Best Disease Self Management Companies in Pennsylvania, United States
The 96 best Disease Self Management companies in Pennsylvania, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Medical Guardian.
Our analysis of 50 Disease Self Management companies
$3.0b in tracked funding; 94% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Disease Self Management companies in Pennsylvania
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Medical Guardian Provider of medical alert system for older adults | $105M | 65 mo ago | Seed | 178 178 → 380 (+113%) | Geoff Gross Founder & CEO | — | 1 job opening |
| 2 | Ebb Therapeutics Provider of IoT-enabled wearables for sleep monitoring | $45M | 113 mo ago | Series B | 13 | Don Spence Member Board Of Directors | — | — |
| 3 | Apollo Neuroscience Developer of wearable technology for stress reduction, sleep improvement, and performance enhancement | $31M | 26 mo ago | Series A | 12 | Kathryn Fantauzzi Co-Founder & CEO | 20 patents Wearable haptic actuators for transcutaneous neuromodulation and sensory stimulation | — |
| 4 | GraphWear Developer of wearable smart patch that tracks hydration levels in real time from sweat | $25M | 56 mo ago | Series B | 27 | Rajatesh Gudibande Co-Founder | — | — |
| 5 | LifeLens Developer of wireless ECG monitor for personal health monitoring use | $25M | 7 mo ago | Series B | 45 | David Robins Co-Founder | 5 patents Patents concentrated in health & consumer products | — |
| 6 | Intelomed Non-invasive sensor platform for cardiovascular monitoring | $13M | 113 mo ago | Series B | 5 | — | 64 patents Non‑invasive pulse‑volume waveform monitoring for respiratory and cardiovascular stress detection | — |
| 7 | Tango belt Provider of wearable belt for hip protection during fall | $10M | 102 mo ago | Series A | 14 | Robert Buckman Co-Founder | — | — |
| 8 | OneTouch Provider of healthcare devices for diabetes management | $7M | 357 mo ago | Series A | — | Valerie Asbury CEO | — | — |
| 9 | Strados Labs Provider of a wearable device for breathing monitoring | $6M | 55 mo ago | Series A | 14 | Yu Au Co-Founder & VP Clinical Affairs | 14 patents AI-powered respiratory and physiological signal detection and analysis for health monitoring | — |
| 10 | Revive Internet first brand offering subscription-based urinary incontinence devices for women | $4M | 47 mo ago | Series A | 4 | Steve Bollinger Founder | 43 patents Modular, portable cardiac defibrillation devices and related software integrity systems | — |
| 11 | Connexion Provider of AI-based solutions and apps for employee wellness | $2M | 100 mo ago | Seed | — | Steven Dailey CEO | — | — |
| 12 | Pinmed Personalized intelligent medicine through hardware, software, and custom solutions | $2M | 143 mo ago | Funding Raised | 2 | — | — | — |
| 13 | NewCare Solutions Home sensors which monitors activities of elderly people and alerts for emergency situation | $2M | 156 mo ago | Deadpooled | 1 | — | 4 patents Patents concentrated in health & consumer products | — |
| 14 | SilentAlert Monitor Home sensors which monitors activities of elderly people and alerts for emergency situation | $2M | 161 mo ago | Deadpooled | 1 | William Kaigler Founder & CEO | — | — |
| 15 | Resilient Lifescience Provider of drug overdose detection device | $2M | 13 mo ago | Seed | 5 | Charlie Proctor Co-Founder | — | — |
| 16 | Wearable Health Solutions Cloud-based platform providing wearable medical alarm system | $2M | 123 mo ago | Public | 11 | — | — | — |
| 17 | Noctem Provider of telemedicine platform to optimise sleep management solutions | $1M | 4 mo ago | Seed | 17 | Anne Germain Founder & CEO | — | — |
| 18 | Cerora Developer of objective biosensor technology for brain health assessment. | $955K | 122 mo ago | Seed | 6 | — | 25 patents Neuro‑ophthalmic eye‑tracking and multimodal brain health diagnostic platforms | — |
| 19 | OhanaLink Technologies SaaS-based digital communication tool for providers and patients | $663K | 37 mo ago | Seed | 11 | Kara Wasser Founder & CEO | — | — |
| 20 | OK2StandUP Provider of AI-based devices for fall prevention in elderly people | $460K | 32 mo ago | Seed | 4 | Eunice Yang Founder & CEO | — | — |
| 21 | Invivomon Blood glucose monitors | $301K | 189 mo ago | Deadpooled | — | Heer Gandhi Lead Engineer And Co-Founder | — | — |
| 22 | DoseCue Medication adherence solution | $296K | 131 mo ago | Deadpooled | — | Mark Burrows President & CEO | 4 patents Smart, data-enabled medication containers and adherence monitoring systems for dose tracking | — |
| 23 | Cogwear Developer of performance and health monitoring headbands | $256K | 42 mo ago | Seed | 7 | Arjun Ramakrishnan Co-Founder | 9 patents Wearable flexible bioelectronic sensors and self‑aligning EEG electrodes for physiological monitoring | — |
