Best Orthopedics Companies in Pennsylvania, United States
The 56 best Orthopedics companies in Pennsylvania, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Small Bone Innovations.
Our analysis of 50 Orthopedics companies
$3.4b in tracked funding; 82% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Orthopedics companies in Pennsylvania
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Small Bone Innovations Suite of orthopedic products for small bones and joints | $181M | 175 mo ago | 68 | — | — | — | 41 patents Small bone orthopedic implants for ankle fusion and wrist hemiarthroplasty | — |
| 2 | Centinel Spine Developer of spinal devices to treat degenerative disc disease 48Funding top 21%Moat top 21%Patents top 35%Innovation top 40% All 11 signals ▾Fundingtop 21% Moattop 21% Patentstop 35% Innovationtop 40% Producttop 40% Talentbottom 49% Growthbottom 47% Marketbottom 46% Techbottom 38% Globalbottom 37% Newsbottom 24% Funding: Raised $176M across 4 rounds · 4 rounds over 9 yrs (0.4/yr) Moat: Editorial + unicorn rating 8/10 · IP moat: 96 patents rank vs industry peers · Fliar Intelligence Index 48/100 | $176M | 16 mo ago | 130 | Steven Murray CEO | SalesforceVimeoBootstrap+12 | Top 10M | 96 patents Spinal intervertebral fixation implants with tissue‑sparing insertion mechanisms | 1 partnership |
| 3 | Conventus Flower Orthopedics Developer of medical device for orthopedic diseases | $110M | 37 mo ago | 21 | Bradley Niemann CEO | WordPressMySQLPHP+17 | Top 10M | — | — |
| 4 | Trice Medical Minimally invasive solutions for orthopedic and podiatric procedures, improving patient outcomes | $85M | 35 mo ago | 72 72 → 52 (-28%) | — | WordPressMySQLMariaDB+34 | Top 50M | — | — |
| 5 | Code Biotherapeutics Developer of gene therapies for rare diseases | $85M | 49 mo ago | 41 | Robert Getts Co-Founder & CTO | Cart FunctionalityWixSentry+17 | Top 50M | 25 patents Patents concentrated in chemistry & materials | — |
| 6 | Tarsa Therapeutics Developer of oral treatment for postmenopausal osteoporosis | $79M | 107 mo ago | 2 | — | — | — | — | — |
| 7 | Orthovita Orthobiologics and biosurgery products | $46M | 227 mo ago | 330 | — | — | — | 172 patents Bioactive bone graft materials and specialized orthopedic surgical delivery instruments. | — |
| 8 | Fibrocell Science Developer of autologous cell and gene therapies for diseases of the skin, connective tissue and joints | $35M | 90 mo ago | 19 | — | — | — | — | — |
| 9 | Carmell Biotech company specializing in the development of plasma-based bioactive materials for tissue repair. | $20M | 72 mo ago | 7 | Rajiv Shukla CEO | — | — | 2 patents Plasma-assisted synthesis of specialty plastics and biodegradable polymers | — |
| 10 | Xylos Corporation Biomaterials for surgical implants | $11M | 179 mo ago | — | Gonzalo Serafica Co-Founder | — | — | 53 patents Microbial cellulose biomedical materials: implants, wound dressings, and oxidation processing | — |
| 11 | Gentis Biomaterial implants to treat degeneration of the spine | $10M | 191 mo ago | 7 | Charles Cohen Co-Founder | — | — | 6 patents Polymerizable biomaterial emulsions and resorbable scaffolds for tissue engineering applications. | — |
| 12 | Knee Creations Minimally invasive procedure for subchondral bone defects | $10M | 164 mo ago | — | Michael J. Simpson President & CEO | — | — | 197 patents Patents concentrated in health & consumer products | — |
| 13 | Premia Spine Developed implant systems for spinal conditions | $7M | 145 mo ago | 1 | — | WordPressMySQLPHP+37 | Top 1M | — | — |
| 14 | Flexuspine Spinal segment replacement of lumbar spine | $3M | 165 mo ago | — | Charles R. Gordon Co-Founder | — | — | 54 patents Expandable intervertebral fusion and articulating spinal implants for vertebral body fixation | — |
| 15 | Waypoint Orthopedics Provider of decision support solutions for orthopedic surgery 10Talent top 38%Funding bottom 46%Global bottom 37%Market bottom 17% All 4 signals ▾Talenttop 38% Fundingbottom 46% Globalbottom 37% Marketbottom 17% Talent: 2 named leaders on record · 2 C-suite/founder profiles curated Funding: Raised $3.0M across 8 rounds · 8 rounds over 5 yrs (1.6/yr) rank vs industry peers · Fliar Intelligence Index 10/100 | $3M | 4 mo ago | 2 | Stephen Banco Founder | — | — | — | — |
