Best Neurology Companies in San Francisco, United States
The 82 best Neurology companies in San Francisco, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Denali Therapeutics.
Our analysis of 50 Neurology companies
$7.4b in tracked funding; 74% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Neurology companies in San Francisco
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Denali Therapeutics Developer of therapies to treat neurodegenerative diseases | $347M | 27 mo ago | 377 377 → 582 (+54%) | 2015 | Alexander Schuth Co-Founder | WordPressApple iCloud MailTypeScript+24 | 1,002 patents Neurodegenerative antibody therapies and enzyme‑fusion biologics for lysosomal disease treatment | — |
| 2 | Neurona Therapeutics Developer of cell-based therapies to treat intractable neurological diseases 55Funding top 22%Moat top 31%Growth top 32%AI top 45% All 8 signals ▾Fundingtop 22% Moattop 31% Growthtop 32% AItop 45% Talentbottom 49% Marketbottom 43% Globalbottom 39% Techbottom 30% Funding: Raised $316M across 9 rounds · 9 rounds over 18 yrs (0.5/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 55/100 | $316M | 14 mo ago | 67 67 → 116 (+73%) | 2008 | Cory Nicholas CEO | Apple iCloud MailApache HTTP ServerMicrosoft Advertising+5 | — | 1 award |
| 3 | Merge Labs Developer of brain-computer interfaces to maximize human ability, agency, experience 48Talent top 28%Funding top 31%AI top 45%Patents top 49% All 8 signals ▾Talenttop 28% Fundingtop 31% AItop 45% Patentstop 49% Innovationbottom 49% Techbottom 45% Globalbottom 42% Marketbottom 31% Talent: 3 named leaders on record · 3 C-suite/founder profiles curated Funding: Raised $250M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) rank vs industry peers · Fliar Intelligence Index 48/100 | $250M | 5 mo ago | — | 2025 | Sumner Norman Co-Founder | Apple iCloud MailGoogle WorkspaceNode.js+9 | 40 patents Real-time multi-user AR streaming and collaborative 3D object interaction | — |
| 4 | Alector Developing immuno-modulatory therapies for dementia and other neurodegenerative disorders | $215M | 94 mo ago | 211 211 → 140 (-34%) | 2013 | — | DrupalApple iCloud MailMicrosoft 365+26 | 611 patents Therapeutic antibodies targeting neurodegeneration and immune modulation proteins. | — |
| 5 | Unity Biotechnology Developer of therapeutics solutions for numerous diseases of aging | $206M | 70 mo ago | 32 | 2009 | Jan Van Deursen Cofounder | DrupalPHPAmazon Web Services+20 | 244 patents Senolytic drugs and Tie‑2/VEGF antibodies for treating ocular vascular diseases | — |
| 6 | Tenvie Developer of small molecule therapies for neurological, cardiometabolic, and ophthalmic diseases | $200M | 17 mo ago | — | 2012 | Brian Cuneo Co-Founder & CLO | — | — | 4 job openings |
| 7 | ESCAPE Bio Developer of therapeutic solutions for treating genetic neurodegenerative diseases | $167M | 69 mo ago | 39 | 2015 | Julie Smith CEO | — | — | — |
| 8 | Alto Neuroscience AI-driven drug discovery platform for neurological diseases based on patients biomarkers 72Funding top 12%Patents top 25%Growth top 30%Moat top 32% All 11 signals ▾Fundingtop 12% Patentstop 25% Growthtop 30% Moattop 32% Innovationtop 33% Techtop 45% AItop 45% Globalbottom 49% Talentbottom 49% Newsbottom 44% Marketbottom 40% Funding: Raised $145M across 9 rounds · 9 rounds over 7 yrs (1.3/yr) Patents: 57 patents matched (strict assignee match) · 57 filings since 2022 vs 0 in 2017-21 rank vs industry peers · Fliar Intelligence Index 72/100 | $145M | 3 mo ago | 34 | 2019 | Amit Etkin Founder & CEO | BugHerdApple iCloud MailGoogle Workspace+15 | 57 patents Biomarker-guided neuropsychiatric therapeutics targeting depression and anhedonia | 1 award |
| 9 | Nura Bio Provider of solution for diagnosis of a neurological disorder and neuroprotective medicines | $141M | 21 mo ago | 25 | 2018 | Marc Freeman Co-Founder | — | — | — |
| 10 | Verge Genomics Developer of artificial intelligence powered platform for drug discovery and development | $134M | 54 mo ago | 46 46 → 27 (-41%) | 2015 | Peyton Huang Non-Executive Director and Co-Founder | — | — | 1 launch · 1 partnership |
