Best Disease Self Management Companies in San Diego, United States
The 81 best Disease Self Management companies in San Diego, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: ResMed.
Our analysis of 50 Disease Self Management companies
$3.0b in tracked funding; 94% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Disease Self Management companies in San Diego
| # | Company | Disclosed funding | Last round | Stage | Founder | Employees | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | ResMed Therapeutic devices to treat sleep apnea and respiratory disorders | $500M | 83 mo ago | Public | Michael Farrell Chief Executive Officer | 10,140 10,140 → 9,071 (-11%) | Amazon WebstoreWordPressApple iCloud Mail+34 | 346 patents Advanced CPAP/BiPAP devices with smart humidification, mask fit analytics, and cloud data management | 1 internship · 1 launch · 1 award |
| 2 | Cue Health Provider of health monitoring system for diagnosing diseases like influenza | $406M | 61 mo ago | Deadpooled | — | 726 | — | 123 patents Rapid point‑of‑care molecular diagnostics using isothermal nucleic‑acid amplification and sample‑collection devices | — |
| 3 | Biolinq Provider of a wearable biosensor platform for diabetes monitoring 67Innovation top 13%Funding top 17%Patents top 17%Moat top 26% All 10 signals ▾Innovationtop 13% Fundingtop 17% Patentstop 17% Moattop 26% Talenttop 38% Growthtop 45% Marketbottom 45% Globalbottom 43% Techbottom 39% Newsbottom 18% Innovation: 189 patents (top 11% of patent-holders) · 161 filings since 2022 vs 28 in 2017-21 Funding: Raised $175M across 15 rounds · 15 rounds over 12 yrs (1.2/yr) rank vs industry peers · Fliar Intelligence Index 67/100 | $175M | 15 mo ago | Series C | Jared Tangney Co-Founder | 91 | Webflowcore-jsjQuery+11 | 189 patents Minimally invasive continuous biomarker monitoring via microneedle sensor arrays | — |
| 4 | Lively Provider of non-wearable devices and mobile app for monitoring elders | $82M | 168 mo ago | Series C | Arlene Harris Founder | — | — | — | — |
| 5 | Zerigo Health Developer of UVB light therapy devices for monitoring Psoriasis, Vitiligo, and Eczema | $75M | 56 mo ago | Series B | Lisa R CEO | 37 | HubSpot CMS HubApple iCloud MailMicrosoft 365+20 | — | 4 job openings |
| 6 | Dexcom Provider of a wearable device for glucose monitoring | $53M | 74 mo ago | Public | Kevin Sayer CEO & President | 9,600 9,600 → 8,782 (-9%) | Apple iCloud MailMicrosoft 365Salesforce+24 | 4,656 patents Continuous glucose monitoring sensors, data transmission, and glycemic management software | — |
| 7 | GlySens Implantable Continuous glucose monitoring device | $47M | 72 mo ago | Late Stage | William Markle CEO | 29 | — | 70 patents Continuous implantable glucose monitoring with integrated insulin delivery error correction | — |
| 8 | BetterNight Provider of app and assesments for sleep improvement | $39M | 39 mo ago | Series C | Dave French Founder & CEO | 350 | Squarespace CommerceSquarespaceApple iCloud Mail+24 | — | — |
| 9 | Companion Medical Medtronic Diabetes: Innovative solutions for diabetes management and insulin delivery | $21M | 77 mo ago | Acquired | Sean Saint CEO & President | — | — | — | — |
| 10 | Tensys Medical Continuous hemodynamic monitoring systems | $20M | 264 mo ago | Deadpooled | — | 3 | — | — | — |
| 11 | Vessel Provider of a personalized mobile app and test kit for tracking nutrition | $14M | 44 mo ago | Seed | Jon Carder Co-founder | 32 | WordPress Site EditorWordPressMySQL+11 | 19 patents Advanced natural gas purification and processing technologies for fluid treatment applications. | — |
