173 investors have funded 52 Life Sciences companies head-officed in Chicago, across 254 rounds (Mar 2000 – Feb 2026). They are ranked by how many Chicago companies in this market they have actually backed.
"In Chicago" describes the companies, not the investor: most of the money in any city comes from somewhere else, and the Where the money comes from section below shows exactly where it came from here.
Ranked by companies backed in this market and city, then by round count. "Led" counts rounds recorded with this investor as lead.
| # | Investor | Based in | Stages here | Companies | Rounds | Led | Latest | Portfolio total |
|---|---|---|---|---|---|---|---|---|
| 1 | Portal Innovations | Chicago, United States | SeedSeries A | 4 | 5 | 2 | Apr 2025 | 11 |
| 2 | Revolution | Washington, DC, United States | Series CSeries DSeries E+ | 3 | 7 | 2 | Oct 2024 | 216 |
| 3 | Orbimed | New York City, United States | Series ASeries B | 3 | 4 | 2 | Jun 2025 | 422 |
| 4 | New Enterprise Associates | Menlo Park, United States | Series CSeries DSeries E+ | 2 | 6 | 4 | Oct 2024 | 1,110 |
| 5 | Illinois Ventures | Chicago, United States | Series DSeries E+Seed | 2 | 6 | 3 | Jan 2015 | 29 |
| 6 | Novo Holdings | Hellerup, Denmark | Series BSeries E+ | 2 | 4 | 1 | Dec 2020 | 286 |
| 7 | Gopher Angels | Minneapolis, United States | Series BSeries ASeries C | 2 | 4 | 1 | Oct 2019 | 19 |
| 8 | SOSV | Cork, Ireland | Seed | 2 | 3 | — | Feb 2023 | 446 |
| 9 | Y Combinator | Mountain View, United States | Seed | 2 | 2 | 2 | Jan 2023 | 5,648 |
| 10 | Techstars | New York City, United States | Seed | 2 | 2 | 1 | Jan 2024 | 3,580 |
| 11 | F-Prime Capital | Cambridge, United States | Series BSeries A | 2 | 2 | 1 | Nov 2014 | 306 |
| 12 | Gener8tor | Madison, United States | Seed | 2 | 2 | 2 | Oct 2022 | 323 |
| 13 | M25 | Chicago, United States | Seed | 2 | 2 | 1 | Feb 2019 | 95 |
| 14 | Lilly | Indianapolis, United States | Series BSeries A | 2 | 2 | — | Apr 2025 | 110 |
| 15 | T. Rowe Price | Baltimore, United States | Series DSeries E+ | 1 | 5 | 3 | Dec 2020 | 214 |
| 16 | Deerfield | New York City, United States | Series CPost-IPO | 1 | 4 | — | Mar 2021 | 182 |
| 17 | Baillie Gifford | Edinburgh, United Kingdom | Series E+ | 1 | 4 | 2 | Dec 2020 | 123 |
| 18 | Redmile Group | San Francisco, United States | Series C | 1 | 3 | 3 | May 2017 | 113 |
| 19 | Franklin Templeton Investments | New York City, United States | Series E+ | 1 | 3 | 2 | Dec 2020 | 140 |
| 20 | Unilever Ventures | London, United Kingdom | Series DSeries CSeries B | 1 | 3 | 2 | Mar 2012 | 88 |
| 21 | Grove Ventures | Tel Aviv Yafo, Israel | Series BSeries ASeed | 1 | 3 | 1 | Mar 2022 | 34 |
| 22 | Polaris Partners | Boston, United States | Series ASeries B | 1 | 2 | — | Feb 2016 | 330 |
| 23 | USVP | Menlo Park, United States | Series ASeries B | 1 | 2 | — | Jun 2025 | 243 |
| 24 | Alpha Wave Global | New York City, United States | Series A | 1 | 2 | 1 | Jan 2024 | 130 |
| 25 | TA | Boston, United States | Series BSeries A | 1 | 2 | — | Aug 2000 | 181 |
| 26 | Vertex Ventures Israel | Savyon, Israel | Series ASeed | 1 | 2 | 1 | Jul 2020 | 71 |
| 27 | RiverVest Venture Partners | St. Louis, United States | Series ASeries B | 1 | 2 | — | Jun 2025 | 51 |