| 11 | Blackthorn Therapeutics Developer of therapeutics for neurodevelopmental disorders | $130M | 84 mo ago | 38 | 2014 | — | — | — | — |
| 12 | Cortexyme Developer of therapeutics to treat neurodegenerative diseases | $108M | 76 mo ago | 21 | 2012 | Casey Lynch Co-Founder & CEO | — | 82 patents Gingipain enzyme inhibitors for treating periodontal and neurodegenerative diseases | — |
| 13 | Ambagon Developer of small-molecule therapeutics for the treatment of cancer | $103M | 16 mo ago | 49 | 2020 | Luc Brunsveld Co-Founder | WordPressMySQLPHP+20 | — | — |
| 14 | Cleave Therapeutics Developer of VCP/p97 inhibitors for oncology and neurodegenerative diseases | $103M | 82 mo ago | 18 | 2010 | Raymond Deshaies Co-Founder | — | — | — |
| 15 | Nudge Developer of whole-brain interfaces intended to improve human-brain interaction | $100M | 11 mo ago | — | 2024 | Quintin Frerichs Co-Founder | Apple iCloud MailGoogle WorkspaceRadix UI+8 | 12 patents Patents concentrated in health & consumer products | — |
| 16 | Openwater Provider of imaging technologies for medical diagnosis and treatments | $100M | 22 mo ago | — | 2016 | Mary Lou Jepsen Founder & CEO | Wix eCommerceCart FunctionalityWix+17 | — | — |
| 17 | AGY Therapeutics Small molecule and antibody drugs for neurology and oncology | $99M | 266 mo ago | — | 1998 | — | — | — | — |
| 18 | Blade Therapeutics Antifibrotic treatment strategies that address a wide variety of congenital and acquired diseases of fibrosis. | $93M | 80 mo ago | 30 | 2015 | — | — | — | — |
| 19 | CoMentis Pharma company focused on research and development for Neurovascular disease | $86M | 123 mo ago | 33 | 2004 | Scott Harkonen President and CEO | — | 89 patents Synthesis of chromane heterocycles and quinuclidine α7‑nicotinic modulators for neuro‑drugs | — |
| 20 | Concentric Analgesic Developer of platform for developing pro-drugs | $85M | 85 mo ago | 24 | 2014 | John Donovan Co-Founder & President | — | — | — |
| 21 | Perceive Bio Developer of therapeutics to treat diabetes and eye diseases | $78M | 41 mo ago | 12 | 2021 | Anne Rubin President | — | — | — |
| 22 | Switch Therapeutics Developer of therapeutics for neurological disorders | $72M | 39 mo ago | 25 | 2020 | Dee Datta Co-Founder & CEO | — | — | — |
| 23 | Therini Bio Limited information available | $62M | 13 mo ago | 13 13 → 15 (+15%) | 2016 | Daniel Burgess CEO | — | — | — |
| 24 | CODA Biotherapeutics Developer of gene therapy-based analgesics for the treatment of neuropathic pain disorder | $62M | 54 mo ago | 22 | 2014 | Mitchell H Finer Co-Founder | — | 32 patents Therapeutic peptide/protein compositions targeting neurological disorders. | — |
| 25 | XWPharma Developer of drugs for treating neurological disorders like epilepsy, Parkinson's & others | $58M | 69 mo ago | 15 | 2014 | Leonard Blum President & CEO | — | 22 patents Formulating gamma‑hydroxybutyric acid derivatives and excipient granulation for drug delivery | — |
| 26 | Noctrix Health Developer of wearable therapeutic device to treat neurological disorders | $57M | 9 mo ago | 8 | 2016 | — | WordPressApple iCloud MailMySQL+16 | — | — |
| 27 | ReviR Therapeutics Developer of RNA-based therapeutics for multiple diseases 35Funding top 26%AI top 45%Moat top 47%Talent bottom 49% All 8 signals ▾Fundingtop 26% AItop 45% Moattop 47% Talentbottom 49% Marketbottom 36% Globalbottom 36% Techbottom 31% Newsbottom 18% Funding: Raised $54.0M across 3 rounds · 3 rounds over 4 yrs (0.8/yr) AI: Product described with: machine learning rank vs industry peers · Fliar Intelligence Index 35/100 | $54M | 2 mo ago | 29 | 2021 | Yang Li Co-Founder | UbuntuElement UIVue.js+6 | — | — |
| 28 | Mahzi Developer of therapeutics for rare genetic neurodevelopmental disorders | $53M | 56 mo ago | 7 | 2018 | Yael Weiss CEO | WordPressMySQLPHP+18 | — | — |
| 29 | Titan Pharma A specialty pharmaceutical company developing proprietary therapeutics for select chronic diseases | $38M | 11 mo ago | 11 | 1992 | — | Apple iCloud MailMicrosoft 365Apache HTTP Server+8 | — | — |
