Best Nanotechnology Companies in Massachusetts, United States
The 83 best Nanotechnology companies in Massachusetts, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: 6K.
Our analysis of 50 Nanotechnology companies
$6.5b in tracked funding; 78% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Nanotechnology companies in Massachusetts
| # | Company | Disclosed funding | Last round | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|
| 1 | 6K Provider of nanotechnology-based metal powders 60Funding top 15%Talent top 28%Moat top 31%Tech top 34% All 8 signals ▾Fundingtop 15% Talenttop 28% Moattop 31% Techtop 34% Growthtop 47% Marketbottom 41% Globalbottom 37% Newsbottom 21% Funding: Raised $300M across 17 rounds · 17 rounds over 12 yrs (1.4/yr) Talent: 3 named leaders on record · 3 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 60/100 | $300M | 23 mo ago | 62 62 → 153 (+147%) · sector median +56% | Awanish Raj Co-Founder & CTO | — | — |
| 2 | Aura Biosciences Provider of therapies to target and destroy cancer cells | $215M | 63 mo ago | 21 | — | 98 patents Viral nanoparticle platforms for cancer immunotherapy, diagnostics, and HPV vaccine delivery | — |
| 3 | Aspen Aerogel Provider of thermal insulation solutions | $198M | 59 mo ago | 548 548 → 454 (-17%) · sector median +56% | Donald Young President and CEO | — | 1 award |
| 4 | Aera Developer of genetic medicines across a wide range of therapeutic areas | $193M | 40 mo ago | 70 | Feng Zhang Founder | 2 patents Deployable-wing UAVs and modular aerial vehicle structures for compact storage | — |
| 5 | Nantero Ankle and Foot Center of Tampa Bay providing specialized podiatric care | $155M | 76 mo ago | 50 | — | 782 patents Carbon‑nanotube resistive RAM and 3D in‑memory computing architectures | — |
| 6 | QD Vision Offers quantum dot technology solutions for display applications | $134M | 127 mo ago | 14 | — | 552 patents Near‑eye AR/VR holographic displays and smart electrochromic eyewear technologies. | — |
| 7 | Kala Pharmaceuticals Developer of ophthalmic treatments based on its mucosal penetrating product platform 45Funding top 22%Product top 24%Talent top 33%News top 34% All 12 signals ▾Fundingtop 22% Producttop 24% Talenttop 33% Newstop 34% Moattop 35% Patentstop 37% Innovationtop 41% Techbottom 49% Marketbottom 42% Growthbottom 42% Globalbottom 40% Fin. healthbottom 36% Funding: Raised $115M across 14 rounds · 14 rounds over 17 yrs (0.8/yr) Product: 2 distinct product lines · Company stage: Public rank vs industry peers · Fliar Intelligence Index 45/100 | $115M | 3 mo ago | 34 34 → 80 (+135%) · sector median +56% | Justin Hanes Co-Founder | 267 patents Ocular drug formulations, crystalline therapeutics, and mucosal nanoparticle delivery systems. | — |
| 8 | RainDance Developer of nucleic acid detection and quantification systems | $112M | 147 mo ago | 105 | Kathy Ordonez CEO | 127 patents Microfluidic droplet platforms for digital PCR and single‑molecule/particle analysis | — |
| 9 | Dicerna Pharmaceuticals Developer of drugs by using RNA interference technology platform | $106M | 90 mo ago | 337 | — | 992 patents RNAi therapeutics targeting disease-related genes for metabolic and infectious disorders | — |
| 10 | ZwitterCo Manufacturer of wastewater treatment systems using membrane technology 60Funding top 24%Product top 30%Innovation top 33%Moat top 37% All 11 signals ▾Fundingtop 24% Producttop 30% Innovationtop 33% Moattop 37% Techtop 38% Talenttop 38% Patentstop 39% Growthtop 40% Globalbottom 39% Marketbottom 38% Newsbottom 21% Funding: Raised $102M across 5 rounds · 5 rounds over 6 yrs (0.8/yr) Product: 8 distinct product lines · Company stage: Series B rank vs industry peers · Fliar Intelligence Index 60/100 | $102M | 23 mo ago | 57 57 → 86 (+51%) · sector median +56% | Christopher Drover Co-Founder & CTO | 14 patents Zwitterionic cross‑linkable polymers for advanced filtration and ion‑exchange membranes. | 1 launch |
