Best Nanotechnology Companies in Pennsylvania, United States
The 39 best Nanotechnology companies in Pennsylvania, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Iroko.
Our analysis of 50 Nanotechnology companies
$6.5b in tracked funding; 78% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Nanotechnology companies in Pennsylvania
| # | Company | Disclosed funding | Last round | Employees | Founder | Stage | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Iroko European real estate investment expert, offering accessible and responsible savings solutions | $215M | 121 mo ago | 4 | — | Funding Raised | WebflowChart.jsBootstrap+26 | — | — |
| 2 | Plextronics Developer of conductive polymers and inks for electronic printing | $59M | 155 mo ago | 31 | — | Acquired | — | 292 patents Conductive polymers for organic photovoltaics, OLEDs, and solid-state capacitors. | — |
| 3 | Nucleonics Developing RNAi therapeutics for Hepatitis B and C, using eiRNA technology | $52M | 262 mo ago | — | John Maraganore CEO | Acquired | — | 46 patents RNAi-based antiviral therapeutics and gene‑silencing platforms for hepatitis viruses | — |
| 4 | Zynerba Pharma Transdermal synthetic cannabinoid therapy to treat neurological disorders | $13M | 49 mo ago | 27 | — | Acquired | WordPressMySQLPHP+12 | — | — |
| 5 | Arieca Provider of thermally conductive rubber | $10M | 22 mo ago | 4 | Navid Kazem Co-Founder & CEO | Series A | WordPressMySQLPHP+21 | 45 patents Advanced liquid‑metal thermal interface materials for high‑performance electronic packaging | — |
| 6 | Liquid X Manufacturer of functional metallic inks | $10M | 44 mo ago | 9 | — | Series A | — | — | — |
| 7 | Crystalplex Develops alloy gradient quantum dots (QDs) for the Optoelectronics industry | $6M | 86 mo ago | 4 | Matt Bootman CEO & President | Series A | — | 41 patents Quantum dot dispersion, stabilization, and integration into light-emitting modules | — |
| 8 | Avisi Technologies Developer of nano-materials 21News top 34%Talent top 41%Funding top 42%Moat top 47% All 8 signals ▾Newstop 34% Talenttop 41% Fundingtop 42% Moattop 47% Patentsbottom 42% Globalbottom 39% Innovationbottom 35% Marketbottom 30% News: 4 BI events in 12 mo (of 8 tracked, 1 types) · Top themes: Funding Talent: Analyst team rating 4/5 · 1 named leader on record rank vs industry peers · Fliar Intelligence Index 21/100 | $5M | 6 mo ago | 15 | Rui Jiang Co-Founder & CEO | Series A | — | 4 patents Ophthalmic therapeutic devices for tunable drug delivery to treat eye diseases | 1 award |
| 9 | Tiptek Provider of probes for atomic force microscopy (AFM) applications | $4M | 17 mo ago | — | Scott Lockledge Co-Founder & CEO | Funding Raised | — | 16 patents Manufacturing and design of scanning probe and electron microscope probes | — |
| 10 | Fischer Block Developer of power system management and sensor data analytics for smart grid | $4M | 96 mo ago | 3 | — | Series A | — | 26 patents Predictive maintenance and condition monitoring for power generation assets, especially wind turbines. | — |
| 11 | Keystone Nano Drug delivery platforms based on nanotechnology | $2M | 47 mo ago | 8 | — | Deadpooled | — | — | — |
| 12 | Graphene Frontiers Graphene and graphene-based device manufacturer | $2M | 155 mo ago | 9 | — | Funding Raised | — | 9 patents Graphene film transfer processes for substrate handling and integration | — |
| 13 | BioHybrid Solutions Developer of protein-polymer conjugates for drug delivery | $2M | 52 mo ago | 23 | — | Seed | — | 8 patents Patents concentrated in health & consumer products | — |
| 14 | NanoVision Diagnostics Optical biomarkers for cancer diagnostics | $2M | 151 mo ago | — | Mike Lang Co-Founder & CEO | Deadpooled | — | — | — |
| 15 | Minus Nine Technologies Nano & micro-sized particles based coatings | $1M | 199 mo ago | 16 | — | Acquired | — | — | — |
| 16 | Phoenix Innovating nanoLC-MS and microLC-MS solutions for enhanced biomolecule detection | $1M | 90 mo ago | — | Sau Lan Tang Staats President & CEO | Seed | — | 208 patents Neutron imaging systems and high‑power ion‑beam generators for material analysis | — |
| 17 | NanoPack Developer of nanocoatings for packaging | $1M | 213 mo ago | — | Howard Kravitz Co-CEO | Seed | — | 30 patents Patents concentrated in transport & manufacturing processes | — |
