Best High Tech Companies in St. Louis, United States
The 53 best High Tech companies in St. Louis, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: The Climate.
Our analysis of 306 High Tech companies
$95.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best High Tech companies in St. Louis
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | The Climate Digital farming solutions to maximize results and empower farmers | $109M | 169 mo ago | 154 | — | Adobe Experience ManagerApple iCloud MailGoogle Workspace+22 | Top 1M | 1,778 patents Precision agriculture via satellite remote sensing for soil, water, and crop management | — |
| 2 | Capacity AI based information and data integration management solution | $86M | 11 mo ago | 102 | David Karandish Founder and CEO | WordPressApple iCloud MailGoogle Workspace+40 | Top 5M | 8 patents Ergonomic tractor seating systems and refractory mortar/coating compositions for construction. | — |
| 3 | Balto AI-based real-time guidance tool for contact centers on cloud | $52M | 59 mo ago | 80 | Marc Bernstein Co-Founder & CEO | WordPress Block EditorWordPressApple iCloud Mail+48 | Top 5M | — | — |
| 4 | Stereotaxis Surgical robotics company advancing minimally invasive endovascular intervention for improved patient care | $52M | 73 mo ago | 122 122 → 193 (+58%) | — | DrupalPHPSalesforce+29 | Top 10M | 257 patents Magnetically guided robotic catheters for cardiac electrophysiology and remote interventional navigation | 1 launch |
| 5 | SentiAR Provider of a 3D visualization platform for interventional cardiac procedures 35Funding top 23%Moat top 25%Talent top 28%Patents top 34% All 9 signals ▾Fundingtop 23% Moattop 25% Talenttop 28% Patentstop 34% Innovationtop 37% Globalbottom 39% Marketbottom 25% Techbottom 22% Newsbottom 22% Funding: Raised $23.3M across 11 rounds · 11 rounds over 9 yrs (1.2/yr) Moat: Editorial + unicorn rating 7/10 · IP moat: 55 patents rank vs industry peers · Fliar Intelligence Index 35/100 | $23M | 2 mo ago | 8 | Michael Southworth Co-Founder | — | — | 55 patents Intraoperative AR guidance for cardiac electrophysiology using HMDs, gaze control, and ultrasound. | — |
| 6 | SureCam Provider of fleet dash cameras and GPS vehicle tracking products | $12M | 30 mo ago | 67 | Max Hillman CEO | HubSpot CMS HubApple iCloud MailMicrosoft 365+26 | Top 1M | — | — |
| 7 | RF Controls Developer of RFID based identification systems for commercial applictions | $10M | 115 mo ago | 7 | Todd Spence Co-Founder & CAO | WordPressMySQLPHP+15 | Top 50M | 120 patents Patents concentrated in computing, sensing & instrumentation | — |
| 8 | Noonlight Provider of a personal safety mobile application | $10M | 79 mo ago | 16 16 → 33 (+106%) | Zach Winkler Co-Founder & CEO | WebflowApple iCloud MailZoho+19 | Top 5M | 14 patents Real-time emergency assistance platforms integrating alarm data processing and user safety communication. | 1 partnership |
| 9 | Aisle411 Provider of an AR-based indoor navigation solution for businesses | $9M | 150 mo ago | 11 | Matthew Kulig Co-Founder & CEO | — | — | 21 patents Indoor retail positioning and product location services using voice and mapping technologies | — |
| 10 | Acera Surgical Provider of synthetic electrospun scaffolds for regenerative medical applications | $6M | 93 mo ago | 98 | — | Apple iCloud MailMicrosoft 365Windows Server+12 | Top 10M | 55 patents Hybrid-scale fiber matrices for advanced tissue engineering and regenerative medical implants | 1 partnership |
| 11 | Atomation Provider of software and hardware platform for IoT applications | $6M | 14 mo ago | 13 | Eran Keshet Co-Founder & CTO | — | — | — | — |
| 12 | Aker Smart farming calculators and tools for efficient land, resource, and profit management | $6M | 52 mo ago | 6 | — | — | — | 131 patents Patents concentrated in construction | — |
| 13 | Textel Provider of a text and cloud-based customer support chatbot for enterprises | $5M | 70 mo ago | 85 | — | — | — | — | — |
| 14 | Prattle Analytics Watch live soccer matches today with HD quality for free | $4M | 113 mo ago | 30 | — | — | — | — | — |
| 15 | NeuroLutions Developer of robotic glove controlled by brain | $2M | 17 mo ago | 9 | Eric Leuthardt Co-Founder | WordPressApple iCloud MailGoogle Workspace+27 | Top 5M | 70 patents BCI-driven neurorehabilitation and assistive orthotic devices for motor control and pain relief | — |
| 16 | Disruptel Provider of a search engine for products and video content | $2M | 65 mo ago | 9 | Alex Quinn Founder & CEO | — | — | 6 patents Advanced control systems for high‑speed printing and output device management | — |
| 17 | OxyBand Advanced transdermal oxygen therapy for wound healing and tissue regeneration | $700K | 195 mo ago | 4 | Amie Franklin President & CEO | — | — | 44 patents Advanced wound care technologies: diffusion dressings, gas delivery, and infrared monitoring. | — |
| 18 | Applied Particle Technology Developer of environmental sensors for measuring aerosols in the air | $534K | 70 mo ago | 6 | — | WebflowApple iCloud MailMicrosoft 365+10 | Top 50M | — | — |