| 12 | Oculir Developer of a non-invasive glucose monitoring device | $7M | 246 mo ago | Deadpooled | W. Tate Scott ex-CEO | — | — | 16 patents Non‑invasive ocular analyte sensing via wearable electromagnetic spectroscopy devices | — |
| 13 | toSense Innovating healthcare with connected solutions, medical devices, and advanced technologies | $5M | 100 mo ago | Acquired | Bobby Kandaswamy CEO | 8 | — | 131 patents Wearable physiological sensors for continuous cardiac and vital sign monitoring | — |
| 14 | Sense4Baby Remote fetal monitoring systems for healthcare providers | $4M | 158 mo ago | Acqui-Hired | Jessica Grossman ex-CEO | — | — | — | — |
| 15 | Persperion Diagnostics Developer of medical device fo sweat analysis | $4M | 13 mo ago | Series A | Xinyu Liu Co-Founder | 4 | — | — | — |
| 16 | ArcSecond Developer of wearable products for visceral experiences | $2M | 68 mo ago | Deadpooled | Nathan Ramasarma Co-Founder & CEO | — | — | 3 patents Geospatial data analysis, sensor orientation calibration, and contextual acoustic mapping technologies. | — |
| 17 | SleepScore Labs Sleep monitoring devices and applications | $2M | 81 mo ago | Seed | Colin Lawlor Founder & Chief Executive Officer | 34 34 → 47 (+38%) | WordPressMySQLPHP+26 | — | 4 job openings |
| 18 | Quasar Innovating dry EEG sensors and psychophysiological monitoring systems for diverse applications | $1M | 16 mo ago | Funding Raised | Walid Soussou CEO | — | — | 7 patents Patents concentrated in health & consumer products | — |
| 19 | Advanced Brain Monitoring Provider of neuro-diagnostics devices for researchers and clinical trials | $1M | 9 mo ago | Early Stage | — | 41 | WebflowjQuery-pjaxMicrosoft Advertising+12 | 104 patents Patents concentrated in health & consumer products | — |
| 20 | CIPRA.ai AI based platform offering personalized and proactive chronic care solutions | $1M | — | Seed | Pohan Chiang Co-Founder | 35 | WordPressMySQLPHP+20 | — | — |
| 21 | Nightingale Labs Provider of a cloud-enabled health platform for patients | $708K | 35 mo ago | Funding Raised | Kevin King Co-Founder | — | — | — | — |
| 22 | Thrive Smart baby feeder | $500K | 124 mo ago | Seed | — | 3 | — | 2 patents Rodent trapping devices for pest control, specifically mechanical capture mechanisms. | — |
| 23 | Cognionics Provider of mobile EEG solutions for neurophysiological monitoring | $381K | 165 mo ago | Funding Raised | Mike Chi Founder & CEO | — | — | 30 patents Dry EEG and biopotential sensing hardware with low‑impedance electrodes | — |
| 24 | Pillsmart Provider of evidence-based products to shape medication interaction using behavioral science | $379K | 60 mo ago | Funding Raised | — | 3 | — | — | — |
| 25 | MintHealth Blockchain-based mobile health records platform motivating healthy behaviors | $376K | 99 mo ago | Deadpooled | Vishal Verma Co-Founder & Director | — | — | — | — |
| 26 | Stella Wearables Wearable tech optimizing sun exposure and health behaviors for wellness | $150K | 80 mo ago | Seed | Nicolas Gonzalez Co-Founder & CEO | — | — | 5 patents Wearable UV radiation monitoring sensors for personal exposure measurement | — |
| 27 | Hydrostasis Provider of a hydration monitoring system for athletes | $120K | 48 mo ago | Seed | Debbie Chen Founder & CEO | 6 | WebflowTypekitGoogle Font API+8 | 11 patents Wearable medical devices measuring tissue hydration levels for health monitoring | — |
Top 12 Disease Self Management companies in San Diego
#1
Series C · San Diego, California · founded 2012 · 91 employees$175.1Mraised▾
Provider of a wearable biosensor platform for diabetes monitoring. It offers a wireless microsensor that enables users to understand their metabolism and blood glucose levels in real-time.