| 16 | Toetal Solutions Provider of the platform that offers solutions for foot and ankle deformities 14Moat top 45%Innovation top 49%Patents bottom 49%Talent bottom 49% All 7 signals ▾Moattop 45% Innovationtop 49% Patentsbottom 49% Talentbottom 49% Fundingbottom 45% Globalbottom 33% Marketbottom 17% Moat: Editorial + unicorn rating 4/10 · IP moat: 3 patents Innovation: 3 patents (top 91% of patent-holders) · 3 filings since 2022 vs 0 in 2017-21 rank vs industry peers · Fliar Intelligence Index 14/100 | $2M | 2 mo ago | 2 | William Rhoda Co-Founder | — | — | 3 patents Interphalangeal joint prosthetic devices and implantation techniques | — |
| 17 | Blue Belt Tech Computer-assisted technology and robotic orthopedic surgery | $2M | 140 mo ago | 113 | Branislav Jaramaz Founder & CTO | — | — | — | — |
| 18 | Bionic Yantra Developer of robotic exoskeleton devices for rehabilitation and personal mobility | $2M | 86 mo ago | 3 | Vaidyanathan Narayanan Co-Founder | WixSentryYouTube+12 | Top 50M | — | — |
| 19 | Stabiliz Ortho Medical device for orthopaedic trauma | $2M | 93 mo ago | 4 | Doug Cerynik CEO | — | — | — | — |
| 20 | Synergy Biomedical Bioactive glass bone graft solutions for improved bone healing | $1M | 148 mo ago | 8 | — | — | — | 25 patents Regional composite structures for implantable medical devices and related manufacturing methods. | — |
| 21 | OrthogenRx Developer of generic Class III medical devices in orthopedics | $1M | 111 mo ago | 1,522 | — | Cart FunctionalityWordPressMySQL+14 | Top 50M | 12 patents Precise intra-articular needle placement for joint injections and crosslinked hyaluronic acid gels. | — |
| 22 | Pace Surgical Manufacturer of foot and ankle fixation devices and plating systems | $600K | 6 mo ago | — | Jeffrey O’Donnell Jr. CEO | — | — | — | — |
| 23 | Epic Extremity Develops orthopedic products | $575K | 111 mo ago | 1 | — | — | — | — | 1 launch |
| 24 | ActivAided Biofunctional gear optimizing posture, relieving pain, and regaining life | $175K | 158 mo ago | — | Kelly Collier CEO | — | — | — | — |
| 25 | Novastep Orthotics Orthotic device for assisting limb movement | $100K | 162 mo ago | — | Michael McDonnell Founder & CEO | — | — | — | — |
Top 12 Orthopedics companies in Pennsylvania
#1
Series C · West Chester, Pennsylvania · founded 2008 · 130 employees$175.9Mraised▾
Developer of spinal devices to treat degenerative disc disease. The products include No-Profile Anterior Lumbar Integrated Interbody System, Lateral Integrated Interbody System, No-Profile Anterior Cervical Integrated Interbody System, and Posterior Cervical Stabilization System. It uses Ti active technology and STALIF technology to provide spine surgeons with titanium, endplate-facing, Integrated Interbody systems.
- Feb 2025Conventional Debt$60M
- Mar 2024Series C$3.2M
- Apr 2020Series C$40.5M
- Jan 2018Conventional Debt—
#2
Seed · Philadelphia, Pennsylvania · founded 2021 · 2 employees$2.5Mraised▾
Provider of the platform that offers solutions for foot and ankle deformities. It offers the ZipToe Hammertoe System which consists of a sterile packed procedure kit and implant to address ridged hammertoe deformity.
- Apr 2026Seed$100K
- Sep 2024Seed$100K
- Mar 2024Seed$430K
- Dec 2023Seed$150K
#3
Seed · Philadelphia, Pennsylvania · founded 2020 · 2 employees$3Mraised▾
Provider of decision support solutions for orthopedic surgery. The company offers the product Waypoint GPS. The features allow doctors to see the color of the bone as they traverse through the pedicle in preparation for screw placement. They also provide a smart pedicle probe that utilizes proprietary color-sensing technology.
- Mar 2026Seed$300K
- Sep 2025Seed$50K
- Jun 2025Seed$30K
- Dec 2024Seed$35K
#4
Seed · Malvern, Pennsylvania · founded 2023$600Kraised▾
Manufacturer of foot and ankle fixation devices and plating systems. The company provides anatomically specific solutions for trauma and reconstruction. Products feature a low-profile design intended to minimize irritation and enhance mobility during recovery. The company's variable locking mechanism may eliminate screw migration, providing stability. The plating system combines a low-profile design with pathology-specific solutions tailored to the anatomy.