| 19 | AppsCo Unified identity access management solutions software | $500K | 109 mo ago | 1 | Marko Jevtovic Co-Founder & COO | WordPressMySQLPHP+24 | Top 10M | — | — |
| 20 | redlyst Provider of facial biometrics system for access control and threat detection | $250K | 87 mo ago | — | Patrick Doherty Founder | — | — | — | — |
| 21 | Simerse Provider of synthetic data solutions for AI models | $150K | 57 mo ago | 5 | — | — | — | — | — |
| 22 | Keybot Provides solution for visitor management | $120K | 100 mo ago | — | Daniel Dawson Co-Founder | — | — | — | — |
| 23 | Strayos Provider of cloud-based data analytics software for drone images | $100K | 56 mo ago | 18 | Ravi Sahu Founder & CEO | SentryZohoUbuntu+16 | Top 10M | — | — |
Top 12 High Tech companies in St. Louis
#1
Series B · St. Louis, Missouri · founded 2017 · 8 employees$23.3Mraised▾
Provider of a 3D visualization platform for interventional cardiac procedures. Using a head-up display, it enables a clinician to see the anatomic model and allows for accurate and safe procedures.
- Apr 2026Series B$1.5M
- Apr 2025Series B$2.5M
- Apr 2023Series B$8.5M
- Apr 2021Series A$5.1M
#2
Series D · St. Louis, Missouri · founded 2017 · 102 employees$86.5Mraised▾
AI-based information and data integration management solution. It allows users to handle the company knowledge, enterprise search, knowledge management, knowledge sharing, and data integration management solutions. It uses artificial intelligence, natural language processing, and machine learning technologies. It also handles process automation solutions. It caters to solutions to asset management, banking, credit unions, education, mortgage, and wealth management solutions.
- Aug 2025Conventional Debt$50M
- Jul 2025Series D$42.6M
- Sep 2023Series D$182.4M
- May 2020Series C$38.9M
#3
Seed · St. Louis, Missouri · founded 2014 · 13 employees$5.6Mraised▾
Atomation is dedicated to forming an IoT platform, incorporating both cloud-based analytics and mobile SDK for developers. It aims to help easily create smart objects enabling interaction with these objects, analytics based on them and real time decisions based on the results. It has clients in agriculture, medical, electricity and logistics space where it partners with the organizations to make the objects easily connect with cloud and draw real time insights from it.
- May 2025Seed$2.3M
- Feb 2022Seed$825K
- Nov 2020Seed$200K
- Sep 2020Seed$16.4K
#4
Series A · St. Louis, Missouri · founded 2007 · 9 employees$2Mraised▾
NeuroLutions is developing devices based on brain-computer interface technology restoring functions in patients disabled due to neurological injury. It is developing a robotic glove that the user can wear it on their hand and a headset.
- Feb 2025Series A$26.5M
- Sep 2022Grant (prize money)$2M
- Jun 2015Seed$1.1M
- Nov 2008Seed$625K
#5
Series B · St. Louis, Missouri · founded 2013 · 67 employees$11.5Mraised▾
Provider of fleet dash cameras and GPS vehicle tracking products. The company offers camera options, including multicamera systems, front-facing, dual-facing, front and rear, and waterproof dash cameras. Features include GPS tracking, cloud storage, live streaming, and driver coaching. The company provides solutions for industries such as construction, oil, gas, mining, utility services, and moving companies.
- Jan 2024Series B$12.5M
- Jan 2024Conventional Debt$23.5M
- May 2022Series B$11.5M
#6
Series B · St. Louis, Missouri · founded 2017 · 80 employees$52Mraised▾
Offers an AI-based real-time guidance tool for contact centers on the cloud. It offers two solutions real-time coaching for agents along with the smart checklist, dynamic prompts, notification, sticky note, and leader board, Real-time management for managers with features agent performance analysis, win rate analysis, and trend analysis.
- Aug 2021Series B$37.5M
- Oct 2020Series A$10M
- Sep 2019Seed$3M
- Oct 2018Seed$1.2M
#7
Acquired · St. Louis, Missouri · founded 2006 · 154 employees$108.5Mraised▾
Digital farming solutions to maximize results and empower farmers. They offer an all-in-one digital farming solution, empowering farmers with data-driven insights and innovative ag tech. The platform connects crop data, enables field scouting, builds prescriptions, and analyzes yield data in real-time. They provide hardware like FieldView Drive to empower farming missions. Resources include guides, a knowledge center, blog, videos, and podcasts. They focus on secure data, maximizing time, staying ahead, and boosting profits. The company aims to help farmers sustainably increase productivity and profitability with digital tools, enabling informed decisions from planning to harvest. They combine digital tools with physical products to enhance farming profitability and sustainability. They partner with other digital farming tools to make the technology more open, accessible and impactful for farmers.
