Best Artificial Intelligence Companies in Illinois, United States
The 93 best Artificial Intelligence companies in Illinois, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Tempus.
Our analysis of 101 Artificial Intelligence companies
$80.5b in tracked funding; 99% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Artificial Intelligence companies in Illinois
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Tempus 🦄 Developer of genomic testing and artificial intelligence tools for medicine | $1.1B | 44 mo ago | 772 | Eric Lefkofsky Founder & CEO | Cart FunctionalityWordPressApple iCloud Mail+33 | Top 1M | 594 patents AI-powered medical diagnostics: imaging biomarkers, liquid biopsy genomics, and cardiac ECG analysis | — |
| 2 | Uptake 🦄 Cloud-based platform for predictive analytics and asset performance management | $282M | 96 mo ago | 102 102 → 120 (+18%) | Bradley Keywell Co-Founder & Executive Chairman | WordPress Block EditorWordPressApple iCloud Mail+22 | Top 5M | 35 patents Predictive maintenance and performance analytics for industrial assets using AI-driven modeling. | — |
| 3 | FourKites 🦄 Developer of AI and web-based visibility solutions for the supply chain | $243M | 44 mo ago | 24 | Mathew Elenjickal co-Founder & CEO | Cart FunctionalityWordPressSentry+40 | Top 500k | 14 patents Real-time logistics visibility and predictive shipment tracking using geofencing and network data | — |
| 4 | Loop Provider of a logistics data platform offering freight audit and visibility 67AI top 18%Funding top 21%Growth top 35%Patents top 35% All 10 signals ▾AItop 18% Fundingtop 21% Growthtop 35% Patentstop 35% Moattop 38% Innovationtop 41% Techtop 43% Talentbottom 49% Globalbottom 40% Marketbottom 39% AI: Classified as an AI company · Holds AI/ML patents (G06N-family CPC) Funding: Raised $65.0M across 4 rounds · 4 rounds over 5 yrs (0.8/yr) rank vs industry peers · Fliar Intelligence Index 67/100 | $65M | 2 mo ago | 47 | Matt McKinney Co-Founder & CEO | WebflowSentryApple iCloud Mail+27 | Top 5M | 75 patents Blockchain-enabled payment and load‑management systems for electric‑vehicle charging infrastructure | — |
| 5 | Market Logic Provider of AI-powered market and competitive intelligence platform for businesses | $50M | 108 mo ago | 321 321 → 171 (-47%) | Olaf Lenzmann Co-Founder & CTO | WordPressApple iCloud MailMicrosoft 365+32 | Top 5M | — | 2 partnerships |
| 6 | Narrative Science Provider of an AI-based content creation solution | $48M | 110 mo ago | 64 | — | — | — | — | — |
| 7 | Pando Provider of AI-powered solutions for freight management and supply chain | $45M | 37 mo ago | 250 | Abhijeet Manohar Co-Founder & CTO | WordPressHubSpot CMS HubApple iCloud Mail+36 | Top 5M | 2 patents Patents concentrated in health & consumer products | — |
| 8 | Gideon Developer of autonomous mobile robots for material handling in various industries | $39M | 26 mo ago | 127 | Edin Koco Co-Founder | WordPressMySQLPHP+23 | Top 10M | — | 1 job opening |
| 9 | K1x Provider of AI-powered automation software for K-1, K-3, and 990 tax reporting 55Funding top 26%AI top 30%Growth top 35%Moat top 37% All 12 signals ▾Fundingtop 26% AItop 30% Growthtop 35% Moattop 37% Newstop 41% Patentstop 45% Producttop 49% Talentbottom 48% Innovationbottom 47% Techbottom 45% Marketbottom 40% Globalbottom 33% Funding: Raised $35.0M across 3 rounds · 3 rounds over 4 yrs (0.8/yr) AI: Classified as an AI company · Product described with: ai-powered rank vs industry peers · Fliar Intelligence Index 55/100 | $35M | 2 mo ago | 61 | Neal Schneider Co-Founder | WordPress Block EditorWordPressMySQL+28 | Top 10M | 6 patents Patents concentrated in computing, sensing & instrumentation | 1 award |
