Best Immunotherapy Companies in San Diego, United States
The 79 best Immunotherapy companies in San Diego, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Halozyme.
Our analysis of 50 Immunotherapy companies
$8.8b in tracked funding; 69% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Immunotherapy companies in San Diego
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Halozyme Developer of drug delivery technologies for the treatment of various diseases | $1.3B | 46 mo ago | Public | 373 373 → 536 (+44%) · sector median +7% | Helen Torley CEO & President | 715 patents Enabling subcutaneous delivery of biologics via hyaluronidase and advanced injector devices | — |
| 2 | Ambrx Developer of Antibody drug conjugates to treat cancers, metabolic disorders and cardiovascular disorders | $346M | 67 mo ago | Acquired | 79 | Lawson Macartney President & Ceo | 1,276 patents Protein engineering and antibody-drug conjugates for therapeutic biologics | — |
| 3 | Capstan Therapeutics Developer of cell therapies for a broad range of diseases | $340M | 27 mo ago | Acquired | 75 | Laura Shawver CEO | — | — |
| 4 | Poseida Therapeutics Developer of gene therapies for treating cancer and liver orphan disease by using gene editing technologies | $324M | 34 mo ago | Acquired | 259 | — | 426 patents Patents concentrated in chemistry & materials | — |
| 5 | Sorrento Therapeutics Developer of immuno therapeutics for cancer, inflammation, and autoimmune diseases 67Funding top 20%Patents top 20%Market top 26%Moat top 30% All 12 signals ▾Fundingtop 20% Patentstop 20% Markettop 26% Moattop 30% Innovationtop 32% Growthtop 45% Fin. healthtop 45% Partnerstop 45% Talentbottom 49% Globalbottom 44% Techbottom 31% Newsbottom 27% Funding: Raised $282M across 17 rounds · 17 rounds over 17 yrs (1.0/yr) Patents: 1,073 patents matched (strict assignee match) · 312 filings since 2022 vs 587 in 2017-21 rank vs industry peers · Fliar Intelligence Index 67/100 | $282M | 14 mo ago | Public | 949 | Henry Ji Co-Founder & CEO | 1,073 patents Targeted antibody-drug conjugates and resiniferatoxin-based therapies for cancer and neurodegeneration | — |
| 6 | BlossomHill Therapeutics Provider of the drug for the treatment of oncology and autoimmune disorders 55Funding top 20%Patents top 21%Innovation top 23%Moat top 26% All 7 signals ▾Fundingtop 20% Patentstop 21% Innovationtop 23% Moattop 26% Newsbottom 42% Globalbottom 42% Marketbottom 34% Funding: Raised $260M across 3 rounds · 3 rounds over 5 yrs (0.6/yr) Patents: 133 patents matched (strict assignee match) · 133 filings since 2022 vs 0 in 2017-21 rank vs industry peers · Fliar Intelligence Index 55/100 | $260M | 6 mo ago | Series B | 14 | — | 133 patents Design of macrocyclic kinase inhibitors targeting KRAS, EGFR, and related oncogenic pathways | 3 job openings |
| 7 | PaxVax Oral vaccines against infectious diseases such as cholera, bird flu, HIV & others. | $212M | 126 mo ago | Acquired | 138 | — | 27 patents Adenoviral vector vaccine platforms and spray‑drying formulation technologies for infectious disease vaccines | — |
| 8 | Candid Therapeutics Developer of therapeutics for autoimmune diseases 40Funding top 17%Growth top 38%News top 48%Moat top 48% All 8 signals ▾Fundingtop 17% Growthtop 38% Newstop 48% Moattop 48% Talentbottom 49% Techbottom 38% Globalbottom 38% Marketbottom 32% Funding: Raised $206M across 2 rounds · 2 rounds over 2 yrs (1.0/yr) Growth: 1 acquisition/expansion move in 24 mo · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 40/100 | $206M | 3 mo ago | Acquired | — | Ken Song CEO | — | — |
| 9 | VelosBio Developer of therapeutic solutions for the treatment of cancer | $204M | 71 mo ago | Acquired | 30 | David Johnson CEO | 55 patents Targeted cancer therapeutics using ROR1-specific antibody‑drug conjugates and bispecific antibodies | — |
| 10 | Artiva Developer of therapeutics for autoimmune diseases and cancer | $198M | 64 mo ago | Public | 15 | — | 6 patents Architectural floor lighting fixtures with arch-shaped multi‑light designs | — |