- Jun 2012Series C$50M
- Feb 2011Series B$40.2M
- Oct 2007Series A$14.7M
- Jan 2007Series A$3.6M
#8
Public · St. Louis, Missouri · founded 1990 · 122 employees$52Mraised▾
Surgical robotics company advancing minimally invasive endovascular intervention for improved patient care. It pioneers and globally leads in surgical robotics for minimally invasive endovascular intervention. The mission centers on discovering, developing, and delivering robotic systems, instruments, and information solutions for the interventional laboratory. These innovations empower physicians to provide exceptional patient care with robotic precision and safety, expand access to minimally invasive therapy, and enhance productivity, connectivity, and intelligence in the operating room. They focus on robotic magnetic navigation, cardiac ablation, electrophysiology, and endovascular procedures. The company aims to revolutionize surgical practice through innovation and technology, improving outcomes for patients with heart rhythm disorders and other endovascular conditions.
- May 2020Post IPO$15M
- Aug 2019Post IPO$25M
- Oct 2016Post IPO$24M
- May 2012Post IPO$18.5M
#9
Acquired · St. Louis, Missouri · founded 2016 · 6 employees$5.5Mraised▾
Smart farming calculators and tools for efficient land, resource, and profit management. This platform provides farmers with essential calculators and tools to optimize their operations. It focuses on empowering farmers to make data-driven decisions regarding land measurement, cost management, water usage, and profitability analysis. The platform offers tools such as acres to square meters converter, fuel cost calculator, tank volume calculator, and ROI calculator. By integrating simple math with insights from remote sensing and crop diagnostics, farmers can improve efficiency, reduce waste, and enhance overall farm performance. This is a B2C platform that helps in smart farming through data and calculators.
- Mar 2022Seed$2.4M
- Aug 2019Seed$2.6M
- Jun 2018Seed$571K
- May 2017Grant (prize money)$400K
#10
Acquired · St. Louis, Missouri · founded 2013 · 16 employees$9.8Mraised▾
Provider of a personal safety mobile application. It enables users to open the application, and hold the thumb on the safe button. Users need to release the button and enter the 4 digit pin. In case of a user not entering the password, local police will be notified based on location. The app is available for both iOS and Android devices.
- Dec 2019Series A$6.6M
- Apr 2019Conventional Debt$1M
- Aug 2017Seed$3.2M
- Aug 2017Conventional Debt$1M
#11
Series A · St. Louis, Missouri · founded 2006 · 7 employees$9.8Mraised▾
Developer of RFID-based identification systems for commercial applications. Its chief offering Intelligent Tracking and Control System is an automatic data capture system that offers real-time location system (RTLS) functionality and relies only on the use of passive or battery-assisted passive (BAP) UHF RFID tags to identify, locate and track items. The core technology behind the solution combines smart antennas, mathematical algorithms, and signal processing techniques to transmit low-power RF signals into an area being monitored and receiving signals returned by tags in order to capture tag IDs. The target market includes retail, government, manufacturing, aerospace, and defense industries.
- Dec 2016Series A$6M
- Dec 2012Seed$99K
- Dec 2012Seed$3M
- Nov 2012Seed$713.4K
#12
Series A · St. Louis, Missouri · founded 2008 · 11 employees$9.1Mraised▾
Aisle411 provides an AR-based indoor navigation solutions for businesses. Using retail mapping and location service, it allows shoppers to navigate through retail stores through the support of a variety of indoor positioning technologies including wi-fi, beacon, magnetic, visible light communication, & more. It also provides indoor analytics by measuring & monitoring customer behavior and provides solutions for optimizing product placement based on store traffic with data analytics. Its clients include Walgreens, Toys R Us, Mediamarkt, and more.
- Jan 2014Series A$6.3M
- Sep 2012Angel$250K
- Feb 2012Seed$50K
- Nov 2010Angel$2.1M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of High Tech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Semiconductors is moving in the United States
A read on the academic research around Semiconductors — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,739 United States-affiliated papers.
- Georgia Institute of Technology489
- IMEC343
- Intel325
- Purdue University West Lafayette218
- Industrial Technology Research Institute177
- Photonics56→121
- Photonic integrated circuit49→81
- Artificial neural network3→29
- Detector25→48
- Scalability53→73
- Photonics45→59
- Artificial neural network2→14
- Rapid single flux quantum2→12
- Detector20→29
- Image sensor2→11
- Photonics10→28
- Hardware security module6→13
- Thermal10→16
- Automotive industry2→8
- Photonic integrated circuit9→14
Where semiconductors is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing semiconductors patents in the United States
United States semiconductors patent filing is cooling — 112,775 filings from 8,000 assignees (2016–2025), led by IBM, Applied Materials, Intel; annual filings 11572→7675.
- IBM19691
- Applied Materials13119
- Intel11689
- Micron Technology10011
- Texas Instruments4804
- LAM RES4667
- Sandisk Technologies3051
- Qualcomm2897
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.