| 11 | Cerulean Pharma Making Nanoparticle-Drug Conjugates (NDCs) designed to target tumors, reduce toxicity, and enable combinations | $89M | 116 mo ago | 20 | — | 247 patents Cyclodextrin‑based polymer drug conjugates for targeted delivery and autoimmune therapy | — |
| 12 | actnano Provider of nanocoatings for diversified applications 62Patents top 24%Moat top 25%Funding top 26%Innovation top 27% All 10 signals ▾Patentstop 24% Moattop 25% Fundingtop 26% Innovationtop 27% Growthtop 31% Techtop 49% Marketbottom 43% Newsbottom 42% Globalbottom 42% Talentbottom 40% Patents: 54 patents matched (strict assignee match) · 49 filings since 2022 vs 5 in 2017-21 Moat: Editorial + unicorn rating 7/10 · IP moat: 54 patents rank vs industry peers · Fliar Intelligence Index 62/100 | $82M | 20 mo ago | 45 45 → 98 (+118%) · sector median +56% | Taymur Ahmad Founder and CEO | 54 patents Polymer surface coatings that reduce friction/stiction and provide anti‑fog performance. | — |
| 13 | Helicos BioSciences DNA-sequencing instrument based on imaging individual DNA molecules. | $77M | 192 mo ago | 12 | — | 241 patents High-throughput nucleic acid sequencing, single‑cell analysis, and synthetic nucleotide technologies | — |
| 14 | ReadCoor Innovating single-cell, spatial, and in situ biology tools for researchers | $56M | 77 mo ago | 53 | — | 29 patents Spatial genomics: high‑resolution mapping of DNA/RNA variants in tissue sections | 1 partnership |
| 15 | Phio Pharmaceuticals Developer of RNAi-based therapeutics for cancer immunology | $55M | 36 mo ago | 12 12 → 16 (+33%) · sector median +56% | — | — | — |
| 16 | Nanoramic Provider of nanotech based electrode materials for supercapacitors 72Growth top 17%Funding top 19%Patents top 26%Moat top 28% All 10 signals ▾Growthtop 17% Fundingtop 19% Patentstop 26% Moattop 28% Talenttop 28% Innovationtop 31% Newstop 34% Marketbottom 47% Globalbottom 40% Techbottom 33% Growth: Headcount 39 → 66 (+69%) across vintages · Fresh capital in last 24 mo Funding: Raised $49.6M across 24 rounds · 24 rounds over 16 yrs (1.5/yr) rank vs industry peers · Fliar Intelligence Index 72/100 | $50M | 7 mo ago | 66 66 → 50 (-24%) · sector median +56% | John Cooley Founder & CEO | 36 patents Advanced electrode designs and binders for high‑performance rechargeable battery storage | — |
| 17 | TransMolecular Provider of tumor specific drug delivery technology | $48M | 208 mo ago | 7 | — | 50 patents Chlorotoxin-based drug delivery systems targeting metastatic and angiogenic tumors | — |
| 18 | Metalenz Manufacturer of meta-optic materials for multiple applications | $47M | 44 mo ago | 26 26 → 42 (+62%) · sector median +56% | Robert Devlin Co-Founder & CEO | 78 patents Metasurface-based polarization control for imaging, projection, and depth-sensing optics | — |
| 19 | PixarBio Trusted online lottery site offering Toto Macau 4D with fast deposits | $42M | 100 mo ago | 23 | — | 38 patents Injectable neuro‑scaffolds and NaV1.7‑targeted analgesic compounds for pain and spinal injury treatment | — |
| 20 | Chasm Technologies Manufacturer of carbon nanotechnology materials for various applications and industries 29Funding top 31%Moat top 39%Tech top 50%Talent bottom 49% All 9 signals ▾Fundingtop 31% Moattop 39% Techtop 50% Talentbottom 49% Growthbottom 41% Globalbottom 37% Partnersbottom 35% Newsbottom 34% Marketbottom 33% Funding: Raised $33.7M across 7 rounds · 7 rounds over 10 yrs (0.7/yr) Moat: Editorial + unicorn rating 7/10 · 9 curated direct competitors tracked rank vs industry peers · Fliar Intelligence Index 29/100 | $34M | 21 mo ago | 28 28 → 29 (+4%) · sector median +56% | David Arthur CEO / Co-Founder | — | — |
