Vitamin D
One supplement, every record we hold on it: which conditions the evidence actually supports it for, what the people taking it ask, what is sold, what is patented, and what the businesses behind it earn.
Trace vitamin D across Prism's evidence, research, news, patent, community and company records — the conditions it is linked to and how well each is supported, the questions people taking it actually ask, and the industry built around it.
Related records across every corpus we hold, not a severity score.
Built 2026-09-18 · Measurement windows and limitations
The evidence graph
14,565 extracted claims link vitamin d to 4,455 distinct conditions. The graph below ranks them by evidence strength rather than by how often each is written about — for this subject, and for most, those are different answers.
Sized by claims at high or very high evidence strength. A dashed ring marks a link whose claims since 2023 outnumber 2019–2022 by more than two to one.
Most sentences of the form “low vitamin d raises the risk of…” are about a shortfall, not about taking more. The record keeps vitamin d deficiency as a separate subject, and it carries 1,790 risk claims against 373 filed under vitamin d itself — 83% of the combined total. Where the same condition appears in both lanes here, that is usually why: osteoporosis, rickets, cardiovascular disease, multiple sclerosis, cancer.
- multiple sclerosis4 strong / 22
- fractures4 strong / 20
- falls4 strong / 11
- cancer3 strong / 32
- cardiovascular disease3 strong / 24
- stroke3 strong / 20
- type 2 diabetes3 strong / 15
- breast cancer2 strong / 17
- hypertension2 strong / 11
- hypercalcemia1 strong / 18
- covid-199 strong / 123
- gi disease9 strong / 9
- cancer7 strong / 65
- osteoarthritis7 strong / 16
- diabetes6 strong / 36
- type 2 diabetes6 strong / 21
- depression5 strong / 47
- sarcopenia5 strong / 13
- type 2 diabetes mellitus4 strong / 12
- cardiovascular disease4 strong / 11
- cancer26 strong / 336
- colorectal cancer17 strong / 69
- heart disease14 strong / 151
- diabetes12 strong / 151
- type 2 diabetes8 strong / 72
- influenza8 strong / 28
- severe asthma exacerbation8 strong / 8
- stroke7 strong / 21
- osteoporosis6 strong / 250
- depression6 strong / 100
- depression5 strong / 8
- inflammation2 strong / 25
- cancer cells2 strong / 6
- fractures2 strong / 3
- bone mineralization1 strong / 5
- immune response1 strong / 5
- viruses1 strong / 5
- breast cancer1 strong / 5
Written about most, supported least
Links with the widest gap between how often they are claimed and how often a strong study carries the claim.
| Linked term | Claims | High-strength | Share |
|---|---|---|---|
| diabetes | 119 | 1 | 0.8% |
| osteoporosis | 250 | 6 | 2.4% |
| osteoporosis | 111 | 3 | 2.7% |
| covid-19 | 160 | 5 | 3.1% |
| bone health | 61 | 2 | 3.3% |
| dementia | 91 | 3 | 3.3% |
What kind of study the claims come from
Every source document classified by design.
Every node here is a live subject in the disease evidence explorer: selecting one opens it as the centre of its own graph, with every other condition it touches.
Research landscape
29,030 research records carry this condition as an indexed subject heading between 2012 and 2025 — 2,309 of them randomised trials and 1,248 meta-analyses. The mix matters more than the total: it is what the evidence strengths in the graph above are built from.
Research records per year
Indexed research records, 2012–2025.
Trials and syntheses per year
Drawn on their own scale; they are a small share of the total.
