Best HealthTech Companies in St. Louis, United States
The 83 best HealthTech companies in St. Louis, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Express Scripts.
Our analysis of 305 HealthTech companies
$32.1b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best HealthTech companies in St. Louis
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Stage | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Express Scripts SaaS-based pharmacy benefit management solutions | $258M | 324 mo ago | 16,291 | — | Cart FunctionalityDrupalApple iCloud Mail+34 | Acquired | 800 patents Pharmacy data integration, inventory management, and real-time analytics for prescription fulfillment | — |
| 2 | Appistry Developer of tools for clinical labs, hospitals to practice genomically enhanced medicine | $44M | 124 mo ago | 16 | Guerry Semones Co-Founder | — | Deadpooled | 21 patents Distributed, fault‑tolerant middleware for request‑process‑task handling in networked computing | — |
| 3 | SteadyMD Telemedicine platform for concierge primary care | $40M | 37 mo ago | 190 | Guy Friedman Co-Founder & CEO | WordPressMySQLPHP+37 | Acquired | — | — |
| 4 | Hicuity Health Provider of patient engagement services | $27M | 35 mo ago | 233 233 → 225 (-3%) | Lou Silverman CEO | WordPressMySQLPHP+27 | Series C | — | — |
| 5 | SentiAR Provider of a 3D visualization platform for interventional cardiac procedures 35Funding top 23%Moat top 25%Talent top 28%Patents top 34% All 9 signals ▾Fundingtop 23% Moattop 25% Talenttop 28% Patentstop 34% Innovationtop 37% Globalbottom 39% Marketbottom 25% Techbottom 22% Newsbottom 22% Funding: Raised $23.3M across 11 rounds · 11 rounds over 9 yrs (1.2/yr) Moat: Editorial + unicorn rating 7/10 · IP moat: 55 patents rank vs industry peers · Fliar Intelligence Index 35/100 | $23M | 1 mo ago | 8 | Michael Southworth Co-Founder | — | Series B | 55 patents Intraoperative AR guidance for cardiac electrophysiology using HMDs, gaze control, and ultrasound. | — |
| 6 | Rezilient Provider of robotic telehealth device and cloud-based software for clinics and patients | $13M | 22 mo ago | 18 | Jeff Gamble Founder & COO | WebflowGSAPLenis+18 | Series A | — | 1 job opening · 2 awards |
| 7 | Sparo App and smart spirometer for detecting lung health | $4M | 95 mo ago | 4 | Abigail Cohen Co-Founder & Co-CEO | — | Acqui-Hired | 18 patents Home-based spirometry devices with gamified data collection and automated analysis | — |
| 8 | Gateway EDI Medical claims processing solutions for health care providers | $3M | 205 mo ago | 300 | — | — | Acqui-Hired | — | — |
| 9 | VedaPointe Digital data exchange and business intelligence platform for healthcare providers | $3M | 23 mo ago | 27 | Glen Schuster CEO | — | Seed | — | 1 partnership |
| 10 | Healthy Bytes Fitness and wellness center | $2M | 70 mo ago | 21 | Amy Roberts Founder & CEO | — | Seed | — | — |
| 11 | NeuroLutions Developer of robotic glove controlled by brain | $2M | 16 mo ago | 9 | Eric Leuthardt Co-Founder | WordPressApple iCloud MailGoogle Workspace+27 | Series A | 70 patents BCI-driven neurorehabilitation and assistive orthotic devices for motor control and pain relief | — |
| 12 | Blue Strata Healthcare technology company providing software and services for care continuum | $2M | 130 mo ago | 11 | — | — | Seed | — | — |
| 13 | Barnes-Jewish Hospital Online platform to find information and book appointments with the doctors | $1M | 24 mo ago | 7,316 | — | DNNMicrosoft ASP.NETBootstrap+17 | Funding Raised | 80 patents Targeted molecular imaging agents and therapeutics for cardiovascular and musculoskeletal diseases | — |
| 14 | HIPAAtrek HIPAA compliance software simplifying policy management, training, and breach risk assessment | $975K | 95 mo ago | 14 | Sarah Badahman Co-Founder | WordPress Block EditorElementorDivi+31 | Seed | — | — |
