Best Life Sciences Companies in Nashville, United States
The 48 best Life Sciences companies in Nashville, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: SmileDirectClub.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in Nashville
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SmileDirectClub Developer of customized dental aligners | $440M | 66 mo ago | Deadpooled | Jordan Katzman Co-Founder | 2014 | — | 132 patents AI-driven 3D imaging and treatment planning for orthodontic tooth movement | — |
| 2 | Appello Pharmaceuticals Developer of small molecules for the treatment of neurological disorders | $40M | 55 mo ago | Series B | Brian Laden CEO | 2017 | — | — | — |
| 3 | Amytrx Therapeutics Developer of therapies for the treatment of inflammatory diseases | $23M | 31 mo ago | Series A | Jacek Hawiger Founder | 2014 | — | — | — |
| 4 | VenoStent Developer of a shape memory polymer stent for vascular surgery | $23M | 4 mo ago | Series A | Timothy Boire President and CEO | 2017 | — | 15 patents 3D‑printed photocrosslinkable vinyl polymers for vascular grafts and perivascular wraps | — |
| 5 | Rootine Provider of personalized nutrition supplements | $14M | 47 mo ago | Series A | — | 2018 | ShopifyTailwind CSSReact+30 | — | — |
| 6 | Nusirt Specialty company engaged in developing treatment for chronic diseases | $13M | 116 mo ago | Series C | — | 2007 | — | — | — |
| 7 | AngelEye Health Provider of video, data, and analysis solutions for pediatric patient care 48Funding top 33%Growth top 37%News top 44%Tech top 48% All 8 signals ▾Fundingtop 33% Growthtop 37% Newstop 44% Techtop 48% Talentbottom 49% Marketbottom 41% Moatbottom 38% Globalbottom 37% Funding: Raised $12.2M across 6 rounds · 6 rounds over 4 yrs (1.5/yr) Growth: 1 acquisition/expansion move in 24 mo · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $12M | 8 mo ago | Series C | Christopher Rand CEO | 2013 | WordPress Block EditorElementorWordPress+28 | — | — |
| 8 | PATH EX Developing blood-cleansing device to remove pathogens from circulating blood | $6M | 15 mo ago | Series A | Sinead Miller Co-Founder & CEO | 2016 | — | 45 patents Patents concentrated in health & consumer products | — |
| 9 | IQuity Provider of RNA-based diagnostics for autoimmune disorders | $4M | 47 mo ago | Series A | — | 2013 | — | 12 patents Analyzing disease biomarkers via lncRNA expression and claims data for diagnosis | — |
| 10 | IDBiologics Developer of antibodies to treat infectious diseases | $4M | 65 mo ago | Series A | James Crowe Co-Founder | 2017 | — | — | — |
| 11 | Molecular Sensing Innovative molecular sensing for drug discovery and development | $4M | 143 mo ago | Series A | Scot Weinberger Co-Founder | 2006 | — | 30 patents Interferometric biosensing platforms for label-free detection of biomolecular interactions | — |
| 12 | Healing Innovations Robotic neurorehabilitation technology improving mobility and independence for neurological injury recovery | $3M | 21 mo ago | Funding Raised | — | 2018 | WebflowTypekitcore-js+14 | — | 2 job openings · 1 partnership · 1 expansion |
| 13 | Insight Genetics Molecular diagnostics company that is working to enhance the diagnosis, monitoring and treatment of cancer. | $3M | 129 mo ago | Acquired | — | 2007 | — | 42 patents ALK fusion detection and targeted therapy diagnostics for cancer | — |
| 14 | VenX Medical Develops devices for the treatment of spider and reticular veins | $3M | 146 mo ago | Deadpooled | David Barella ex-President & CEO | 2009 | — | — | — |
| 15 | InvisionHeart Digital patient diagnosis and management ECG machine and system | $2M | 146 mo ago | Deadpooled | Josh Nickols CEO | 2013 | — | — | — |
| 16 | Etheros Pharmaceuticals Developer of small molecule enzyme mimetics for neuroprotection and healthspan extension | $2M | 18 mo ago | Seed | Laura Dugan Co-Founder | 2022 | — | — | — |
| 17 | Care Technology Systems Remote monitoring and assessment tools for senior citizens | $710K | 156 mo ago | Seed | Jim Anderson Founder & President | 2010 | — | — | — |
