Best Disease Self Management Companies in Chicago, United States
The 42 best Disease Self Management companies in Chicago, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Xeris Pharmaceuticals.
Our analysis of 50 Disease Self Management companies
$3.0b in tracked funding; 94% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Disease Self Management companies in Chicago
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Xeris Pharmaceuticals Developer of liquid-stable injectables for the delivery of drugs | $155M | 55 mo ago | 294 294 → 506 (+72%) | 2005 | Steve Prestrelski Co-Founder & CSO | 249 patents Stable drug formulations in aprotic polar solvents for hormones, peptides, and biologics | 1 internship · 1 award |
| 2 | Higi Gamified app for personal health management | $95M | 74 mo ago | 53 53 → 75 (+42%) | 2012 | — | 17 patents Integrated automated blood pressure cuffs with arm circumference sizing and ocular biomolecule detection | 1 partnership |
| 3 | Visibly Online vision test technology for providers | $50M | 40 mo ago | 29 29 → 62 (+114%) | 2012 | — | 19 patents Automated eye‑exam technologies for refraction, astigmatism and visual‑field assessment | — |
| 4 | Rise Provider of an application for tracking sleep | $16M | 62 mo ago | 12 12 → 25 (+108%) | 2014 | Leon Sasson Co Founder | — | — |
| 5 | Cardiosense Developer of wearable sensor and AI platform for cardiac monitoring | $15M | 44 mo ago | 15 | 2020 | Amit Gupta Co-Founder & CEO | 2 patents Wearable/implantable physiological monitoring sensors and health data analytics platforms | — |
| 6 | Reliefband Drug-free wearable tech for fast, effective nausea and vomiting relief | $6M | 105 mo ago | 10 | 2015 | — | 4 patents Patents concentrated in health & consumer products | — |
| 7 | SkinIO Online platform to keep track of skin cancer | $5M | 42 mo ago | 27 | 2008 | — | 7 patents Digital skin imaging and UV monitoring for dermatological abnormality detection | — |
| 8 | Neopenda Provider of wearable neonatal signs monitor 16Moat top 38%Funding top 42%Tech top 43%Talent bottom 49% All 12 signals ▾Moattop 38% Fundingtop 42% Techtop 43% Talentbottom 49% Productbottom 47% Growthbottom 43% Globalbottom 37% Innovationbottom 36% Patentsbottom 25% Marketbottom 22% Fin. healthbottom 19% Newsbottom 18% Moat: Editorial + unicorn rating 7/10 · IP moat: 3 patents Funding: Raised $2.7M across 12 rounds · 12 rounds over 8 yrs (1.5/yr) rank vs industry peers · Fliar Intelligence Index 16/100 | $3M | 4 mo ago | 14 | 2015 | Teresa Cauvel Co-founder and CTO | 3 patents Remote neonatal vital sign monitoring and data analytics devices | — |
| 9 | Aivo Health Provider of software-based solutions for chronic back pain management | $2M | 59 mo ago | 7 | 2018 | Rolf Sormo CTO & Founder | — | — |
| 10 | Renalis Provider of solutions for pelvic health | $944K | 23 mo ago | 3 | 2019 | Missy Lavender Founder & CEO | 4 patents Digital platforms delivering pelvic health education and management tools | — |
| 11 | CareBand Provider of location-based monitoring technology for healthcare and safety applications | $517K | 58 mo ago | 8 | 2014 | — | 33 patents LPWAN-enabled industrial IoT, long-range object tracking, and wearable health-monitoring solutions | — |
| 12 | Luna Lights Developer of smart devices for night time fall detection | $375K | 111 mo ago | 3 | 2014 | — | — | — |
| 13 | Bold Diagnostics Provider of diagnostic platform for blood pressure monitoring | $250K | 98 mo ago | 1 | 2015 | Jay Pandit Co-Founder | — | — |
| 14 | Brain.fm Developer of music designed to enhance focus and cognitive performance | $225K | 101 mo ago | 13 | 2014 | Daniel Clark CEO | 576 patents Robotic navigation, sensor calibration, and feature mapping for autonomous systems | — |
| 15 | Diasend Diabetes data management platform transitioning to Glooko, offering device syncing and tracking | $192K | 115 mo ago | 10 | 2005 | — | — | — |
Top 12 Disease Self Management companies in Chicago
#1
Seed · Chicago, Illinois · founded 2015 · 14 employees$2.7Mraised▾
Provider of wearable neonatal signs monitor. The device is a small low-cost neonatal vital signs monitor integrated into a baby hat and uses a simple sensor array to measure heart rate, respiratory rate, blood oxygen saturation, and temperature. The sensors are powered by rechargeable batteries, and wirelessly transmit data to a central monitor which alerts attending healthcare professionals when a newborn is in immediate danger. It is intended for critically ill newborns being cared for in hospitals in low-resource countries such as Uganda.
- Apr 2026Conventional Debt$35K
- Nov 2024Conventional Debt$200K
- Sep 2022Conventional Debt$700K
- Apr 2021Seed$1.4M
#2
Public · Chicago, Illinois · founded 2005 · 294 employees$155.4Mraised▾
Developer of liquid-stable injectables for the delivery of drugs. The company is developing a stable, ready-to-inject glucagon formulation "Gvoke" which is indicated for the treatment of severe hypoglycemia in adult and pediatric patients with diabetes. The company has developed proprietary formulation technologies such as XeriSol and XeriJect which are currently being evaluated for subcutaneous and intramuscular delivery of highly-concentrated, non-aqueous, ready-to-use formulations of peptides, proteins, and antibodies.