| 15 | iDocsWeb Telehealth solution for long-term care, skilled nursing facilities, and assisted living | $840K | 94 mo ago | 4 | — | — | Seed | — | — |
| 16 | EDIS Drug data integration platform for pharmaceutical strategy development | $504K | 123 mo ago | 6 | Dan Bemus Co-Founder & Board Member | — | Deadpooled | — | — |
| 17 | Medinexo Telemedicine marketplace platform for providers | $354K | 120 mo ago | 11 | Jorge Toro President & CEO | — | Seed | — | — |
| 18 | Drug Design Methodologies Provider of drug design methodologies with a focus on ligand refinement software | $226K | 100 mo ago | — | Chris Ho Owner | — | Funding Raised | — | — |
| 19 | SanusEO Mobile texting and web services to support population health management | $200K | 119 mo ago | 11 | — | — | Deadpooled | — | — |
| 20 | nimble Provider of revenue cycle management solutions for surgical clinics | $150K | 199 mo ago | 237 | Nader Samii CEO | WordPress Block EditorCart FunctionalityWooCommerce+35 | Funding Raised | 12 patents Digital pharmacy validation and remote subscription management platforms for e‑commerce transactions | 1 job opening |
| 21 | Provider Pool On-demand recruitment platform provider | $100K | 57 mo ago | 4 | — | — | Deadpooled | — | — |
Top 12 HealthTech companies in St. Louis
#1
Series B · St. Louis, Missouri · founded 2017 · 8 employees$23.3Mraised▾
Provider of a 3D visualization platform for interventional cardiac procedures. Using a head-up display, it enables a clinician to see the anatomic model and allows for accurate and safe procedures.
- Apr 2026Series B$1.5M
- Apr 2025Series B$2.5M
- Apr 2023Series B$8.5M
- Apr 2021Series A$5.1M
#2
Series A · St. Louis, Missouri · founded 2016 · 18 employees$12.6Mraised▾
Rezilient provides robotic telehealth devices for clinics. The physicians can assume control of a mobile medical robot in the network, allowing them to deliver telehealthcare physically. Through this device, doctors can perform physical assessments through video conferencing.
- Aug 2024Series A$10M
- Aug 2021Seed$2.5M
- Sep 2020Seed$120K
#3
Series A · St. Louis, Missouri · founded 2007 · 9 employees$2Mraised▾
NeuroLutions is developing devices based on brain-computer interface technology restoring functions in patients disabled due to neurological injury. It is developing a robotic glove that the user can wear it on their hand and a headset.
- Feb 2025Series A$26.5M
- Sep 2022Grant (prize money)$2M
- Jun 2015Seed$1.1M
- Nov 2008Seed$625K
#4
Acquired · St. Louis, Missouri · founded 2016 · 190 employees$39.5Mraised▾
SteadyMD is a telemedicine platform that aims to provide concierge primary care services to users via chat, video, or phone call. The company promises a dedicated doctor who gets to know the patient closely and becomes a personal medical advisor. In addition, the platform stores all the data on consultations and provides a place for users to store information on weight, blood pressure, and other vitals.
- May 2023Series C—
- Mar 2021Series B$28M
- Apr 2020Series A$6M
- Sep 2019Series A$2.6M
#5
Series C · St. Louis, Missouri · founded 2004 · 233 employees$27.4Mraised▾
Provider of patient engagement services
- Jun 2023Series C—
- Mar 2016Series C$11.5M
- Jul 2015Series C$7.3M
- Feb 2014Unattributed$241K
#6
Seed · St. Louis, Missouri · founded 2019 · 27 employees$2.7Mraised▾
Digital data exchange and business intelligence platform for healthcare providers. The company has developed software that enables users to exchange clinical and administrative healthcare data with each other. It has features for customizing platforms, data collection, data access, and more.
- Jul 2024Seed$2.7M
#7
Acquired · St. Louis, Missouri · founded 1986 · 16291 employees$258.2Mraised▾
SaaS-based pharmacy benefit management solutions. The company provides pharmacy benefit management services to help manage prescription drug benefits for health plans, employers, and government programs.
