Best Orthopedics Companies in Israel
The 63 best Orthopedics companies in Israel in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: CartiHeal.
- Orthopedics Market: Rising Burden of Orthopedic Diseases in Developed
Our analysis of 50 Orthopedics companies
$3.4b in tracked funding; 82% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Orthopedics companies in Israel
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | CartiHeal Provider of implant for bone and cartilage regeneration | $66M | 71 mo ago | Acquired | 26 | Nir Altschuler CEO & Founder | — | — |
| 2 | Ossio Bone regeneration biocomposite 72Funding top 25%Growth top 28%Moat top 29%Patents top 31% All 10 signals ▾Fundingtop 25% Growthtop 28% Moattop 29% Patentstop 31% Innovationtop 35% Techtop 37% Talenttop 38% Newstop 45% Markettop 50% Globalbottom 37% Funding: Raised $61.4M across 5 rounds · 5 rounds over 8 yrs (0.6/yr) Growth: Web rank 10,000,000 → 5,000,000 YoY · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 72/100 | $61M | 4 mo ago | Series C | 74 | Orahn Preiss Bloom Founder & President | 128 patents Patents concentrated in health & consumer products | 1 launch · 1 partnership · 1 expansion |
| 3 | OrthoSpace Biodegradable balloon system for rotator cuff tear | $24M | 114 mo ago | Acquired | 6 | Assaf Dekel Co-Founder | — | — |
| 4 | Discure Technologies Developer of minimally invasive, bioelectronic solutions to treat spinal and synovial joint conditions 10Funding top 40%Moat top 45%Talent bottom 45%Global bottom 40% All 7 signals ▾Fundingtop 40% Moattop 45% Talentbottom 45% Globalbottom 40% Patentsbottom 30% Newsbottom 18% Innovationbottom 7% Funding: Raised $16.0M across 2 rounds · 2 rounds over 2 yrs (1.0/yr) Moat: Editorial + unicorn rating 4/10 · IP moat: 5 patents rank vs industry peers · Fliar Intelligence Index 10/100 | $16M | 21 mo ago | Series A | — | Yuval Mandelbaum CEO | 4 patents Computer‑assisted surgical systems and load‑bearing prosthetic implant technologies. | — |
| 5 | NLT Spine Minimally invasive spinal surgery instruments | $14M | 171 mo ago | Acquired | 17 | — | 126 patents Expandable spinal fixation implants with worm‑gear actuation and deflectable segment technology. | — |
| 6 | Nurami Medical Developer of nanofiber and sealant technology for the soft tissue repair 40Moat top 25%Growth top 35%Product top 35%Patents top 37% All 9 signals ▾Moattop 25% Growthtop 35% Producttop 35% Patentstop 37% Fundingtop 41% Innovationtop 42% Globalbottom 40% Techbottom 38% Marketbottom 28% Moat: Editorial + unicorn rating 7/10 · IP moat: 37 patents Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 40/100 | $12M | 15 mo ago | Series C | 16 | — | 37 patents Biocompatible adhesive and multilayer scaffold matrices for tissue repair and regeneration. | 1 launch |
| 7 | Regencure Biocompatible polymeric membrane implants for bone reconstruction | $12M | 156 mo ago | Series A | — | Moshe Tzabari Founder & CEO | — | — |
| 8 | OrthoSpin External fixation system for bone injuries, bone lengthening & limb deformities | $8M | 74 mo ago | Acquired | 8 | — | 17 patents Motorized, adjustable spinal fixation strut devices for orthopedic surgery | — |
| 9 | NurExone Developer of drugs for neurological disorders 40Funding top 36%Tech top 36%Talent top 38%News top 46% All 7 signals ▾Fundingtop 36% Techtop 36% Talenttop 38% Newstop 46% Growthtop 47% Marketbottom 29% Globalbottom 25% Funding: Raised $7.2M across 9 rounds · 9 rounds over 2 yrs (4.5/yr) Tech: 34 technologies across 5/8 capability areas · Cloud: Akamai rank vs industry peers · Fliar Intelligence Index 40/100 | $7M | 3 mo ago | Public | — | Lior Shaltiel Chief Executive Officer | — | 1 partnership |
| 10 | ApiFix Implant for treatment of scoliosis | $5M | 85 mo ago | Acquired | 8 | — | 105 patents Adjustable spinal fixation and biasing devices for vertebral implants | — |
| 11 | Bonus Biogroup Autologous cell-based 3D grafts for bone transplantation | $5M | 120 mo ago | Public | 57 | Shai Meretzki Founder & CEO | 2 patents Biomimetic bone prosthetic implants for orthopedic reconstruction | — |
| 12 | ProChon Biotech Develops and commercializes regenerative biology-based products for acute and chronic articular cartilage… | $4M | 197 mo ago | Acqui-Hired | — | Patrick O'Donnell CEO | 88 patents Engineered fibroblast growth factor (FGF) protein variants for targeted therapeutic applications | — |
| 13 | CoreBone Developer of a bioactive, coral-based bone graft material | $4M | 56 mo ago | Series A | 5 | — | 5 patents Coral-derived bioactive bone graft biomaterials for orthopedic defect repair | — |
