Best Life Sciences Companies in San Jose, United States
The 110 best Life Sciences companies in San Jose, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Outset Medical.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in San Jose
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Outset Medical Provider of hemodialysis machine with touchscreen display | $458M | 17 mo ago | 372 372 → 567 (+52%) · sector median +46% | 2003 | Leslie Trigg Chief Executive Officer | — | 1 partnership |
| 2 | Rani Therapeutics Developer of technology for the oral delivery of large drug molecules 72Growth top 22%Funding top 23%Patents top 24%Talent top 27% All 11 signals ▾Growthtop 22% Fundingtop 23% Patentstop 24% Talenttop 27% Innovationtop 28% Newstop 30% Moattop 35% Techtop 45% Marketbottom 49% Fin. healthbottom 44% Globalbottom 42% Growth: Revenue +59% YoY · Fresh capital in last 24 mo Funding: Raised $234M across 6 rounds · 6 rounds over 13 yrs (0.5/yr) rank vs industry peers · Fliar Intelligence Index 72/100 | $234M | 7 mo ago | 163 | 2012 | Mir Imran Founder | 456 patents Oral ingestible devices for delivering biologic therapeutics to the gastrointestinal tract | 1 launch |
| 3 | MetricStream Developer of software for governance risk and compliance management processes | $213M | 104 mo ago | 1,255 1,255 → 1,216 (-3%) · sector median +46% | 1999 | Gaurav Kapoor Co-Founder | 14 patents Enterprise governance platforms for hierarchical data traversal, visualization, and access control | 1 award |
| 4 | BrightInsight Provider of digital health solutions for clinical trials 57Funding top 18%Moat top 31%Growth top 35%Market top 50% All 8 signals ▾Fundingtop 18% Moattop 31% Growthtop 35% Markettop 50% Techbottom 49% Talentbottom 49% Newsbottom 43% Globalbottom 37% Funding: Raised $166M across 4 rounds · 4 rounds over 7 yrs (0.6/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 57/100 | $166M | 5 mo ago | 165 165 → 145 (-12%) · sector median +46% | 2017 | Frederik Smits Co-founder & Managing Director | — | — |
| 5 | Intrapace Laparoscopically inserted pacemaker to stimulate Stomach | $143M | 153 mo ago | 1 | 2001 | Mir Imran Founder | 154 patents Implantable gastric devices and sensor feedback systems for obesity treatment | — |
| 6 | Restoration Robotics Robot based hair transplant solution | $140M | 79 mo ago | 22 | 2002 | — | 430 patents Automated hair transplantation and hair loss treatment devices and planning systems | — |
| 7 | DFine Spine solutions: vertebral compression fracture, tumor ablation, and bone biopsy | $126M | 149 mo ago | 1,903 | 2004 | — | 305 patents Percutaneous tumor ablation devices with parameter-modulated energy delivery | — |
| 8 | Complete Genomics Developer of DNA sequencing platform for human genome sequencing and analysis | $125M | 190 mo ago | 114 114 → 240 (+111%) · sector median +46% | 2006 | Radoje Drmanac Co-Founder & CSO | 467 patents Patents concentrated in chemistry & materials | — |
| 9 | Si-Bone Titanium implant fixation system | $103M | 120 mo ago | 344 344 → 560 (+63%) · sector median +46% | 2008 | Laura Francis Chief Executive Officer | 294 patents Patents concentrated in health & consumer products | 1 launch |
| 10 | ProteinSimple Provider tools to help researchers with protein analysis | $94M | 181 mo ago | 157 157 → 183 (+17%) · sector median +46% | 2004 | — | 144 patents Microfluidic capillary electrophoresis devices for high‑throughput analyte separation and detection | — |
| 11 | C8 MediSensors Continuous glucose monitoring products | $70M | 168 mo ago | 25 | 2003 | — | 64 patents Advanced reflective optical spectroscopy and high‑NA imaging for biomedical analysis. | — |
| 12 | Ariosa Diagnostics Domain management, brand protection, and cyber security solutions provider | $68M | 174 mo ago | 246 | 2008 | — | 163 patents Non‑invasive prenatal genetic testing using cell‑free fetal DNA analysis | — |
