Best Life Sciences Companies in Saint Paul, United States
The 56 best Life Sciences companies in Saint Paul, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Cardiovascular Systems.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in Saint Paul
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cardiovascular Systems Developer of devices for treating peripheral and coronary vascular disease | $121M | 160 mo ago | 780 | — | — | — | 4,124 patents Intravascular stents, catheters, and thrombectomy devices for cardiovascular interventions | — |
| 2 | EnteroMedics Satiety induction through vagal nerve block | $62M | 105 mo ago | 63 | — | — | — | 146 patents Implantable neuromodulation systems for metabolic and cardiovascular regulation | — |
| 3 | Aria CV Device for pulmonary hypertension | $44M | 11 mo ago | 17 | Dan Gladney Chief Executive Officer | — | — | 59 patents Implantable cardiovascular pressure-regulating devices for pulmonary hypertension treatment | — |
| 4 | AbiliTech Medical Developer of assistive devices for upper-limb neuromuscular conditions | $20M | 57 mo ago | 10 | — | — | — | — | — |
| 5 | Minnetronix Medical Manufacturer of multiple devices for neurocritical patients | $20M | 68 mo ago | 263 | Rich Nazarian Retired Founder and CEO Minnetronix Medical | — | — | — | — |
| 6 | Esteem Hearing Developer of implanted hearing devices | $19M | 194 mo ago | 22 | — | — | — | — | 1 launch |
| 7 | Cardio Flow Developer of orbital atherectomy platform for treating calcified and fibrotic plaque | $16M | 25 mo ago | 2 | Michael Kallok President and CEO | WordPressMySQLPHP+16 | Top 10M | 170 patents Coronary rotational atherectomy and intravascular lithotripsy devices for plaque removal | — |
| 8 | CNS Therapeutics Intrathecal Baclofen in pre-filled syringes and vials | $13M | 162 mo ago | — | Richard Penn Co-Founder & CSO | — | — | — | — |
| 9 | Apogen Biotech Developing therapies targeting cancer drug resistance and tumor evolution | $11M | 94 mo ago | 5 | — | — | — | — | — |
| 10 | MarPam Pharma Provider of chimeric antigen receptor (CAR) based therapeutics solution for treating HIV | $9M | 14 mo ago | 5 | — | — | — | — | — |
| 11 | Wilson Wolf Innovating cell and gene therapy manufacturing with G-Rex technology | $9M | 177 mo ago | 27 | John Wilson CEO | WordPressMySQLPHP+15 | Top 10M | 235 patents Closed, gas‑permeable bioreactor systems for large‑scale T‑cell/immune cell manufacturing | — |
| 12 | Shape Medical Systems Innovative cardiopulmonary exercise testing solutions for streamlined diagnosis and therapy optimization | $8M | 46 mo ago | 6 | Andrew Hofmeister CEO | Board Leadership | — | — | — | — |
| 13 | Phenomix Sciences Provider of test for personalized management of obesity | $8M | 6 mo ago | 9 | Michael Camilleri Co-Founder | Concrete CMSPHPUbuntu+17 | Top 50M | — | — |
| 14 | GRIP Developer of medical diagnostic technology designed for rapid, accurate pathogen detection | $6M | 37 mo ago | 9 | Bruce Batten Founder & CEO | — | — | 333 patents Hand tools for fastener removal, grip enhancement, and socket adapter technologies. | — |
| 15 | Vios Medical Remote patient monitoring system for healthcare providers | $6M | 135 mo ago | 35 | — | WordPressMySQLPHP+36 | Top 10M | — | — |
| 16 | Syntiron Early-stage biotech R&D company focused on human vaccines based on iron-regulated bacterial proteins | $4M | 133 mo ago | — | Richard Shaw CEO | — | — | 5 patents Heterocyclic compound-based immunogenic compositions for bacterial infection protection | — |
| 17 | Agitated Solutions Developer of treatment for hypoxemic respiratory failure | $3M | 11 mo ago | — | Morgan Clyburn Co-Founder & CEO | — | — | 30 patents Microbubble contrast agents and ultrasound‑guided imaging/therapy devices for cardiac and musculoskeletal diagnostics. | — |
| 18 | VivaQuant Provides ECG data analysis solutions for preclinical studies | $1M | 168 mo ago | 4 | Marina Brockway Founder & CTO | — | — | 54 patents Wearable physiological monitoring devices and signal‑processing algorithms for ECG and respiration | — |
| 19 | The Restful Jaw Innovating dental solutions for stability, support, and safety during procedures | $1M | 79 mo ago | — | Eric Schiffman Co-Founder | — | — | 9 patents Oral jaw support devices for sleep apnea and orthodontic therapy | — |
| 20 | Stratix Labs Developer of products for research, development, and quality control applications in microbiology workflows | $1M | 51 mo ago | 7 | Joshua Erickson Founder | — | — | 16 patents Biological delivery systems and UV disinfection efficacy testing for pathogens | — |