- Mar 2025Series C$100M
- Dec 2023Series B$59.1M
- Nov 2021Series B$100M
- Sep 2021Grant (prize money)$1.9M
#2
Early Stage · San Diego, California · founded 1997 · 41 employees$1.2Mraised▾
Advanced Brain Monitoring develops mobile EEG hardware and software, integrating, analyzing and reporting multi-sensor data. The company offers B-Alert EEG Software, X-Series EEG Headsets, Sleep Profiler (to detect sleep-disordered breathing in the home), InsomniCare (web-based solution for diagnosis & treatment of chronic insomnia). The company received FDA clearance for its X-Series System.
- Sep 2025Grant (prize money)$325.7K
- Oct 2019Grant (prize money)$1.5M
- Sep 2018Grant (prize money)$410.6K
- Jul 2017Grant (prize money)$524.6K
#3
Series A · San Diego, California · founded 2022 · 4 employees$4Mraised▾
Developer of medical device fo sweat analysis. The company leverages touch-based sweat-sensing technology to develop a hand-held device that is placed on the skin, and the device measures the chemical composition of the sweat.
- May 2025Conventional Debt$450K
- Jun 2023Series A$4M
#4
Funding Raised · San Diego, California · founded 1997$1.4Mraised▾
Innovating dry EEG sensors and psychophysiological monitoring systems for diverse applications. They are a global leader in noninvasive biosensing systems, specializing in dry sensors for high-fidelity psychophysiological monitoring without gels or sticky pads. Their advanced technology integrates precision hardware with sophisticated algorithms, outputting actionable information about cognitive and physiological states. They build psychophysiological sensing systems to spec and design algorithms that output precise, useful metrics. They offer solutions for human performance, healthcare, and commercial applications, including ambulatory cognitive state evaluation, seizure detection, and integration into wearable devices. Their expertise spans EEG, ECG, EMG, EOG, Pulse Oximetry, respiration, and inertial motion units. They provide unified data streams, eliminating integration headaches and reducing sources of error in physiological monitoring and analysis. They work with both government and commercial organizations to turn concepts into systems, offering expertise from research systems to medical devices.
- Jan 2025Grant (prize money)$500K
- Jan 2025Grant (prize money)$500K
- Jul 2014Grant (prize money)$119K
- Nov 2009Grant (prize money)$147.6K
#5
Deadpooled · San Diego, California · founded 2010 · 726 employees$405.7Mraised▾
Provider of health monitoring system for diagnosing diseases like influenza. The device needs a small sample which is slid into Cue’s disposable cartridges. These cartridges use DNA/RNA amplification and immunoassay chemistry to convert it to digital information that is sent to the mobile. The software delivers a personalized mobile health dashboard, which stores test results and connects directly with on-demand telemedicine and prescription services.
- May 2021Series D$235M
- Oct 2020Grant (prize money)$481M
- Jun 2020Series C$102.6M
- Jul 2018Series B$45M
#6
Public · San Diego, California · founded 1989 · 10140 employees$500Mraised▾
Therapeutic devices to treat sleep apnea and respiratory disorders. The roducts include Masks (Nasal pillows, Nasal masks, Full-face masks, Paediatric masks, and Non-vented masks), Devices (Range of CPAP, VPAP, Ventilators, etc), Humidifiers, and Accessories. It has also developed a non-contact sleep tracking system that helps users analyze and improve sleep. The system records the light, noise, and temperature conditions in the room, and syncs with smartphones to provide feedback and suggestions.
- Jul 2019Conventional Debt$500M
- Oct 2016Post IPO—
#7
Series C · San Diego, California · founded 1995 · 350 employees$39Mraised▾
BetterNight provides an app for sleep improvement. It helps in improving insomnia/sleep deprivation problems using digital therapeutic featuring cognitive behavioral therapy. It also provides telehealth, in-home test, and remote patient monitoring for consult, diagnosis, and treatment of sleep apnea.