- Jun 1999Conventional Debt$250M
- Conventional Debt$8.2M
#8
Funding Raised · St. Louis, Missouri · founded 1996 · 7316 employees$1.4Mraised▾
Online platform to find information and book appointments with the doctors. The platform enables users to discover information on doctors based on their medical profession and address. Also, it provides medical information on diseases, healthcare supplements, tests & procedures and many more.
- 2024Grant (prize money)$59.5K
- 2023Grant (prize money)$57K
- 2022Grant (prize money)$15.9K
- 2021Grant (prize money)$16.4K
#9
Deadpooled · St. Louis, Missouri · founded 2001 · 16 employees$44.3Mraised▾
Appistry tools streamline the analysis of genomic data and make it easier for clinical labs, research institutions, and hospital practices to act on. The company provides CloudDx, a cloud-based system that helps institutions conduct patient-centered translational research and hospitals to implement genome-scale tests based on next-generation sequencing (NGS) into routine patient care. The company also offers Cancer Genome Analysis Suite that provides a set of integrated tools to address issues in getting results from cancer genome NGS datasets.
- Jan 2016Series E$4.1M
- Feb 2015Conventional Debt$10.2M
- Feb 2014Conventional Debt$10.3M
- Aug 2013Series E$4.9M
#10
Acqui-Hired · St. Louis, Missouri · founded 2012 · 4 employees$4.5Mraised▾
Sparo has developed an app and smart spirometer for detecting lung health. The smart portable spirometer called Wing is used to measure the lung health (FEV1 and Peak Flow) and is connected to the app which alerts the user in case of respiratory disorders. The data can be stored in the cloud and shared with care team for medication advice, emergency, or rehabilitation.
- Jun 2018Seed$1.9M
- Aug 2017Seed$265.9K
- Aug 2017Seed$265.9K
- Sep 2016Seed$487.8K
#11
Seed · St. Louis, Missouri · founded 2013 · 21 employees$2.2Mraised▾
Operator of technology-enabled, health care services intended to provide a healthy lifestyle through nutritional counseling. The company's platform lets dietitians see what, when, where, and why their clients are eating and thus seek medical care for diabetes, high blood pressure, cardiovascular disease, and orthopedic issues, enabling dietitians to help clients to achieve a healthy lifestyle without any additional cost by utilizing their own health benefits.
#12
Acqui-Hired · St. Louis, Missouri · founded 1983 · 300 employees$2.8Mraised▾
Gateway EDI, formerly known as Office Tech provides medical claims processing solutions for health care providers. Offers products to simplify claims reimbursement and revenue management. The company’s solutions provide electronic claims processing, real-time eligibility verification, point-and-click access to identify and recover missing revenue, automate secondary claims and electronic remittance advice and tools to ease patient payment collection. Acquired by Trizetto in February, 2011.
- Apr 2009PE$2.8M
- Jan 2009PE—
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of HealthTech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health is moving in the United States
A read on the academic research around Digital Health — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,843 United States-affiliated papers.
- Design Intelligence421
- Harvard University383
- Johns Hopkins University295
- University of North Carolina at Chapel Hill206
- University of Washington173
- Health care9→240
- Wearable computer6→129
- Health informatics25→140
- Remote patient monitoring11→76
- Informatics10→60
- Health care36→766
- Health informatics113→495
- Psychological intervention20→320
- Public health34→290
- Intervention (counseling)5→193
- Health care98→1170
- Health informatics213→712
- Public health73→525
- Psychological intervention26→368
- Health administration110→363
Where digital health is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing medical devices patents in the United States
United States medical devices patent filing is accelerating — 666,693 filings from 8,000 assignees (2016–2025), led by Covidien, Boston Scient Scimed, Medtronic; annual filings 63466→63610.
- Covidien29348
- Boston Scient Scimed24762
- Medtronic22394
- Becton Dickinson18249
- Procter & Gamble16178
- Ethicon ENDO Surgery13723
- Kimberly Clark12440
- Ethicon11761
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.