Best HealthTech Companies in Irvine, United States
The 142 best HealthTech companies in Irvine, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Cryoport.
Our analysis of 305 HealthTech companies
$32.1b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best HealthTech companies in Irvine
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Cryoport Provider of cold chain logistics for the life sciences industry | $153M | 73 mo ago | 795 | 1999 | Jerrell Shelton Chief Executive Officer | 228 patents Cryogenic temperature-controlled shipping containers and modular logistics systems | — |
| 2 | Masimo Provider of wide range of devices to monitor health parameters | $151M | 46 mo ago | 2,200 2,200 → 3,672 (+67%) | 1989 | Joe Kiani Founder | 2,303 patents Non‑invasive multi‑parameter patient monitoring, especially pulse oximetry and signal processing | 2 launchs · 1 expansion |
| 3 | Kareo Developer of software for clinical documentation billing and patient management | $146M | 92 mo ago | 313 | 2004 | Dan Rodrigues Co-Founder & CEO | — | — |
| 4 | Breathe Technologies Portable respiratory therapy systems | $60M | 97 mo ago | 97 | 2005 | — | 371 patents Non‑invasive mechanical ventilation hardware and integrated patient‑interface jet pump systems | — |
| 5 | LifeMasters Supported SelfCare Health improvement and chronic disease management programs and services | $59M | 219 mo ago | 143 | 1994 | — | 3 patents Personalized health risk assessment and patient management recommendation software | — |
| 6 | HyperIce Internet first brand offering smart devices for physical fitness | $52M | 35 mo ago | 175 | 2011 | Jim Huether CEO | 2 patents Phototherapy and exercise recovery devices for therapeutic light and muscle regeneration | 2 launchs |
| 7 | Tahmo Provider of smart devices to monitor vital health | $31M | 93 mo ago | 2 | 2018 | Arif Quronfleh Founder | — | — |
| 8 | Movn Health Provider of care planning and coordination tool | $30M | 47 mo ago | 62 | 2013 | Shuo Qiao Co-Founder & CTO | — | — |
| 9 | Seragon Provider of AI-based platform for epigenetics and transcriptomics for treating aging and physiological… | $30M | 152 mo ago | 25 | 2005 | Carlos Arazati Founder & CEO | — | — |
| 10 | Viseon Provider of digital visualization solutions for surgeons | $29M | 24 mo ago | 24 | 2017 | Alex Thomson Co-Founder | 37 patents Integrated camera-retractor systems and image overlay for enhanced intra‑operative visualization | 3 launchs |
| 11 | GATC AI-based omic data analysis platform for researchers and professionals | $22M | 38 mo ago | 27 | 2020 | — | — | — |
| 12 | Huckleberry Provider of mobile app for sleep monitoring | $16M | 55 mo ago | 13 | 2018 | Seng all Co-Founder & CTO | 5 patents AI-powered personalized audio guidance and sleep monitoring analytics for infant care | — |
| 13 | Path Central Web-based LIS for Pathologists | $15M | 162 mo ago | 26 | 2009 | — | — | — |
| 14 | TC3 Health Offers payment validity solutions to healthcare payers | $12M | 236 mo ago | 65 | 2001 | — | — | — |
| 15 | Docbot AI-based disease diagnosis tool for decision making | $8M | 60 mo ago | 5 | 2013 | — | 15 patents Patents concentrated in health & consumer products | — |
| 16 | CuraPatient AI based platform offering claims management solutions | $8M | 46 mo ago | 10 | 2014 | Charles Rockefeller Co-Founder | — | — |
| 17 | TadHealth Comprehensive electronic health record platform for students and staff | $8M | 15 mo ago | — | 2021 | Ben Greiner Founder & Chief Executive Officer | — | — |
| 18 | Cercacor Blood hemoglobin monitoring device for athletes | $8M | 102 mo ago | 59 59 → 118 (+100%) | 1998 | — | — | — |
| 19 | Tagnos Healthcare workflow orchestration software optimizing hospital operations and patient care | $6M | 73 mo ago | 29 | 2010 | Neeraj Bhavani Founder & Board Member | 13 patents Patents concentrated in computing, sensing & instrumentation | — |
| 20 | Accenx Clinical lab providing PCR testing, research tools, and integration solutions | $4M | 207 mo ago | — | 1997 | David Cheng Founder | — | — |
| 21 | Branchpoint Technologies Medical devices for neuromonitoring and neurocritical care | $4M | 85 mo ago | — | 2011 | Nicholas Hu CEO | 7 patents Wireless intracranial pressure monitoring devices and systems for real-time brain health tracking | — |
| 22 | Virtual Dental Care Provider of software for tele dentistry | $3M | 75 mo ago | 25 | 2016 | Richard Lee CEO | — | — |
| 23 | Capillary Biomedical Provider of implants for continuous glucose monitoring | $3M | 68 mo ago | 1,922 | 2014 | — | 19 patents Subcutaneous insulin infusion devices with advanced insertion and delivery control mechanisms. | — |
| 24 | MolecularWare Develops data management software | $2M | 298 mo ago | — | 1998 | Richard Ki ex-CEO | — | — |