| 28 | Burrill and Company | Wuxi, China | Series CSeries B | 1 | 2 | — | Dec 2008 | 57 |
| 29 | BP Ventures | London, United Kingdom | Series DSeries E+ | 1 | 2 | 2 | Jan 2014 | 65 |
| 30 | Venture Investors | Madison, United States | Series CSeries B | 1 | 2 | — | Dec 2008 | 51 |
| 31 | Healthbox | Chicago, United States | Seed | 1 | 2 | — | Feb 2015 | 64 |
| 32 | KdT Ventures | Black Mountain, United States | Series ASeed | 1 | 2 | 1 | Feb 2023 | 44 |
| 33 | Merieux Equity Partners | Lyon, France | Series C | 1 | 2 | 1 | Mar 2018 | 36 |
| 34 | Debiopharm | Lausanne, Switzerland | Series ASeries B | 1 | 2 | 1 | Mar 2022 | 33 |
| 35 | Malaysian Life Sciences Capital Fund | Kuala Lumpur, Malaysia | Series DSeries C | 1 | 2 | — | Mar 2012 | 15 |
| 36 | The University of Chicago | Chicago, United States | Seed | 1 | 2 | — | Jan 2018 | 18 |
| 37 | Barings | London, United Kingdom | Series E+ | 1 | 2 | 1 | Jan 2015 | 15 |
| 38 | Wild Basin Investments | Austin, United States | Series C | 1 | 2 | — | Mar 2018 | 12 |
| 39 | Ambria Capital | San Juan, Puerto Rico | Post-IPO | 1 | 2 | 2 | Mar 2021 | 6 |
| 40 | Afternic | Cambridge, United States | Series CSeries B | 1 | 2 | — | Dec 2008 | 5 |
| 41 | Heartland Angels | Skokie, United States | Series BSeries C | 1 | 2 | — | Oct 2017 | 4 |
| 42 | Seerave | Jersey City, United States | Seed | 1 | 2 | — | Feb 2023 | 2 |
| 43 | McNair Group | Mount Pleasant, United States | Series C | 1 | 2 | — | Dec 2016 | 2 |
| 44 | TWB Partners | Rome, Italy | Series BSeries C | 1 | 2 | — | Oct 2017 | 1 |
| 45 | Quantitative Investment Management | Charlottesville, United States | Series DSeries C | 1 | 2 | 1 | Mar 2012 | 1 |
| 46 | Walder Ventures | Skokie, United States | SeedSeries A | 1 | 2 | 1 | Apr 2025 | 1 |
| 47 | PFG | Glenorchy, Australia | Series CSeries B | 1 | 2 | 2 | Oct 2017 | 1 |
| 48 | Alumni Ventures | New York City, United States | Series A | 1 | 1 | — | Feb 2023 | 607 |
| 49 | Alchemist Accelerator | San Francisco, United States | Seed | 1 | 1 | 1 | Sep 2020 | 517 |
| 50 | Wellfound | New York City, United States | Seed | 1 | 1 | 1 | Sep 2022 | 397 |
| 51 | Fidelity Investments | Boston, United States | Series B | 1 | 1 | 1 | Sep 2023 | 358 |
| 52 | DCVC | Palo Alto, United States | Series A | 1 | 1 | 1 | Apr 2025 | 265 |
| 53 | RA Capital Management | Boston, United States | Series B | 1 | 1 | 1 | Jun 2025 | 317 |
| 54 | HAX | San Francisco, United States | Seed | 1 | 1 | 1 | Oct 2018 | 283 |
| 55 | IndieBio | San Francisco, United States | Seed | 1 | 1 | 1 | Jun 2019 | 252 |
| 56 | Valor Equity Partners | Chicago, United States | Series B | 1 | 1 | — | Sep 2023 | 184 |
| 57 | Mountain View, United States | Series E+ | 1 | 1 | 1 | Dec 2020 | 216 | |
| 58 | MassChallenge | Boston, United States | Seed | 1 | 1 | 1 | May 2018 | 254 |
| 59 | MPM Capital | Boston | Series B | 1 | 1 | 1 | May 2010 | 127 |
| 60 | Village Global | San Francisco, United States | Seed | 1 | 1 | 1 | Sep 2022 | 188 |
| 61 | Vertex Ventures | Singapore | Series B | 1 | 1 | — | Mar 2022 | 127 |
| 62 | Casdin Capital | New York City, United States | Series B | 1 | 1 | — | Sep 2021 | 136 |
| 63 | SR One | Redwood City, United States | Series B | 1 | 1 | 1 | May 2010 | 117 |
