Best Healthcare IT Companies in St. Louis, United States
The 46 best Healthcare IT companies in St. Louis, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Hicuity Health.
Our analysis of 90 Healthcare IT companies
$11.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Healthcare IT companies in St. Louis
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Hicuity Health Provider of patient engagement services | $27M | 37 mo ago | Series C | Lou Silverman CEO | 2004 | WordPressMySQLPHP+27 | — | — |
| 2 | SentiAR Provider of a 3D visualization platform for interventional cardiac procedures 35Funding top 23%Moat top 25%Talent top 28%Patents top 34% All 9 signals ▾Fundingtop 23% Moattop 25% Talenttop 28% Patentstop 34% Innovationtop 37% Globalbottom 39% Marketbottom 25% Techbottom 22% Newsbottom 22% Funding: Raised $23.3M across 11 rounds · 11 rounds over 9 yrs (1.2/yr) Moat: Editorial + unicorn rating 7/10 · IP moat: 55 patents rank vs industry peers · Fliar Intelligence Index 35/100 | $23M | 3 mo ago | Series B | Michael Southworth Co-Founder | 2017 | — | 55 patents Intraoperative AR guidance for cardiac electrophysiology using HMDs, gaze control, and ultrasound. | — |
| 3 | Rezilient Provider of robotic telehealth device and cloud-based software for clinics and patients | $13M | 23 mo ago | Series A | Jeff Gamble Founder & COO | 2016 | WebflowGSAPLenis+18 | — | — |
| 4 | Gateway EDI Medical claims processing solutions for health care providers | $3M | 207 mo ago | Acqui-Hired | — | 1983 | — | — | — |
| 5 | VedaPointe Digital data exchange and business intelligence platform for healthcare providers | $3M | 25 mo ago | Seed | Glen Schuster CEO | 2019 | — | — | 1 partnership |
| 6 | Healthy Bytes Fitness and wellness center | $2M | 72 mo ago | Seed | Amy Roberts Founder & CEO | 2013 | — | — | — |
| 7 | NeuroLutions Developer of robotic glove controlled by brain | $2M | 18 mo ago | Series A | Eric Leuthardt Co-Founder | 2007 | WordPressApple iCloud MailGoogle Workspace+27 | 70 patents NeuroBCI-driven rehabilitation orthoses and assistive devices for motor impairment | — |
| 8 | Blue Strata Healthcare technology company providing software and services for care continuum | $2M | 131 mo ago | Seed | — | 2012 | — | — | — |
| 9 | HIPAAtrek HIPAA compliance software simplifying policy management, training, and breach risk assessment | $975K | 97 mo ago | Seed | Sarah Badahman Co-Founder | 2014 | WordPress Block EditorElementorDivi+31 | — | — |
| 10 | iDocsWeb Telehealth solution for long-term care, skilled nursing facilities, and assisted living | $840K | 96 mo ago | Seed | — | 2013 | — | — | — |
| 11 | Medinexo Telemedicine marketplace platform for providers | $354K | 122 mo ago | Seed | Jorge Toro President & CEO | 2014 | — | — | — |
| 12 | SanusEO Mobile texting and web services to support population health management | $200K | 121 mo ago | Deadpooled | — | 2012 | — | — | — |
| 13 | nimble Provider of revenue cycle management solutions for surgical clinics | $150K | 201 mo ago | Funding Raised | Nader Samii CEO | 2003 | WordPress Block EditorCart FunctionalityWooCommerce+35 | 12 patents Digital pharmacy validation and remote subscription/e‑commerce management platform | 1 job opening |
| 14 | Provider Pool On-demand recruitment platform provider | $100K | 58 mo ago | Deadpooled | — | 2018 | — | — | — |
Top 12 Healthcare IT companies in St. Louis
#1
Series B · St. Louis, Missouri · founded 2017 · 8 employees$23.3Mraised▾
Provider of a 3D visualization platform for interventional cardiac procedures. Using a head-up display, it enables a clinician to see the anatomic model and allows for accurate and safe procedures.
- Apr 2026Series B$1.5M
- Apr 2025Series B$2.5M
- Apr 2023Series B$8.5M
- Apr 2021Series A$5.1M
#2
Series A · St. Louis, Missouri · founded 2016 · 18 employees$12.6Mraised▾
Rezilient provides robotic telehealth devices for clinics. The physicians can assume control of a mobile medical robot in the network, allowing them to deliver telehealthcare physically. Through this device, doctors can perform physical assessments through video conferencing.
- Aug 2024Series A$10M
- Aug 2021Seed$2.5M
- Sep 2020Seed$120K
#3
Series A · St. Louis, Missouri · founded 2007 · 9 employees$2Mraised▾
NeuroLutions is developing devices based on brain-computer interface technology restoring functions in patients disabled due to neurological injury. It is developing a robotic glove that the user can wear it on their hand and a headset.
- Feb 2025Series A$26.5M
- Sep 2022Grant (prize money)$2M
- Jun 2015Seed$1.1M
- Nov 2008Seed$625K
#4
Series C · St. Louis, Missouri · founded 2004 · 233 employees$27.4Mraised▾
Provider of patient engagement services
- Jun 2023Series C—
- Mar 2016Series C$11.5M
- Jul 2015Series C$7.3M
- Feb 2014Unattributed$241K
#5
Seed · St. Louis, Missouri · founded 2019 · 27 employees$2.7Mraised▾
Digital data exchange and business intelligence platform for healthcare providers. The company has developed software that enables users to exchange clinical and administrative healthcare data with each other. It has features for customizing platforms, data collection, data access, and more.