| 25 | Allevion Therapeutics Developer of smart wearable for the treatment of essential tremors and other movement-related disorders | $1M | 27 mo ago | 3 | 2017 | — | — | — |
| 26 | Vena Vitals Provider of wearable sticker for monitoring blood pressure | $1M | 33 mo ago | 10 | 2019 | Michelle Khine Co-Founder | 6 patents Wearable multi‑channel sensor arrays for real‑time physiological signal monitoring | — |
| 27 | ClearPoint Neuro Developer of MRI-guided stereotactic system for neurological interventions | $1M | 13 mo ago | 38 | 1998 | Joe Burnett President and CEO | 97 patents Minimally invasive neurosurgical targeting, delivery tools, and controlled infusion systems | 1 launch · 1 partnership |
| 28 | TinyKicks Fetal sensor to detect baby movement | $1M | 113 mo ago | — | 2014 | Michelle Khine Co-Founder | — | — |
| 29 | PrescribeWellness SaaS based communication solution for the healthcare industry | $1M | 166 mo ago | 1 | 2010 | — | — | — |
| 30 | The Blue Box Smart device and companion app for monitoring breast cancer | $543K | 11 mo ago | — | 2020 | Judit Benet Co-Founder & CEO | 30 patents Self‑cleaning HVAC coil and filter technologies for automated heat‑exchange maintenance | 2 awards |
| 31 | ACS Diagnostics Provider of ECG monitoring device | $300K | 145 mo ago | 37 | 1981 | — | — | — |
| 32 | Planet DDS Dental practice management software solution in the cloud | $200K | 82 mo ago | 10 | 2003 | — | — | 2 launchs |
| 33 | Greenfield Groves Provider of an AI-based teleconsultation and health benefits management software for employees and individuals | $128K | 66 mo ago | 8 | 2018 | Lindsay Giguiere Founder & CEO | — | — |
| 34 | CenSyn Provider of EEG for rapid screening of non-convulsive seizures in neuro-ICU patients | $105K | 56 mo ago | 15 | 2019 | Ayushi Patel CEO | 12 patents Wearable EEG monitoring and fast indoor positioning/navigation technologies for medical applications | — |
| 35 | Sprightly Provider of end-to-end COVID-19 diagnostic platform for workplaces | $105K | 58 mo ago | — | 2015 | Justin Li Co-Founder | — | — |
Top 12 HealthTech companies in Irvine
#1
Public · Irvine, California · founded 2021$8Mraised▾
Comprehensive electronic health record platform for students and staff. It provides a comprehensive mental health platform specifically for educational institutions, including K-12 schools, to streamline behavioral health services and reduce barriers to care. The platform offers a purpose-built electronic health record system and supports healthcare.
- Feb 2025Series A$7.9M
- Oct 2021Seed$125K
#2
Public · Irvine, California · founded 1998 · 38 employees$1.3Mraised▾
Developer of MRI-guided stereotactic system for neurological interventions. It specializes in precise navigation systems for brain and spine procedures, enabling device, cell, and gene therapies with real-time imaging and minimally invasive techniques.
- May 2025Post IPO—
- Dec 2020Post IPO$7.5M
- May 2017Post IPO$13.2M
- Dec 2015Series B$5.3M
#3
Seed · Irvine, California · founded 2020$542.7Kraised▾
Smart device and companion app for monitoring breast cancer. The company at-home testing device and app for women to self-diagnose the biomarkers associated with breast cancer.
- Jul 2025Seed$3.5M
- Jul 2024Seed$542.7K
- Jun 2022Grant (prize money)$79.8K
- Oct 2021Seed—
#4
Series B · Irvine, California · founded 2017 · 24 employees$29.4Mraised▾
Provider of digital visualization solutions for surgeons. It offers MaxView 4K Video Imaging Platform that offers visualization for minimally invasive spine surgery, MaxView Posterior for minimally invasive surgery of posterior spine, and MaxView 4K Imager for video recording, and routing signals.
- Jun 2024Series B—
- Feb 2020Series B$29.4M
#5
Series C · Irvine, California · founded 2011 · 175 employees$52.5Mraised▾
Internet first brand offering smart devices for physical fitness. It develops muscle recovery, rehabilitation, and ice compression wraps for knees, ankles, shoulders, backs, wrists, and elbows. It provides ice compression therapy devices with patented air release technology. It also offers a fitness and recovery device that uses pressure and vibration to improve the body's overall performance.
- Jul 2023Venture Debt$100M
- Nov 2021Series C—
- Oct 2020Series C$48M
- Sep 2018Angel—
#6
Acquired · Irvine, California · founded 1989 · 2200 employees$151.2Mraised▾
Provider of wide range of devices to monitor health parameters. The company offers a wide range of products across various categories include wearables Masimo W1 that provides untethered continuous pulse oximetry with visual and haptic notifications, Masimo W1 sport to track hydration levels, wireless earbuds with Masimo Adaptive Acoustic Technology for personalized sound, and Baby Monitoring Masimo Stork that tracks temperature, pulse rate, and oxygen saturation.
