Best Orthopedics Companies in North Carolina, United States
The 33 best Orthopedics companies in North Carolina, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: AskBio.
Our analysis of 50 Orthopedics companies
$3.4b in tracked funding; 82% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Orthopedics companies in North Carolina
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | AskBio Developer of AAV technologies for treating genetic and complex disorders | $235M | 74 mo ago | 900 | 2001 | Jude Samulski Co-Founder & CSO | WordPress Block EditorElementorWordPress+25 | 75 patents AAV vector design and delivery for kidney and neurological gene therapies | — |
| 2 | Avadim Health Provider of healthcare solutions | $109M | 78 mo ago | 94 | 2007 | — | WordPress Block EditorWordPressApple iCloud Mail+24 | — | — |
| 3 | CytexOrtho Developer of bio-artificial devices to treat musculoskeletal diseases 32Funding top 38%Talent top 38%Growth top 41%Fin. health bottom 45% All 7 signals ▾Fundingtop 38% Talenttop 38% Growthtop 41% Fin. healthbottom 45% Techbottom 41% Globalbottom 32% Marketbottom 24% Funding: Raised $24.4M across 17 rounds · 17 rounds over 4 yrs (4.2/yr) Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 32/100 | $24M | 18 mo ago | 10 | 2006 | Frank Moutos Co-Founder | WordPressMySQLPHP+16 | — | — |
| 4 | Bioventus Manufacturer of healing therapy products | $12M | 144 mo ago | 950 | 2012 | — | WordPressApple iCloud MailMicrosoft 365+29 | 104 patents Patents concentrated in chemistry & materials | — |
| 5 | TranS1 Medical device company delivering innovative spine surgery solutions | $12M | 282 mo ago | 32 | 2002 | — | — | 207 patents Minimally invasive spinal surgery tools, distraction devices, and intervertebral implants | — |
| 6 | Doron Therapeutics Provider of therapeutics for orthopedic indications | $11M | 23 mo ago | — | 2023 | Alessandra Pavesio Co-Founder & CEO | — | — | — |
| 7 | Sparta Biomedical Developing cartilage-like implants to treat osteoarthritis and restore joint function | $5M | 37 mo ago | 6 | 2017 | Dimitrios Angelis Co-Founder | WebflowjsDelivrGoogle Hosted Libraries+10 | — | — |
| 8 | Diamond Orthopedic Innovating orthopedic fixation with faceted bone screw technology for enhanced healing | $4M | 107 mo ago | 6 | 2016 | Roy Bivens CEO | — | — | — |
| 9 | Nutek Ortho Orthopaedic solutions innovator: minimally invasive fracture fixation for early patient mobility | $3M | 171 mo ago | 3 | 2006 | — | — | — | — |
| 10 | Reselute Developer of solutions for the treatment of orthopedic-related infections | $3M | 17 mo ago | 5 | 2022 | Jake Donovan Co-Founder and Head of Product Development | — | 3 patents Orthopedic intramedullary fixation devices with drug‑eluting coatings for bone healing | — |
| 11 | Quadvantage Developer of medical devices for orthopedic surgery | $1M | 37 mo ago | 2 | 2020 | Tom Gutierrez CEO | — | — | — |
| 12 | Akros Medical A medical device for orthopedic surgery | $1M | 94 mo ago | — | 2014 | Chuck Horrell Co-Founder & CEO | — | — | — |
| 13 | Shoulder Options Orthopedic devices for shoulder injuries | $500K | 155 mo ago | — | 2007 | Scott Humphrey Founder & Chief Innovation Officer | — | 14 patents Shoulder joint prosthesis orientation, glenoid/humeral implants, and fracture fixation devices | — |
Top 12 Orthopedics companies in North Carolina
#1
Seed · Durham, North Carolina · founded 2006 · 10 employees$24.4Mraised▾
Developer of bio-artificial devices to treat musculoskeletal diseases. It offers an implant derived from orthogonal fiber weaving process that replicate the properties of native articular cartilage and bone. It is surgically implanted to restore damaged joint cartilage due to wear and tear injury, and osteoarthritis.