| 13 | Vascular Architects Developer of devices for the treatment of peripheral vascular disease and nonvascular obstructions | $55M | 261 mo ago | — | 1999 | — | 17 patents Peripheral vascular stents and drug‑eluting delivery systems for arterial interventions | — |
| 14 | Baxano Parenting advice, family stories, and tips for stronger family bonds | $51M | 150 mo ago | 40 | 2005 | Tony Recupero ex-CEO | 113 patents Minimally invasive surgical instruments for tissue removal and modification, especially spinal procedures | — |
| 15 | Broncus Developer of solutions for diagnosing and treating lung disease | $44M | 64 mo ago | 36 36 → 63 (+75%) · sector median +46% | 1998 | Hong Xu CEO | 2 patents Advanced medical imaging and therapy planning for radiation oncology and lung surgery | 1 partnership |
| 16 | Aridis Pharma Provider of human monoclonal antibodies against infectious diseases | $42M | 42 mo ago | 34 | 2005 | Vu Truong Founder & CEO | — | — |
| 17 | Reviva Pharmaceuticals Develops therapeutic drugs for treatment of central nervous system | $41M | 109 mo ago | 4 | 2006 | Laxminarayan Bhat President and CEO | 161 patents Liposomal drug delivery of Brilaroxazine for psoriasis and arylpiperazine therapies for pulmonary fibrosis | — |
| 18 | NeoGuide Systems Robotic endoscopic technology | $39M | 236 mo ago | — | 2000 | Amir Belson Founder and Chief Technology Officer | — | — |
| 19 | Accellix Developer of immunotherapy-based assay delivery platform | $36M | 54 mo ago | 71 | 2007 | — | — | — |
| 20 | Venclose Radiofrequency ablation system for treating venous reflux disease | $27M | 78 mo ago | 43 | 2014 | Brady Esch Founder & CEO | 29 patents Minimally invasive venous ablation and catheter-based therapies for varicose veins. | — |
| 21 | Vantis Vascular Provider of a medical device for vascular interventions | $24M | 16 mo ago | — | 2022 | Jason Turner CEO | 49 patents Patents concentrated in health & consumer products | — |
| 22 | Aveta System Manufacturer of hysteroscopy for operating rooms | $23M | 72 mo ago | 57 57 → 127 (+123%) · sector median +46% | 2016 | Csaba Truckai CEO | — | — |
| 23 | Chronix Biomedical Developer of non-invasive diagnostics for cancer | $22M | 81 mo ago | 2 | 1997 | — | 106 patents Patents concentrated in chemistry & materials | — |
| 24 | HemoSense Rapid Point-of-Care Coagulation analyzer | $18M | 234 mo ago | — | 1997 | Arvind Jina Founder | 8 patents Viscosity-based blood coagulation/lysis monitoring and particle fraction analysis | — |
| 25 | Cellworks Developer of a biosimulation platform | $17M | 161 mo ago | 140 | 2005 | — | 26 patents Combination therapies targeting metabolic and signaling pathways for cancer treatment | — |
| 26 | MAUI Imaging Developer of smart solutions to capture bone, soft tissue data | $15M | 12 mo ago | 14 | 2006 | David Specht Co-Founder & CEO | 227 patents Advanced multi‑aperture and sparse‑array ultrasound imaging for enhanced tissue characterization | — |
| 27 | Pulsar Vascular Offers an endovascular platform to address the needs of bifurcation aneurysms. | $13M | 129 mo ago | 21 | 2005 | — | 122 patents Endovascular devices for aneurysm sealing, vascular closure, and physiological opening occlusion | — |
| 28 | Corventis Medical technology company providing healthcare solutions and support | $10M | 198 mo ago | 67 | 2007 | — | 129 patents Bioimpedance-based patient monitoring and wearable physiological sensor devices | — |
| 29 | Arc Bio Genomics service provider | $7M | 51 mo ago | 20 | 2014 | — | — | — |
| 30 | Cessation Therapeutics Developer of immunotherapy based vaccines to manage addictions | $7M | 26 mo ago | 8 | 2017 | John Harkey Co-CEO | — | — |
| 31 | Corinth MedTech Provider of resectoscope for surgical procedure and fluid management solution | $5M | 65 mo ago | 12 | 2014 | — | 33 patents Innovative surgical instruments for minimally invasive procedures and related device methods. | — |