| 21 | N12 Technologies Manufactures advanced composite reinforced products. | $30M | 129 mo ago | 22 | — | 5 patents Cartridge-based nanostructured thin‑film dispensing and nanoreinforced composite manufacturing | — |
| 22 | Nanoscale Comp Manufacturer of nanotech-based ultracapacitors | $29M | 55 mo ago | 9 | Ron Wohl CEO | — | — |
| 23 | Nano Terra Provides coating products for multiple industries | $26M | 105 mo ago | 18 | George Whitesides Co-Founder | 96 patents Wearable foot sensors and customizable insoles for gait and pressure monitoring | — |
| 24 | Apogee Intradermal drug delivery system using nanotechnology and MEMS | $23M | 177 mo ago | — | Herbert Stein Chairman & CEO | 54 patents Patents concentrated in health & consumer products | — |
| 25 | Minerva Biotechnologies Developer of cell therapy and antibodies to treat cancer | $19M | 31 mo ago | 24 | — | 480 patents Therapeutic/diagnostic MUC1 antibodies, NME7 bacterial enzymes, stem‑cell dopaminergic neuron production | — |
| 26 | Xtalic Nanostructured metal alloys for sustainable, high-performance applications | $18M | 80 mo ago | 20 20 → 45 (+125%) · sector median +56% | — | 149 patents Nanocrystalline metal alloy coatings for magnetic inductors and wireless power transfer | — |
| 27 | Alnylam Developer of RNA interference-based therapeutics for multiple disorders | $17M | 70 mo ago | 2,100 2,100 → 2,892 (+38%) · sector median +56% | Paul Schimmel Co-Founder | — | — |
| 28 | Aphios Developer of therapeutic products and enabling technology platforms for healthcare | $17M | 20 mo ago | 12 | — | 81 patents Pathogen inactivation in blood products and nanotech drug delivery for cannabinoids | — |
| 29 | NBD Nanotechnology Provider of surface nanocoatings with diversified properties | $17M | 63 mo ago | 10 | Tyler Graf Founder/Chief Technology Officer | — | — |
| 30 | NanoView Biosciences Provider of a nanotechnology based molecular diagnostic platform | $16M | 51 mo ago | 24 | — | — | — |
| 31 | SunDensity Provider of nanotech-enabled PV coatings | $14M | 55 mo ago | 11 | Nishikant Sonwalkar Founder & President | 18 patents Patents concentrated in electrical & electronics | — |
| 32 | Osmoses Producer of molecular filters | $14M | 32 mo ago | 11 | Zachary Smith Co-Founder | 5 patents Advanced ladder polymer hollow‑fiber membranes for high‑performance fluid separation | — |
| 33 | Adaptive Surface Producer of materials and coatings that repel fluids | $9M | 51 mo ago | 9 | David Ward Co-Founder & CEO | 42 patents Patents concentrated in chemistry & materials | — |
| 34 | Signa Blok Developer of peptide therapeutics targeting receptor signaling 32Funding top 42%Innovation top 43%Product bottom 44%Market bottom 37% All 5 signals ▾Fundingtop 42% Innovationtop 43% Productbottom 44% Marketbottom 37% Globalbottom 29% Funding: Raised $7.3M across 15 rounds · 15 rounds over 14 yrs (1.1/yr) Innovation: 2 product lines rank vs industry peers · Fliar Intelligence Index 32/100 | $7M | 14 mo ago | — | — | — | — |
| 35 | Emitech Developer of electronic devices based on nanomaterials & nanocomposites | $5M | 15 mo ago | — | Igor Levitsky Co-Founder | 6 patents Optical porous photonic‑crystal chemoresistive sensors for vapor and particulate detection | — |
| 36 | Entrega Technology for oral delivery of complex payloads | $5M | 102 mo ago | — | Daphne Zohar Founder & CEO | 33 patents Ionically chargeable hydrogel oral dosage forms for enhanced drug delivery | — |