| 10 | eSpark Learning Personalized learning on the iPad for schools | $31M | 53 mo ago | 41 41 → 29 (-29%) | Eric Dahlberg Chief Executive Officer | WordPress Block EditorWordPressApple iCloud Mail+34 | Top 100k | — | — |
| 11 | Ascent Cloud-based platform to track and automate financial regulatory compliance | $27M | 79 mo ago | 47 | Brian Clark Founder | WordPressMySQLPHP+28 | Top 5M | 71 patents HVAC fan and housing systems plus ultrasonic transducer manufacturing technologies | 1 job opening · 1 award |
| 12 | Mattiq Developer of an experimentation platform for accelerating materials discovery and design 53AI top 18%Moat top 31%Patents top 32%Innovation top 34% All 9 signals ▾AItop 18% Moattop 31% Patentstop 32% Innovationtop 34% Talenttop 38% Fundingtop 43% Techbottom 48% Globalbottom 35% Marketbottom 28% AI: Classified as an AI company · Holds AI/ML patents (G06N-family CPC) Moat: Editorial + unicorn rating 7/10 · IP moat: 16 patents rank vs industry peers · Fliar Intelligence Index 53/100 | $24M | 18 mo ago | 19 | Andrey Ivankin Co-Founder & Chief Technology Officer | WordPressApple iCloud MailGoogle Workspace+25 | Top 10M | 16 patents AI-driven design of functional materials and mixed‑metal electrocatalysts for energy applications | — |
| 13 | Thoughtful AI-powered healthcare administration platform to automate tasks | $20M | 14 mo ago | 16 | Alex Zekoff Co-Founder & CEO | WebflowZohoYouTube+29 | Top 5M | — | — |
| 14 | Vermill Provider of AI rights management platform protecting and licensing digital content | $16M | 15 mo ago | 21 | Dan Neely Co-Founder & CEO | WordPress Block EditorWordPressMySQL+34 | Top 10M | — | — |
| 15 | ModelOp Platform offering machine learning model deployment and management | $16M | 22 mo ago | 36 | Stu Bailey Co-Founder | WebflowTypekitGoogle Font API+20 | Top 50M | 20 patents Containerized machine‑learning model execution platforms with performance instrumentation and diagnostics | 1 launch · 3 awards |
| 16 | Neurensic Regulatory compliance using Artificial Intelligence | $9M | 111 mo ago | 186 | — | — | — | — | — |
| 17 | Samya.ai AI-based SaaS platform for consumer packaged goods companies | $6M | 77 mo ago | 61 | — | — | — | 5 patents Patents concentrated in computing, sensing & instrumentation | — |
| 18 | Rippleshot Provider of AI-driven banking fraud analytics and detection platform solutions | $5M | 94 mo ago | 10 10 → 13 (+30%) | Yueyu Fu Co-Founder | Webflowcore-jsSwiper+16 | Top 50M | — | — |
| 19 | QuillBot Provider of an AI-based paraphrasing tool | $4M | 74 mo ago | 171 171 → 358 (+109%) | Anil Jason Co-Founder | SentryZendeskQuill+28 | Top 5k | — | — |
| 20 | iAsk AI Developer of an AI search engine providing detailed, accurate responses | $4M | 20 mo ago | — | Dominik Mazur Co-Founder & CEO | SentryZendeskErlang+14 | Top 50k | — | — |
| 21 | Tagado Provider of SaaS-based ML and NLP technology for data collection and analytics platform for marketing | $4M | 43 mo ago | 10 | — | — | — | — | — |
| 22 | Identomat Provider of AI-powered identity verification and KYC/AML compliance platform | $3M | 17 mo ago | 32 | Zurab Kotaria Co-Founder & COO | Webflow EcommerceWebflowZoho+21 | Top 5M | — | — |
| 23 | Semantify Knowledge based Data Discovery and Analytics Platform | $3M | 121 mo ago | 25 | — | — | — | — | — |
| 24 | Blinkfire Analytics Sports media analytics | $3M | 108 mo ago | 27 27 → 50 (+85%) | Juan Luis Hortelano Co-founder and COO | Chart.jsBootstrapGoogle Cloud+26 | Top 1M | 11 patents AI-powered image analysis and automated media content review/valuation systems | — |
| 25 | Telnyx Provider of voice AI platform with global telecommunications infrastructure | $2M | 139 mo ago | 106 | — | DocusaurusZendeskApple iCloud Mail+34 | Top 500k | 16 patents Cloud-based secure virtual private mobile and IP networking services | 1 launch |