| 11 | Solve Therapeutics Developer of antibody-based therapies targeting tumor-specific antigens for cancer treatment 55Funding top 16%Moat top 40%Global top 45%Market bottom 49% All 5 signals ▾Fundingtop 16% Moattop 40% Globaltop 45% Marketbottom 49% Talentbottom 49% Funding: Raised $195M across 2 rounds · 2 rounds over 2 yrs (1.0/yr) Moat: Soonicorn · 10 curated direct competitors tracked rank vs industry peers · Fliar Intelligence Index 55/100 | $195M | 7 mo ago | Series D | — | Dave Johnson Founder & CEO | — | — |
| 12 | Shoreline Biosciences Developer of cell-based therapeutic solutions for cancer treatment | $183M | 55 mo ago | Series B | 98 | Dan Kaufman Co-Founder | — | — |
| 13 | Janux Therapeutics Developer of immunotherapeutics for the treatment of cancer | $181M | 62 mo ago | Public | 59 59 → 121 (+105%) · sector median +7% | David Campbell President | 170 patents Bispecific T‑cell‑engaging antibodies and cleavable linkers for tumor antigen targeting | — |
| 14 | Turnstone Biologics Developer of oncolytic viral immunotherapies for cancer treatment | $172M | 59 mo ago | Acquired | 80 | John Bell Co-Founder | 61 patents Engineered tumor-infiltrating lymphocytes and ex vivo T‑cell expansion for cancer immunotherapy | — |
| 15 | BioAtla Developer of immunotherapies for cancer using active biologics platform | $162M | 71 mo ago | Public | 41 41 → 35 (-15%) · sector median +7% | Jay Short Chairman | 698 patents Therapeutic antibodies and engineered proteins for targeted cancer and aging cell treatments | — |
| 16 | Lassen Therapeutics Developer of therapeutics to treat cancer | $116M | 30 mo ago | Series B | 6 | Mark Barrett Founder | — | — |
| 17 | MBrace Therapeutics Provider of a technology platform for the development of antibody-drug conjugate to treat cancer | $110M | 31 mo ago | Series B | — | Isan Chen Co-Founder & CEO | — | — |
| 18 | Adcentrx Therapeutics Developer of next-generation targeted therapies for cancer | $101M | 30 mo ago | Series A | 35 | — | — | — |
| 19 | IconOVir Developer of cancer therapeutics using the oncolytic virus | $97M | 36 mo ago | Series B | 35 | Mark Mccamish President and CEO | — | — |
| 20 | AnaptysBio Developer of immunology therapeutics for cancer and inflammatory diseases | $86M | 131 mo ago | Public | 101 101 → 74 (-27%) · sector median +7% | — | 326 patents Therapeutic antibodies/modulators targeting immune checkpoints and cytokine receptors for inflammation | — |
| 21 | Aspyrian Therapeutics Photoimmunotherapy to treat Head and Neck Cancer. | $83M | 107 mo ago | Acqui-Hired | 36 | — | — | — |
| 22 | Cidara Therapeutics Developer of novel anti-infectives for infectious diseases (bacterial and fungal) | $78M | 19 mo ago | Acquired | 90 90 → 48 (-47%) · sector median +7% | Jeff Stein CEO | 275 patents Patents concentrated in health & consumer products | — |
| 23 | Fate Therapeutics Developer of cellular immuno-therapeutics for the treatment of cancer and immune disorders | $78M | 71 mo ago | Public | 181 181 → 227 (+25%) · sector median +7% | Scott Wolchko President & CEO | 606 patents Patents concentrated in chemistry & materials | 2 job openings |
| 24 | Tr1X Developer of T cell-based products to treat autoimmune and inflammatory diseases | $75M | 14 mo ago | Series A | 7 | David Vries Co-Founder | 35 patents Engineered IL-10‑secreting CAR‑CD4+ T cell immunotherapies for cancer treatment | — |
| 25 | OncoSec Medical Developer of intratumoral immunotherapies to harness the body's immune system to fight cancer | $69M | 90 mo ago | Acquired | 26 | — | 148 patents Cancer immunotherapy response biomarkers and electroporation-based gene delivery technologies. | — |
| 26 | Bird Rock Bio Antibody therapeutics to G-Protein Coupled Receptors targets validated with small molecules | $63M | 113 mo ago | Acquired | 14 | — | — | — |
| 27 | Tracon Pharma Developer of antibody therapeutics for the treatment of cancer and fibrotic diseases | $55M | 69 mo ago | Deadpooled | 17 | — | — | — |