| 18 | GenHunter Provider of a technology platform for gene expression analysis | $524K | 181 mo ago | Funding Raised | — | 1992 | Cart FunctionalityBigCommerceTwitter Ads+14 | 8 patents Patents concentrated in chemistry & materials | — |
| 19 | EndoTheia Developer of medical devices for endoscopic surgery | $500K | 18 mo ago | Seed | — | 2018 | WixSentryBootstrap+10 | 20 patents Flexible endoscopic devices and stone extraction tools for minimally invasive surgery. | — |
| 20 | Defiance Fuel Brand of energy drinks | $250K | 137 mo ago | Seed | — | 2009 | — | — | — |
| 21 | Virtuoso Surgical Developer of robotic endoscopic surgery system | $180K | 5 mo ago | Series A | — | 2016 | WordPressMySQLPHP+27 | 28 patents Patents concentrated in health & consumer products | — |
Top 12 Life Sciences companies in Nashville
#1
Series A · Nashville, Tennessee · founded 2017 · 18 employees$22.8Mraised▾
Developer of a shape memory polymer stent for vascular surgery. The SelfWrap, is an external stent, used for venous access in hemodialysis patients. The stent, is a polymer wrap, provides a mechanical support and reduces vein collapse, at the point of surgery, by promoting vein growth in dialysis patients.
- Apr 2026Series A$10M
- May 2025Grant (prize money)$2.5M
- Apr 2025Grant (prize money)$2.5M
- Jun 2024Series A$4M
#2
Series C · Nashville, Tennessee · founded 2013 · 48 employees$12.2Mraised▾
Provider of video, data, and analysis solutions for pediatric patient care. It delivers integrated systems for clinical analysis, navigation, discharge management, and feeding documentation. The systems connect care teams and families to ensure a smooth transition to health. The technology offers bedside cameras with live-streaming patient viewing and secure messaging. It also provides support services to keep systems running.
- Dec 2025Series C$9M
- Mar 2025Series B$3M
- Nov 2022Series B$11.2M
- Feb 2022Seed$1M
#3
Series A · Nashville, Tennessee · founded 2016 · 2 employees$6.3Mraised▾
PATH EX is developing a blood-cleansing device to remove pathogens from circulating blood. They are developing an extracorporeal blood-cleansing device designed to remove multi-drug resistant bacteria and bacterial endotoxin from circulating blood. its Pre-clinical studies demonstrated a reduction of 95% bacteria in a single pass.
- May 2025Series A$5M
- Sep 2021Grant (prize money)$25K
- Oct 2020Grant (prize money)$100K
- Jun 2018Grant (prize money)$910K
#4
Series A · Nashville, Tennessee · founded 2016 · 10 employees$179.8Kraised▾
Developer of robotic endoscopic surgery system. The system delivers robotically controlled, needle-sized manipulators to apprehend, manipulate, and cut tissues. It is used in various areas of surgery, including neurologic, thoracic, orthopedic, urologic, and gynecologic procedures.
- Feb 2026Series A$2.9M
- Nov 2023Grant (prize money)$1.8M
- Aug 2023Seed$179.8K
#5
Deadpooled · Nashville, Tennessee · founded 2014 · 1360 employees$439.5Mraised▾
Developer of customized dental aligners. The online platform can be used to order the aligners by taking teeth impressions and the company develops customized invisible aligners for the users.
- Feb 2021Post IPO$350M
- Oct 2018Series C$380M
- Jul 2017Series B$12.8M
- 2016Series B$46.7M
#6
Funding Raised · Nashville, Tennessee · founded 2018 · 11 employees$3.3Mraised▾
Robotic neurorehabilitation technology improving mobility and independence for neurological injury recovery. This company develops market-leading robotic technology to increase access to better rehabilitation. Their flagship product is a 3-in-1 rehab station facilitating seated, standing, and walking neurorehabilitation. This innovative approach caters to a wide variety of use cases, treatment programs, and clinics. They are committed to pushing boundaries in neuro rehabilitation through cutting-edge technology and research. They foster collaboration with patients, staff, and partners to create tailored solutions. The company empowers patients and staff to take control of their rehabilitation journey and achieve their goals. They serve inpatient, outpatient, skilled nursing, LTACH, and community wellness centers, addressing conditions like stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s, and cerebral palsy.
