Best Immunology Companies in San Francisco, United States
The 54 best Immunology companies in San Francisco, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Alumis.
Ranked: Best Immunology companies in San Francisco
| # | Company | Disclosed funding | Last round | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|
| 1 | Alumis Developer of therapeutics for the treatment of auto-immune disease | $529M | 24 mo ago | 16 | Martin Babler CEO | 88 patents TYK2 kinase inhibitor compounds and formulations for inflammatory disease treatment. | — |
| 2 | Sonoma Biotherapeutics Developer of T-cell-based therapies for autoimmune and degenerative diseases | $335M | 59 mo ago | 74 74 → 66 (-11%) | Fred Ramsdell Co-Founder | 54 patents Engineered immune cell therapies using chimeric antigen receptors and cytokine receptor designs | 1 job opening |
| 3 | Portola Pharma Developer of therapeutics for cardiovascular and autoimmune diseases | $296M | 85 mo ago | 369 | — | — | — |
| 4 | Lycia Therapeutics Developer of protein degradation drugs for the treatment of cancer and auto-immune disease | $227M | 26 mo ago | 22 22 → 37 (+68%) | Carolyn Bertozzi Founder | — | — |
| 5 | Attralus Developer of drugs for the treatment of Amyloid diseases | $197M | 29 mo ago | 23 | Jonathan Wall Co-Founder | 50 patents Engineered Fc‑fusion and antibody‑peptide biologics for amyloid disease therapy | — |
| 6 | DICE Developer of small molecule therapeutics for multiple disorders | $192M | 58 mo ago | 90 | — | 36 patents Video surveillance analytics and network communication protocol technologies | — |
| 7 | Verge Genomics Developer of artificial intelligence powered platform for drug discovery and development | $134M | 55 mo ago | 46 46 → 27 (-41%) | Peyton Huang Non-Executive Director and Co-Founder | — | 1 launch · 1 partnership |
| 8 | Walking Fish Therapeutics Developer of cell-based therapeutic solutions for treating cancer & immunological disorders | $123M | 53 mo ago | 37 | Seenu Kothakota Co-Founder | — | — |
| 9 | Crescendo Bioscience CLIA Laboratory focused on autoimmune and inflammatory diseases | $122M | 162 mo ago | 128 | — | — | — |
| 10 | Ouro Medicines Developer of therapeutics for people living with chronic immune-mediated diseases | $120M | 18 mo ago | — | Jaideep Dudani CEO | — | — |
| 11 | Blade Therapeutics Antifibrotic treatment strategies that address a wide variety of congenital and acquired diseases of fibrosis. | $93M | 80 mo ago | 30 | — | — | — |
| 12 | Principia Biopharma Developer of small-molecule drugs targeting autoimmune diseases and cancer | $90M | 131 mo ago | 122 | — | 717 patents Small-molecule BTK and immunoproteasome inhibitors for autoimmune and thrombotic therapies | — |
| 13 | TRexBio Developer of therapeutics for immunology and cancer 45Funding top 20%Moat top 31%News top 46%Talent bottom 49% All 6 signals ▾Fundingtop 20% Moattop 31% Newstop 46% Talentbottom 49% Marketbottom 47% Globalbottom 36% Funding: Raised $85.0M across 4 rounds · 4 rounds over 5 yrs (0.8/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 45/100 | $85M | 5 mo ago | 65 | Johnston Erwin CEO | — | — |
| 14 | Electra Therapeutics Developer of therapies for immunological diseases and cancer | $84M | 9 mo ago | 4 | Adam Rosenthal Co-Founder & CEO | — | 1 launch |
| 15 | Symic Biomedical Developer of compounds to protect against tissue degradation and promote healing during illness or injury | $84M | 86 mo ago | 2 | — | 18 patents Synthetic extracellular‑matrix‑binding peptidoglycan biomaterials for wound and tissue repair | — |