- Jan 2022Post IPO—
- Mar 2021Post IPO$27M
- Mar 2018Series C$10M
- May 2017Series C$30.1M
#3
Series B · Chicago, Illinois · founded 2012 · 29 employees$50.2Mraised▾
Online vision test technology for providers. It helps in connecting the consumer with an ophthalmologist or optometrist for prescribing glasses, and contact lenses, and renewing the prescriptions. Also, doctors can register their practice for vision test technology for their patients through teleconsultation.
- Apr 2023Series B$24.6M
- Aug 2020Series A$6.5M
- Sep 2019Series A$1.1M
- Apr 2019Series A$6.2M
#4
Seed · Chicago, Illinois · founded 2019 · 3 employees$944Kraised▾
Provider of solutions for pelvic health. The platform provides solutions to improve experiences and outcomes for people with pelvic health conditions. It is designed to tackle the biggest challenges in pelvic health management.
- Sep 2024Grant (prize money)$307K
- Aug 2023Conventional Debt$25K
- 2022Seed$100K
- Sep 2021Seed$824K
#5
Acquired · Chicago, Illinois · founded 2012 · 53 employees$95.2Mraised▾
Higi provides a gamified app for personal health management. Through its "high Stations" provides free screenings for blood pressure, weight, pulse, and body mass index. Its platform is directed at community-health and wellness and allows consumers to collect and share their health and activity data with trusted partners or communities to win rewards.
- Jun 2020Series C$31.4M
- Jul 2018Series C—
- Jul 2018Series C$23.8M
- Mar 2017Series B—
#6
Series A · Chicago, Illinois · founded 2020 · 15 employees$15.1Mraised▾
Developer of wearable sensor and AI platform for cardiac monitoring. The company provides a medical-grade wearable device that measures seismocardiogram, photoplethysmogram, and electrocardiogram signals. Clinical artificial intelligence algorithms translate sensor signals into digital biomarkers. Integrated software solutions aggregate data into actionable clinical insights, designed to streamline workflows.
- Dec 2022Series A$15.1M
#7
Series A · Chicago, Illinois · founded 2008 · 27 employees$5Mraised▾
Online platform to keep track of skin cancer. Users can take photos of the skin to map moles and use follow-up photos over time to keep track of changes. The platform can automatically analyze photos to spot changes and identify potentially malignant skin moles which need examination by a physician.
- Feb 2023Series A$1.5M
- Oct 2020Series A$1.4M
- May 2019Seed$511.2K
- Apr 2018Seed$1.5M
#8
Series A · Chicago, Illinois · founded 2014 · 12 employees$15.5Mraised▾
Provider of an application for tracking sleep. The company offers an application to track how much sleep you owe your body and also offers sleep to control it. It offers sleep challenges and recommendations for improving the quality of sleep.
- Jun 2021Series A$10M
- 2018Seed$5.5M
#9
Series A · Chicago, Illinois · founded 2015 · 10 employees$6Mraised▾
Drug-free wearable tech for fast, effective nausea and vomiting relief. This company offers clinically proven, FDA-cleared neuromodulation devices providing a drug-free solution for nausea and vomiting. Their patented technology gently stimulates the wrist to control nausea signals in the brain. The products are effective for various conditions, including motion sickness, morning sickness, chemotherapy-induced nausea, anxiety, and migraines. They offer a range of wearable devices and accessories available for purchase through their online shop, including bundles and gift cards. They provide customer support through FAQs, a help center, and contact options. They also offer financing options and free shipping for orders over a certain amount. The website includes features like account login, cart, search, and a quiz to help customers find the right product. They also offer FSA/HSA eligibility.
- Nov 2017Series A$1000K
- Sep 2015Series A$5M
#10
Deadpooled · Chicago, Illinois · founded 2018 · 7 employees$2.4Mraised▾
Aivo Health is a provider of software-based solutions for chronic back pain management. It provides a mobile app that acts as a personal health coach and supports in tracking chronic pain. The app helps in medication management, symptoms management, and allows personal trainers to give fitness and exercise advice to guide chronic pain.
- Sep 2021Seed$2.4M
#11
Funding Raised · Chicago, Illinois · founded 2014 · 8 employees$517.4Kraised▾
Provider of location-based monitoring technology for healthcare and safety applications. The company delivers solutions for addiction treatment, contact tracing, and dementia and Alzheimer’s care. It offers products for patient tracking in hospitals and for developmental disabilities. The company’s technology includes real-time location tracking and activity monitoring.
- Sep 2021Grant (prize money)$288.6K
- Sep 2019Grant (prize money)$228.8K
#12
Acquired · Chicago, Illinois · founded 2014 · 3 employees$375Kraised▾
Luna Lights is an automated lighting system for detecting falls. Its solution consists of pressure-sensing pads that turn on guided lights whenever they sense pressure. This time is sent to the cloud where if the return time exceeds a certain preset time then a family member or caregiver is alerted regarding a possible fall.
- May 2017Seed$150K
- Jul 2016Seed$225K
- Aug 2015Grant (prize money)$5K
- Jun 2015Grant (prize money)$30K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Disease Self Management coverage by sub-theme.
Regulatory-risk over time falling
Funding & growth over time
funding flat · growth flat
How research on Digital Health in Chicago is moving
A read on the academic research around Digital Health in Chicago — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 127 papers.
- University of Illinois Chicago68
- University of Chicago47
- Loyola University Chicago14
- Chicago Department of Public Health12
- Chicago State University2
- Wearable computer3
- SNOMED CT3
- Interoperability3
- Unstructured data3
- Key (lock)3
- Informatics1→5
- mHealth1→4
- Telemedicine1→3
- Data science1→3
- Health informatics2→12
- Health administration1→8
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.