- Jul 2024Seed$2.7M
#6
Seed · St. Louis, Missouri · founded 2013 · 21 employees$2.2Mraised▾
Operator of technology-enabled, health care services intended to provide a healthy lifestyle through nutritional counseling. The company's platform lets dietitians see what, when, where, and why their clients are eating and thus seek medical care for diabetes, high blood pressure, cardiovascular disease, and orthopedic issues, enabling dietitians to help clients to achieve a healthy lifestyle without any additional cost by utilizing their own health benefits.
#7
Acqui-Hired · St. Louis, Missouri · founded 1983 · 300 employees$2.8Mraised▾
Gateway EDI, formerly known as Office Tech provides medical claims processing solutions for health care providers. Offers products to simplify claims reimbursement and revenue management. The company’s solutions provide electronic claims processing, real-time eligibility verification, point-and-click access to identify and recover missing revenue, automate secondary claims and electronic remittance advice and tools to ease patient payment collection. Acquired by Trizetto in February, 2011.
- Apr 2009PE$2.8M
- Jan 2009PE—
#8
Seed · St. Louis, Missouri · founded 2012 · 11 employees$1.7Mraised▾
Healthcare technology company providing software and services for care continuum. The company delivers solutions across home health, hospice, behavioral health, long-term care, and other healthcare settings. It offers software designed to optimize resident care, streamline operations, and ensure regulatory compliance. The company's solutions include electronic health records (EHR), revenue cycle management, financial management, and payroll management. They provide advisory, strategic consulting, compliance, education, outsourced, professional, and managed services. The company focuses on value-based care, care coordination, interoperability, and analytics. The company aims to improve operational efficiencies, financial performance, and patient outcomes through its integrated software and service offerings. The company provides cloud based software solutions.
- Aug 2015Seed$1.7M
#9
Seed · St. Louis, Missouri · founded 2014 · 14 employees$975Kraised▾
HIPAA compliance software simplifying policy management, training, and breach risk assessment. It is a comprehensive solution designed to organize, automate, and report on every aspect of HIPAA compliance. This software offers features like BAA and contract management, HIPAA training modules, policy management tools, and breach management solutions. It helps healthcare organizations streamline their compliance processes, moving away from manual methods like spreadsheets. The platform provides centralized access to contracts, policies, training materials, and documents, with automated version tracking. It also automates security reminders and training video assignments, with built-in reporting to track progress and prove compliance. The software includes expert-built policy, BAA, and NPP templates, along with training videos and resources. Consulting options are available for Security Risk Analysis and Privacy Gap Assessments. It is a cloud-based SaaS platform that offers a user-friendly interface and aims to provide compliance confidence to its users.
- Jul 2018Seed$925K
- Jun 2015Grant (prize money)$50K
- Mar 2015Grant (prize money)$10K
- Sep 2014Seed$50K
#10
Seed · St. Louis, Missouri · founded 2013 · 4 employees$840Kraised▾
Telehealth solution for long-term care, skilled nursing facilities, and assisted living. This platform is a telemedicine solution designed to address the needs of long-term care and skilled nursing facilities, offering residents of assisted living communities instant access to medical care. It provides features like behavioral health support, family participation, a specialist network, and on-call coverage. The platform integrates with EMR systems, is mobile-friendly, and offers billing solutions. It aims to improve care, reduce hospital readmissions, and create an environment of treatment in place. It connects patients with providers, including specialists, and facilitates remote assessments and care plan establishment. The platform supports electronic health record storage and offers tools for billing telemedicine encounters. It provides a turn-key telemedicine platform built specifically for long-term care behavioral health providers.
- Aug 2018Seed$270K
- Apr 2017Seed$165K
- Oct 2016Seed$300K
- Nov 2014Seed$105K
#11
Seed · St. Louis, Missouri · founded 2014 · 11 employees$354Kraised▾
MEDINEXO is an online telemedicine marketplace for providers. The platform enable primary caregivers the ability to consult a specialist. It connects primary care givers to experts and specialists so that the patients benefit and receive quality treatment in places where medical care is lacking.
- Jun 2016Seed$354K
#12
Funding Raised · St. Louis, Missouri · founded 2019 · 5 employees$75Kraised▾
Developer of a drug adherence monitoring system to reduce readmission. The company offers CloudConnect smart catheter a reinvented IV line with an embedded mechanoelectrical sensor that detects when a medication source is connected and clinicians can detect non-adherence in real time and make treatment decisions and prevent costly readmissions based on objective data.
- Nov 2022Grant (prize money)$75K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare IT coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health is moving in the United States
A read on the academic research around Digital Health — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,843 United States-affiliated papers.
- Design Intelligence421
- Harvard University383
- Johns Hopkins University295
- University of North Carolina at Chapel Hill206
- University of Washington173
- Health care9→240
- Wearable computer6→129
- Health informatics25→140
- Remote patient monitoring11→76
- Informatics10→60
- Health care36→766
- Health informatics113→495
- Psychological intervention20→320
- Public health34→290
- Intervention (counseling)5→193
- Health care98→1170
- Health informatics213→712
- Public health73→525
- Psychological intervention26→368
- Health administration110→363
Where digital health is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing digital health patents in the United States
United States digital health patent filing is accelerating — 2,575 filings from 1,291 assignees (2016–2025), led by Boeing, Honeywell INT, Advanced Neuromodulation Systems; annual filings 173→270.
- Boeing150
- Honeywell INT129
- Advanced Neuromodulation Systems96
- General Electric91
- Hamilton Sundstrand67
- IBM65
- OTIS Elevator50
- Sikorsky Aircraft49
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.