| 16 | Vera Therapeutics Developer of therapeutic solutions for the treatment of immunological and inflammatory diseases | $80M | 65 mo ago | 46 | Marshall Fordyce Founder & CEO | — | — |
| 17 | Kezar Life Sciences Developer of drugs targeting protein homeostasis for autoimmune disorders | $78M | 107 mo ago | 56 | John Fowler Co-Founder and Board Director | 157 patents Synthesis and formulation of peptide epoxyketone immunoproteasome inhibitors for protein secretion blockade | — |
| 18 | Rigel Developer of drugs for hematologic disorders, cancer, and rare immune disease | $76M | 65 mo ago | 147 147 → 292 (+99%) | Raul Rodriguez President and CEO | 6 patents Patents concentrated in computing, sensing & instrumentation | 3 partnerships |
| 19 | IgGenix Developer of therapeutic solutions for treating food allergy | $75M | 41 mo ago | 12 | Stephen Quake Co-Founder | 36 patents Peptide-based diagnostics and therapeutics targeting allergic disease prediction and treatment | — |
| 20 | Second Genome Developer of microbiome-based personalized medicine for a wide range of human health disorders | $64M | 108 mo ago | 37 | — | 135 patents Therapeutic proteins/peptides targeting gut barrier and immune modulation for autism and cancer | — |
| 21 | Therini Bio Limited information available | $62M | 14 mo ago | 13 13 → 15 (+15%) | Daniel Burgess CEO | — | — |
| 22 | Federation Bio Developer of biotherapeutic products for immune and metabolic disease | $50M | 69 mo ago | 39 | Michael Fischbach Co-Founder | — | — |
| 23 | Tolerion Developer of therapeutics to treat autoimmune diseases | $43M | 77 mo ago | 12 | John Statham Founder | 17 patents Stabilized DNA therapeutics and immunomodulatory treatments for type 1 diabetes | — |
| 24 | Siolta Therapeutics Provider of microbiome therapeutics for treating multiple diseases | $42M | 28 mo ago | 14 | Nikole Kimes Founder & CEO | — | — |
| 25 | GigaGen Developer of T-cell and antibody-based therapeutics | $36M | 102 mo ago | 36 | — | 198 patents Engineering recombinant polyclonal therapeutic proteins and immune‑repertoire fusion constructs. | — |
| 26 | Pathway Therapeutics Develops isoform specific inhibitors for oncology and inflammation | $29M | 160 mo ago | — | Julie Cherrington ex-CEO | — | — |
| 27 | Getsetup Developer of peptide-based therapies and companion diagnostics for autoimmune and infectious diseases | $23M | 56 mo ago | 86 | Deval Delivala Co-Founder | — | — |
| 28 | IMIDomics Developer of medicines for the treatment of immune-mediated inflammatory diseases | $16M | 28 mo ago | 25 | Sara Marsal Co-Founder | — | — |
| 29 | Osprey Pharmaceuticals USA Inflammatory/immune disease medications | $15M | 206 mo ago | — | Jack M. Anthony ex-CEO | — | — |
| 30 | X-37 Developer of drugs for cancer, autoimmune diseases and anticoaguulation using AI technology | $14M | 80 mo ago | 3 | David Collier Co-Founder & CEO | — | — |
| 31 | ParcelBio Developer of programmable technology to deliver mRNA to diverse cell types in the body | $13M | 5 mo ago | — | Christopher Carlson Co-Founder | — | — |
| 32 | Shennon Biotechnologies Developer of immune cell therapies against solid tumors and autoimmune disease | $13M | 40 mo ago | 8 | Li Sun Founder/CEO | 10 patents Engineered immune cell therapies and high-throughput microfluidic cell interaction screening | 5 job openings · 1 internship |
| 33 | Linkage Biosciences Life sciences solutions provider, enabling scientific research, discovery, and diagnostics | $13M | 158 mo ago | 34 | — | — | — |
| 34 | Infinimmune Developer of antibody-based drugs to treat various diseases | $12M | 43 mo ago | 10 | Michael Gibbons Co-Founder | — | — |
