Best Healthcare Companies in South Dakota, United States
The 56 best Healthcare companies in South Dakota, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Lifescape.
Ranked: Best Healthcare companies in South Dakota
| # | Company | Disclosed funding | Employees | Stage | Founded | Founder | Tech stack | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Monument Health Integrated health care system services provider | — | 2,430 | Funding Raised | 1878 | — | WordPressApple iCloud MailMicrosoft 365+24 | — |
| 2 | Avera Mckennan Provider of resources and support for individuals with intellectual disabilities | $300K | 2,254 | Funding Raised | 2008 | — | — | — |
| 3 | Lifescape Provider of rehabilitation and support services for children and adults with disabilities | $5M | 1,048 | Funding Raised | 2014 | Linwood Thompson Founder & Co-CEO | WordPressApple iCloud MailMicrosoft 365+14 | — |
| 4 | Sioux Falls Specialty Hospital Standalone multispeciality hospital | — | 324 | Unfunded | 1985 | Blake Curd CEO | HubSpot CMS HubApple iCloud MailBootstrap+16 | — |
| 5 | Bethany Lutheran Home Chain of senior living centers | — | 300 | Funding Raised | 1950 | — | Concrete CMSPHPBootstrap+5 | — |
| 6 | Madison Regional Health System Health System | — | 269 | Funding Raised | 1884 | Tamara Miller CEO | WordPress Block EditorWordPressApple iCloud Mail+21 | 1 job opening |
| 7 | Huron Regional Standalone multispeciality hospital | — | 261 | Unfunded | 1978 | David Dick CEO | TypeScriptFacebook LoginMicrosoft ASP.NET+23 | — |
| 8 | PatientCare EMS Solutions Provider of ambulance and healthcare logistic services | — | 246 | Funding Raised | 2018 | Herman Schwarz CEO | WordPressMySQLPHP+22 | 1 partnership · 1 award |
Top 11 Healthcare companies in South Dakota
#1
Funding Raised · Sisseton, South Dakota · founded 2013 · 23 employees$499.8Kraised▾
Coteau Health Care System is a 25-bed, critical access, acute care, community non-profit hospital. We serve approximately 21,000 residents in the Glacial Lakes Region in Northeast South Dakota as well as West Central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton; the Browns Valley Clinic in Browns Valley, Minnesota; and the Rosholt Clinic in Rosholt, South Dakota.
- May 2025Grant (prize money)$499.8K
#2
Acquired · Aberdeen, South Dakota · founded 2014 · 16 employees$2.8Mraised▾
Chain of general clinics
- May 2021Seed$2.8M
#3
Funding Raised · Sioux Falls, South Dakota · founded 2014 · 1048 employees$5.2Mraised▾
Provider of rehabilitation and support services for children and adults with disabilities. Services include inpatient and outpatient rehabilitation programs, specialized therapies (occupational, physical, speech-language), autism services, clinical psychology, and assistive technology. The organization also offers residential services, school-based contracts, and community-based support programs. A subsidiary provides orthotic and prosthetic services, as well as wheelchair and mobility equipment. The organization's mission is to empower individuals to live their best lives.
- Nov 2017Conventional Debt$5.2M
#4
Seed · Sioux Falls, South Dakota · founded 2010$4Mraised▾
MitoGenetics is a US-based company developing mitochondrial therapeutics for chronic metabolic and neurodegenerative diseases. It develops therapeutics for mitochondrial diseases like type 2 diabetes, obesity, heart disease, hypertension, Alzheimer’s and Parkinson’s that have been linked to mitochondrial dysfunction. The company claims that it uses a novel group of patented and patent-pending therapeutic products to manipulate mitochondria. The company is looking for strategic partners from the pharmaceutical industry and venture capital.
- Apr 2016Seed$2.5M
- Mar 2014Seed$1.5M
#5
Seed · Sioux Falls, South Dakota · founded 2012 · 8 employees$630Kraised▾
Developer of healthcare technologies designed to improve patient care. The company designs technological systems that reduce strain on patients and market products and services that assist hospitals, clinics, and ambulatory care centers meet compliance requirements in the area of safe patient handling on patients, enabling medical practitioners to improve patient care and provide a safer workplace for all medical professionals.
- Nov 2015Seed$400K
- Mar 2014Seed$210K
- Oct 2012Seed$20K
#6
Deadpooled · Yankton, South Dakota · founded 2002 · 55 employees$696.7Kraised▾
Provider of healthcare services. The company's healthcare services include in-patient and out-patient treatment services, family medicine clinic, physical therapy clinic and medical imaging services, enabling patients to get a wide range of medical facilities and services.
#7
Funding Raised · Flandreau, South Dakota · founded 2008 · 2254 employees$300Kraised▾
Provider of resources and support for individuals with intellectual disabilities. It offers various programs designed to enhance independence and community integration. The organization focuses on advocacy, education, and residential services. It aims to empower individuals and promote their well-being through personalized assistance.
- Aug 2010Grant (prize money)$300K
#8
Funding Raised · Rapid City, South Dakota · founded 1983 · 31 employees—raised▾
Provider of senior living community services
#9
Funding Raised · Madison, South Dakota · founded 1884 · 269 employees—raised▾
Health System
#10
Funding Raised · Sioux Falls, South Dakota · founded 1950 · 300 employees—raised▾
Chain of senior living centers
#11
Funding Raised · Rapid City, South Dakota · founded 1878 · 2430 employees—raised▾
Monument Health is an integrated health care system with multiple hospitals, specialty centers, clinics, and caregivers, providing coordinated care for better health outcomes.
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Healthcare coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.