- Aug 2022Post IPO—
- Dec 2018Conventional Debt$150M
- Aug 2016Grant (prize money)$1.2M
#7
Public · Irvine, California · founded 1999 · 795 employees$153Mraised▾
Provider of cold chain logistics for the life sciences industry. The company's products includes GMP-compliant storage, secondary packaging & labeling, regulatory & QP services, drug return & destruction, and kit production. Cryoport is the provider of supply chain solutions for temperature-sensitive materials, serving biopharmaceutical, IVF, and surrogacy, and animal health organizations around the world.
- May 2020Post IPO$100M
- Dec 2018Post IPO$25M
- Apr 2016Post IPO$2.5M
- Mar 2016Post IPO$46.2K
#8
Series B · Irvine, California · founded 2020 · 27 employees$22.3Mraised▾
AI-based omic data analysis platform for researchers and professionals. The company has devised a personalized medical omic analysis platform MAT that assists with predictive multi-omic datasets. The platform developed by the company supports biological data sets for pathway analysis, dataset evaluation, and more. The AI technology used in the software assists with biological pathway analysis for disease pathology, drug discovery, and other therapeutic solutions.
- Apr 2023Series B$26M
- Dec 2021Series A$10.6M
- Sep 2021Seed$1.7M
#9
Series E · Irvine, California · founded 2004 · 313 employees$146.3Mraised▾
Developer of software for clinical documentation billing and patient management. This platform integrates electronic health records with tools for scheduling appointments, processing insurance claims, and managing patient communications. The system automates administrative tasks such as clinical note generation, eligibility verification, and payment collection. It provides functionality for telehealth consultations, electronic prescriptions, and laboratory result tracking. The software supports various medical practices by centralizing operational workflows into a single interface to facilitate clinical and financial tasks.
- Sep 2018Series E$9.9M
- Aug 2015Grant (prize money)$242.5K
- Jul 2015Series E$55.4M
- Oct 2014Conventional Debt$15M
#10
Series A · Irvine, California · founded 2013 · 62 employees$30Mraised▾
Provider of care planning and coordination tool. The company has developed a platform where patients can connect with providers, and assist with workflow management. It features care coordination, enrollment management, patient engagement, and more.
- Jul 2022Series A$20M
- Apr 2021Series A$6M
- Apr 2019Series A—
- Feb 2017Seed—
#11
Seed · Irvine, California · founded 2017 · 3 employees$1.5Mraised▾
Developer of smart wearable for the treatment of essential tremors and other movement-related disorders. The device can be worn around the wrist or ankle for delivering multimodal stimulation with proprietary delivery algorithms to reduce tremors. Its device learns and adjusts the use of each stimulation modality to optimize patient response.
- Mar 2024Seed$1.5M
- May 2018Seed—
#12
Acquired · Irvine, California · founded 2005 · 97 employees$60Mraised▾
Breathe Technologies is a developer and manufacturer of medical technologies for treating lung diseases and sleep-disordered breathing. Breathe's wearable ventilator, NIOV, weighs only one pound, fits in the palm of the hand, and has a battery that lasts up to 4 hours before needing to be recharged. NIOV delivers a mixture of oxygen and air through a nasal interface. NIOV nasal interface covers just the nostrils, leaving the mouth unobstructed so that the patient can speak while the device is in use. NIOV requires a pressure source to work, therefore it needs an oxygen cylinder or other pressurized oxygen sources. It features the company’s proprietary, portable, open-airway platform, and is FDA cleared for patients with respiratory insufficiency such as those with COPD, Interstitial Lung disease, Post Lung transplant, Neuromuscular disorders. It is commercially available for both the institutional and homecare settings. Investors include KPCB, Johnson & Johnson, Delphi Ventures, Synergy Ventures, DAG Ventures, and Morgan Creek.
- May 2018Conventional Debt—
- Oct 2017Series D$6.3M
- Aug 2017Series D$8.5M
- Jun 2014Series C$7.2M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of HealthTech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Irvine is moving
A read on the academic research around Digital Health in Irvine — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 80 papers.
UC Irvine and affiliates predominantly research digital mental health interventions and mHealth applications, with concerns slightly outweighing breakthroughs, yielding a cautiously mixed outlook.
- University of California, Irvine73
- Irvine University14
- UC Irvine Health3
- Irvine Valley College3
- University of California, Irvine Medical Center3
- Remote patient monitoring2
- Real-time computing2
- Health informatics2
- Health care2
- Wireless sensor network1
- Health informatics6
- Mental health6
- Health care6
- Psychological intervention5
- mHealth4
- Mental health10
- Health care9
- Psychological intervention9
- Health informatics7
- Public health4
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.