| 32 | Previvo Genetics Developer of preimplantation genetic diagnostics and screening device | $3M | 117 mo ago | — | 2012 | John Buster Founder | 47 patents Reproductive medicine devices for uterine lavage and in‑vivo embryo recovery/processing | — |
| 33 | SEA Medical Systems Fluid monitoring for intravenous infusion management | $3M | 173 mo ago | — | 2008 | Michael J. Weickert Founder | — | — |
| 34 | BioNex Solutions Developer of laboratory automation robot for bio-pharmaceuticals and biotech | $3M | 101 mo ago | 38 38 → 44 (+16%) · sector median +46% | 2009 | Tony Lima President and CEO | 11 patents Patents concentrated in computing, sensing & instrumentation | — |
| 35 | Microsonic Systems Provider of ultrasonic sample processing | $2M | 189 mo ago | 11 | 2004 | — | — | — |
| 36 | SeaChange Provider of computer -aided drug discovery platform | $2M | 161 mo ago | — | 2009 | Michael Keiser Founder & Chairman | 51 patents Biodiesel‑glycerol fuel emulsions and advanced liquid purification technologies. | — |
| 37 | MIODx Developer of diagnostic products based on genomics and immune sequencing | $2M | 121 mo ago | 6 | 2014 | — | 7 patents Non‑invasive multivariate molecular diagnostics for disease detection | — |
| 38 | Microsonic Systems Developer of an automated sample preparation platform using microsonic technology | $1M | 189 mo ago | — | 2006 | Vibhu Vivek Co-Founder & CTO | — | — |
| 39 | Business Catalyst Develops in-vivo animal model for R&D applications | $1M | 203 mo ago | 9,771 | 2004 | — | — | — |
| 40 | StelaGenomics Developer of dual fertilization and feed control system | $1M | 146 mo ago | — | 2011 | Simon Goldbard CEO | — | — |
| 41 | Shield Bio Provides technology for developing precision drugs for treating infectious diseases | $920K | 97 mo ago | 28 | 2016 | Fred Turner Co-Founder & CEO | — | — |
| 42 | Molecular Vista Manufacturer of nanoscale IR microscopes and spectroscopy tools for analysis | $660K | 73 mo ago | 10 10 → 14 (+40%) · sector median +46% | 2011 | Kumar Wickramasinghe Co-Founder | 45 patents Advanced scanning probe microscopy instrumentation and cantilever actuation/detection technologies | — |
| 43 | Semler Scientific Developer of point-of-care devices for screening peripheral arterial disease | $499K | 135 mo ago | 126 | 2007 | — | — | — |
| 44 | Simulated Surgical Systems Developer of robotic surgery simulator | $450K | 182 mo ago | 2 | 2009 | — | — | — |
| 45 | LiquiLume Diagnostics Optofluidic based immunodiagnostic platform | $422K | 168 mo ago | — | 2010 | Philip Measor Co-Founder & CEO | — | — |
| 46 | Single Cell Technology Pioneering antibody discovery platform delivering actionable leads through comprehensive data capture | $324K | 64 mo ago | 9 | 2008 | Chun-Nan Chen CEO & CSO | 32 patents Monoclonal antibody therapeutics targeting viral antigens and immune‑checkpoint proteins | — |
| 47 | AkibaH Innovative smartphone case glucose meter for convenient diabetes care | $288K | 111 mo ago | 1 | 2013 | — | — | — |
| 48 | Reveal Biosensors Developer of tissue oxymeter | $225K | 103 mo ago | 2 | 2016 | Guy Hatch Co-Founder & CTO | 22 patents Non‑invasive physiological monitoring and bio‑signal management for respiratory and metabolic metrics | — |
| 49 | zPREDICTA Provider of tumor-specific in vitro 3D models for drug development | $220K | 120 mo ago | 3 | 2014 | — | 14 patents Isolation of invasive/metastatic cancer cells and immuno‑oncology therapeutic screening | — |
Top 12 Life Sciences companies in San Jose
#1
Series C · San Jose, California · founded 2017 · 165 employees$166.1Mraised▾
BrightInsight provides digital health solutions for clinical trials. Their platform enables improving patient engagement and adherence, continuous remote patient monitoring, and dose management algorithms (cloud-based algorithm). It analyzes data from connected medical devices, combination products, apps, and software. The company's Quality Management System is ISO 13485: 2016 certified.