| 37 | TenasiTech Additives for high performance composite polymers with Nano technology | $4M | 132 mo ago | 2 | Richard Marshall CEO | — | — |
| 38 | Metalmark Developer of 3D nanostructured ceramic coatings for air purification | $4M | 51 mo ago | 3 | Sissi Liu CEO & Co-Founder | — | — |
| 39 | Optodot Developerof nanoporous separators for batteries | $4M | 92 mo ago | 11 | Steve Carlson President & CEO | 136 patents Nanoporous battery separators with integrated electrode coatings and enhanced thermal conductivity | — |
| 40 | Privo Technologies Provider of nanotechnology-based drug delivery systems | $3M | 58 mo ago | 10 | — | 2 patents Targeted microparticle drug delivery and cell-based injection therapeutics. | — |
| 41 | Novarials Manufacturer of inorganic nanowires nanotubes and various other nanomaterial products | $3M | 132 mo ago | — | Xinjie Zhang Founder & President | 7 patents Ceramic nanowire separators and membranes for high‑performance batteries and filtration | — |
| 42 | Vuronyx Technologies Technology based on Joule heating to produce carbon fiber | $2M | 72 mo ago | — | Sandip Agarwal Founder & CEO | — | — |
| 43 | Vivtex Developer of oral drug delivery system | $2M | 46 mo ago | 10 10 → 23 (+130%) · sector median +56% | Douglas Eby Co-Founder & CEO | 9 patents Mucosal drug delivery formulations enhancing therapeutic agent permeation and mucopenetration. | — |
| 44 | Molecular Loop Developer of technology for targeted DNA sequencing | $2M | 52 mo ago | 12 | Greg Porreca Founder and CEO | 17 patents Genomic sequencing and structural variant detection using multiplex nucleic acid methods | — |
| 45 | Magnolia Solar Manufacturing thin film solar cell modules | $2M | 164 mo ago | — | — | 22 patents Patents concentrated in electrical & electronics | — |
| 46 | Spero Devices Provider of CMOS nanotechnology co-processors for mobile devices | $1M | 77 mo ago | 5 | Jai Gupta Co-Founder & CEO | — | — |
| 47 | Advanced Silicon Group Innovating biosensor technology for faster, cheaper, and multiplexed protein analysis | $1M | 25 mo ago | 6 | Marcie Black Co-Founder & CEO | — | — |
| 48 | Novopyxis Provider of nanotech-based drug delivery systems | $856K | 72 mo ago | 4 | Daniel Vannoni Chairman and Co-Founder | 37 patents Aerosol drug delivery systems for AT2R-modulating therapeutics | — |
| 49 | Bandgap Engineering Solutions for Nano-structuring of Si | $750K | 177 mo ago | 3 | Chris Hobson Founder | — | — |
| 50 | NanoLab Manufacturer of carbon based nano-materials | $534K | 196 mo ago | 4 | — | 23 patents Advanced wear‑monitoring sensors for bearings, nanostructured chemical sensors, and transparent conductive films | — |
Top 12 Nanotechnology companies in Massachusetts
#1
Public · Waltham, Massachusetts · founded 2009 · 34 employees$115.5Mraised▾
Developer of ophthalmic treatments based on its mucosal penetrating product platform. It offers therapies for severe ophthalmic diseases. The company’s MPP drug delivery technology platform allows therapeutic agents to pass through the mucus layer(tears) of the ocular surface, facilitating penetration into deeper tissues of the eye, including the aqueous humor and retina. Its solutions are used in treating severe ophthalmic diseases, including ocular inflammation and wet age-related macular degeneration. Its drug pipeline includes KPI-121, an ophthalmic MPP suspension in development for the treatment of post-surgical inflammation , dry eye , meibomian gland disease. Also developing MPP based topical drugs for AMD (orphan indication). It has applications in the treatment of both anterior and posterior chamber eye diseases.
