Best Disease Self Management Companies in Illinois, United States
The 74 best Disease Self Management companies in Illinois, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Xeris Pharmaceuticals.
Our analysis of 50 Disease Self Management companies
$3.0b in tracked funding; 94% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Disease Self Management companies in Illinois
| # | Company | App-install YoY | Disclosed funding | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain.fm Developer of music designed to enhance focus and cognitive performance | +46% | $225K | 13 | Daniel Clark CEO | SentryFacebook LoginGoogle Sign-in+23 | Top 100k | 576 patents Robotic mapping, sensor calibration, and feature detection for autonomous navigation systems. | — |
| 2 | Rise Provider of an application for tracking sleep | +38% | $16M | 12 12 → 25 (+108%) | Leon Sasson Co Founder | SentryTailwind CSSReact+17 | Top 1M | — | — |
| 3 | Curable App-based chronic pain relief using mind-body techniques and pain science | +15% | — | 12 | Lisa Boyette Founder & Co-CEO | Google CloudFacebook PixelGoogle Analytics+8 | Top 1M | — | — |
| 4 | SuperBetter Empowering youth mental health through game-based resilience and wellbeing | +7% | $100K | 8 | Keith Wakeman CEO | UbuntuVimeoReact+12 | Top 10M | — | — |
| 5 | Neopenda Provider of wearable neonatal signs monitor 16Moat top 38%Funding top 42%Tech top 43%Talent bottom 49% All 12 signals ▾Moattop 38% Fundingtop 42% Techtop 43% Talentbottom 49% Productbottom 47% Growthbottom 43% Globalbottom 37% Innovationbottom 36% Patentsbottom 25% Marketbottom 22% Fin. healthbottom 19% Newsbottom 18% Moat: Editorial + unicorn rating 7/10 · IP moat: 3 patents Funding: Raised $2.7M across 12 rounds · 12 rounds over 8 yrs (1.5/yr) rank vs industry peers · Fliar Intelligence Index 16/100 | — | $3M | 14 | Teresa Cauvel Co-founder and CTO | WixSentryBootstrap+14 | Top 10M | 3 patents Remote neonatal vital sign monitoring and data analytics devices | — |
| 6 | Sibel Health Developer of wireless medical monitoring devices for clinical and remote use 32Funding top 25%Moat top 31%Talent bottom 49%Growth bottom 42% All 8 signals ▾Fundingtop 25% Moattop 31% Talentbottom 49% Growthbottom 42% Techbottom 41% Marketbottom 38% Globalbottom 36% Newsbottom 17% Funding: Raised $50.0M across 6 rounds · 6 rounds over 6 yrs (1.0/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 32/100 | — | $50M | 47 | Steve Xu Co-Founder & CEO | WordPressApple iCloud MailGoogle Workspace+24 | Top 10M | — | 1 award |
| 7 | Rhaeos Developer of a noninvasive device to monitor CSF and manage hydrocephalus 35Talent top 28%Funding top 32%Patents top 32%Innovation top 34% All 9 signals ▾Talenttop 28% Fundingtop 32% Patentstop 32% Innovationtop 34% Moattop 38% Globalbottom 40% Marketbottom 24% Techbottom 23% Newsbottom 18% Talent: 4 named leaders on record · 4 C-suite/founder profiles curated Funding: Raised $12.8M across 13 rounds · 13 rounds over 6 yrs (2.2/yr) rank vs industry peers · Fliar Intelligence Index 35/100 | — | $13M | 10 10 → 20 (+100%) | Amit Ayer Co-Founder | — | — | 16 patents Medical wearable temperature sensors and non‑invasive fluid flow monitoring for patient diagnostics | — |
| 8 | Xeris Pharmaceuticals Developer of liquid-stable injectables for the delivery of drugs | — | $155M | 294 294 → 506 (+72%) | Steve Prestrelski Co-Founder & CSO | DrupalApple iCloud MailPHP+32 | Top 5M | 249 patents Stable drug formulations, especially levothyroxine, using aprotic polar solvents | 1 internship · 1 award |
| 9 | Visibly Online vision test technology for providers | — | $50M | 29 29 → 62 (+114%) | — | Apple iCloud MailGoogle WorkspaceNode.js+15 | Top 5M | 19 patents Camera‑based ophthalmic diagnostics for refraction, astigmatism, and visual‑field assessment | — |
| 10 | Endotronix Provider of device for Measurement of Hemodynamic parameters for heart failure maangement | — | $155M | 104 | Michael Nagy Engineer & product development | WordPressSentryMySQL+32 | Top 10M | 234 patents Implantable wireless physiological monitoring using MEMS sensors and multi-frequency excitation | — |
| 11 | Renalis Provider of solutions for pelvic health | — | $944K | 3 | Missy Lavender Founder & CEO | — | — | 4 patents Digital pelvic health education and management platform delivering personalized therapeutic content. | — |
| 12 | Higi Gamified app for personal health management | — | $95M | 53 53 → 75 (+42%) | — | Cart FunctionalitySquarespace CommerceSquarespace+25 | Top 5M | 17 patents Automated cuff blood pressure/arm circumference measurement devices and ocular biomolecule detection systems. | 1 partnership |
