Best Cardiac and Vascular Disorders Companies in Irvine, United States
The 31 best Cardiac and Vascular Disorders companies in Irvine, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Endologix.
Ranked: Best Cardiac and Vascular Disorders companies in Irvine
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Endologix Minimally invasive treatments for aortic disorders | $507M | 91 mo ago | Public | 488 488 → 490 (+0%) | — | 332 patents Endovascular stent graft systems for aortic aneurysm repair and related catheter technologies | — |
| 2 | JenaValve Technology Provider of pericardial transcatheter aortic valve replacement and delivery system | $364M | 58 mo ago | Acquired | 55 | John Kilcoyne CEO | 167 patents Self‑expanding heart valve prostheses, delivery catheters, and anchoring frames | — |
| 3 | TherOx Super saturated oxygen therapy for reducing cardiac muscle damage | $113M | 102 mo ago | Acqui-Hired | 12 | — | 106 patents Bubble‑free medical gas enrichment and delivery systems for intravascular therapies | — |
| 4 | Aviir Diagnostic tests for cardiovascular disorders | $67M | 160 mo ago | Deadpooled | — | Douglas S. Harrington CEO | 9 patents Cardiovascular disease diagnostic biomarkers and assay technologies | — |
| 5 | CardiAQ Valve Technologies Technology for Transcatheter Mitral valve replacement | $45M | 167 mo ago | Acquired | 9 | — | 73 patents Implantable heart valve prostheses and minimally invasive delivery/sealing devices | — |
| 6 | MiCardia Device for mitral valve repair | $30M | 163 mo ago | Series A | 4 | — | 125 patents Adjustable cardiac valve prostheses and transcatheter valve repair technologies | — |
| 7 | Innova Vascular Developer of medical device for the minimally invasive treatment of vascular disease | $22M | 17 mo ago | Series A | — | Sanjay Shrivastava Founder & CEO | — | — |
| 8 | Lombard Medical Technologies Innovative solutions for aortic disease treatment, improving patient outcomes globally | $21M | 197 mo ago | Series A | 5 | Simon Hubbert ex-CEO | — | — |
| 9 | Insightra Developer of Intra-Aortic Balloon Catheter for surgery | $20M | 134 mo ago | Series D | 8 | — | — | — |
| 10 | SmartHealth Developer precision diagnostics for vascular, metabolic, and oncological diseases | $17M | 23 mo ago | Series B | 17 | Larry Dentice CEO | 44 patents Patents concentrated in transport & manufacturing processes | — |
| 11 | Onset Medical Corporation Domain marketplace facilitating secure transactions and transfers with buyer protection | $17M | 166 mo ago | Acquired | — | Joe Bishop ex-President & CEO | — | — |
| 12 | MindFrame Developer of a medical device for the treatment of ischemic stroke | $16M | 173 mo ago | Acquired | 6 | Ken Charhut President & CEO | 48 patents Neurovascular devices for acute stroke clot removal and thrombus management | — |
| 13 | Theraheart Manufacturer of minimally invasive medical devices for heart failure patients | $12M | 13 mo ago | Series B | — | Wei Gan Founder & CEO | 25 patents Innovative shunting catheters with expandable puncture, ablation, and tissue‑removal features | — |
| 14 | Trimedyne Holmium:YAG laser manufacturer providing advanced surgical solutions and laser fibers | $5M | 238 mo ago | Late Stage | 40 | — | 11 patents Laser-based minimally invasive tissue ablation and fat cell lysis devices for medical use | — |
| 15 | Vibrato Medical Developer of a therapeutic device for peripheral arterial disease | $4M | 17 mo ago | Series A | 8 | Juliana Elstad Chief Executive Officer and Board Member | — | — |
| 16 | Laguna Tech USA Developer of heart valve systems to treat valve regurgitation | $3M | 10 mo ago | Series A | — | Gilbert Madrid CEO | — | — |
| 17 | Lombard Medical Innovative solutions for aortic disease treatment, improving patient outcomes globally | $3M | 138 mo ago | Acquired | 30 | Kurt Lemvigh Chief Executive Officer | — | — |
| 18 | Vena Vitals Provider of wearable sticker for monitoring blood pressure | $1M | 38 mo ago | Seed | 10 | Michelle Khine Co-Founder | 6 patents Wearable multi-channel biosensor arrays for real-time physiological signal monitoring | — |
| 19 | enVVeno Medical Developer of medical device for the the treatment of venous diseases | $874K | 37 mo ago | Public | 31 | Norman Jaffe Founder | — | — |
| 20 | ACS Diagnostics Provider of ECG monitoring device | $300K | 150 mo ago | Early Stage | 37 | — | — | — |
| 21 | Edwards Lifesciences Developer of medical devices for structural heart disease | — | 101 mo ago | Public | 19,800 | Bernard Z CEO | 12,412 patents Transcatheter heart valve delivery devices and balloon catheter technologies for cardiac interventions | — |
Top 12 Cardiac and Vascular Disorders companies in Irvine
#1
Series B · Irvine, California · founded 2023$11.6Mraised▾
Manufacturer of minimally invasive medical devices for heart failure patients. The company develops solutions for individuals experiencing heart failure symptoms. It focuses on addressing the needs of medical professionals and patients. The company's devices aim to improve the lives of those affected by cardiac conditions.