| 21 | Impleo Medical Developer of minimally invasive therapy for GERD | $975K | 71 mo ago | 1 | Juliana Elstad CEO & President | — | — | — | — |
| 22 | EPIEN Medical Developer of cleansing devices to treat infected tissue surfaces and remove biofilm | $900K | 58 mo ago | 14 | Roger Barrett Founder & VP Operations | WordPressMySQLPHP+16 | Top 50M | — | — |
| 23 | Zurich Medical Cardiovascular device innovator focused on cost-effectiveness and ease of use | $881K | 51 mo ago | 18 | Paul Gam Chairman and CEO | Apple iCloud MailMicrosoft 365HSTS+2 | Top 50M | — | — |
| 24 | BioMedix Diagnostic solutions for value-based care, population health, and vascular assessment | $682K | 163 mo ago | 15 | — | WordPressMySQLPHP+29 | Top 5M | 23 patents Patents concentrated in health & consumer products | — |
| 25 | RespirTech Airway clearance devices and support for respiratory conditions | $500K | 172 mo ago | 137 137 → 187 (+36%) | Dylan Bourns Co-Founder | Adobe Experience ManagerJavaRaphael+15 | Top 10M | 8 patents Advanced chest compression and respiratory therapy devices with integrated physiological monitoring. | 1 job opening |
| 26 | Quench Medical Provider of therapeutics and drug delivery technology for treating respiratory diseases | $300K | 17 mo ago | 2 | — | — | — | — | — |
| 27 | FemtoFluidics Developer of microfluidics technology for drug discovery | $275K | 18 mo ago | — | Zachary Xiong Co-Founder | — | — | 2 patents Digital microfluidic platforms for high-throughput chemical library synthesis | — |
| 28 | Nirva Medical Developer of a device to treat heart attack | $260K | 134 mo ago | — | Pramote Hochareon Founder | — | — | — | — |
Top 12 Life Sciences companies in Saint Paul
#1
Series B · Saint Paul, Minnesota · founded 2010 · 17 employees$43.6Mraised▾
Aria CV is developing a medical device designed to improve the lives of patients living with the disease of pulmonary hypertension. Founded in 2010 by Drs. John Scandurra and Karl Vollmers, former Fellows at the University of Minnesota’s Medical Devices Center. Aria CV has an exclusive license to certain patents from the University of Minnesota. Aria CV’s device reduces the workload on the right side of the heart.
- Aug 2025Series B$1.4M
- Sep 2024Series B$2.2M
- Feb 2020Series B$31M
- Jan 2020Series A$666.6K
#2
Series A · Saint Paul, Minnesota · founded 2017 · 9 employees$7.6Mraised▾
Provider of test for personalized management of obesity. The company has developed a blood test that helps in weight loss management. It has used technology for using precision medicine for obesity treatment. The test assists with the diagnosis, medication, procedure selection, and more.
- Dec 2025Series A$2.5M
- Feb 2025Grant (prize money)$2M
- May 2024Grant (prize money)$2.3M
- Apr 2024Series A$5.5M
#3
Funding Raised · Saint Paul, Minnesota · founded 2019 · 5 employees$9.2Mraised▾
Developer of biologic therapies designed to offer a one-time treatment for the durable remission of HIV. The company's therapies enhance a patient's own immune system to be able to kill HIV in places where it hides, enabling patients to overcome treatment with other medications including antiretrovirals.
- Apr 2025Grant (prize money)$306.5K
- Feb 2025Grant (prize money)$2.3M
- Feb 2025Grant (prize money)$2.1M
- Mar 2024Grant (prize money)$302.2K
#4
Series A · Saint Paul, Minnesota · founded 2020$2.7Mraised▾
Developer of treatment for hypoxemic respiratory failure. It provides microbubble treatments that provide saline as contrast taht is used during ultrasound procedures for diagnostics and therapies.
- Jul 2025Series A$6.5M
- Sep 2022Grant (prize money)$282K
- Mar 2022Seed$2.7M
#5
Series A · Saint Paul, Minnesota · founded 2014 · 2 employees$15.7Mraised▾
Developer of orbital atherectomy platform for treating calcified and fibrotic plaques. It offers FreedomFlow a modern atherectomy platform that provides physicians a way to treat complex PAD in a wide range of vessel diameters and has application in Atherectomy, Coronary Artery Disease, Peripheral Artery Disease, and Carotid Artery Disease.
- Jun 2024Series A$400K
- May 2023Series A$2M
- Aug 2021Series A$200K
- Apr 2021Series A$2.7M
#6
Funding Raised · Saint Paul, Minnesota · founded 2017 · 2 employees$299.8Kraised▾
Provider of therapeutics and drug delivery technology for treating respiratory diseases. The company offers novel aerosol platform technology to deliver medicine and inhaled chemotherapy medication into deep areas of the lung for treating pulmonary airway diseases like COPD, asthma, and cystic fibrosis.