| 64 | Baird Capital | Chicago, United States | Series A | 1 | 1 | 1 | Sep 2021 | 122 |
| 65 | Osage University Partners | Bala Cynwyd, United States | Series B | 1 | 1 | — | Sep 2021 | 108 |
| 66 | Forbion | Naarden, Netherlands | Series B | 1 | 1 | 1 | Jun 2025 | 108 |
| 67 | M Ventures | Amsterdam, Netherlands | Series B | 1 | 1 | 1 | Apr 2024 | 95 |
| 68 | Lightbank | Chicago, United States | Series C | 1 | 1 | — | Oct 2024 | 121 |
| 69 | Austin Technology Incubator | Austin, United States | Series A | 1 | 1 | 1 | Jan 2014 | 148 |
| 70 | Pfizer | New York City, United States | Series A | 1 | 1 | 1 | Jan 2024 | 110 |
| 71 | HPA | Chicago, United States | Seed | 1 | 1 | 1 | Mar 2022 | 94 |
| 72 | Hatteras Venture Partners | Durham, United States | Series A | 1 | 1 | 1 | Dec 2022 | 75 |
| 73 | S32 | Sunnyvale, United States | Series B | 1 | 1 | 1 | Mar 2022 | 82 |
| 74 | Pontifax | Herzliya, Israel | Series B | 1 | 1 | — | Sep 2021 | 74 |
| 75 | Jumpstart Foundry | Nashville, United States | Seed | 1 | 1 | 1 | May 2017 | 113 |
| 76 | Logos | San Francisco, United States | Series B | 1 | 1 | — | Sep 2021 | 99 |
| 77 | Sanofi Ventures | Paris, France | Series B | 1 | 1 | 1 | Mar 2022 | 79 |
| 78 | Omega Funds | Boston, United States | Series B | 1 | 1 | 1 | Sep 2021 | 83 |
| 79 | Citadel | Chicago, United States | Series B | 1 | 1 | — | Sep 2021 | 99 |
| 80 | SaaS Ventures | Washington, DC, United States | Seed | 1 | 1 | — | Feb 2019 | 77 |
| 81 | Bay City Capital | San Francisco, United States | Series C | 1 | 1 | — | May 2017 | 60 |
| 82 | Lumira Ventures | Toronto, Canada | Series A | 1 | 1 | 1 | Jan 2024 | 54 |
| 83 | Pfizer Venture Investments | New York City, United States | Series B | 1 | 1 | — | May 2010 | 58 |
| 84 | Bristol-Myers Squibb | New York City, United States | Series A | 1 | 1 | 1 | Jan 2024 | 64 |
| 85 | GE Capital | Norwalk, United States | Series E+ | 1 | 1 | — | Jan 2014 | 72 |
| 86 | Better Ventures | Oakland, United States | Seed | 1 | 1 | — | Nov 2020 | 65 |
| 87 | NVentures | Santa Clara, United States | Series B | 1 | 1 | — | Sep 2023 | 63 |
| 88 | Impact Engine | Chicago, United States | Seed | 1 | 1 | 1 | Jul 2016 | 54 |
| 89 | Builders VC | San Francisco, United States | Series C | 1 | 1 | — | Oct 2024 | 53 |
| 90 | Africinvest | Paris, France | PE | 1 | 1 | 1 | Feb 2009 | 57 |
| 91 | LionBird | Tel Aviv, Israel | Seed | 1 | 1 | 1 | Jul 2019 | 36 |
| 92 | Prime Movers Lab | Jackson, United States | Series A | 1 | 1 | 1 | Feb 2023 | 39 |
| 93 | Sectoral | Montreal, Canada | Series A | 1 | 1 | 1 | Dec 2020 | 42 |
| 94 | MATH Venture Partners | Chicago, United States | Seed | 1 | 1 | — | Feb 2019 | 37 |
| 95 | T1D Fund | Boston, United States | Series A | 1 | 1 | 1 | Jan 2024 | 34 |
| 96 | i2E | Oklahoma City, United States | Seed | 1 | 1 | 1 | Apr 2019 | 41 |
| 97 | Broadview Ventures | Boston, United States | Series A | 1 | 1 | 1 | Dec 2022 | 36 |
| 98 | Thomas, McNerney & Partners | Stamford, United States | Series B | 1 | 1 | — | May 2010 | 26 |
| 99 | Roche | Basel, Switzerland | Series A | 1 | 1 | 1 | Jan 2024 | 31 |
| 100 | WARF | Madison, United States | Series A | 1 | 1 | 1 | Jan 2025 | 34 |
Showing the top 100 of 173. Search the full investor set →
Head office of the investors on this page.