- Oct 2024Grant (prize money)$2M
- Sep 2024Grant (prize money)$1M
- Aug 2020Grant (prize money)$223.4K
- May 2018Conventional Debt$75K
#7
Seed · Nashville, Tennessee · founded 2022$1.7Mraised▾
Developer of small molecule enzyme mimetics for neuroprotection and healthspan extension. It offer drugs which mimic the endogenous enzymes, superoxide dismutase and catalase, that prevent oxidative and inflammatory injury to which neural tissue is sensitive.
- Jan 2025Seed$600K
- Nov 2023Seed$300K
- Feb 2023Seed$775K
#8
Series A · Nashville, Tennessee · founded 2014 · 3 employees$22.9Mraised▾
Developer of therapies for the treatment of inflammatory diseases. The lead therapeutic peptide AMTX-100 is bioengineered from human protein sequences that modulate the immune system by a natural process, reducing pathogenesis in a range of conditions.
- Dec 2023Series A$725K
- May 2022Series A$18M
- Aug 2020Series A$3.6M
- Jul 2016Seed$600K
#9
Seed · Nashville, Tennessee · founded 2018 · 7 employees$500Kraised▾
Developer of medical devices for endoscopic surgery. The company harnesses the power of micro-machined smart materials to create highly dexterous manipulators to improve therapeutic outcomes in complex flexible endoscopic procedures.
- Feb 2025Grant (prize money)$1.4M
- Sep 2024Seed$500K
#10
Series B · Nashville, Tennessee · founded 2017 · 1 employees$39.5Mraised▾
Developer of small molecules for the treatment of neurological disorders. The company is developing small molecules, which are positive allosteric modulators of metabotropic glutamate receptor 4. The company's products inlcude AP-472 and AP-612 for Parkinson's, Pain, and Depression.
#11
Series A · Nashville, Tennessee · founded 2018 · 21 employees$14.5Mraised▾
Provider of personalized nutrition supplements. The company offers personalized daily vitamins and nutrition reports based on DNA, blood levels, and lifestyle data. It aslo enables to track health progress.
- Sep 2022Series A$10M
- Apr 2021Seed$4.1M
- Apr 2018Seed$120K
#12
Series A · Nashville, Tennessee · founded 2013 · 9 employees$4.3Mraised▾
Provider of RNA-based diagnostics for autoimmune disorders. Its proprietary algorithm IQIsolate compares a patient's RNA expression profile with that of a database of healthy people in order to arrive at a diagnosis. The company is currently developing a diagnostic panel for multiple sclerosis and gastroenterological diseases like irritable bowel syndrome and inflammatory bowel disease.
- Sep 2022Grant (prize money)$248.3K
- Sep 2019Grant (prize money)$1.1M
- May 2017Series A$2.4M
- Jan 2017Grant (prize money)$1.1M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Biotechnology is moving in the United States
A read on the academic research around Biotechnology — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 6,260 United States-affiliated papers.
- Harvard University209
- Cornell University177
- University of Tennessee at Chattanooga140
- Howard Hughes Medical Institute126
- Johns Hopkins University121
- Gene33→164
- Transcription (linguistics)11→79
- Antibody11→62
- Genome6→56
- Mutation7→56
- Gene8→110
- Cell culture3→62
- Gene expression3→62
- Fermentation2→54
- Downregulation and upregulation1→50
- Agriculture19→58
- Antibiotic resistance15→45
- Public health4→31
- Gene6→30
- Production (economics)5→29
Where biotechnology is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing biotechnology patents in the United States
United States biotechnology patent filing is accelerating — 457,918 filings from 8,000 assignees (2016–2025), led by Genentech, UNIV California, Regeneron Pharma; annual filings 36884→44446.
- Genentech18078
- UNIV California17948
- Regeneron Pharma16082
- Amgen10495
- Monsanto Technology9742
- UNIV Pennsylvania8521
- Harvard College7460
- UNIV Texas7378
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.