Best Disease Self Management Companies in Italy
The 52 best Disease Self Management companies in Italy in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Empatica.
Italy's Disease Self Management sector is smaller than the headlines suggest, but the underlying numbers tell a more interesting story. Our directory tracks 52 companies in Italy with $46M in total disclosed funding, and Empatica alone accounts for $31M of that pool, which means the remaining field is scrappy and early-stage by definition. ComfTech has pulled in $8M, and the rest, Domethics, Biotechware, WinMedical, are operating well under the $2M mark. No unicorns here yet. But the global backdrop makes that gap feel like opportunity: the disease self-management market sits at roughly $4.8B today and is forecast to reach $16.8B by 2033, compounding at 13.4% annually as lifestyle-driven chronic conditions push patients toward digital, at-home management tools.
So what's actually moving the needle right now? Post-Covid complications, mindfulness-linked health tracking, and the broader shift to online management solutions are all feeding demand in ways that didn't exist five years ago. If you're mapping this sector, the investor roster matters: Europa, EIC Fund, CDP Venture Capital, and Cariplo Factory are the names backing Italian plays. I'd watch data privacy regulation closely too, since increased digital connectivity keeps compliance friction high for any company scaling a connected device or monitoring platform here.
- ResearchAndMarkets.com
Our analysis of 50 Disease Self Management companies
$3.0b in tracked funding; 94% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Disease Self Management companies in Italy
| # | Company | Disclosed funding | Last round | Stage | Founder | Founded | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Empatica Developer of a wrist band to monitor physiological signals 64Tech top 23%Product top 34%Funding top 35%Growth top 35% All 11 signals ▾Techtop 23% Producttop 34% Fundingtop 35% Growthtop 35% Talenttop 38% Markettop 42% Moatbottom 44% Innovationbottom 43% Globalbottom 43% Customersbottom 41% Patentsbottom 38% Tech: 49 technologies across 6/8 capability areas · Cloud: Amazon Cloudfront, Amazon S3 Product: 5 published apps (41.5k installs) · Company stage: Series B rank vs industry peers · Fliar Intelligence Index 64/100 | $31M | 44 mo ago | Series B | Melih Sadi Founder & Owner | 2011 | SanityApple iCloud MailGoogle Workspace+23 | 2 patents Wearable electrodermal activity sensors with current‑compensation circuitry for accurate skin conductance monitoring | 1 job opening |
| 2 | ComfTech Provider of smart garments for physiological monitoring | $8M | 95 mo ago | Series A | — | 2010 | WordPressMySQLPHP+19 | 26 patents Sensor‑integrated garments for continuous vital‑sign monitoring, especially neonatal respiration | — |
| 3 | Biotechware Telemedicine integrated platform for remote cardiac monitoring | $2M | 105 mo ago | Series A | Alessandro Sappia Founder | 2011 | — | 3 patents Portable ECG devices for real-time cardiac monitoring and diagnostics | 1 partnership |
| 4 | imaginary Online platform providing gamified training for patient medical education and rehabilitation | $2M | 54 mo ago | Funding Raised | — | 2004 | — | — | — |
| 5 | WinMedical Wearable device for remote patient monitoring applications | $1M | 176 mo ago | Seed | — | 2009 | — | 22 patents Wireless medical sensor/actuator networks and radiopharmaceutical patient monitoring devices | — |
| 6 | Domethics Provider of smart watches for health tracking | $780K | 26 mo ago | Seed | Samuele Rocca CEO | 2014 | WordPress Block EditorCart FunctionalityWooCommerce+11 | — | — |
| 7 | Morecognition Inc Provider of AI-based smart devices and software solutions for people with motor impairment | $168K | 105 mo ago | Funding Raised | — | 2016 | — | 3 patents EMG-based muscle activation detection and identification for human‑machine interface | 1 job opening |
| 8 | Mr Doc App to detect disease conditions | $111K | 77 mo ago | Funding Raised | Fabio Rebecchi CEO and Principal Data Scientist | 2017 | — | — | — |
Top 12 Disease Self Management companies in Italy
#1
Series B · Milano, Umbria · founded 2011 · 133 employees$30.9Mraised▾
Developer of a wristband to monitor physiological signals. The E4 wristband for researchers measures blood volume pulse, electrodermal activity, skin temperature and activity. It also offers Embrace, a wristband to monitor physiological stress, arousal, sleep and physical activity which provides seizure monitoring.
- Nov 2022Series B—
- Aug 2022Series B$25.9M
- Apr 2021Grant (prize money)$353.1K
- Mar 2021Grant (prize money)$115.9K
#2
Seed · Turin, Piedmont · founded 2014 · 6 employees$779.9Kraised▾
Provider of smart watches for health tracking. It monitors the heart health through ECG and PPG, heart and respiratory rate, blood oxygen and body temperature of users and sends alerts if there is any abnormality. It also offers a telemedicine consultation service on its marketplace platform.
- May 2024Seed$779.9K
#3
Funding Raised · Milan, Lombardy · founded 2004 · 9 employees$2.1Mraised▾
Online platform providing gamified training for patient medical education and rehabilitation. The company has provided eHealth solutions for patients through rehabilitation games for personalized physical therapy for patients with stroke, multiple sclerosis, and Parkinson's disease. The other solution is the training and education for the medical professional on various healthcare topics in the form of games.
- Jan 2022Grant (prize money)$256.2K
- Nov 2019Grant (prize money)$67.6K
- Jan 2019Grant (prize money)$366K
- Dec 2018Grant (prize money)$172.8K
#4
Series A · Monza, Lombardy · founded 2010 · 10 employees$8.1Mraised▾
Provider of smart garments for physiological monitoring. The smart garments are composed of textile sensors capable of monitoring and collecting biometric data and parameters of the wearer. The app allows users to view the data collected by the textile and electronic component.