- Sep 2025Series B$11.6M
#2
Series A · Irvine, California · founded 2018$21.9Mraised▾
Developer of medical device for the minimally invasive treatment of vascular disease. It offers Laguna Clot Retriever System and Malibu Aspiration Catheter System for minimally invasive solutions to treat arterial and venous thromboembolism.
- May 2025Series A$10M
- Mar 2024Series A$5.7M
- Jun 2021Series A$6.2M
#3
Series A · Irvine, California · founded 2021$3.2Mraised▾
Developer of heart valve systems to treat valve regurgitation. It offers heart valve replacement technology combines balloon-expandable valve systems for stenosis and self-expandable technologies for superior heart valve performance and to treat aortic regurgitation.
- Dec 2025Series A$3.2M
#4
Series A · Irvine, California · founded 2016 · 8 employees$4Mraised▾
Developer of a therapeutic device for peripheral arterial disease. The ultrasound device offers a noninvasive treatment for critical limb ischemia and peripheral arterial disease to improve tissue perfusion, reduce symptoms and save limbs.
- May 2025Grant (prize money)$300K
- Mar 2025Grant (prize money)$300K
- Mar 2025Grant (prize money)$300K
- Jan 2022Grant (prize money)$300K
#5
Series B · Irvine, California · founded 1979 · 17 employees$17Mraised▾
Developer precision diagnostics for vascular, metabolic, and oncological diseases. The company offer SmartPath Dx and SmartVascular Dx for diagnosing vascular inflammation and pathology. Other products include SmartLung Dx and SmartKidney Dx to detect lung cancer and kidney diseases.
#6
Acquired · Irvine, California · founded 2006 · 55 employees$363.7Mraised▾
Provider of pericardial transcatheter aortic valve replacement and delivery system. It offers Trilogy Valve with locator technology that includes a root valve sewn onto a stent and a delivery system for the treatment of aortic valve stenosis for treatment of patients suffering from the aortic valve insufficiency.
- Dec 2021Series C$100M
- Jan 2020Series C$66.5M
- Jun 2019Series C$14.5M
- Jan 2018Conventional Debt$14.3M
#7
Public · Irvine, California · founded 1992 · 488 employees$507.4Mraised▾
Endologix develops and manufactures minimally invasive treatments for aortic disorders. Endologix’s flagship product is the Powerlink System, which is an endovascular stent graft for the treatment of abdominal aortic aneurysms (AAA). AAA is a weakening of the wall of the aorta, resulting in a balloon-like enlargement. Once AAA develops, it continues to enlarge and, if left untreated, becomes increasingly susceptible to rupture. It acquired Nellix, a developer of medical devices for the minimally invasive treatment of aortic aneurysms.
- Apr 2019Conventional Debt$52.2M
- Aug 2018Post IPO$210.5M
- Apr 2017Conventional Debt$179.7M
- Jul 2016Conventional Debt$50M
#8
Acqui-Hired · Irvine, California · founded 1995 · 12 employees$113.4Mraised▾
TherOx is a private medical device company which has developed the super-saturated oxygen (SSO2) therapy system and cartridge. The intent of this therapy is to salvage damaged heart tissue by placing a high concentration of oxygen into the patient’s blood plasma and delivering it directly to the area impacted by the heart attack. It is used as a complement to percutaneous coronary intervention and stenting. The product is yet to receive FDA approval. The company is backed by Kleiner Perkins Caufield and Byers, New Science Ventures, Integral Capital Partners, Aperture Venture Partners, DAG Ventures and Cross Creek Capital.
- May 2018Conventional Debt$15M
- Jul 2015Series D$16.8M
- Sep 2014Series C$1M
- Nov 2013Series C$5.6M
#9
Deadpooled · Irvine, California · founded 2005$66.7Mraised▾
Aviir developed diagnostic tests for cardiovascular disorders. Its proprietary biomarker panel and algorithms enabled accurate diagnosis and prognosis of cardiovascular disease. Its flagship product MIRISK VP used protein biomarkers associated with inflammation-mediated unstable arterial plaques. The company filed for bankruptcy in Jan 2014.
- Jun 2013Series B$30M
- Sep 2012Conventional Debt$8M
- Dec 2011Series A$3.8M
- Jun 2011Series A$3M
#10
Acquired · Irvine, California · founded 2007 · 9 employees$45.4Mraised▾
CardiAQ Valve Technologies was developing approaches to heart valve replacement, initially focused on transcatheter mitral valve implantation. The product will enable physicians to implant a new mitral valve without the need for open-heart surgery. The company was acquired by Edwards Lifesciences in July 2015.
- Dec 2012Series B$37.3M
- Jan 2010Series A$6.5M
- Oct 2009Seed—
- May 2009Seed$109K
#11
Series A · Irvine, California · founded 2004 · 4 employees$29.5Mraised▾
MiCardia has developed its Dynoplasty technology for mitral valve repair. Product was CE marked in 2011. Not available in the US.
- Apr 2013Series A$3.7M
- Jul 2012Series A$4.4M
- Jun 2011Series A$2.6M
- Mar 2010Series A$4.8M
#12
Seed · Irvine, California · founded 2019 · 10 employees$1.4Mraised▾
Provider of wearable sticker for monitoring blood pressure. The sticker contains soft stretchable sensors that measure continuous blood pressure and provides an understanding of cardiovascular health.
- Aug 2023Seed—
- Aug 2023Grant (prize money)$295.9K
- May 2022Grant (prize money)$842.8K
- Feb 2021Grant (prize money)$256K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Cardiac and Vascular Disorders coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.