Rounds by stage — where in a company's life this money arrives.
Total disclosed size of each round, not one investor's share.
How active this market has been.
Life Sciences companies head-officed in Chicago that took money from these investors.
| Company | Backers | Rounds | Disclosed | Latest round |
|---|---|---|---|---|
| Xeris Pharmaceuticals xerispharma.com |
12 | 20 | $532.2M | Post-IPO Jan 2022 |
| Chromatin chromatininc.com |
11 | 24 | $358.6M | Series E+ Jan 2015 |
| Tempus tempus.com |
8 | 26 | $3.6B | Series E+ Dec 2020 |
| Vanqua Bio vanquabio.com |
8 | 8 | $680M | Series B Sep 2021 |
| Nucle AI nucleai.ai |
8 | 12 | $241.5M | Series B Apr 2024 |
| Grove Biopharma grovebiopharma.com |
8 | 10 | $222M | Series A Apr 2025 |
| Madison Scientific madisonscientific.com |
8 | 8 | $80M | Series A Jan 2025 |
| Luna Lights lunalights.org |
8 | 9 | $1.5M | Seed May 2017 |
| Cour Pharma courpharma.com |
7 | 8 | $765M | Series A Jan 2024 |
| Dimension Inx dimensioninx.com |
7 | 9 | $82.2M | Series A Feb 2023 |
| Halo halo.science |
7 | 7 | $18.2M | Seed Sep 2022 |
| Sparrow Pharmaceuticals sparrowpharma.com |
6 | 9 | $625M | Series B Jun 2025 |
| NeuroTherapeutics Pharma ntprx.com |
6 | 6 | $258M | Series B May 2010 |
| Cardiosense cardiosense.com |
6 | 6 | $90.6M | Series A Dec 2022 |
| BiomeSense biomesense.com |
6 | 8 | $31M | Seed Feb 2023 |
| Evozyne evozyne.com |
5 | 5 | $405M | Series B Sep 2023 |
| Wesana Health wesanahealth.com |
5 | 6 | $8.2M | Post-IPO Mar 2021 |
| Hubly hublysurgical.com |
5 | 5 | $6M | Seed Jul 2023 |
| Pathos pathos.com |
4 | 4 | $248M | Series C Oct 2024 |
| Attune Medical attune-medical.com |
4 | 9 | $81.5M | Series C Oct 2017 |
| Rmark Bio rmarkbio.com |
4 | 4 | $6M | Seed Feb 2019 |
| Neopenda neopenda.com |
4 | 4 | $4.9M | Seed Apr 2021 |
| SIA sia.health |
3 | 3 | $23M | Series B Dec 2021 |
| MetaMe Health metamehealth.com |
3 | 3 | $9.9M | Seed Mar 2022 |
| Questia questia.com |
2 | 3 | $220M | Series B Aug 2000 |
| Novaerus novaerus.com |
2 | 3 | $35M | Series B Feb 2016 |
| Novian Health novianhealth.com |
2 | 2 | $22M | Unattributed Feb 2013 |
| MAIA maiabiotech.com |
2 | 2 | $16M | Series A May 2021 |
| ClostraBio clostrabio.com |
2 | 3 | $13.6M | Series A Sep 2022 |
| OrisDX orisdx.com |
2 | 2 | $8M | Seed May 2025 |
| Flow Medical flowmedical.co |
2 | 2 | $5M | Seed Dec 2024 |
| Validfor validfor.com |
2 | 2 | $2.4M | Seed Feb 2026 |
| Arkim arkim.co |
2 | 2 | — | Seed Oct 2020 |
| Biologos biologos.com |
2 | 2 | — | PE Nov 2015 |