- Mar 2026Post IPO$1.8M
- Jan 2026Post IPO$2.3M
- Dec 2024Post IPO$10.8M
- Jun 2024Post IPO$12.5M
#2
Series E · Boston, Massachusetts · founded 2009 · 66 employees$49.6Mraised▾
Provider of nanotech based electrode materials for supercapacitors. It offers nanotech-enabled electrodes, ultracapacitors, and thermal interface gap filler pads for electric vehicle batteries. Its features include low cost, high cell-level energy density, fast charging performance, thermal interface gap filler and roll-to-roll coating, and calendering equipment.
- Nov 2025Series E$54M
- Sep 2025Series D—
- Apr 2025Grant (prize money)$47.5M
- Jan 2025Grant (prize money)$47.5M
#3
Series E · North Andover, Massachusetts · founded 2011 · 62 employees$300.3Mraised▾
Provider of nanotechnology-based metal powders. It develops microwave-based plasma technology to develop nano metal powders. It has applications in additive manufacturing, batteries, lighting and display materials, semiconductor CMP, federal and defense specialties, ceramics, advanced coatings, and nano-engineered powders.
- Jul 2024Series E$82M
- Dec 2023Grant (prize money)$50M
- Dec 2023Grant (prize money)$23.4M
- Oct 2023Grant (prize money)$50M
#4
Series C · Cambridge, Massachusetts · founded 2012 · 45 employees$82.2Mraised▾
Provider of nanocoatings for diversified applications. It develops environmental resistant coatings. This includes consumer electronics, where it creates a durable barrier that conducts electricity, does not trap heat, has no keep-out areas, and is highly reworkable. It prevents the buildup of light-obstructing agents in solar panels. It also finds similar applications in automotive, wearables, and textiles.
- Oct 2024Series C$3M
- Mar 2024PE$40M
- Nov 2022Series B$8M
- Jan 2022Series B—
#5
Series B · Somerville, Massachusetts · founded 2018 · 57 employees$101.7Mraised▾
Zwitter manufactures wastewater treatment systems using membrane technology. Uses nanofiltration technology that claims to stop 98% of organic molecules, enabling efficient water recycling and reducing fouling of membranes in industrial water treatment applications. Has nanoscale pores that are built from self-assembling zwitterionic polymers.
- Jul 2024Series B$58.4M
- May 2022Series A$33.4M
- Mar 2021Seed$5.9M
- Oct 2020Seed$1.9M
#6
Series C · Westwood, Massachusetts · founded 2005 · 28 employees$33.7Mraised▾
Manufacturer of carbon nanotechnology materials for various applications and industries. The company provides materials for transparent heaters used in automotive and industrial settings. It also offers materials for transparent antennas, EMI shielding, low carbon cement, and battery applications. These materials cater to industries including commercial and industrial concrete, automotive, and consumer electronics.
- Sep 2024Series C$5M
- Mar 2023Conventional Debt$8.3M
- Jul 2021Series C$15.3M
- Jan 2021Grant (prize money)$500K
#7
Funding Raised · Shrewsbury, Massachusetts · founded 2009$7.3Mraised▾
Developer of peptide therapeutics targeting receptor signaling. The company's core therapeutic focus is on cancer, atherosclerosis, inflammation, and immune disorders. Their therapeutic modality is derived from work on their proprietary model of cellular signaling called Signaling Chain Homo-Oligomerization (SCHOOL), which has enabled the company to develop a new class of peptides that are designed to allosterically disrupt ligand-receptor recognition and/or interaction and thereby modulate the signaling through the receptor.