- Jan 2026Series C$13M
- Mar 2021Series C$101M
- Jun 2020Series B$40.1M
- Sep 2019Series A$25M
#2
Public · San Jose, California · founded 2012 · 163 employees$234.1Mraised▾
Developer of technology for the oral delivery of large drug molecules. The company has a proprietary platform is capable of delivering a wide range of biologics for the treatment of various chronic diseases. The company develops RaniPill capsule has broad applications for the treatment of acromegaly, rheumatoid arthritis, psoriatic arthritis, growth hormone deficiency, osteoporosis, Crohn’s disease, hemophilia, diabetes, among other diseases.
- Oct 2025Post IPO$60.3M
- Dec 2020Series E$69M
- Nov 2020Series E$50M
- Feb 2018Series E$53M
#3
Public · San Jose, California · founded 2003 · 372 employees$457.9Mraised▾
Provider of hemodialysis machine with touchscreen display. The company's product "Tablo" is a hemodialysis machine with a touchscreen display, which offers step-by-step pictures and conversational instructions.
- Jan 2025Post IPO$3.9M
- Feb 2020Series E$125M
- Aug 2018Series D$132M
- Jun 2017Series C$4.3M
#4
Series D · San Jose, California · founded 2006 · 14 employees$15.2Mraised▾
Developer of smart solutions to capture bone, soft tissue data. It offers flagship product the K3900 imaging system for emergency medicine, trauma care, neurosurgery, and other applications. The technology uses patented methods and hardware described as Computed Echo Tomography combining principles of ultrasound and computational imaging.
- May 2025Series D$14.7M
- Mar 2021Series B$1.5M
- Aug 2020Grant (prize money)$254.9K
- Sep 2016Series B$7M
#5
Series B · San Jose, California · founded 2022$24Mraised▾
Provider of a medical device for vascular interventions. It focuses on developing performance driven technology for vascular interventions. It allows the inner microcatheter and outer delivery catheter to one unit when locked, providing pushability to traverse through the most calcific and tortuous anatomies.
- Jan 2025Grant (prize money)$3.8M
- Jan 2025Grant (prize money)$3.8M
- Sep 2024Series B$14.3M
- May 2024Series A$5M
#6
Public · San Jose, California · founded 2005 · 34 employees$42.1Mraised▾
Provider of human monoclonal antibodies against infectious diseases. The company's lead human antibodies candidates are against hospital-acquired pneumonia, ventilator-associated pneumonia, and cystic fibrosis. The company’s products target infectious diseases, including nosocomial infections, cystic fibrosis, and severe wound infections. In addition, it offers mAb discovery technology platform that enables the recovery of rare, naturally occurring protective antibodies generated by the human immune system.
