5 | Nico Dosenbach Co-Founder | — | Seed | — | — |
| 18 | HIPAAtrek HIPAA compliance software simplifying policy management, training, and breach risk assessment | $975K | 95 mo ago | 14 | Sarah Badahman Co-Founder | WordPress Block EditorElementorDivi+31 | Seed | — | — |
| 19 | iDocsWeb Telehealth solution for long-term care, skilled nursing facilities, and assisted living | $840K | 94 mo ago | 4 | — | — | Seed | — | — |
| 20 | TrackMy Solutions Digital vaccination management tool for providers and employees | $395K | 39 mo ago | 24 | Jeremy Elias Founder & CEO | Wix eCommerceWixSentry+17 | Seed | — | 1 partnership |
| 21 | Medinexo Telemedicine marketplace platform for providers | $354K | 120 mo ago | 11 | Jorge Toro President & CEO | — | Seed | — | — |
| 22 | SmartCare Consultant SmartCare is cloud-based technology which uses Sensor Fusion to aggregate data discretely collected through… | $350K | 141 mo ago | 11 | Bryan Jefferson CEO | — | Deadpooled | — | — |
| 23 | Mediprocity Messaging app focused on healthcare professionals | $333K | 122 mo ago | 10 | Mason Rothert CEO / Co-Founder | Node.jsZohoTailwind CSS+15 | Seed | — | 1 partnership · 1 expansion |
| 24 | SanusEO Mobile texting and web services to support population health management | $200K | 119 mo ago | 11 | — | — | Deadpooled | — | — |
| 25 | nimble Provider of revenue cycle management solutions for surgical clinics | $150K | 199 mo ago | 237 | Nader Samii CEO | WordPress Block EditorCart FunctionalityWooCommerce+35 | Funding Raised | 12 patents Digital pharmacy validation and remote subscription management platforms for e‑commerce transactions | 1 job opening |
| 26 | Provider Pool On-demand recruitment platform provider | $100K | 56 mo ago | 4 | — | — | Deadpooled | — | — |
| 27 | iRheum Provider of software for rheumatoid diagnosis | $100K | 168 mo ago | — | Jarrod Townsend Co-Founder | — | Deadpooled | — | — |
Top 12 Healthcare IT companies in Missouri
#1
Series B · St. Louis, Missouri · founded 2017 · 8 employees$23.3Mraised▾
Provider of a 3D visualization platform for interventional cardiac procedures. Using a head-up display, it enables a clinician to see the anatomic model and allows for accurate and safe procedures.
- Apr 2026Series B$1.5M
- Apr 2025Series B$2.5M
- Apr 2023Series B$8.5M
- Apr 2021Series A$5.1M
#2
Series D · Maryland Heights, Missouri · founded 2001 · 1375 employees$241Mraised▾
AI-powered solutions for value-based primary care transformation. It partners with health systems, physician groups, and payers to improve patient outcomes, reduce costs, and streamline operations through its Tom platform.
- Apr 2024Series D$100M
- Oct 2023Conventional Debt$50M
- Jul 2014PE$71M
- May 2014PE$71M
#3
Acquired · Saint Louis, Missouri · founded 2008 · 2 employees$10.5Mraised▾
Radiologics provides clinical trial software for imaging. XNAT CR, their platform helps in image data management for clinical trials. The platform offers file transfer and verification, integration with clinical data, automation of image processing routines, and connectivity with preferred imaging workstations. It has DICOM features that enable secure storage, verification, query, and retrieval of DICOM data.
- May 2025Grant (prize money)$8.7M
- Sep 2020Grant (prize money)$255.9K
- Sep 2017Grant (prize money)$1.5M
- 2016Grant (prize money)$50K
#4
Series A · St. Louis, Missouri · founded 2016 · 18 employees$12.6Mraised▾
Rezilient provides robotic telehealth devices for clinics. The physicians can assume control of a mobile medical robot in the network, allowing them to deliver telehealthcare physically. Through this device, doctors can perform physical assessments through video conferencing.