| 35 | Granza Bio Developer of therapeutics for the treatment of cancer | $8M | 24 mo ago | — | Ashwin Nandakumar Co-Founder & CEO | — | 1 award |
| 36 | TippingPoint Biosciences Developer of therapeutics for treating diseases caused by dysfunctional genome chromatin packaging | $7M | 3 mo ago | — | Geeta Narlikar Co-Founder | — | 1 partnership |
| 37 | Apeximmune Therapeutics Developer of biologics for cancer and auto-immune disease | $6M | 15 mo ago | 3 | — | — | — |
| 38 | Alixia Provider of cancer drug discovery and development platform | $2M | 24 mo ago | 5 | Helen Chen Co-Founder & CEO | — | — |
| 39 | Adheron Therapeutics Biotech firm pioneering therapies for autoimmune, inflammatory, and fibrotic diseases | $2M | 131 mo ago | — | David Lee Co-Founder | — | — |
| 40 | Ditto Biosciences Developer of therapies targeting autoimmune diseases by leveraging parasite biology | $500K | 6 mo ago | — | Emily Weiss Co-Founder & CTO | — | — |
| 41 | Serenity Bioworks Developer of protein-based therapeutics to address various medical conditions | $310K | 71 mo ago | 3 | Cody Shirriff Co-Founder & CEO | — | — |
| 42 | Beeline Therapeutics Developer of cell therapeutics for immunological diseases | $250K | 87 mo ago | — | Dimitre Simeonov Co-Founder | — | — |
Top 12 Immunology companies in San Francisco
#1
Series B · San Francisco, California · founded 2019 · 65 employees$85Mraised▾
Developer of therapeutics for immunology and cancer. The company is developing transformative therapies by using a technology that maps human tissue and manipulates Tregs and other immune cells in a tissue-specific and disease-specific fashion.
- Jan 2026Series B$50M
- Nov 2024Series B$84M
- Mar 2022Series A$26M
- Jun 2021Series A$59M
#2
Series C · San Francisco, California · founded 2018 · 4 employees$84Mraised▾
Developer of therapies for immunological diseases and cancer. The company focuses on the development of therapies that target signal regulatory proteins (SIRP) for the treatment of immunological diseases and cancer. The company's lead product ELA026, is a monoclonal antibody to treat secondary hemophagocytic lymphohistiocytosis (sHLH).
- Oct 2025Series C$183M
- Dec 2023Series B—
- Feb 2022Series B$84M
#3
Seed · San Francisco, California · founded 2022$7Mraised▾
Developer of therapeutics for treating diseases caused by dysfunctional genome chromatin packaging. The company's proprietary platform addresses major limitations and challenges seen in the healthcare space by recreating the biological context of cancer-driving chromatin states in a controlled, cell-free environment. It focuses on disrupting or restoring the unique protein-protein and protein-DNA networks that package cell genomes.
- Apr 2026Seed$4.5M
- Seed$2.5M
#4
Seed · San Francisco, California · founded 2023$13.2Mraised▾
Developer of programmable technology to deliver mRNA to diverse cell types in the body. The company has proprietary nanoparticle technology, which is ‘STAmP’, stabilizes the mRNA and utilizes an interchangeable, lock-and-key-like targeting mechanism which enables fully customizable mRNA medicines for kidney disorders, chronic liver diseases, and immune system dysregulation.
- Feb 2026Seed$13.2M
#5
Series A · San Francisco, California · founded 2016 · 13 employees$62.4Mraised▾
Limited information available
- May 2025Series A$39M
- Jan 2025Grant (prize money)$3M
- Mar 2023Conventional Debt—
- Mar 2023Series A$36M
#6
Acquired · San Francisco, California · founded 2024$120Mraised▾
Developer of therapeutics for people living with chronic immune-mediated diseases. It offers a lead therapeutic candidate OM336 targeting B cell biology for the treatment of multiple myeloma and immune-mediated diseases.