- Apr 2025Grant (prize money)$4.8M
- Nov 2024Seed$125K
- Sep 2023Grant (prize money)$282.3K
- Jun 2022Conventional Debt$250K
#2
Seed · Durham, North Carolina · founded 2022 · 5 employees$2.7Mraised▾
Developer of solutions for the treatment of orthopedic-related infections. The company uses proprietary technology to develop a medical device for the treatment of orthopedic implant-related infections.
- May 2025Seed$2.4M
- Mar 2024Seed$2M
- May 2023Seed$700K
- Feb 2022Grant (prize money)$255.2K
#3
Series A · Chapel Hill, North Carolina · founded 2023$11Mraised▾
Provider of therapeutics for orthopedic indications. It offers a lead product MOTYS an intra-articular biologic drug derived from placental tissue. It delivers a host of beneficial growth factors with potent anti-inflammatory, tissue-protective and regenerative capabilities pivotal to the progressive and degenerative disease of osteoarthritis.
- Nov 2024Series A$11M
#4
Acquired · Durham, North Carolina · founded 2001 · 900 employees$235Mraised▾
Developer of AAV technologies for treating genetic and complex disorders. The company is engaged in the development and delivery of novel protein and cellular-based therapies through the design of proprietary recombinant Adeno associated virus (AAV) Biological Nano Particles (BNP). The gene delivery technology platform provides unsurpassed transduction efficiency, "ramp-up" expression capabilities, with tissue targeting and de-targeting properties. Its product pipeline includes drugs to treat muscular dystrophy, hemophilia B, congestive heart failure, epilepsy, retinitis pigmentosa, and osteoporosis.
- Sep 2020Grant (prize money)$2.7M
- Apr 2019PE$235M
- Aug 2014Grant (prize money)$270K
- Sep 2010Grant (prize money)$321K
#5
Series E · Asheville, North Carolina · founded 2007 · 94 employees$108.9Mraised▾
Avadim Health provides healthcare solutions. The company identifies various needs in healthcare and addresses them. The company offers foam sprays for muscle cramps, nutrition products for maintaining muscle health, and skin cleansers.
- Apr 2020Series E$318.8K
- Jan 2020Series D$66.5K
- Dec 2019Series C$30K
- Sep 2019Series C$339.3K
#6
Seed · Research Triangle Park, North Carolina · founded 2017 · 6 employees$5Mraised▾
Developing cartilage-like implants to treat osteoarthritis and restore joint function. They are focused on creating innovative solutions for cartilage degeneration using a chemically engineered cartilage platform. Their lead product, aims to provide immediate pain reduction and full range of motion for patients with osteoarthritis and cartilage defects. They are developing a pipeline of implants for various joints, addressing a significant unmet clinical need. The company operates at the intersection of chemistry, mechanical engineering, and biology, seeking to advance the standard of care for osteoarthritis and improve patients' quality of life. They are focused on medical devices, biomaterials, and regenerative medicine.
- Sep 2023Convertible Debt—
- Dec 2021Seed$5M
#7
Seed · Raleigh, North Carolina · founded 2020 · 2 employees$1.4Mraised▾
Developer of medical devices for orthopedic surgery. It offer products for ACL reconstruction surgery which include EZ Shape Bone Plug Guide, VariBlade, COBRA harvester, QuadSabre, Disposable Blades, and other fixation devices.