- Mar 2023Series C$33M
- Feb 2023Series C$33M
- Mar 2021Series B—
- Oct 2019Unattributed$6M
#8
Series B · San Diego, California · founded 2014 · 37 employees$75.3Mraised▾
Developer of UVB light therapy devices for monitoring Psoriasis, Vitiligo, and Eczema. The company has developed a UV therapy based device that facilitates the treatment of chronic skin conditions. It uses advanced phototherapy technology that delivers a precise dose of light on the skin for treating multiple skin diseases. Its ultraviolet B (NB-UVB) light can penetrate the skin, and prevent the growth of affected skin cells for psoriasis. It also offers an integrated mobile app for the visualization of results.
- Oct 2021Series B$43M
- Nov 2019Series A$2.6M
- Nov 2019Series A$18M
- Dec 2017Seed$1M
#9
Public · San Diego, California · founded 1999 · 9600 employees$52.7Mraised▾
Provider of a wearable device for glucose monitoring. It provides a wearable patch that enables users to measure glucose levels in real-time. It has the capability to send data wirelessly to a display device through a transmitter and the touch screen receiver displays real-time glucose data. In 2022, the company recorded annual revenues of $3.02B and a net profit of $0.29B.
- Apr 2020Post IPO$1.1B
- Dec 2018Post IPO$850M
- May 2016Post IPO$7.2M
- Sep 2014Grant (prize money)$224.4K
#10
Late Stage · San Diego, California · founded 1997 · 29 employees$47Mraised▾
GlySens Incorporated, a biomedical technology company, that develops implantable continuous glucose monitoring devices. Its device indicates the current blood glucose level, shows a historical chart of the previous blood glucose values, provides adjustable automatic warnings of high and low blood glucose readings, and stores. The GlySens fully implanted sensor demonstrated up to 18 month lifetime in preclinical testing, links wirelessly to an external receiver and provide continuous glucose measurement, recording, and alerts regarding hypo- and hyperglycemic glucose excursions.
- Jun 2020Unattributed$15M
- Dec 2015Unattributed$20M
- Jan 2015Unattributed$12M
- Nov 2014Grant (prize money)$2M
#11
Seed · San Diego, California · founded 2015 · 32 employees$14.5Mraised▾
Provider of a personlized mobile app and test kit for tracking nutrition. The company has developed a test strip that uses the urine sample to analyze nutritional requirements in one's body. It also developed an app that is used to scan the strip results and provide a personalized nutrition plan to the users.
- Oct 2022Seed$1.5M
- Jan 2022Seed$200K
- Jan 2021Seed$14.2M
#12
Series C · San Diego, California · founded 1996$82.3Mraised▾
Provider of non-wearable devices and mobile app for monitoring elders. The mobile app can be connected with smartwatches for monitoring the activities. Also, various alert devices and cell phones are provided by the company.
- Jun 2012Conventional Debt$7M
- Jun 2012Series C$704.6K
- Jun 2008Series C$38M
- Aug 2007Series B$36.6M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Disease Self Management coverage by sub-theme.
Regulatory-risk over time falling
Funding & growth over time
funding flat · growth flat
How research on Digital Health is moving in the United States
A read on the academic research around Digital Health — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 8,843 United States-affiliated papers.
- Design Intelligence421
- Harvard University383
- Johns Hopkins University295
- University of North Carolina at Chapel Hill206
- University of Washington173
- Health care9→240
- Wearable computer6→129
- Health informatics25→140
- Remote patient monitoring11→76
- Informatics10→60
- Health care36→766
- Health informatics113→495
- Psychological intervention20→320
- Public health34→290
- Intervention (counseling)5→193
- Health care98→1170
- Health informatics213→712
- Public health73→525
- Psychological intervention26→368
- Health administration110→363
Where digital health is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing digital health patents in the United States
United States digital health patent filing is accelerating — 2,575 filings from 1,291 assignees (2016–2025), led by Boeing, Honeywell INT, Advanced Neuromodulation Systems; annual filings 173→270.
- Boeing150
- Honeywell INT129
- Advanced Neuromodulation Systems96
- General Electric91
- Hamilton Sundstrand67
- IBM65
- OTIS Elevator50
- Sikorsky Aircraft49
Common questions
Sweetie watches where the money and the users are piling in. She covers sector wealth and momentum — the install curves and revenue pools that show which corners of the market are quietly on fire.