- Dec 2022Post IPO$4.8M
- Oct 2020Post IPO$8.5M
- Jan 2017Grant (prize money)—
- Dec 2016Series B$13.6M
#7
Series A · San Jose, California · founded 2017 · 8 employees$6.8Mraised▾
Developer of immunotherapy based vaccines to manage addictions. It offer drug conjugate vaccine molecules to overcome addictions such as overcome the opioid, heroin, morphine, fentanyl, alcohol and nicotine addiction use disorders. It contains drug-like “hapten” linked to an immunogenic protein and formulated with immune-stimulating substances directing the immune system to produce antibodies and induce immunity to drugs of abuse.
- Mar 2024Series A$1M
- Oct 2023Grant (prize money)—
- May 2022Series A$5.8M
- Jun 2019Grant (prize money)$210.6K
#8
Series D · San Jose, California · founded 1999 · 1255 employees$213.4Mraised▾
Developer of software for governance risk and compliance management processes. This platform provides tools for enterprise risk management, operational risk, and regulatory compliance. It includes features for internal audit, policy management, and third-party risk assessment. The software assists organizations in identifying, monitoring, and mitigating risks across various business functions. It also supports cybersecurity compliance, business continuity planning, and incident management through automated workflows and data analytics.
- Oct 2017Series D$25M
- Mar 2017Series D$65.4M
- Aug 2014Series C$60M
- Apr 2013Series B$48.5M
#9
Public · San Jose, California · founded 2002 · 22 employees$139.9Mraised▾
Restoration Robotics commercializes their image-guided robotic system (ARTAS) that enables follicular (hair) unit extraction. The physician-assisted ARTAS system uses image guidance and intelligent algorithms to optimize follicular unit harvesting resulting in precise and consistent results. Has been cleared for use in forty-six countries, with additional clearances pending.
- Nov 2019Post IPO$50.5M
- May 2018Conventional Debt$20M
- Aug 2016Series D$23.9M
- May 2015Series D$4.8M
#10
Deadpooled · San Jose, California · founded 2001 · 1 employees$143.3Mraised▾
IntraPace has developed an implantable system to treat obesity. It is built on the technology used in cardiac pacemakers and defibrillators. Product abiliti is designed to be implanted via standard laparoscopic instruments without making any changes to the anatomy of the digestive system or placing any limitations on what a person can eat or drink. The implanted system consists of a stimulator – a small, battery-powered device similar to a cardiac pacemaker placed on the lesser curvature of the stomach near the pes anserinus, and a lead containing a stimulation electrode and food sensor placed across the wall of the stomach. Based on the technology in cardiac pacemakers, the abiliti system provides stimulation to the stomach when food or drink is detected. The stimulation enhances the sense of fullness that a patient feels when they eat or drink, helping them to reduce the volume of food ingested.
- Aug 2013Series D$3.3M
- Mar 2013Conventional Debt$624K
- Aug 2012Series D$6.2M
- Apr 2012Series D$2.2M
#11
Acquired · San Jose, California · founded 2007 · 71 employees$35.8Mraised▾
Accellix is involved in developing immunotherapy-based assay delivery platforms. It consists of dry reagents and a microfluidic cartridge. It offers bead assays, cell assays, and enzymatic PCR. The company also offers services like diluent processing, laser/optics, and photon capture, electronics, and more.
- Dec 2021Series D$10M
- Jul 2020Series D$5M
- Jun 2020Series D$9.5M
- Jun 2014Series A$7M
#12
Acqui-Hired · San Jose, California · founded 2004 · 1903 employees$125.9Mraised▾
Spine solutions: vertebral compression fracture, tumor ablation, and bone biopsy. This company provides innovative medical devices and procedural solutions for treating vertebral pathologies. Their offerings include spinal augmentation systems, advanced energy ablation technologies, and bone biopsy tools. They focus on minimally invasive procedures designed to reduce pain and improve patient quality of life. They offer physician education, training courses, and resources to support healthcare professionals. Their products are used in hospitals and medical facilities. They are committed to corporate sustainability and ethical practices.
- Dec 2013Series E$17.5M
- Oct 2011Series D$15M
- Jul 2010Series D$36.2M
- Mar 2010Series C$5.8M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.