- Aug 2018Series A$8.1M
- Nov 2015Grant (prize money)$52.9K
- May 2015Grant (prize money)$56K
#5
Series A · Turin, Piedmont · founded 2011 · 18 employees$2.4Mraised▾
Biotechware is a business venture which conceived a telemedicine integrated platform for remote cardiac monitoring, aimed at pharmacies. Biotechware solution permits to record a professional grade ECG directly at the pharmacy with a device. The record is then remotely reviewed and reported by a qualified cardiologist and made available to the patient through a secure website. CardioPad Pro is that portable device for professional recording remote electrocardiograms, with cloud platform to store, archive and process data more quickly.
- Oct 2017Series A$2.4M
#6
Seed · Cascina, Tuscany · founded 2009 · 33 employees$1.1Mraised▾
WinMedical offers a platform for remote patient monitoring applications. The solution consists of a small class IIA CE marked wearable sensor unit WinPack that can monitor body vitals like blood pressure, heart rate, respiration rate, SpO2, and body temperature. Different sensor modules can be added or removed from the WinPack depending on the requirement. WinPack can communicate using the WiFi or Bluetooth. The company also provides supporting software called Early Evaluation Center for analysing the data collected by the WinPack. The software is available for hospital and home applications.
- Nov 2011Seed$1.1M
#7
Funding Raised · Milan, Lombardy · founded 2019$30.8Kraised▾
Developer of digital tools and online programs for neurological rehabilitation. The company develops and commercializes technology-driven products and services for individuals with neurological conditions, epilepsy, complex neurological pathologies, and those with special needs. It offers an online platform designed to enhance the skills of young individuals with Cerebral Palsy, motor impairments, and multiple disabilities. Additionally, the company provides tools to assist families in managing epilepsy and supports research initiatives in the field.
- Jun 2022Grant (prize money)$30.8K
#8
Funding Raised · Rome, Lazio · founded 2017 · 6 employees$110.5Kraised▾
Mr. Doc has developed an app is used for the detection of disease conditions and coordinate with a physician. The user has to hold the finger on the smartphone camera to trace the PPG to detect several heart conditions, glycemia, and Parkinson's disease.
- Jan 2020Grant (prize money)$55.1K
- Aug 2019Grant (prize money)$55.4K
#9
Funding Raised · Torino, Piemonte · founded 2016 · 3 employees$167.7Kraised▾
Provider of AI-based smart devices and software solutions for people with motor impairment. It provides a remote sensor device that assists patients to monitor the movement of the arm and hand muscles. The device can be connected to the mobile app via a Bluetooth device that can monitor symptoms like muscle weakness, poor stamina, lack of muscle control, or total paralysis.
- Sep 2017Grant (prize money)$59K
- Jun 2017Grant (prize money)$56.1K
- Jan 2017Grant (prize money)$52.7K
#10
Funding Raised · Rovereto, Trentino South Tyrol · founded 2014 · 4 employees$72.4Kraised▾
Neurab develops and markets Neurotablet, a cognitive rehabilitation tablet app for patients with acquired cognitive impairment. The application trains the patient's different cognitive functions with targeted exercises, utilizing the plasticity of the brain to recover or compensate for lost cognitive abilities. The application is for therapists, health care institutions, and caregivers dealing with the rehabilitation of patients who have suffered brain damage.
- Jul 2017Grant (prize money)$28.4K
- Jul 2016Grant (prize money)$44K
#11
Seed · Rome, Lazio · founded 2015$75Kraised▾
MEMiO is digital health startup that provides mobile app as a solution for medication adherence. Provides a medication reminder service via SMS on a subscription basis. Started with designing IoT that provides the right pill at the right time and is associated with a wearable reminder that activates an acoustic signal to remind the elderly to take the medication on time, but curren;t only App is functional. Winner of InnovAction Lab 2015.
- Dec 2015Angel$60K
- 2015Seed$15K
#12
Deadpooled · Catania, Sicily · founded 2016$44Kraised▾
HelParkinson is a tool for monitoring of patients with neurodegenerative diseases. The platform connects patients and doctors and allows doctors to remotely monitor patients using a webcam. The platform uses "depth room" technology. It allows patients to perform monitoring exercises in front of computer or smart TV. The program records activities, classifies them on the basis of appropriate clinical pattern and send the information to physicians and care givers. A visual symbol notifies patient if he/she in visual range. Patients can monitor their performance and can respond to doctor messages through voice recording. The chat feature allows doctors to communicate with patients anytime. The company states that it will also share data in a completely secure and anonymous manner with research centers to aid in research and development. The company also claims that the interface can be controlled by patients through simple gestures and does not need input devices.
- Jul 2016Grant (prize money)$44K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Disease Self Management coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health is moving in Italy
A read on the academic research around Digital Health — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 1,312 Italy-affiliated papers.
- Ministry of Health313
- Istituti di Ricovero e Cura a Carattere Scientifico51
- Università Cattolica del Sacro Cuore50
- University of Milan41
- Politecnico di Milano39
- Wearable computer1→26
- Health informatics1→17
- Public health1→12
- Remote patient monitoring2→12
- Telemedicine1→11
- Health care4→140
- Health informatics13→78
- Psychological intervention2→47
- Public health6→44
- Telemedicine1→33
- Health care9→190
- Health informatics22→124
- Public health10→92
- Health administration18→95
- Psychological intervention2→65
Where digital health is researched across Italy
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.