| 30 | Adynxx Developer of oligonucleotide technology for developing chronic pain management drugs | $36M | 80 mo ago | 7 | 2007 | — | — | 66 patents Nucleic‑acid‑based therapeutics and delivery systems for pain relief via gene expression modulation | — |
| 31 | Neuro42 AI Provider of MRI and robotics technology for neurology | $30M | 9 mo ago | 34 | 2020 | Abhita Vohra Co-Founder & CSO | WebflowSwiperjQuery+8 | 42 patents Low-field MRI hardware integration, AI‑enhanced image reconstruction, and electromagnetic interference mitigation. | — |
| 32 | OncoSynergy Developer of resistance mechanism inhibitors to treat cancer 11Funding top 28%Moat top 32%Patents bottom 48%Global bottom 42% All 6 signals ▾Fundingtop 28% Moattop 32% Patentsbottom 48% Globalbottom 42% Innovationbottom 33% Marketbottom 18% Funding: Raised $26.7M across 7 rounds · 7 rounds over 8 yrs (0.9/yr) Moat: Editorial + unicorn rating 5/10 · IP moat: 26 patents rank vs industry peers · Fliar Intelligence Index 11/100 | $27M | 1 mo ago | 3 | 2011 | — | — | 26 patents Therapeutic anti‑integrin β1 antibodies for oncology applications | — |
| 33 | Reset Therapeutics Developer of psychedelic therapeutics for mental illness | $25M | 96 mo ago | 26 | 2008 | — | — | — | — |
| 34 | Herophilus Developer of drug discovery platform to treat neurological disorders | $25M | 93 mo ago | 28 | 2017 | Sean Escola Co-Founder and Chief Neuroscientist | — | 8 patents Neuroimmune organoid platforms and epigenetic MECP2 modulation for neuroinflammatory therapies | — |
| 35 | SiteOne Therapeutics Sodium ion channel 1.7 (Na 1.7) inhibitors for acute and chronic pain. | $24M | 13 mo ago | — | 2010 | John Mulcahy Co-Founder & CEO | — | — | — |
| 36 | SOLEY Therapeutics Developer of stem cell secreted factors for the treatment of myocardial infarction and stroke | $20M | 5 mo ago | 10 | 2018 | Yerem Yeghiazarians Co-Founder & CEO | — | — | 1 job opening |
| 37 | iZumi Bio Development of stem cell lines and stem cell therapeutics. | $20M | 206 mo ago | 61 | 2007 | John Walker CEO | — | — | — |
| 38 | Lighthouse Pharma Developer of therapeutics for neurology and infectious diseases 11Funding top 46%Talent bottom 49%Tech bottom 45%Global bottom 25% All 5 signals ▾Fundingtop 46% Talentbottom 49% Techbottom 45% Globalbottom 25% Marketbottom 18% Funding: Raised $15.2M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) Talent: 1 named leader on record · 1 C-suite/founder profile curated rank vs industry peers · Fliar Intelligence Index 11/100 | $15M | 2 mo ago | 4 | 2019 | Casey Lynch Chief Executive Officer | WixSentryBootstrap+10 | — | — |
| 39 | Epiodyne Developing opioid medicines for pain management and opioid use disorder | $14M | 50 mo ago | 4 | 2016 | Douglas Crawford CEO | — | 25 patents Design and synthesis of novel opioid receptor ligands for pain and addiction therapeutics. | — |
| 40 | Xalud Therapeutics Gene therapy company restoring immune balance to treat chronic inflammation | $12M | 74 mo ago | 19 | 2009 | — | — | — | — |
| 41 | Darmiyan Platform for presymptomatic diagnosis of neurodegenerative disorders | $10M | 32 mo ago | 16 | 2015 | — | WordPressMySQLPHP+18 | 7 patents AI-driven neuroimaging analysis for brain disorder diagnosis | — |
| 42 | Eumentis Therapeutics Developer of therapeutics for neuropsychiatric conditions | $10M | 39 mo ago | 5 | 2019 | Mark Tepper President & CEO | — | — | — |
| 43 | Montara Therapeutics Developer of therapeutics for neurological diseases | $8M | 15 mo ago | — | 2023 | Kevan Shokat Co-Founder | — | — | 1 launch · 1 award |
| 44 | GABAeron Developer of stem cell-based therapies to treat neurodegenerative diseases | $8M | 18 mo ago | — | 2017 | Sheng Ding Co-Founder | — | — | — |
| 45 | Nine Square Therapeutics Developer of small molecule therapeutics for treating people with movement disorders | $4M | 33 mo ago | 9 | 2020 | Matthew Jacobson Co-Founder & Director | — | — | — |
| 46 | Elysium Therapeutics Developing innovative solutions to combat opioid overdose and reduce opioid abuse | $2M | 4 mo ago | 2 | 2013 | Alex Sturmer President | — | — | — |