| 24 | Hera Global Tech Wearable device and app for PERS | $256K | 70 mo ago | Funding Raised | 6 | Elizabeth Larue Co-Founder | — | — |
| 25 | Vital Start Health Provider of a VR-based platform for maternity wellness | $250K | 50 mo ago | Seed | 3 | John Chuo Co-Founder | — | — |
| 26 | RTM Vital Signs Real-time implantable blood pressure sensor and vital sign monitoring system | $175K | 16 mo ago | Seed | 2 | Jeff Joseph Co-Founder | 47 patents Acoustic respiratory monitoring sensors and implantable cardiovascular monitoring devices | — |
| 27 | AbiliLife Providing comfort and support for patients with neurodegenerative disease | $170K | 116 mo ago | Seed | 1 | Courtney Williamson Founder & CEO | 5 patents Wearable sensor‑embedded physiotherapy vest for ambulatory patient monitoring and feedback | — |
| 28 | InnaMed Provider of a wearable device for blood glucose level monitoring | $155K | 111 mo ago | Deadpooled | 13 | — | 8 patents Patents concentrated in computing, sensing & instrumentation | — |
| 29 | Naima Health Provider of an AI-based patient engagement platform for doctors and patients | $100K | 51 mo ago | Seed | 6 | Alex Davis Co-Founder | — | — |
Top 12 Disease Self Management companies in Pennsylvania
#1
Series B · Warminster, Pennsylvania · founded 2014 · 45 employees$24.6Mraised▾
Developer of wireless ECG monitor for personal health monitoring use. The monitor is indicated for use on patients who may be asymptomatic. It can also be used for patients who may suffer from transient symptoms. These symptoms include palpitations, shortness of breath, dizziness, and fatigue. The monitor is intended for use by patients eighteen years or older. The system is not yet cleared for other indications.
- Nov 2025Series B$15.1M
- Jun 2024Series B$18.4M
- Sep 2021Series A$78.2K
- Jul 2020Series A$3.2M
#2
Seed · Pittsburgh, Pennsylvania · founded 2018 · 17 employees$1.5Mraised▾
Noctem provides a telemedicine platform to optimize sleep management solutions. The company offers a digital platform which helps the practitioners and sleeps clinics to give real-time personalized sleep recommendation solutions to patients for better health outcomes.
- Feb 2026Seed$1.5M
#3
Seed · Pittsburgh, Pennsylvania · founded 2012 · 5 employees$1.8Mraised▾
Provider of drug overdose detection device. The company has developed a wearable medical device to prevent opioid overdose deaths using naloxone.
- May 2025Grant (prize money)$454.5K
- Sep 2024Grant (prize money)$399.6K
- Mar 2024Grant (prize money)$275K
- Dec 2022Seed$600K
#4
Series A · Pittsburgh, Pennsylvania · founded 2017 · 12 employees$30.7Mraised▾
Developer of wearable technology for stress reduction, sleep improvement, and performance enhancement. The product uses gentle vibrations to modulate the vagus nerve, impacting heart rate variability and promoting relaxation and better sleep. It offers various vibration patterns designed to address specific needs, such as stress management, improved focus, and sleep optimization. The technology is backed by scientific research and is intended as a wellness tool to support a healthy lifestyle.
- Apr 2024Series A$500K
- Feb 2023Series A$9.3M
- Mar 2022Series A$15M
- Feb 2021Series A$5.9M
#5
Seed · Philadelphia, Pennsylvania · founded 2005 · 178 employees$105Mraised▾
Provider of medical alert system for older adults. The company has two product lines namely at-home and on-the-go. The at-home products comprise a pendant and a base station. The pendant allows the user to send a wireless signal to the base station, which then uses the landline telephone to alert the monitoring center. The base station features a two-way speaker that allows the user to communicate with an operator to dispatch emergency or non-emergency services. The on-the-go products comprise portable medical alert devices that come with a built-in GPS and an SOS button. The products offered by the company interface with a companion application that enables family members to adapt monitoring parameters to the needs of the resident and can be used as a self-monitored or professionally monitored service.
- Jan 2021Seed—
- Jan 2020Conventional Debt$105M
#6
Seed · Fort Washington, Pennsylvania · founded 2014 · 2 employees$175Kraised▾
RTM has developed a real-time implantable blood pressure sensor and a vital sign monitoring system. The system will continuously monitor the arterial BP waveform and other vital sign data of both ambulatory patients with cardiovascular disease and ambulatory patients at risk for a serious adverse event. The vital sign data will be transmitted to a central monitoring station via a wireless network for clinical interpretation.