| 26 | Clockwork AI & cloud-based cash flow management solutions for small businesses | $2M | 50 mo ago | 11 | Fady Hawatmeh Founder and CEO | WebflowGSAPEmotion+22 | Top 10M | 2 patents Pricing algorithms and sales platforms for home repair and service commerce | 2 launchs |
| 27 | ProvenAir Provider of AI-powered platform for aircraft records management and compliance | $2M | 23 mo ago | 13 | James Boccarossa CEO | SanityNode.jsTailwind CSS+13 | Top 50M | — | — |
| 28 | Arvist Provider of AI-powered solutions for warehouse quality control and compliance | $1M | 10 mo ago | 7 | Werner Stapela Co-Founder | — | — | — | — |
| 29 | Altris AI-based diagnostic solution for ophthalmologists | $1M | 17 mo ago | 15 | Andrey Kuropyatnyk Founder & CEO | WordPressMySQLPHP+26 | Top 10M | — | 1 launch |
| 30 | Brain.fm Developer of music designed to enhance focus and cognitive performance | $225K | 99 mo ago | 13 | Daniel Clark CEO | SentryFacebook LoginGoogle Sign-in+23 | Top 100k | 576 patents Robotic mapping, sensor calibration, and feature detection for autonomous navigation systems. | — |
| 31 | Rhetora Cloud and AI based cold calling sales enablement solutions for sales teams | $120K | 33 mo ago | 6 | Luka Eric Co-Founder & CEO | — | — | — | — |
Top 12 Artificial Intelligence companies in Illinois
#1
Series C · Chicago, Illinois · founded 2021 · 47 employees$65Mraised▾
Provider of a logistics data platform offering freight audit and visibility. The platform unifies shipment and tracking data, enabling logistics teams to operate efficiently. It offers features such as parcel contract intelligence and carrier payments. The platform provides tools for cost allocation, decision intelligence, and transportation network optimization.
- Apr 2026Series C$95M
- Oct 2023Series B$35M
- Nov 2022Series A$24M
- 2021Seed$6M
#2
Series B · Chicago, Illinois · founded 2022 · 61 employees$35Mraised▾
Provider of AI-powered automation software for K-1, K-3, and 990 tax reporting. This software automates the receipt and production of K-1s, streamlining the process for both investors and advisors. It also offers automated 990 exempt reporting and filing, including e-filing capabilities. The platform integrates with various other software solutions and provides support, training, and onboarding services. The software aims to reduce manual effort, costs, and risks associated with alternative investment tax compliance.
- Apr 2026PE$175M
- Sep 2024PE$20M
- Dec 2022Series B$15M
#3
Series A · Chicago, Illinois · founded 2020 · 16 employees$20Mraised▾
AI-powered healthcare administration platform to automate tasks. The company offers solutions for automating revenue cycle management, streamlining company processes, and implementing robotic process automation (RPA).
- Apr 2025PE—
- Jul 2024Series A$20M
#4
Seed · Skokie, Illinois · founded 2020 · 19 employees$24.1Mraised▾
Developer of an experimentation platform for accelerating materials discovery and design. The platform transforms materials discovery from trial-and-error methods to intelligence-driven design. The company aims to unlock the materials blueprint, igniting the next era of human progress.
- Dec 2024Seed$4.5M
- Sep 2024Grant (prize money)$275K
- Jul 2023Grant (prize money)$1.3M
- Feb 2023Grant (prize money)$199.7K
#5
Series A · Chicago, Illinois · founded 2021 · 21 employees$16Mraised▾
Provider of AI rights management platform protecting and licensing digital content. The platform offers tools to manage terms, conditions, and usage rights for content. It helps content owners protect against unauthorized use, deepfakes, and distribution. The platform also provides content monitoring and risk assessment services. It aims to enable content owners to capitalize on revenue streams from generative AI.