| 14 | Sunlight Medical Bone assessment devices for children and adults | $3M | 253 mo ago | Deadpooled | — | — | — | — |
| 15 | UPnRIDE Robotics Developing wheeled robotic device for upright and seated mobility | $3M | 110 mo ago | Seed | 5 | — | 22 patents Adaptive wheelchair self‑leveling systems and ergonomic knee support for mobility devices | — |
| 16 | Mininvasive Arthroscopic device for Rotator Cuff Repair (RCR) in Shoulder | $2M | 144 mo ago | Series A | 2 | — | 92 patents Minimally invasive arthroscopic orthopedic instruments for bone tunneling and suturing | — |
| 17 | ZygoFix Provider of miniature screwless spine fusion implant | $2M | 50 mo ago | Seed | 4 | Ofer Levy CEO | 18 patents Spinal facet joint distraction/fusion prostheses and implant delivery systems | 2 launchs |
| 18 | SetBone Medical Developer of bone cement for the treatment of vertebral compression fractures | $2M | 52 mo ago | Seed | 4 | Royi Kaufmann Co-Founder & CEO | — | — |
| 19 | Regenovation Biotech drug development company working on drugs for tissue repair and regeneration | $1M | 130 mo ago | Deadpooled | — | Andrew Pearlman Co-Founder | — | — |
| 20 | Amorphical Amorphous calcium carbonate for osteoporosis & other calcium-related diseases | $1M | 147 mo ago | Seed | 15 | Yossi Ben Founder & CEO | 218 patents Amorphous calcium carbonate formulations for therapeutic and athletic performance applications | 2 job openings |
| 21 | Arcuro Medical Developer of a repair system for meniscus tears of the knee | $670K | 17 mo ago | Series A | 12 | — | — | — |
| 22 | PerSimiO Personalized simulation solutions in orthopedics | $529K | 128 mo ago | Funding Raised | — | Eitan Segall Co-Founder & CEO | 5 patents Automated bone imaging segmentation and patient-specific biomechanical analysis tools. | — |
| 23 | ReSymmetry Developer of smart exoskeleton for seating and mobility assistance | $100K | 82 mo ago | Funding Raised | — | Efrat Shenhod Founder & CEO | 3 patents Ergonomic smart seating systems that actively monitor and adjust user posture. | — |
Top 12 Orthopedics companies in Israel
#1
Series C · Caesarea, Haifa District · founded 2014 · 74 employees$61.4Mraised▾
Ossio focuses on orthopedic fixation using bone regeneration technology. The company has developed OSSIOfiber, a biocomposite material platform that contains reinforcing synthetic bone fibers and bioabsorbable polymer resin. The fiber provides mechanical strength and the resin provides binding property and promotes bone growth.
- Feb 2026Conventional Debt$50M
- Dec 2024Series C$27.6M
- Oct 2022Series C$38.5M
- Mar 2019Series A$22M
#2
Public · Haifa, Haifa District · founded 2020$7.2Mraised▾
Developer of drugs for neurological disorders. It biologically-guided exosome therapy based on ExoTherapy platform technology for the treatment of acute spinal cord injury. It use exosomes as nanocarriers to deliver drug for neuron rewiring and regeneration.
- Mar 2026Post IPO$279.9K
- Aug 2025Post IPO$147.8K
- Apr 2025Post IPO$1.6M
- Jan 2025Post IPO$434.5K
#3
Series C · Nazareth, Northern District · founded 2014 · 16 employees$12.4Mraised▾
Nurami Medical is a developer of nanofiber and sealant technology for soft tissue repair. It has developed its first product which is a dural substitute patch for neurosurgeries to prevent cerebrospinal fluid leakage and regenerate the damaged dura protecting the brain. The product is in preclinical trials. It is also working on the next-generation of ArtiFascia that will be able to adhere to tissues without the need for sutures.
- Mar 2025Series C$30M
- Nov 2020Series B$6M
- Dec 2016Seed$645.8K
- 2014Seed$800K
#4
Series A · Petah Tikva, Central District · founded 2019$16Mraised▾
Developer of minimally invasive, bioelectronic solutions to treat spinal and synovial joint conditions. it offers minimally invasive, implantable device to treat and reverse degenerative disc disease by restoring the discs healthy fluid dynamics, cushioning and stability to the spine, revive disc cells, and accelerate tissue healing, to reduce pain and restore function.
- Sep 2024Series A$11M
- Seed$5M
#5
Series A · Misgav, Northern District · founded 2013 · 12 employees$670Kraised▾
Developer of a repair system for meniscus tears of the knee. It uses proprietary SuperBall repair system that has developed a knotless all-suture implant and a delivery system for meniscus repair. The system preserves meniscus functionality, repairs hard-to-reach areas, provides full meniscus coverage and is easy to operate.