- Vitamin D29,007 · steady
- 25-hydroxyvitamin D7,754 · falling
- Vitamins5,850 · rising
- Calcium2,999 · steady
- Biomarkers2,584 · falling
- Parathyroid Hormone2,154 · falling
- Receptors, Calcitriol1,946 · steady
- Cholecalciferol1,588 · rising
- Calcifediol1,010 · rising
- Calcium, Dietary998 · falling
- Bone Density Conservation Agents793 · falling
- Blood Glucose684 · steady
- VDR protein, human654 · steady
- Calcitriol617 · steady
- Risk Factors3,707
- Calcium2,999
- Biomarkers2,584
- Parathyroid Hormone2,156
- Bone Density2,033
- Receptors, Calcitriol1,947
- Body Mass Index1,356
- Diet1,193
- Osteoporosis1,178
- Seasons1,148
- Nutritional Status1,091
- Obesity1,049
- COVID-191,025
- Calcium, Dietary998
- Nutrients1,711
- PloS one665
- The Journal of steroid biochemistry and molecular biology564
- The Journal of clinical endocrinology and metabolism392
- Scientific reports381
- International journal of molecular sciences364
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA259
- The American journal of clinical nutrition224
- Frontiers in endocrinology195
- Medicine191
Counts are research records carrying the subject heading, not a measure of research quality or spend. Randomised trials and meta-analyses are recorded study designs. Rising and falling compare records per year in 2012–2021 against 2022–2025, because the two windows are different lengths.
News attention
140,355 articles across five years matched this subject. News volume measures attention, not incidence or severity — it is included here because the gap between what is covered and what is supported is one of the things this report is for.
Matched coverage per month
140,355 articles, 2021-05 to 2026-05. The final month is drawn dashed: the most recent weeks are still being ingested and always read low.
What changed between the last two years
Themes by share of coverage
Gaining share of coverage
Losing share
Change in each theme's share of matched coverage between 2024-05–2025-05 (57,050 articles) and 2025-05–2026-05 (28,451 articles). A share change is not a percentage-point change, and a theme can gain share while its raw count falls.
How the coverage reads
Sentiment of every matched article
- supplements for cognitive function enhancement86,395
- herbal supplements and their uses84,220
- dietary supplements and nutraceuticals14,790
- protein shakes and supplements5,075
- nail health supplements and vitamins3,642
- sports nutrition and performance supplements3,604
- egg nutrition profiles (protein, vitamins)2,352
- probiotics and gut health supplements2,319
- regulations and safety of dietary supplements2,182
- hair growth supplements and vitamins2,106
- vitamin deficiency symptoms and solutions2,087
- vitamin d sources and supplementation2,055
- cbd1,447
- b12516
- intel258
- ferrari163
- nato158
- cadillac145
- poppi143
- fmi137
- costco135
- pepsico134
- social media130
- keto114
What the people taking it ask
139,490 typed signals from 139,488 public conversations. The research record says what it is supported for; this says what the people actually taking it want to know — and 8 of the 12 most repeated questions are asking how much to take.
Signals per year and what they were doing
Every typed signal, and the kind of message it came from
What the conversation is about
Share of signals by aspect
What people ask most
Recurring questions and requests for help, de-duplicated. Wording is as written, lightly tidied.
- Is this safe to take weekly i'm scared to take it?8 times
- How much vitamin d do you take?7 times
- How much vitamin d should i take?6 times
- How much IU per day should i consume?5 times
- How much vitamin d should i be taking?5 times
- Is 10,000 units of vitamin D 3 too much (daily)?5 times
- Is taking very high doses of vitamin d worth it?4 times
- How can i increase vitamin d if my body isn't able to absorb it and i'm intolerant to all dairy products?4 times
- How much vitamin d should i take and when can i expect to feel better?4 times
- Will 4000 ui of vitamin d be good?4 times
- Do i need a vitamin d supplement to correct a deficiency or is increased sun exposure adequate?3 times
- What is the difference between IU and IE?3 times
What people take it for
Conditions named alongside it, with how the reports read. Positive share counts only signals the model judged either way; neutral mentions are excluded from it.