- Jan 2025Series A$120M
#7
Public · San Francisco, California · founded 2003 · 16 employees$529Mraised▾
Developer of therapeutics for the treatment of auto-immune disease. The lead candidate SK-001 is a potentially best-in-class TYK2 inhibitor for psoriasis treatment. The TYK2 is a gene that encodes a member of the tyrosine kinase which is a key mediator of inflammation and autoimmune diseases.
- Jul 2024Post IPO$40M
- Mar 2024Series C$259M
- 2023Series B—
- Jan 2022Series B$200M
#8
Series C · San Francisco, California · founded 2020 · 22 employees$226.7Mraised▾
Developer of protein degradation drugs for the treatment of cancer and auto-immune disease
- Apr 2024Series C$106.6M
- Sep 2021Series B$70.1M
- Jun 2020Series A$50M
#9
Series B · San Francisco, California · founded 2019 · 23 employees$197Mraised▾
Developer of drugs for the treatment of Amyloid diseases. The lead product AT-01 uses a polybasic peptide radiotracer technology and helps in the diagnostic of amyloid diseases. Other products include AT-02 & AT-03 which are PAR-SAP components that mediate binding to all types of amyloid and the Fc stimulates the immune system to remove amyloid.
- Feb 2024Series B$56M
- Sep 2021Series B$116M
- Sep 2020Series A$25M
- Dec 2019Conventional Debt$175K
#10
Series A · San Francisco, California · founded 2017 · 3 employees$6Mraised▾
Developer of biologics for cancer and auto-immune disease. The company has a technology platform that combines bioinformatics with biological assays to identify immune-modulating targets to treat cancer, autoimmune disease, and transplantation.
- Apr 2025Series A$21.3M
- Jun 2023Grant (prize money)$399.6K
- Mar 2021Seed$6M
#11
Seed · San Francisco, California · founded 2025$500Kraised▾
Developer of therapies targeting autoimmune diseases by leveraging parasite biology. The company identifies proteins from viruses, ticks, and worms to treat autoimmune disorders. These proteins could potentially calm and redirect the immune system. The company's platform identifies proteins with therapeutic potential for autoimmune diseases.
- Jan 2026Seed$500K
#12
Series C · San Francisco, California · founded 2016 · 14 employees$42Mraised▾
Provider of microbiome therapeutics for treating multiple diseases. The company is focusing on the development of targeted human microbiome therapeutics for the prevention and treatment of chronic inflammatory diseases, starting with allergic diseases. The company's flagship product is STMC-103H for treating atopic dermatitis, food allergy, and allergic asthma.
- Mar 2024Series C$12M
- Aug 2023Grant (prize money)$300K
- Feb 2022Grant (prize money)$2.9M
- Sep 2020Series B$30M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Immunology coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Immunology & Immunotherapy is moving in the United States
A read on the academic research around Immunology & Immunotherapy — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 13,913 United States-affiliated papers.
- Dana-Farber Cancer Institute608
- The University of Texas MD Anderson Cancer Center559
- Harvard University524
- Cornell University416
- Brigham and Women's Hospital408
- Immune system88→1414
- Tumor microenvironment30→481
- Cancer41→483
- Cancer immunotherapy35→460
- T cell23→340
- Immune system205→2094
- Cancer86→884
- Oncology71→760
- Internal medicine109→672
- Tumor microenvironment72→632
- Immune system67→663
- Cancer40→389
- Oncology24→257
- Disease16→242
- Clinical trial11→209
Where immunology is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing immunology patents in the United States
United States immunology patent filing is accelerating — 10,389 filings from 4,528 assignees (2016–2025), led by UNIV California, Memorial Sloan Kettering Cancer , US Health; annual filings 785→970.
- UNIV California399
- Memorial Sloan Kettering Cancer 350
- US Health315
- UNIV Texas296
- Iovance Biotherapeutics284
- Abbvie270
- UNIV Pennsylvania237
- DANA Farber Cancer INST222