- Feb 2025Grant (prize money)$1.7M
- Sep 2023Grant (prize money)$1.7M
- May 2019Grant (prize money)$236.4K
- Oct 2017Seed$175K
#7
Series B · Philadelphia, Pennsylvania · founded 2015 · 27 employees$24.8Mraised▾
GraphWear technologies is a developer of wearable sweat patch that monitors dehydration, glucose and lactic acid, all from users sweat. The sweat sensor is real-time and pairs to a smartphone.
- Oct 2021Series B$20.5M
- Apr 2018Series A$4.2M
- 2016Seed$100K
- Apr 2016Seed—
#8
Series B · Pittsburgh, Pennsylvania · founded 2008 · 13 employees$45Mraised▾
Provider of IoT-enabled wearables for sleep monitoring. The company has developed a wearable insomnia therapy device that reduces the time it takes to fall asleep and enter deep, restorative sleep. The wearable headband has a fluid-filled cushion, to deliver continuous ideal-temperature cooling for comfortable sleep. The system includes a bedside temperature controller for adjustable cooling, headgear, fluid cartridge replenishes cooling fluid and an optional wake-up setting that automatically stops cooling before wake-up time.
- Jan 2017Series B$38M
- Mar 2012Series A$7M
- Apr 2011Grant (prize money)$2M
#9
Series A · Philadelphia, Pennsylvania · founded 2016 · 14 employees$6.4Mraised▾
Provider of a wearable device for breathing monitoring. It monitors the sound of the lungs and alerts the user of the wheezing sounds. This allows the user to manage their symptoms at an early stage and avoid the risk of asthma attacks. Its features include noise-cancelling capabilities, cloud storage, AI-based analytics, clinical record integration, and an integrable mobile application.
- Nov 2021Series A$4.5M
- May 2020Conventional Debt$250K
- Apr 2019Seed$1.9M
- 2018Seed—
#10
Seed · Pittsburgh, Pennsylvania · founded 2017 · 16 employees$25Kraised▾
Behaivior is a provider of devices for deaddiction. It uses pattern-detection and machine learning algorithms for monitoring opioid addiction. Its software takes real-time data streams from wearable devices that detect heart rate, heart rate variability, skin temperature, motion, and galvanic skin response (which is related to stress levels). This data is combined with other digital information about behavior, such as GPS location. As behavior and physiology changes, software screens users for whether or not they are in a pre-relapse craving state, and therefore at higher risk of relapsing in the near future.
- Jan 2025Grant (prize money)$1.7M
- Jan 2025Grant (prize money)$1.7M
- Sep 2022Grant (prize money)$1.7M
- Sep 2020Grant (prize money)$255K
#11
Series B · Wexford, Pennsylvania · founded 2005 · 5 employees$12.5Mraised▾
Non-invasive sensor platform for cardiovascular monitoring. Informatics System is composed of a pulse oximeter and a software application installed and operated on a personal computer. The pulse oximeter device is indicated for use in measuring, displaying and storing functional oxygen saturation of arterial hemoglobin (SpO2) and pulse rate of adult and pediatric patients. It is intended for spot checking and/or data collection and recording of patients who are well or poorly perfused. The intended use environments are hospitals, medical facilities, ambulatory, sub-acute and sleep studies.
- Jan 2017Conventional Debt$502.4K
- Jan 2016Series B$1.9M
- Jul 2014Series B$3.8M
- Sep 2013Series B$4M
#12
Series A · Pittsburgh, Pennsylvania · founded 2018 · 4 employees$3.9Mraised▾
Internet first brand offering subscription-based urinary incontinence devices for women The company offers reusable devices for the prevention of urinary leakage. The device is made of silicone. The company also offers replacement strings. The company offers its products on a monthly subscription basis.
- Jul 2022Series A$3.9M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Disease Self Management coverage by sub-theme.
Regulatory-risk over time falling
Funding & growth over time
funding flat · growth flat
How research on Digital Health in Pennsylvania is moving
A read on the academic research around Digital Health in Pennsylvania — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 75 papers.
University of Pennsylvania and Penn State lead Pennsylvania's digital health research, focusing heavily on mental health interventions and EHR systems, with a contested tone reflecting dominant concern-oriented findings.
- University of Pennsylvania46
- Pennsylvania State University12
- California University of Pennsylvania10
- University of Pennsylvania Health System7
- Hospital of the University of Pennsylvania4
- Informatics4
- Health care4
- Key (lock)3
- Health informatics2
- Workflow1
- Health informatics2→6
- Health care2→8
- Health informatics1→6
- Health administration1→4
- Public health1→4
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.