| Condition | Mentions | Of those judged | Side-effect reports | Cost & access |
|---|---|---|---|---|
| vitamin d deficiency | 3,966 | 74% positive | 31 | 1 |
| depression | 3,336 | 80% positive | 34 | 0 |
| hair loss | 2,112 | 94% positive | 5 | 0 |
| acne | 1,642 | 82% positive | 47 | 0 |
| eczema | 1,291 | 92% positive | 4 | 0 |
| anxiety | 1,244 | 76% positive | 48 | 0 |
| fatigue | 1,133 | 90% positive | 7 | 0 |
| psoriasis | 1,118 | 87% positive | 1 | 0 |
| hypothyroidism | 1,048 | 88% positive | 8 | 0 |
| deficiency | 1,013 | 71% positive | 13 | 0 |
These are lived-experience signals, not clinical evidence and not a representative survey: the people who post are not a sample of everyone with the condition, and a treatment discussed more is usually a treatment prescribed more. Read them next to the evidence graph, not instead of it.
Where it is written about
Three different geographies of the same subject: where the news reports it, which regions carry that coverage, and where the companies working on it are based. None of them measures where the disease actually is.
Where the news is written
140,355 matched articles · 59 countries with coverage
States and regions
Matched articles by reported region
| State or region | Country | Articles |
|---|---|---|
| New York | United States | 1,955 |
| California | United States | 1,724 |
| Noord-Brabant | Netherlands | 1,546 |
| Maine | United States | 1,047 |
| Texas | United States | 970 |
| Tennessee | United States | 844 |
| Florida | United States | 774 |
| Illinois | United States | 661 |
| New Jersey | United States | 642 |
| Michigan | United States | 542 |
| England | United Kingdom | 528 |
| Pennsylvania | United States | 519 |
| Colorado | United States | 462 |
| Catalonia | Spain | 451 |
| Arizona | United States | 429 |
| Washington | United States | 418 |
| Massachusetts | United States | 416 |
| Georgia | Georgia | 401 |
| Singapore | Singapore | 369 |
| Maharashtra | India | 364 |
Where the companies are
One point per recorded headquarters
8,447 of 8,596 companies record a headquarters location; 4,000 of them drawn here.
City tags in the news corpus mix cities with states and acronyms, so this chapter uses country and state tags only. A country's article count reflects reported location and how much news that country produces; the relative-attention view divides that out.
What is being patented
5,517 patent publications between 2010 and 2024 name this subject in their title. Patents show where money expects a return, which is a different signal from either the research record or the news.
Patent publications per year
5,517 publications on the strict match, 2010–2024.
Which ideas are growing inside the filing record
Title-term matches. Change compares filings per year, because the two windows are six years and five.
| Theme in the filing title | 2014–19 | 2020–24 | Per year |
|---|---|---|---|
| stem cell | 4 | 4 | 1.2× |
| metformin | 4 | 1 | 0.3× |
| wound | 9 | 2 | 0.3× |
| islet | 0 | 0 | 0.0× |
- A61K — Medicinal preparations2,763
- A61P — Therapeutic activity of compounds2,712
- G01N — Investigating materials by analysis1,037
- C07C — Acyclic and carbocyclic compounds970
- A23L — Foods and non-alcoholic beverages526
- A23V — Food composition indexing447
- C07K — Peptides293
- Y02P283
- C07F267
- A61Q255
- WISCONSIN ALUMNI RES FOUND436
- DSM IP ASSETS BV191
- OPKO IRELAND GLOBAL HOLDINGS LTD180
- LEO PHARMA AS127
- DELUCA HECTOR F95
- QUEST DIAGNOSTICS INVEST INC94
- CYTOCHROMA INC93
- CLAGETT-DAME MARGARET90
- PLUM LORI A87
- OPKO RENAL LLC75
- TEIJIN PHARMA LTD61
- BERG LLC58
- United States1,388
- Netherlands210
- South Korea180
- Japan167
- France162
- Switzerland151
- Germany142
- Denmark133
- KY124
- Canada116
Publication lags filing by roughly eighteen months, so the last years of this window are structurally incomplete and a fall at the right-hand edge is not a fall in activity. Assignee is whoever the filing names, which includes prolific individual inventors alongside companies.