- Feb 2025Grant (prize money)$299.8K
#7
Acquired · Saint Paul, Minnesota · founded 1989 · 780 employees$121.3Mraised▾
Developer of devices for treating peripheral and coronary vascular disease. The products include Orbital Atherectomy Systems treat calcified and fibrotic plaque in arterial vessels throughout the leg and heart.
- Mar 2013Post IPO$13.5M
- May 2011Post IPO$40.1K
- Dec 2010Post IPO$3.5M
- Jan 2008Post IPO$11.2M
#8
Funding Raised · Saint Paul, Minnesota · founded 2022$274.9Kraised▾
Developer of microfluidics technology for drug discovery. It offer AI-based platform to replace traditional liquid-handling robotics with electronic technology. that can synthesize and manipulate small volumes of liquid for the development of new drugs and therapies.
- Jan 2025Grant (prize money)$274.9K
#9
Public · Saint Paul, Minnesota · founded 2002 · 63 employees$62.1Mraised▾
EnteroMedics has developed VBLOC vagal blocking therapy, a patented therapeutic approach designed to treat a range of gastrointestinal and metabolic diseases. vBloc Therapy is delivered by a pacemaker-like device called the Maestro Rechargeable System that decreases feelings of hunger and fullness by limiting the expansion of the stomach and by reducing the frequency and intensity of stomach contractions. This is achieved by intermittently blocking the primary nerve which carries signals between the brain and stomach to regulate digestive processes. Bloc® Therapy involves a minimally invasive laparoscopic procedure that preserves normal digestive system anatomy.
- Oct 2017Post IPO$61M
- Aug 2017Post IPO$18.1M
- Dec 2016Post IPO$18.8M
- May 2016Post IPO$6M
#10
Series A · Saint Paul, Minnesota · founded 2019 · 9 employees$5.9Mraised▾
Developer of medical diagnostic technology designed for rapid, accurate pathogen detection. The technology enhances existing diagnostic tools, improving sensitivity and specificity for lab-quality results. It offers an easy-to-use format adaptable to various sample types. The process leverages existing infrastructure, reducing development time and expense. It aims to provide actionable medical information for multiple diseases.
- May 2023Series A$5.4M
- Nov 2020Series A$100K
- Jul 2020Series A$350K
- Dec 2019Series A$8.8M
#11
Deadpooled · Saint Paul, Minnesota · founded 2016 · 10 employees$20.1Mraised▾
Developer of assistive devices for upper-limb neuromuscular conditions. The company's flagship product, AbiliTech Assist is an in-home device that provides assistance and support to the elbow and shoulder. The device has applications for Amyotrophic lateral sclerosis (ALS), Multiple sclerosis (MS), spinal cord injuries, and other muscular disorders.
- Oct 2021Series A$2.9M
- Nov 2020Series A$9M
- Dec 2019Series A$7.4M
- May 2018Seed$842.5K
#12
Acquired · Saint Paul, Minnesota · founded 1996 · 263 employees$20Mraised▾
Manufacturer of multiple devices for neurocritical patients. The products provided are spinal cord stimulation devices for chronic pain, urinary incontinence, muscle stimulation, peripheral nerve, intracranial stimulation, and others. It also provides endoscopic imaging systems and test equipment. The company is developing a portfolio of solutions designed to prevent secondary injury and enhance healing for patients. It also developed optical systems that create algorithms for image processing and display to optimize sensor performance and visualization. It provides thermal simulation and modeling techniques that help in electroporation and trans-cellular pharmaceutical delivery. The platform offers neurapheresis therapies for the treatment and return of cerebrospinal fluid.
- Oct 2020Grant (prize money)—
- Aug 2019Grant (prize money)$2.5M
- Sep 2016Grant (prize money)$1.6M
- Sep 2016Grant (prize money)$1.9M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Biotechnology is moving in the United States
A read on the academic research around Biotechnology — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 6,260 United States-affiliated papers.
- Harvard University209
- Cornell University177
- University of Tennessee at Chattanooga140
- Howard Hughes Medical Institute126
- Johns Hopkins University121
- Gene33→164
- Transcription (linguistics)11→79
- Antibody11→62
- Genome6→56
- Mutation7→56
- Gene8→110
- Cell culture3→62
- Gene expression3→62
- Fermentation2→54
- Downregulation and upregulation1→50
- Agriculture19→58
- Antibiotic resistance15→45
- Public health4→31
- Gene6→30
- Production (economics)5→29
Where biotechnology is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing biotechnology patents in the United States
United States biotechnology patent filing is accelerating — 457,918 filings from 8,000 assignees (2016–2025), led by Genentech, UNIV California, Regeneron Pharma; annual filings 36884→44446.
- Genentech18103
- UNIV California17969
- Regeneron Pharma16083
- Amgen10510
- Monsanto Technology9754
- UNIV Pennsylvania8526
- Harvard College7463
- UNIV Texas7382
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.