| 47 | MicroQuin Developer of therapies for treating multiple diseases | $2M | 13 mo ago | 4 | 2016 | Scott Robinson Founder | — | 13 patents Peptide-based anticancer therapeutics and substituted chalcone small‑molecule drugs | — |
| 48 | Humanity Neurotech Developer of medical devices for the treatment of brain disorders | $1M | 25 mo ago | — | 2019 | Blake Gurfein Founder & CEO | — | 3 patents Low‑field magnetic neurostimulation devices for therapeutic pulse‑burst treatments | — |
| 49 | Exin Therapeutics Developer of precision genetic therapies targeting dysregulated neural circuits across various disorders | $500K | 12 mo ago | — | 2024 | Gabriel Santero Co-Founder and CEO | — | — | — |
| 50 | Uncommon Therapeutics Developer of therapeutics for rare, uncommon diseases | $500K | 15 mo ago | — | 2024 | Noah Auerhahn Co-Founder & CEO | — | — | — |
Top 12 Neurology companies in San Francisco
#1
Public · San Francisco, California · founded 2019 · 34 employees$144.7Mraised▾
AI-driven drug discovery platform for neurological diseases based on patients biomarkers. The company's platform measures patients biomarkers like EEG and wearable data, behavioral patterns, genetics, and other factors to develop personalized psychiatric drugs. The company has pipeline of drugs including ALTO-100 for depression, ALTO-101 for neurodegenerative diseases, and more.
- Mar 2026Post IPO$120M
- Oct 2025Post IPO$50M
- Nov 2023Series C$45M
- Jan 2023Venture Debt—
#2
Seed · San Francisco, California · founded 2025$250Mraised▾
Developer of brain-computer interfaces to maximize human ability, agency, experience. It focuses on creating new approaches to interact with the brain. The aim is to develop high-bandwidth brain-computer interfaces. These interfaces integrate with advanced artificial intelligence. The goal is to make the technology safe and accessible. The company seeks to restore lost abilities and support healthier brain states. It also aims to deepen connections and expand creative potential.
- Jan 2026Seed$250M
#3
Series A · San Francisco, California · founded 2021 · 29 employees$54Mraised▾
Developer of RNA-based therapeutics for multiple diseases. The company is leveraging machine learning technology and innovative RNA techniques to develop medicines for the treatment of cancer, rare genetic disorders, and infectious diseases.
- Apr 2026Series A—
- Nov 2025Grant (prize money)$4.6M
- Jul 2024Series A$30M
- Jan 2022Seed$20M
#4
Acquired · San Francisco, California · founded 2011 · 3 employees$26.7Mraised▾
Developer of resistance mechanism inhibitors to treat cancer. It targets multiple hallmarks of cancer progression and have demonstrated efficacy as monotherapy and in strategic combinations. The lead drug program OS2966 therapeutic antibody blocking a cell surface receptor for the treatment of glioblastoma, ovarian, pancreatic cancer, and malignant meningioma.
- May 2022Series A$3.5M
- Nov 2020Conventional Debt$250K
- Sep 2020Series A$3.2M
- Jan 2020Grant (prize money)$300K
#5
Acquired · San Francisco, California · founded 2008 · 67 employees$315.7Mraised▾
Developer of cell-based therapies to treat intractable neurological diseases. It generate therapeutic compositions of a specific type of nerve cell (or neuron) for targeted delivery into the injured nervous system. It offers NRTX-1001, an inhibitory neuron therapy for epilepsy by GABAergic inhibition, reduce seizure activity, and repair the affected neural network.
- Mar 2025Series E$102M
- Feb 2024Series E$120M
- Dec 2022Series D$72M
- Jun 2021Series C$41.5M
#6
Series A · San Francisco, California · founded 2019 · 4 employees$15.2Mraised▾
Developer of therapeutics for neurology and infectious diseases. It offers a pipeline of drug candidates which include LHP588, is a next-generation gingipain inhibitor for gingivalis infection which causes Alzheimer's disease, Parkinson's disease, and oral dyslapsia. It also offers LHP852 for gingivalis infection and LHP803 for coronavirus infection.