- Mar 2025Series A$16M
#6
Tempus 🦄Public · Chicago, Illinois · founded 2015 · 772 employees$1.1Braised▾
Developer of genomic testing and artificial intelligence tools for medicine. This organization provides molecular profiling, algorithmic diagnostic models, and digital pathology services to assist in clinical decision-making. The technology integrates clinical data with sequencing results to identify therapeutic options and potential clinical trial matches. These tools support oncology, neurology, psychiatry, cardiology, and radiology by analyzing biological data to assist in patient care and drug development. The platform facilitates the identification of biomarkers and provides insights into disease progression and treatment responses.
- Oct 2022Series G—
- Oct 2022Conventional Debt—
- Dec 2020Series G$200M
- Mar 2020Series G$100M
#7
Series B · Chicago, Illinois · founded 2016 · 36 employees$16Mraised▾
Platform offering machine learning model deployment and management. It enables data scientists, IT professionals, and business teams to deploy, monitor and govern artificial intelligence models. Has use case in credit scoring, bond trading, model risk management and trading applications.
- Aug 2024Series B$10M
- 2023Series A—
- Mar 2020Series A$6M
#8
Series A · Chicago, Illinois · founded 2021 · 7 employees$1.1Mraised▾
Provider of AI-powered solutions for warehouse quality control and compliance. It automates inspections, detects hazards, enforces safety rules, and monitors restricted areas. The platform integrates with existing systems and equipment, providing real-time alerts and dashboards. It helps to standardize quality checks, reduce errors, and improve overall warehouse efficiency.
- Jul 2025Series A$5.9M
- Nov 2023Seed$1.1M
- 2022Seed$20K
#9
Series D · Chicago, Illinois · founded 2014 · 24 employees$243.3Mraised▾
Developer of AI and web-based visibility solutions for the supply chain. It provides users with real-time visibility solutions for shippers, brokers, 3PLs, and carriers. It uses machine learning and AI to provide predictive insights and real-time supply chain information. It also enables users to calculate shipment arrival times and uses GPS or ELD devices for covering all modes including ocean, rail, parcel, and over-the-road. It provides end-to-end supply chain visibility platform using AI-driven technologies to provide comprehensive real-time tracking and predictive analytics for transportation and logistics management.
- Sep 2022Series D$10M
- Aug 2022Series D$30M
- Jun 2022Series D—
- Mar 2021Series D$100M
#10
Seed · Champaign, Illinois · founded 2019 · 32 employees$3.2Mraised▾
Provider of AI-powered identity verification and KYC/AML compliance platform. The platform offers identity verification using government-issued identification, biometric data, and authoritative sources. It facilitates video-based verification, AML screening, business verification, and age verification. The platform includes modules for ID verification, liveness detection, face matching, and address verification, along with KYC/CDD questionnaires and NFC verification.
- Jan 2025Seed$1M
- Jan 2022Seed$3.2M
#11
Series A · Bolingbrook, Illinois · founded 2015 · 127 employees$38.5Mraised▾
Developer of autonomous mobile robots for material handling in various industries. The company's robots automate manual material-handling jobs in manufacturing, logistics, warehousing, and retail. The robots are designed to work safely with people and equipment. The company's technology aims to improve process stability and throughput.
- Apr 2024Series A$4.6M
- Jun 2021Series A$31M
- Oct 2019Seed$2.9M
- 2016Seed—
#12
Seed · Chicago, Illinois · founded 2022$4.2Mraised▾
Developer of an AI search engine providing detailed, accurate responses. The engine enables users to ask questions in natural language and receive answers. It offers features such as document analysis, image creation, and grammar checking. The platform also provides tools for summarizing web content and brainstorming content ideas.
- Oct 2024Seed$4.2M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Artificial Intelligence coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Artificial Intelligence in Illinois is moving
A read on the academic research around Artificial Intelligence in Illinois — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 93 papers.
UIUC-led Illinois AI research optimistically advances multimodal learning, image retrieval, and graph neural networks, with breakthroughs dominating and minimal concern.
- University of Illinois Urbana-Champaign58
- University of Illinois Chicago22
- University of Illinois System4
- Northern Illinois University4
- Southern Illinois University Edwardsville2
- Robustness (evolution)2→3
- Natural language processing4
- Task (project management)2
- Convolutional neural network2
- Inference2
- Representation (politics)2
- Perspective (graphical)2
- Fidelity2
- Representation (politics)2
- Automation2
- Sentiment analysis2
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.