| 13 | Cardiosense Developer of wearable sensor and AI platform for cardiac monitoring | — | $15M | 15 | Amit Gupta Co-Founder & CEO | — | — | 2 patents Wearable and implantable physiological monitoring devices with data analysis and presentation. | 1 launch |
| 14 | Liv Labs Provider of personalized training classes and pelvic floor exercises | — | $125K | 8 | Carly Price Co-Founder | — | — | — | — |
| 15 | SkinIO Online platform to keep track of skin cancer | — | $5M | 27 | — | WordPressMySQLZoho+34 | Top 10M | 7 patents Digital skin imaging and UV monitoring for dermatological abnormality detection | — |
| 16 | Reliefband Drug-free wearable tech for fast, effective nausea and vomiting relief | — | $6M | 10 | — | Cart FunctionalityShopifyVisa+32 | Top 5M | 4 patents Patents concentrated in health & consumer products | — |
| 17 | Aivo Health Provider of software-based solutions for chronic back pain management | — | $2M | 7 | Rolf Sormo CTO & Founder | — | — | — | — |
| 18 | Agile Health Mobile app for behavior modifications to improve disease conditions for chronic disease patients | — | $3M | 29 | — | — | — | — | — |
| 19 | SNOOZ Smart device for improving the quality of sleep | — | $2M | 7 | Matthew Snyder Co-Founder | Cart FunctionalityShopifyDeliverr+28 | Top 5M | 10 patents Airflow and white-noise generation devices for sleep‑aid and ambient sound applications | 1 job opening |
| 20 | CareBand Provider of location-based monitoring technology for healthcare and safety applications | — | $517K | 8 | — | — | — | 33 patents Patents concentrated in health & consumer products | — |
| 21 | Luna Lights Developer of smart devices for night time fall detection | — | $375K | 3 | — | — | — | — | — |
| 22 | Bold Diagnostics Provider of diagnostic platform for blood pressure monitoring | — | $250K | 1 | Jay Pandit Co-Founder | — | — | — | — |
| 23 | Diasend Diabetes data management platform transitioning to Glooko, offering device syncing and tracking | — | $192K | 10 | — | RubyRuby on RailsEnvoy+13 | Top 50M | — | — |
Top 12 Disease Self Management companies in Illinois
#1
Seed · Chicago, Illinois · founded 2015 · 14 employees$2.7Mraised▾
Provider of wearable neonatal signs monitor. The device is a small low-cost neonatal vital signs monitor integrated into a baby hat and uses a simple sensor array to measure heart rate, respiratory rate, blood oxygen saturation, and temperature. The sensors are powered by rechargeable batteries, and wirelessly transmit data to a central monitor which alerts attending healthcare professionals when a newborn is in immediate danger. It is intended for critically ill newborns being cared for in hospitals in low-resource countries such as Uganda.
- Apr 2026Conventional Debt$35K
- Nov 2024Conventional Debt$200K
- Sep 2022Conventional Debt$700K
- Apr 2021Seed$1.4M
#2
Series C · Niles, Illinois · founded 2018 · 47 employees$50Mraised▾
Developer of wireless medical monitoring devices for clinical and remote use. The company provides devices and data integration for healthcare delivery and patient outcomes. It focuses on vital signs monitoring for neonatal, maternal, and adult care. The company offers technology for clinical trials, research, and hospital settings.
- Mar 2025Series C$30M
- May 2024Grant (prize money)$17.5M
- Aug 2022Series B$33M
- Dec 2021Grant (prize money)$150K
#3
Series A · Evanston, Illinois · founded 2018 · 10 employees$12.8Mraised▾
Developer of a noninvasive device to monitor CSF and manage hydrocephalus. It offers a wireless non-invasive thermal flow sensor that is placed over the neck to monitor the ventricular shunt function and detect or measure CSF. Its data is transferred to an app to manage hydrocephalus.
- Apr 2025Grant (prize money)$298.8K
- Apr 2025Grant (prize money)$4.1M
- Mar 2025Grant (prize money)$1.9M
- Mar 2025Grant (prize money)$306.5K
#4
Public · Chicago, Illinois · founded 2005 · 294 employees$155.4Mraised▾
Developer of liquid-stable injectables for the delivery of drugs. The company is developing a stable, ready-to-inject glucagon formulation "Gvoke" which is indicated for the treatment of severe hypoglycemia in adult and pediatric patients with diabetes. The company has developed proprietary formulation technologies such as XeriSol and XeriJect which are currently being evaluated for subcutaneous and intramuscular delivery of highly-concentrated, non-aqueous, ready-to-use formulations of peptides, proteins, and antibodies.