- Sep 2023Seed$1.4M
#8
Public · Durham, North Carolina · founded 2012 · 950 employees$12Mraised▾
Manufacturer of healing therapy products
- Oct 2014Venture Debt$12M
- May 2012Seed—
#9
Public · Raleigh, North Carolina · founded 2002 · 32 employees$12Mraised▾
Medical device company delivering innovative spine surgery solutions. Focused on providing surgeons with advanced tools that minimize the invasiveness of traditional spine surgery. They specialize in solutions like the Axial Lumbar Interbody Fusion System, designed for safe and reproducible access to vertebral bodies. Their offerings also include the Facet Fusion System, providing posterior fixation with reduced muscle and tissue trauma. They provide resources and training opportunities for surgeons. They are dedicated to advancing spine care through elegant and effective medical devices. Their products aim to improve patient outcomes and surgical experiences in the field of spine surgery.
- May 2003Series B$12M
#10
Seed · Charlotte, North Carolina · founded 2016 · 6 employees$3.5Mraised▾
Innovating orthopedic fixation with faceted bone screw technology for enhanced healing. This company is revolutionizing orthopedic fixation with its patented faceted threadform technology. Their bone screws offer lower insertional torque, increased bone contact, and higher pullout strength, promoting better osteogenesis and device apposition. They focus on advancing orthopedic solutions, providing surgeons with innovative tools for improved patient outcomes. Their products include small bone screw sets, headless compression screw sets, and cannulated screw sets. They are seeking distributors to expand the reach of their innovative product portfolio. They are committed to setting a new fixation standard in orthopedics.
- Nov 2017Seed$3.5M
- Apr 2017Seed$625K
#11
Series A · Kenansville, North Carolina · founded 2006 · 3 employees$3.5Mraised▾
Orthopaedic solutions innovator: minimally invasive fracture fixation for early patient mobility. This company is dedicated to advancing orthopaedic surgery through innovative technologies. Specializing in non-bridging fracture fixation, they utilize multi-planar and multi-directional k-wires and half-pins to stabilize intra and extra-articular fracture fragments. Their system offers axial freedom for precision placement of K-wires, secured by a spherical pin-locking mechanism. The radiolucent plate allows real-time fluoroscopic viewing. The focus is on broad applicability, low infection rates, increased stability, short operative times, preserved vascularity, and limited soft-tissue damage. The goal is to provide reduced complications, increased options for better results, minimally invasive procedures with no permanent implants, and early return to mobility for patients. They offer solutions for shoulder, hand, and wrist fractures.
- Jul 2012Series A$400K
- Mar 2009Series A$3.1M
- Mar 2009Conventional Debt—
#12
Seed · Durham, North Carolina · founded 2014$1Mraised▾
Akros Medical is developing a medical device for orthopaedic surgery. Chuck Horrell founded the company in 2014.
- Dec 2018Seed$464.3K
- Dec 2015Seed$560K
- 2015Venture Debt$75K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Orthopedics coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth flat
How research on Medical Devices is moving in the United States
A read on the academic research around Medical Devices — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 1,830 United States-affiliated papers.
- Johns Hopkins University74
- United States Food and Drug Administration59
- Harvard University54
- Center for Devices and Radiological Health53
- Design Intelligence36
- Biocompatible material2→9
- Robotics7→13
- Health care1→6
- Tissue engineering1→5
- Automation1→5
- Health care2→24
- MEDLINE1→21
- Quality (philosophy)3→15
- Robotic surgery18→29
- Product (mathematics)5→16
- MEDLINE1→36
- Robotic surgery7→24
- Patient safety19→32
- Key (lock)6→19
- Quality (philosophy)10→20
Where medical devices is researched across United States
Location clusters by institution affiliation — each city's volume, stance tone, and a quick read on its hot topic, what's advancing, the opening opportunity, and the main concern.
Who's filing medical devices patents in the United States
United States medical devices patent filing is accelerating — 666,693 filings from 8,000 assignees (2016–2025), led by Covidien, Boston Scient Scimed, Medtronic; annual filings 63466→63610.
- Covidien29348
- Boston Scient Scimed24762
- Medtronic22394
- Becton Dickinson18249
- Procter & Gamble16178
- Ethicon ENDO Surgery13723
- Kimberly Clark12440
- Ethicon11761
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.