| Celsis celsis.com |
1 | 1 | $36.8M | Series B Sep 2009 |
| Clarix Imaging clariximaging.com |
1 | 1 | $10M | Series A Oct 2023 |
| Vodori vodori.com |
1 | 1 | $7.5M | Series A Sep 2021 |
| Edge Surgical edgesurgical.com |
1 | 1 | $5M | Series A Dec 2020 |
| LaGray Chem lagraychem.com |
1 | 1 | $5M | PE Feb 2009 |
| Simergent simergent.com |
1 | 1 | $2.8M | Seed Apr 2019 |
| Diagnostic Photonics diagnosticphotonics.com |
1 | 1 | $1.3M | Seed Sep 2011 |
| Phyter phyterfood.com |
1 | 1 | $1M | Seed Nov 2017 |
| Bold Diagnostics bolddiagnostics.com |
1 | 1 | $250K | Seed Oct 2018 |
| HappiLabs happilabs.org |
1 | 1 | $150K | Seed Jul 2018 |
| TorMagnus Pharmaceuticals tormagnuspharmaceuticals.com |
1 | 1 | $125K | Seed Jan 2023 |
| MicroMGx micromgx.com |
1 | 1 | $100K | Seed Oct 2022 |
| Shevolve Nutrition shevolvenutrition.com |
1 | 1 | $100K | Seed Oct 2022 |
| The Collaboratory thecollaboratory.ai |
1 | 1 | $20K | Seed Jul 2021 |
| Third Opinion thirdopinion.io |
1 | 1 | $20K | Seed Jan 2024 |
| NewPath Probiotics newpathprobiotics.com |
1 | 1 | — |
| Date | Investor | Company | Stage | Round size |
|---|---|---|---|---|
| Feb 2026 | Curiosity | Validfor | Seed | $1.2M |
| Feb 2026 | DOMiNO VenturesLED | Validfor | Seed | $1.2M |
| Jun 2025 | Orbimed | Sparrow Pharmaceuticals | Series B | $95M |
| Jun 2025 | USVP | Sparrow Pharmaceuticals | Series B | $95M |
| Jun 2025 | RiverVest Venture Partners | Sparrow Pharmaceuticals | Series B | $95M |
| Jun 2025 | RA Capital ManagementLED | Sparrow Pharmaceuticals | Series B | $95M |
| Jun 2025 | ForbionLED | Sparrow Pharmaceuticals | Series B | $95M |
| May 2025 | CareQuest Innovation Partners | OrisDX | Seed | $4M |
| May 2025 | Revere PartnersLED | OrisDX | Seed | $4M |
| Apr 2025 | Gradiant | Grove Biopharma | Series A | $30M |
| Apr 2025 | DCVCLED | Grove Biopharma | Series A | $30M |
| Apr 2025 | Lilly | Grove Biopharma | Series A | $30M |
| Apr 2025 | Portal Innovations | Grove Biopharma | Series A | $30M |
| Apr 2025 | Mansueto Office | Grove Biopharma | Series A | $30M |
| Apr 2025 | Walder Ventures | Grove Biopharma | Series A | $30M |
| Apr 2025 | InVivium Capital | Grove Biopharma | Series A | $30M |
| Jan 2025 | WARFLED | Madison Scientific | Series A | $10M |
| Jan 2025 | Central Illinois Angels | Madison Scientific | Series A | $10M |
| Jan 2025 | Stateline Angels | Madison Scientific | Series A | $10M |
| Jan 2025 | mHUB | Madison Scientific | Series A | $10M |
Life Sciences investors in other cities
Other markets in Chicago