| 28 | Primmune Therapeutics Developer of immunotherapies for treating cancer 42Funding top 21%Talent top 28%Product top 35%Innovation top 38% All 8 signals ▾Fundingtop 21% Talenttop 28% Producttop 35% Innovationtop 38% Moattop 39% Techbottom 40% Globalbottom 36% Marketbottom 26% Funding: Raised $46.8M across 8 rounds · 8 rounds over 6 yrs (1.3/yr) Talent: Analyst team rating 4/5 · 4 named leaders on record rank vs industry peers · Fliar Intelligence Index 42/100 | $47M | 4 mo ago | Series B | 9 | Stephen Webber Co-Founder | — | — |
| 29 | Phanes Therapeutics Developer of therapeutic solutions for treating immuno-oncology and eye disease | $40M | 60 mo ago | Series B | 28 | Ming Wang President and CEO | 205 patents Therapeutic antibodies targeting immune checkpoints and tumor-associated antigens | — |
| 30 | Receptos Global biopharmaceutical company discovering, developing, and delivering innovative medicines | $36M | 172 mo ago | Acquired | 68 | — | 254 patents Sphingosine‑1‑phosphate receptor modulators for autoimmune disease therapeutics | 1 partnership |
| 31 | Patara Pharma Immunomodulators (mast cell stabilizers) for allergic & inflammatory diseases. | $34M | 116 mo ago | Deadpooled | — | William Gerhart CEO and Founder | — | — |
| 32 | Calidi Biotherapeutics Developer of gene therapies for the treatment of cancer and other indications | $34M | 22 mo ago | Public | 29 29 → 31 (+7%) · sector median +7% | Megan Camaisa Co-Founder | 47 patents Oncolytic viral therapies using cell carriers and engineered smallpox vaccine platforms | 1 launch |
| 33 | Equillium Developer of therapies for treating autoimmune and inflammatory disorders | $30M | 10 mo ago | Public | 36 36 → 38 (+6%) · sector median +7% | Daniel Bradbury Co-Founder & CEO | 33 patents CD6‑targeted antibody therapeutics for autoimmune and inflammatory diseases | — |
| 34 | Vironexis Biotherapeutics Developer of AAV-delivered T-cell immunotherapies for the treatment of cancer | $26M | 21 mo ago | Seed | — | Timothy Cripe Co-Founder | 15 patents AAV-based gene therapy vectors targeting metastatic cancer prevention and treatment | — |
| 35 | MabVax Human monoclonal antibodies and vaccines for the diagnosis and treatment of various cancers. | $21M | 97 mo ago | Public | 6 | David Hansen President and CEO | — | — |
| 36 | Adamis Pharmaceuticals Developer of therapeutics for treating respiratory disease and allergy | $16M | 76 mo ago | Public | 15 | — | 140 patents Injection devices and drug delivery formulations for emergency and therapeutic applications | — |
| 37 | RyboDyn Developer of immunotherapies for the treatment of cancer 21Talent top 28%Funding top 37%Global bottom 48%Market bottom 15% All 4 signals ▾Talenttop 28% Fundingtop 37% Globalbottom 48% Marketbottom 15% Talent: 3 named leaders on record · 3 C-suite/founder profiles curated Funding: Raised $14.0M across 2 rounds · 2 rounds over 3 yrs (0.7/yr) rank vs industry peers · Fliar Intelligence Index 21/100 | $14M | 3 mo ago | Seed | 3 | Kerry Wilson Co-Founder | — | — |
| 38 | Abintus Developer of in vivo immune cell therapy | $14M | 46 mo ago | Series B | 13 | Carlos Ibanez Founder | — | — |
| 39 | VLP Biotech Developing innovative vaccines and custom recombinant proteins using proprietary platform | $10M | 144 mo ago | Funding Raised | 15 | Dave Milich CEO | — | — |
| 40 | GRI Bio Small molecules targeting the regulation of Natural killer T cells to treat liver diseases. | $10M | 91 mo ago | Public | 5 | — | — | — |
| 41 | PDI Therapeutics Antibody inhibitors to a specific protein disulfide isomerase to improve recognition of tumor cells by the… | $10M | 121 mo ago | Series A | — | Jay Lichter Managing Partner | — | — |
| 42 | Luxvitae Therapeutics Developer of therapeutics for multiple diseases | $8M | 19 mo ago | Series A | — | Mathew Patt Founder | — | — |
| 43 | Decoy Biosystems Developer of small molecule-based immunotherapeutic solutions for the treatment of cancer | $6M | 78 mo ago | Series A | 2 | Michael Newman Founder & CEO | 40 patents Live bacterial therapeutics for treating infections and cancer | — |