#6
Acquired · Kfar Saba, Central District · founded 2009 · 26 employees$65.8Mraised▾
CartiHeal provides of implant for bone and cartilage regeneration. The company has developed a cell-free implant Agili-C that enables bone and cartilage regeneration in a single-step procedure. Agili-C is CE marked for the treatment of focal articular cartilage and osteochondral defects.
- Jul 2020Series D$15M
- Jan 2018Series C$2.5M
- May 2017Series C$18.3M
- Jan 2016Series B$15M
#7
Acquired · Caesarea, Haifa District · founded 2009 · 6 employees$23.6Mraised▾
OrthoSpace develops and commercializes a biodegradable balloon system, InSpace, which is deployed using minimally invasive techniques. The shoulder is a complicated joint that requires the interconnected functioning of tendons, ligaments and bones. The InSpace Balloon, which is implanted between the acromion and the humeral head, creates a space between the bone structures(acromion and humeral head), allowing smooth and frictionless gliding. The system is designed to create a physical barrier between tissues in the subacromial space. The company claims that the InSpace biodegradable balloon system emulates the activity of the normal bursa and offers patients less pain, and a shorter rehabilitation period. As of 2016, The InSpace System has the CE mark and is commercially available in Europe.
- Dec 2016Series B$7M
- May 2015Series B$8M
- Jul 2013Series B$5M
- May 2011Series A$2.6M
#8
Acquired · Kfar Saba, Central District · founded 2006 · 17 employees$14.5Mraised▾
NLT SPINE, specializes in the development and marketing of Minimally Invasive Spinal Surgery (MISS) products for treating degenerative spinal conditions. Their products are based on non-linear core technology that allows inserting large implants and instruments through a small incision. They have developed the product PROW FUSION for Transforaminal Lumbar Interbody Fusion (TLIF) is based on the application of non-linear technology.
- Mar 2012Series A$5.7M
- Mar 2010Series A$8.8M
- 2006Seed—
#9
Acquired · Misgav, Northern District · founded 2014 · 8 employees$8Mraised▾
OrthoSpin is focussed on developing a smart external fixation system for bone injuries, bone lengthening & limb deformities. It has developed a hexapod-shaped external frame system that stabilizes broken bones until healing occurs. The system automatically and continuously adjusts and lengthens the struts according to the prescribed treatment regimen. It also developed a proprietary software program which allows physicians to chart patient progress and to change the treatment schedule.
- Mar 2020Series B$5M
- Jul 2018Series A$3M
- Dec 2015Seed—
#10
Series A · Jerusalem, Jerusalem District · founded 2010$11.5Mraised▾
Regencure is focussed on developing biocompatible polymeric membrane implants for bone reconstruction. Its products are made of microporous AMCA (ammonium methacrylate copolymer type A) and a plasticizer which facilitates the adherence of stem cells recruited to the injured site. It has developed its first product called BoneCure for use in speeding up the bone re-growth in pets. It is now extending the product for human use and is targeting the dental implant and orthopedics markets. As of October 2016, the product is in clinical trials.
- 2013Series A$8M
- Seed$3.5M
#11
Series A · Herzliya, Tel Aviv · founded 2012 · 5 employees$3.7Mraised▾
Developer of a bioactive, coral-based bone graft material. The patented technology embeds bioactive minerals (e.g., silicium) into the skeleton of corals to produce a coral-based bone substitute material with high integration ability.
- Oct 2021Series A$3.7M
- Nov 2013Seed—
#12
Acquired · Misgav, Northern District · founded 2011 · 8 employees$5Mraised▾
ApiFix offers an "internal brace” to correct the spinal curve and maintain it. The ApiFix Internal Brace System is attached to the spine via 2 pedicle screws in an hour long procedure. The expandable rod between the two screws uses a miniature ratchet mechanism that captures incremental deformity corrections at the time of patient is performs side bending exercises to the corrective direction, at home, for 6 months after the operation.The long, incremental process reduces the load on the screws and allows the body to rebuild itself in the correct position. Product is CE Marked.
- May 2019Grant (prize money)$50K
- Apr 2019Series B—
- Nov 2016Series B$5M
- Oct 2013Series B—
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Orthopedics coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Medical Devices is moving in Israel
A read on the academic research around Medical Devices — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 34 Israel-affiliated papers.
- Tel Aviv University5
- Hadassah Medical Center5
- Hebrew University of Jerusalem5
- Ben-Gurion University of the Negev5
- Technion – Israel Institute of Technology4
- Surgical robot3
- Robot2
- Robotics2
- Nanotechnology1
- Biomedical engineering1
- MEDLINE3
- Robotics3
- Risk assessment3
- Robotic surgery2
- Robot2
- Surgical robot1→4
- Robot1→4
Where medical devices is researched across Israel
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.