- Apr 2025Grant (prize money)$1.1M
- Sep 2023Grant (prize money)$278.1K
- Aug 2023Grant (prize money)$272.7K
- Sep 2020Grant (prize money)$249.6K
#8
Funding Raised · Boston, Massachusetts · founded 1993 · 12 employees$16.9Mraised▾
Developer of therapeutic products and enabling technology platforms for healthcare. The company focuses on advancing health through sustainable science, integrating green enabling technology platforms with biotechnology. These platforms improve drug discovery and manufacturing, nanotechnology drug delivery, and pathogen safety. The company develops therapeutics for cancer, infectious diseases, and central nervous system disorders.
- Sep 2024Grant (prize money)$504.7K
- Sep 2023Grant (prize money)—
- Jul 2023Grant (prize money)$335.7K
- Mar 2023Grant (prize money)$600K
#9
Funding Raised · Fall River, Massachusetts · founded 2002$5.3Mraised▾
Emitech is a developer of electronic devices based on nanomaterials & nanocomposites. It claims to develop electronic devices such as chemical nanosensors, photodetectors, hybrid photovoltaics, transparent conductive coating, electro, and optomechanical actuators. The product offered is 'chemical nanosensors' (based on nanoporous photonic crystals infiltrated with sensory fluorescent organics). Offers IR Photodetectors, Bolometers, Polymer Actuators and Field Effect Transistors based on carbon nanotubes, Solar Cells based on organic-inorganic nanocomposites, and many more.
- Mar 2025Grant (prize money)$2.5M
- Sep 2020Grant (prize money)$2.8M
#10
Series B · Boston, Massachusetts · founded 2021 · 70 employees$193Mraised▾
Developer of genetic medicines across a wide range of therapeutic areas. The company is leveraging its proprietary protein nanoparticle (PNP) delivery platform to unlock the full potential of genetic medicines across more disease areas.
- Feb 2023Series A—
- Feb 2023Series B$193M
#11
Public · Marlborough, Massachusetts · founded 2012 · 12 employees$55Mraised▾
Developer of RNAi-based therapeutics for cancer immunology. The company is developing therapeutics that leverage a self-delivering technology to target both tumor and immune cells. It has developed a pipeline of RNA inference (RNAi) therapies for the treatment of disorders such as alopecia areata, warts, and cutaneous metastases of melanoma.
- Jun 2023Post IPO$3M
- Apr 2023Post IPO$4M
- Jan 2021Post IPO$14M
- Apr 2020Post IPO$4.4M
#12
Public · Northborough, Massachusetts · founded 2001 · 548 employees$198.3Mraised▾
Provider of thermal insulation solutions. It provides aerogel-based solutions for energy conservation and asset protection applications.
- Jul 2021Post IPO$75M
- May 2016Grant (prize money)$2.8M
- May 2016Grant (prize money)$1.2M
- Apr 2013Series B$12M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Nanotechnology coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Nanomaterials in Massachusetts is moving
A read on the academic research around Nanomaterials in Massachusetts — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 244 papers.
- Massachusetts Institute of Technology149
- University of Massachusetts Amherst48
- Massachusetts General Hospital20
- University of Massachusetts Lowell17
- University of Massachusetts Boston5
- Nanoparticle12→34
- Plasmon1→7
- Quantum dot4→9
- Drug delivery4→7
- Photonics1→4
- Particle (ecology)1→4
- Catalysis2→5
- Quantum dot2→4
- Nanostructure1→3
- Nanoparticle8
- Nanotechnology5
- Nanomedicine4
- Drug delivery4
- Pharmacology3