| 44 | Toragen Developer of therapeutics targeting oncogenic viruses | $5M | 44 mo ago | Seed | 7 | Andrew Sharabi Founder | 12 patents Pharmaceutical rimantadine salt formulations for cancer and HPV lesion treatment | — |
| 45 | Femta Pharmaceuticals Develops therapeutic monoclonal antibodies | $4M | 188 mo ago | Deadpooled | — | Stephen Keane CEO | — | — |
| 46 | INmuneBIO Provider of immunotherapeutics for the treatment of multiple conditions | $3M | 17 mo ago | Public | 11 11 → 16 (+45%) · sector median +7% | Raymond Tesi CEO & CMO | — | — |
| 47 | Batu Biologics Content creation, digital marketing, and business growth strategies provider | $3M | 101 mo ago | Seed | 3 | — | 37 patents Cancer immunotherapy via oncolytic viruses and anti‑angiogenic endothelial vaccines | — |
| 48 | RIFT Biotherapeutics US-based, early stage biopharma developing therapeutic antibodies for oncology | $2M | 110 mo ago | Deadpooled | 3 | — | — | — |
| 49 | Multimeric Biotherapeutics Developing FortiVac vaccine platform for strong CD8+ T cell responses | $2M | 129 mo ago | Funding Raised | — | Marc Hertz Founder & Chairman | — | — |
| 50 | Antlia Bioscience Developer of peptide-based therapeutic solutions for the treatment of chronic heart failure | $207K | 21 mo ago | Seed | 3 | Nigel Shankley Co-Founder | — | — |
Top 12 Immunotherapy companies in San Diego
#1
Acquired · San Diego, California · founded 2024$206.2Mraised▾
Developer of therapeutics for autoimmune diseases. It focuses on identifying and targeting specific pathways to develop therapies which include CND106 a bispecific antibody that targets and eliminate later stage B-cellsf or autoantibody disease treatment, CND261 targets a broad range of B-cell subtypes for autoimmune diseases.
- Mar 2026Series E$505M
- Sep 2024Series D$370M
#2
Series B · San Diego, California · founded 2020 · 14 employees$259.6Mraised▾
Provider of the drug for the treatment of oncology and autoimmune disorders. The company is involved in drug design and development based on small molecules.
- Nov 2025Series B$84.2M
- Dec 2023Series B$100M
- Mar 2021Series A$71M
#3
Series D · San Diego, California · founded 2021$195Mraised▾
Developer of antibody-based therapies targeting tumor-specific antigens for cancer treatment. The company focuses on advancing antibody-based therapeutics to address unmet medical needs. It refines a chemistry platform while developing targeted radionuclide therapeutics. The company evaluates companion radiodiagnostics for use with other types of targeted cancer therapeutics.
- Nov 2025Series D$120M
- Dec 2024Series C$75M
#4
Series B · San Diego, California · founded 2017 · 9 employees$46.8Mraised▾
Primmune Therapeutics is developing immunotherapies for treating cancer. They are developing a small molecule (orally administered) which is a toll-like receptor 7 (TLR7) agonist (an endosomal innate immune sensor capable of detecting single-stranded ribonucleic acid) helps in systemic activation of innate immunity. It gets expressed on plasmacytoid dendritic cells.
- Jan 2026Series B$8.6M
- Nov 2021Series A$8.4M
- Jan 2021Series A$4M
- Oct 2020Series A$27.4M
#5
Seed · San Diego, California · founded 2022 · 3 employees$14Mraised▾
Developer of immunotherapies for the treatment of cancer. The company has developed antigen discovery and validation platform to create a transformative medicines for patients with cancer.
- Mar 2026Seed$10M
- Jan 2025Seed$4M
- Jun 2023Seed—
#6
Public · San Diego, California · founded 1989 · 949 employees$281.6Mraised▾
Developer of immuno therapeutics for cancer, inflammation, and autoimmune diseases. The company’s lead products are multiple biosimilars and bio better antibodies as well as clinical CAR-T therapies targeting solid tumors. Also, has a portfolio of immuno-oncology antibody programs targeting EGFR, TNF-alpha, CD 25, and IGE. Its lead CAR-T cell therapies are against the carcinoembryonic antigen and prostate-specific membrane antigen.