- Jan 2022Post IPO—
- Mar 2021Post IPO$27M
- Mar 2018Series C$10M
- May 2017Series C$30.1M
#5
Series B · Chicago, Illinois · founded 2012 · 29 employees$50.2Mraised▾
Online vision test technology for providers. It helps in connecting the consumer with an ophthalmologist or optometrist for prescribing glasses, and contact lenses, and renewing the prescriptions. Also, doctors can register their practice for vision test technology for their patients through teleconsultation.
- Apr 2023Series B$24.6M
- Aug 2020Series A$6.5M
- Sep 2019Series A$1.1M
- Apr 2019Series A$6.2M
#6
Acquired · East Peoria, Illinois · founded 2007 · 104 employees$154.8Mraised▾
Provider of device for Measurement of Hemodynamic parameters for heart failure maangement. It develops miniaturized wireless and implantable pressure sensors to communicate pressures that accurately measure cardiac function and provide software and services to personalize the patient care experience. The solution aims to accurately capture pulmonary artery pressure data using a mobile device. The data will be securely transmitted from the remote location to the patient’s Clinical Care Team for review and analysis.
- Oct 2019Series D$69.3M
- Sep 2018Series D$45M
- Feb 2018Series C$37.1M
- Jan 2017Conventional Debt$12M
#7
Seed · Chicago, Illinois · founded 2019 · 3 employees$944Kraised▾
Provider of solutions for pelvic health. The platform provides solutions to improve experiences and outcomes for people with pelvic health conditions. It is designed to tackle the biggest challenges in pelvic health management.
- Sep 2024Grant (prize money)$307K
- Aug 2023Conventional Debt$25K
- 2022Seed$100K
- Sep 2021Seed$824K
#8
Acquired · Chicago, Illinois · founded 2012 · 53 employees$95.2Mraised▾
Higi provides a gamified app for personal health management. Through its "high Stations" provides free screenings for blood pressure, weight, pulse, and body mass index. Its platform is directed at community-health and wellness and allows consumers to collect and share their health and activity data with trusted partners or communities to win rewards.
- Jun 2020Series C$31.4M
- Jul 2018Series C—
- Jul 2018Series C$23.8M
- Mar 2017Series B—
#9
Series A · Chicago, Illinois · founded 2020 · 15 employees$15.1Mraised▾
Developer of wearable sensor and AI platform for cardiac monitoring. The company provides a medical-grade wearable device that measures seismocardiogram, photoplethysmogram, and electrocardiogram signals. Clinical artificial intelligence algorithms translate sensor signals into digital biomarkers. Integrated software solutions aggregate data into actionable clinical insights, designed to streamline workflows.
- Dec 2022Series A$15.1M
#10
Seed · Wilmette, Illinois · founded 2017 · 8 employees$125Kraised▾
Provider of personalized training classes and pelvic floor exercises. The company offers K+ circuit training that includes multiple exercises selected for postpartum recovery and to help runners for full-body fitness goals. Also, it offers a social network to share and discuss pelvic floor exercises and health issues.
- Mar 2025Grant (prize money)$2.2M
- Jan 2022Grant (prize money)$255.1K
- Sep 2021Seed$125K
- Apr 2021Grant (prize money)$2.2M
#11
Series A · Chicago, Illinois · founded 2008 · 27 employees$5Mraised▾
Online platform to keep track of skin cancer. Users can take photos of the skin to map moles and use follow-up photos over time to keep track of changes. The platform can automatically analyze photos to spot changes and identify potentially malignant skin moles which need examination by a physician.
- Feb 2023Series A$1.5M
- Oct 2020Series A$1.4M
- May 2019Seed$511.2K
- Apr 2018Seed$1.5M
#12
Series A · Chicago, Illinois · founded 2014 · 12 employees$15.5Mraised▾
Provider of an application for tracking sleep. The company offers an application to track how much sleep you owe your body and also offers sleep to control it. It offers sleep challenges and recommendations for improving the quality of sleep.
- Jun 2021Series A$10M
- 2018Seed$5.5M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Disease Self Management coverage by sub-theme.
Regulatory-risk over time falling
Funding & growth over time
funding flat · growth flat
How research on Digital Health in Illinois is moving
A read on the academic research around Digital Health in Illinois — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 149 papers.
- University of Illinois Chicago68
- University of Illinois Urbana-Champaign30
- Western Illinois University11
- Illinois College10
- Illinois Department of Public Health9
- Wearable computer6
- Health care5
- SNOMED CT3
- Interoperability3
- Unstructured data3
- Wearable computer1→4
- Remote patient monitoring1→3
- Health care2→20
- Health informatics1→9
Common questions
Sweetie watches where the money and the users are piling in. She covers sector wealth and momentum — the install curves and revenue pools that show which corners of the market are quietly on fire.