- Aug 2024Series A$10M
- Aug 2021Seed$2.5M
- Sep 2020Seed$120K
#5
Series A · St. Louis, Missouri · founded 2007 · 9 employees$2Mraised▾
NeuroLutions is developing devices based on brain-computer interface technology restoring functions in patients disabled due to neurological injury. It is developing a robotic glove that the user can wear it on their hand and a headset.
- Feb 2025Series A$26.5M
- Sep 2022Grant (prize money)$2M
- Jun 2015Seed$1.1M
- Nov 2008Seed$625K
#6
Series C · St. Louis, Missouri · founded 2004 · 233 employees$27.4Mraised▾
Provider of patient engagement services
- Jun 2023Series C—
- Mar 2016Series C$11.5M
- Jul 2015Series C$7.3M
- Feb 2014Unattributed$241K
#7
Seed · St. Louis, Missouri · founded 2019 · 27 employees$2.7Mraised▾
Digital data exchange and business intelligence platform for healthcare providers. The company has developed software that enables users to exchange clinical and administrative healthcare data with each other. It has features for customizing platforms, data collection, data access, and more.
- Jul 2024Seed$2.7M
#8
Series A · Ewing, Missouri · founded 2016 · 11 employees$17.8Mraised▾
Gut health monitoring informatics platform for preterm infants. The platform provides solutions for improving the outcomes for high-risk pregnancy and preterm birth. Its first software solution NICUtrition, a microbial health informatics platform to measure and monitor the gut health of preterm infants.
- Sep 2021Series A$7.6M
- Nov 2019Series A$3.4M
- May 2019Series A$5M
- Nov 2018Series A$1.9M
#9
Acqui-Hired · Clayton, Missouri · founded 1999$14Mraised▾
Quick Study Radiology, formerly known as MedCentral, develops digital imaging solutions for radiology. It provides software solutions for image management, data archiving, disaster recovery services, monitoring and security services, and data distribution. In May 2012, Inland Imaging acquired Quick Study Radiology.
- Jan 2007Series D$3.3M
- Jan 2006Conventional Debt$500K
- Jul 2005Series A$1.2M
- May 2005Series A$2.2M
#10
Seed · Columbia, Missouri · founded 2013 · 2 employees$3.9Mraised▾
Foresite Healthcare has developed solutions for remote monitoring of a patient's health. The FORESITE PATIENTCARE solution enables fall detection technology’s spectrum by shifting the focus from alarm systems towards image detection devices.
- Jun 2021Seed$1.9M
- Dec 2018Seed$2M
#11
Seed · St. Louis, Missouri · founded 2013 · 21 employees$2.2Mraised▾
Operator of technology-enabled, health care services intended to provide a healthy lifestyle through nutritional counseling. The company's platform lets dietitians see what, when, where, and why their clients are eating and thus seek medical care for diabetes, high blood pressure, cardiovascular disease, and orthopedic issues, enabling dietitians to help clients to achieve a healthy lifestyle without any additional cost by utilizing their own health benefits.
#12
Seed · Kansas City, Missouri · founded 2019 · 24 employees$395Kraised▾
Digital vaccination management tool for providers and employees. The company offers a platform that assists with data management for vaccination and clinical information management. It has features for employee immunization tracking, reporting, result tracking, and more.
- Mar 2023Seed$330K
- May 2020Seed$65K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare IT coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Missouri is moving
A read on the academic research around Digital Health in Missouri — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 46 papers.
University of Missouri and Missouri State University lead Missouri's digital-health research, focusing optimistically on AI, EHR systems, and mHealth, with recent output surging post-2020.
- University of Missouri29
- Missouri State University9
- University of Missouri Health System5
- University of Missouri–Kansas City4
- University of Missouri–St. Louis2
- Key (lock)4
- Health care3
- SNOMED CT3
- Interoperability3
- Unstructured data3
- Health informatics1→5
- Health informatics1→5
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.