- Apr 2026Series A$15.2M
#7
Series C · San Francisco, California · founded 2016 · 8 employees$57Mraised▾
Noctrix Health is engaged in developing prescription-grade wearable therapeutic devices. They are developing a medical device for treating chronic neurological disorders, especially to treat the symptoms of restless leg syndrome.
- Aug 2025Conventional Debt—
- Aug 2025Series C$33.5M
- May 2025Grant (prize money)$2.2M
- Jan 2024Series C$40M
#8
Series A · San Francisco, California · founded 2024$100Mraised▾
Developer of whole-brain interfaces intended to improve human-brain interaction. It offers a phased-array ultrasound-based wearable device capable of both imaging and modulating brain activity aiming to enable at-home devices for mood, memory, focus, or treating chronic conditions like pain, addiction, and anxiety.
- Jul 2025Series A$100M
#9
Series C · San Francisco, California · founded 2018 · 10 employees$20Mraised▾
Soley Therapeutics is developing stem cell-secreted factors for the treatment of ischemia-related diseases including myocardial infarction and stroke. These drugs will be administered to patients at the time of heart attack and stroke to minimize the damage in the heart and brain respectively. The company's lead product increases cardiomyocyte (heart muscle) viability, decreases infarct scar size, and improves cardiac function in the acute setting of a heart attack.
- Jan 2026Series C$200M
- Dec 2020Series B$20M
#10
Series A · San Francisco, California · founded 2020 · 34 employees$30Mraised▾
Provider of MRI and robotics technology for neurology. The company is developing an intraoperative MR, AI, and a robot that allows easy access to MR imaging for screening, diagnosis, and interventions of neurological diseases.
- Sep 2025Grant (prize money)$1.9M
- Feb 2025Grant (prize money)$1.9M
- Aug 2024Series A$15.6M
- May 2024Series A$6.7M
#11
Series A · San Francisco, California · founded 2016 · 13 employees$62.4Mraised▾
Limited information available
- May 2025Series A$39M
- Jan 2025Grant (prize money)$3M
- Mar 2023Conventional Debt—
- Mar 2023Series A$36M
#12
Public · San Francisco, California · founded 1992 · 11 employees$37.9Mraised▾
Titan develops proprietary therapeutics for the treatment of select chronic diseases  utilizing its long-term, continuous drug delivery platform, ProNeura. The company's lead product candidate is Probuphine, a six-month buprenorphine implant for the maintenance treatment of opioid addiction.  A New Drug Application for Probuphine was accepted by the U.S. Food and Drug Administration in September 2015 and the FDA has assigned an action date of May 27, 2016. If approved, Probuphine would be the first marketed product to provide maintenance treatment of opioid addiction continuously for six months following a single administration procedure. Other candidates include ropinirole and T3 implants in the preclinical stage for Parkinson's disease and hypothyroidism respectively
- Jun 2025Post IPO$600K
- Feb 2022Post IPO$1.5M
- Oct 2021Grant (prize money)—
- Jan 2021Post IPO$9.7M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Neurology coverage by sub-theme.
Regulatory-risk over time falling
Funding & growth over time
funding falling · growth flat
How research on Neuroscience & Neurotech is moving in the United States
A read on the academic research around Neuroscience & Neurotech — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,477 United States-affiliated papers.
- Neurological Surgery622
- Harvard University448
- University of Florida313
- University of California, San Francisco267
- Emory University266
- Deep brain stimulation180→297
- Neuromodulation38→144
- Stimulation97→176
- Brain stimulation19→78
- Neurostimulation54→105
- Deep brain stimulation859→1079
- Neuromodulation95→285
- Neurostimulation157→315
- Stimulation383→535
- Epilepsy60→211
- Neurostimulation45→123
- Neuromodulation41→110
- Epilepsy21→60
- Transcranial magnetic stimulation17→38
- Chronic pain3→23
Where neurotech is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing neurotech patents in the United States
United States neurotech patent filing is accelerating — 2,059 filings from 781 assignees (2016–2025), led by Boston Scient Neuromodulation, Medtronic, Advanced Neuromodulation Systems; annual filings 205→349.
- Boston Scient Neuromodulation865
- Medtronic277
- Advanced Neuromodulation Systems124
- Cardiac Pacemakers75
- Pacesetter67
- Cyberonics54
- Axonics43
- PREC Neuroscience43