- Apr 2025Post IPO$47.4M
- Sep 2018Conventional Debt—
- Jun 2018Post IPO$150M
- Nov 2016Venture Debt$50M
#7
Series A · San Diego, California · founded 2018 · 7 employees$75Mraised▾
Developer of T cell-based products to treat autoimmune and inflammatory diseases. The Company uses its proprietary platform for the generation of cell therapy products to restore immune tolerance, with the potential to treat autoimmune and inflammatory diseases.
- Apr 2025Grant (prize money)$8M
- 2024Grant (prize money)$4M
- Jan 2024Series A$75M
#8
Public · San Diego, California · founded 2017 · 36 employees$30Mraised▾
Developer of therapies for treating autoimmune and inflammatory disorders. The lead product, itolizumab is a treatment for multiple severe immuno-inflammatory disorders, including graft-versus-host disease, uncontrolled moderate to severe asthma, and SLE / lupus nephritis.
- Aug 2025Post IPO$30M
#9
Acquired · San Diego, California · founded 2013 · 90 employees$78.4Mraised▾
Developer of novel anti-infectives for infectious diseases (bacterial and fungal). Its first product candidate is CD101 IV, an intravenous therapy in phase 1 trials for fungal infections. Besides, it has CD101 topical in the IND-enabling stage for the treatment of acute and recurrent vulvovaginal candidiasis (VVS). It has also developed a proprietary immunotherapy technology platform, Cloudbreak to develop drugs that direct immune cells to eliminate pathogens that cause infectious diseases. Its first Cloudbreak development candidate C001 is for the treatment of invasive aspergillosis.
- Nov 2024Post IPO$105M
- Apr 2024Post IPO$240M
- Sep 2019Post IPO$9M
- May 2018Post IPO$1.6M
#10
Acquired · San Diego, California · founded 2021 · 75 employees$340Mraised▾
Developer of cell therapies for a broad range of diseases. The company's technology comprises targeted lipid nanoparticles (tLNPs), CAR-based immunotherapy, and nucleic acid drug delivery to develop treatment options for patients for oncology, fibrosis, inflammation-related diseases, and monogenic blood disorders.
- Mar 2024Series B$175M
- Jun 2022Series A$102M
- Nov 2021Seed$63M
#11
Public · San Diego, California · founded 2018 · 29 employees$33.8Mraised▾
Developer of gene therapies for the treatment of cancer and other indications. It is a clinical-stage immuno-oncology company developing stem cell-based platforms to deliver oncolytic viruses that target solid tumors and enhance immune responses against metastatic cancer.
- Jul 2024Post IPO$1M
- Mar 2024Post IPO$3.5M
- Jan 2024Post IPO$1M
- Nov 2023Post IPO$195K
#12
Public · San Diego, California · founded 1999 · 373 employees$1.3Braised▾
Developer of drug delivery technologies for the treatment of various diseases. The company's lead product is ENHANZE drug delivery technology, based on the proprietary enzyme rHuPH20, which is used to facilitate the delivery of injected drugs and fluids. Also, it offers Hylenex recombinant an endoglycosidase indicated as an adjuvant to increase the dispersion and absorption of other injected drugs.
- Aug 2022Post IPO$625M
- Nov 2019Post IPO$388.5M
- Jan 2016Venture Debt$150M
- Jan 2014Venture Debt$20M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Immunotherapy coverage by sub-theme.
Regulatory-risk over time falling
Funding & growth over time
funding rising · growth rising
How research on Immunology & Immunotherapy is moving in the United States
A read on the academic research around Immunology & Immunotherapy — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 13,913 United States-affiliated papers.
- Dana-Farber Cancer Institute608
- The University of Texas MD Anderson Cancer Center559
- Harvard University524
- Cornell University416
- Brigham and Women's Hospital408
- Immune system88→1414
- Tumor microenvironment30→481
- Cancer41→483
- Cancer immunotherapy35→460
- T cell23→340
- Immune system205→2094
- Cancer86→884
- Oncology71→760
- Internal medicine109→672
- Tumor microenvironment72→632
- Immune system67→663
- Cancer40→389
- Oncology24→257
- Disease16→242
- Clinical trial11→209
Where immunology is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing immunology patents in the United States
United States immunology patent filing is accelerating — 10,389 filings from 4,528 assignees (2016–2025), led by UNIV California, Memorial Sloan Kettering Cancer , US Health; annual filings 785→970.
- UNIV California399
- Memorial Sloan Kettering Cancer 350
- US Health315
- UNIV Texas296
- Iovance Biotherapeutics284
- Abbvie270
- UNIV Pennsylvania237
- DANA Farber Cancer INST222