| 18 | BioMagnetic Solutions Developer of Ferro-fluid based bio-molecular separation systems | $279K | 127 mo ago | 15 | Ted Liberti Chief Commercial Officer & Co-Founder | Acquired | — | 42 patents Large‑scale immunomagnetic cell separation devices and single‑antibody naive T/B cell depletion | — |
| 19 | QLIDA Diagnostics Portable, Handheld Biomarker detection platform | $250K | 156 mo ago | — | Michael Neidrauer CSO & Founder | Deadpooled | — | — | — |
| 20 | PolyAurum Developer of biodegradable gold nanoparticles (BGNP) for diagnostic and therapeutic indications | $223K | 107 mo ago | 2 | Debra Travers CEO & President | Funding Raised | — | — | — |
| 21 | GTRACK Technologies Online game platform offering max wins, jackpots, and daily bonuses | $150K | 125 mo ago | 3 | Ashwin Amurthur Co-Founder and CTO | Deadpooled | — | — | — |
Top 12 Nanotechnology companies in Pennsylvania
#1
Series A · Philadelphia, Pennsylvania · founded 2017 · 15 employees$5Mraised▾
Developer of nano-materials. It provides users with a platform that develops an ultrathin nanoplate made of alumina, implant material is developed in collaboration with the University of Pennsylvania for treating mid to late-stage glaucoma.
- Feb 2026Series A$10.7M
- Jan 2023Series A$4M
- Jan 2021Seed$1M
- Sep 2020Grant (prize money)$1M
#2
Funding Raised · West Chester, Pennsylvania · founded 2011$4.3Mraised▾
Provider of probes for atomic force microscopy (AFM) applications. It offers hard conductive coating such as a metal diboride film on probes and then the sharpening process to a radius-of-curvature of under 5 nm allows users to obtain AFM images over long periods of use.
- Mar 2025Grant (prize money)$206.5K
- Sep 2024Grant (prize money)$275K
- Jul 2024Grant (prize money)$206.5K
- Apr 2018Grant (prize money)$2.4M
#3
Series A · Pittsburgh, Pennsylvania · founded 2014 · 4 employees$9.8Mraised▾
Provider of thermally conductive rubber
- Nov 2024Conventional Debt$500K
- May 2022Series A$8.2M
- Mar 2021Seed$883.1K
- Feb 2021Grant (prize money)$256K
#4
Funding Raised · Philadelphia, Pennsylvania · founded 2007 · 4 employees$215Mraised▾
European real estate investment expert, offering accessible and responsible savings solutions. The company is an independent asset management firm approved by the AMF, focused on making high-performing and responsible real estate savings solutions accessible. It manages real estate funds with an opportunistic, diversified, and granular investment strategy across Western Europe. The firm aims to provide a satisfying risk/return profile through strategic asset allocation. The company offers various funds, including SCPIs and SCIs, catering to both professional and individual investors. They focus on diversification, granular investments, and identifying opportunities in various sectors of commercial real estate. The company also emphasizes responsible investing, aligning with ISR principles. They provide an online subscription platform for ease of investment.
- Jul 2016Conventional Debt$140M
- Nov 2013Venture Debt$75M
- Oct 2010PE—
#5
Series A · Pittsburgh, Pennsylvania · founded 2010 · 9 employees$9.5Mraised▾
Manufacturer of functional metallic inks. Its technology transforms various metals into ink form which is deposited onto a wide variety of substrates. On applying energy the ink converts to the base metal and exhibits comparable features. Its ink contains actual metal atoms instead of nanoparticles or metal flakes. Its resulting film exhibits high conductivity, thin and precise features, and strong adhesion. Its application is in the aerosol jets in additive manufacturing applications.
- Dec 2022Series A$1.4M
- Oct 2020Series A$1.4M
- Jul 2019Series A$735K
- Apr 2018Series A$1.4M
#6
Acquired · Devon, Pennsylvania · founded 2007 · 27 employees$13Mraised▾
Zynerba Pharmaceuticals (formerly known as AllTranz) is focused on developing synthetic cannabinoid therapeutics for transdermal delivery. Using its proprietary transdermal technologies, it has developed a controlled delivery of therapeutic levels of two cannabinoids cannabidiol (CBD) and Tetrahydrocannabinol (THC). Its lead candidate ZYN002, a CBD gel, is being studied in refractory epilepsy, FXS, and osteoarthritis. It is also developing ZYN001 which uses pro-drug of THC in a transdermal patch to deliver THC and is currently being studied in fibromyalgia and peripheral neuropathic pain.