- Dec 2025Seed$600K
#5
Series D · Horsham, Pennsylvania · founded 2008 · 21 employees$110Mraised▾
Developer of medical device for orthopedic diseases. It offers Flex-Thread Distal Fibula Intramedullary Nail for the treatment of fibula fractures and osteotomies, Flex-Thread Ulna Intramedullary Nail for minimally invasive solution for the treatment of ulna fractures, Flex-Thread Ulna Intramedullary Nail for the treatment of ulna fractures, and sterile implants and instruments for surgical indications.
- 2023Conventional Debt—
- May 2020Series D$24.5M
- Jun 2019Series C$5M
- Dec 2017Venture Debt$12M
#6
Series D · King Of Prussia, Pennsylvania · founded 2012 · 72 employees$85.5Mraised▾
Minimally invasive solutions for orthopedic and podiatric procedures, improving patient outcomes. The company focuses on developing and marketing innovative medical devices and technologies designed to simplify surgical procedures, reduce recovery times, and enhance patient well-being. Their product portfolio includes percutaneous tissue removal systems for treating tendinopathy and bone spurs, endoscopic carpal tunnel and ligament release systems, and high-resolution arthroscopy solutions. These technologies offer physicians the flexibility to treat patients in various settings, such as procedure rooms, ambulatory surgery centers, or hospitals. The company is dedicated to advancing medical education through conferences, webinars, and resource centers, supporting healthcare professionals in adopting and utilizing their cutting-edge solutions. They aim to build a great company that enhances the quality of life through simpler treatments and clinically proven technologies.
- Aug 2023Series D$10.5M
- Aug 2021Series D—
- Mar 2020Series C$2.1M
- Jan 2019Series C$18.3M
#7
Series A · Hatfield, Pennsylvania · founded 2020 · 41 employees$85Mraised▾
Developer of gene therapies for rare diseases. The therapies are developed for the treatment of Duchenne muscular dystrophy and type 1 diabetes. The company has a non-viral gene delivery platform 3DNA that delivers genes of all sizes, improves cellular targeting, and reduces immunogenicity.
- Jun 2022Series A$75M
- Apr 2021Seed$10M
#8
Acquired · Morrisville, Pennsylvania · founded 2004 · 68 employees$181.4Mraised▾
Small Bones Innovations (SBi) makes devices for small bones and joints, particularly focusing on trauma and arthroplasty. The company markets its products in more than 35 countries worldwide. The company was acquired by orthopedic devices firm Stryker in Jun 2014 in an all-cash transaction for up to $375M.
- Dec 2011Conventional Debt$43M
- Dec 2010Series F$15M
- Dec 2010Series E$4.2M
- May 2010Series E$12M
#9
Series B · Philadelphia, Pennsylvania · founded 2009 · 2 employees$78.7Mraised▾
Developer of oral treatment for postmenopausal osteoporosis. The company has developed TBRIA (calcitonin-salmon delayed-release tablets), an oral formulation of calcitonin for the treatment of postmenopausal osteoporosis, and is seeking FDA approval. TBRIA contains salmon calcitonin, a peptide that is manufactured using recombinant DNA technology.
- Jul 2017Series B$549.9K
- Jan 2017Series B$1.6M
- Jul 2016Conventional Debt$1.2M
- Feb 2016Conventional Debt$2M
#10
Acquired · Exton, Pennsylvania · founded 1995 · 19 employees$34.7Mraised▾
Developer of autologous cell and gene therapies for diseases of the skin, connective tissue, and joints. The lead candidate FCX-007 is gene therapy for the treatment of linear scleroderma. Also, developing candidates for arthritis treatment.
- Dec 2018Post IPO$900K
- Jul 2018Post IPO$3.1M
- May 2018Post IPO$5.1M
- Aug 2016Post IPO$18.1M
#11
Series C · Pittsburgh, Pennsylvania · founded 2007 · 7 employees$19.9Mraised▾
Carmell Corp is a biotech company that develops plasma-based bioactive materials to stimulate tissue repair. They focus on regenerative medicine and aesthetics in skincare.
- Jun 2020Series C$50K
- Sep 2019Series C$2.4M
- Jul 2018Series C$5.2M
- Dec 2017Series B$439.2K
#12
Acquired · Malvern, Pennsylvania · founded 1992 · 330 employees$46.5Mraised▾
Orthovita develops orthobiologics and biosurgery products. They have developed, Vitoss™, a synthetic and bioactive bone graft substitute technology. They have also developed, Vitagel, a surgical hemostat to control intra-operative and post-operative bleeding. Orthovita was acquired by Stryker in 2011 for $316 million.
- Jul 2007PE$32.5M
- Aug 2002Series A$14M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Orthopedics coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth flat
What Pennsylvania researches in medical devices
Penn and Penn State lead cautiously contested medical-device research, focusing on healthcare technology and economic evaluations, with concerns outweighing breakthroughs in a mildly optimistic field.
- University of Pennsylvania15
- Pennsylvania State University8
- California University of Pennsylvania4
- University of Pennsylvania Health System3
- Hospital of the University of Pennsylvania1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.