- Jul 2022Post IPO—
- Oct 2014Series B$13M
- Nov 2009Grant (prize money)$4M
- Sep 2009Grant (prize money)$4M
#7
Acquired · Pittsburgh, Pennsylvania · founded 2002 · 31 employees$59.3Mraised▾
Developer of conductive polymers and inks for electronic printing. Its main product is an organic solar cell and OLED lighting system. Its technology is solution processable ink for printed electronics either conductive, photoactive, or semi-conductive. The inks are unable to provide customized solutions.
- Oct 2013Conventional Debt$572.5K
- Jun 2013Series B$2.5M
- Jul 2012Series B$4M
- Apr 2012Conventional Debt$3M
#8
Acquired · Langhorne, Pennsylvania · founded 2001$51.9Mraised▾
Developing RNAi therapeutics for Hepatitis B and C, using eiRNA technology. The company focuses on addressing unmet clinical needs in treating chronic viral infections. Their eiRNA technology enables novel therapeutic options that interfere with viral function while providing a more favorable toxicity profile. They engineer drug candidates to be effective against all genotypes, resistant to viral escape mutants, and compatible with existing therapies. The company utilizes a multi-targeted approach with short hairpin RNA molecules to mediate the destruction of viral RNA. They also focus on DNA delivery and manufacturing technology, using proprietary formulations of cationic lipids to deliver RNAi molecules to target cells.
- Oct 2004Series B$2.7M
- Jun 2004Series B$8.3M
- Apr 2004Series B$40.9M
#9
Series A · Pittsburgh, Pennsylvania · founded 2003 · 4 employees$6.2Mraised▾
Crystalplex works on nanotechnology for wavelength engineering to develop high performance LED lights and displays. The firm develops nanocrystals for photoluminescent, electroluminescent and photovoltaic applications. The nano-illumination technology is capable of yielding light with precisely controlled color temperature and diffusion.
- Jul 2019Conventional Debt$326.1K
- Jun 2019Series A$50K
- Apr 2018Series A$908K
- Oct 2016Series A$2.1M
#10
Deadpooled · State College, Pennsylvania · founded 2005 · 8 employees$2.1Mraised▾
Keystone Nano provides drug delivery platforms based on nanotechnology solutions. It claims to have developed a biocompatible and composite nanoparticle technology called Nanojacket. It also offers NanoLiposomes which are used to deliver active pharmaceutical ingredients (APIs). Its solutions find application in areas like medical, industrial, and scientific applications. It has partnered with various pharma, agricultural, and chemical companies for small projects like principle testing to multi-year development programs.
- Sep 2022Grant (prize money)$2M
- Sep 2009Grant (prize money)$100K
#11
Seed · Pittsburgh, Pennsylvania · founded 2015 · 23 employees$1.5Mraised▾
Developer of protein-polymer conjugates for drug delivery. The company is commercializing the application of proprietary atom transfer radical polymerization (ATRP) chemistry to grow polymers on the surface of proteins. The company is developing applications of its technology platform in therapeutics, diagnostics, medical devices, sensors and biocatalyst development.
- Apr 2022Seed$1.5M
- Aug 2019Grant (prize money)$742.8K
- Jul 2019Grant (prize money)$199K
- Jan 2018Grant (prize money)$225K
#12
Series A · Royersford, Pennsylvania · founded 2013 · 3 employees$3.8Mraised▾
Developer of power system management and sensor data analytics for smart grid. It offers a solution to simplify the installation, operation, and maintenance of large and distributed sensor networks, fault anticipation and detection, substation monitoring, synchrophasor streaming, power quality, troubleshooting, distributed energy resources monitoring, and cyber threat reduction solutions to improve energy reliability and prevent power outages by application of data analytics and predictive analysis techniques intelligent recording devices and a software analytics System, which analyzes three-phase RMS and high-speed data.
- Aug 2018Series A$3.5M
- Feb 2016Seed$300K
- Jan 2015Seed—
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Nanotechnology coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Nanomaterials in Pennsylvania is moving
A read on the academic research around Nanomaterials in Pennsylvania — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 162 papers.
- Pennsylvania State University92
- University of Pennsylvania42
- California University of Pennsylvania30
- Lincoln University - Pennsylvania4
- Pennsylvania Department of Environmental Protection1
- Nanoparticle4→26
- Catalysis2→11
- Polymer2→7
- Nanorod1→6
- Graphene1→5
- Nanoparticle1→16
- Photocatalysis1→4
- Nanocomposite2→4
- Nanoparticle1→4
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.