What the companies are building
The 8,596 companies in this field are not building one thing. Grouping them by what they say they do separates the monitoring hardware from the drugs, the software from the surgery — and shows which approaches are the newer arrivals.
- MMUSA$284MOnline e-commerce platform for fitness supplements
- Bright LifeCare$229MManufacturer of nutritional supplements and health and wellness products
- Zoe$133MProvider of gut health testing services and plant based supplements
- NU Skin$751MManufacturer of anti-aging products
- Bright LifeCare$229MManufacturer of nutritional supplements and health and wellness products
- Nuritas$155MDeveloper of natural active ingredients with scientifically proven health benefits
- MMUSA$284MOnline e-commerce platform for fitness supplements
- Science In Sport$48MBrand of sports nutrition and vitamin products
- Hofseth BioCare$47MManufacturer of salmon oils, calcium bone powder and salmon protein hydrolysate
- Kate Farms$213MProvider of plant-based nutrition drinks
- Nuritas$155MDeveloper of natural active ingredients with scientifically proven health benefits
- Zoe$133MProvider of gut health testing services and plant based supplements
- MMUSA$284MOnline e-commerce platform for fitness supplements
- Else Nutrition$31MInternet-first brand offering plant-based food products for kids on a subscription basis
- HyugaLife$22MProvider of an e-commerce platform that sells authentic health and wellness products
- Hologram Sciences$100MProvider of personalized dietary supplements on the basis of AI-driven diagnostics
- Form Health$66MProvider of expert-led personalized nutrition training for weight loss
- Bioniq$34MProvider of personalized nutritional supplements using patented Swiss granules
- Zoe$133MProvider of gut health testing services and plant based supplements
- Pendulum$109MManufacturer of medical probiotics
- Oragenics$87MDeveloper of novel treatments for infectious diseases and oral mucositis as well as probiotics f
- Once Upon A Farm$108MBrand of organic baby food products
- Prolacta Bioscience$99MHuman milk-based nutrition for vulnerable infants, improving health outcomes
- LactaLogics$92MProvider of human milk-based products for premature and at-risk infants
- Yfood$256MProvider of ready-to-drink and powdered meal replacement products
- Kate Farms$213MProvider of plant-based nutrition drinks
- Fullife$78MManufacturer of effervescent nutritional and pharmaceutical products
Which approaches are newer, and where the money moved
Cohort compares a theme's share of companies founded from 2017 against the field as a whole. Funding compares dollars per year in 2021–2026 against 2015–2020.
| Theme | Companies | Founded ≤2016 | Founded ≥2017 | Cohort | Funding per year |
|---|---|---|---|---|---|
| Personalised nutrition | 396 | 118 | 224 | newer | 4.1× |
| At-home testing | 35 | 10 | 18 | newer | 9.6× |
| Direct-to-consumer retail | 632 | 159 | 247 | typical | 3.7× |
| Women's health | 195 | 63 | 92 | typical | 5.5× |
| General supplement & vitamin brands | 5,131 | 1,643 | 2,254 | typical | 1.3× |
| Sports & performance | 1,163 | 384 | 457 | typical | 0.9× |
| Gummies & novel formats | 268 | 93 | 106 | typical | 2.0× |
| Ageing & longevity | 153 | 61 | 59 | typical | 0.0× |
| Gut & microbiome | 356 | 141 | 128 | typical | 1.5× |
| Plant-based & clean label | 915 | 344 | 302 | typical | 1.2× |
| Children & family | 274 | 116 | 91 | older | 1.9× |
| Ingredients & manufacturing | 1,197 | 581 | 263 | older | 0.4× |
Themes are read from each company's own description of itself, over the 8,326 of 8,596 companies that carry one. A company can sit in more than one theme, so the counts do not sum to the total. Funding counts rounds that state an amount.
Companies & capital
8,596 companies are classified to this field, 753 of them with a funding round on record. This is the commercial edge of the same subject the research and patent chapters describe.
Companies founded per year
By recorded founding year. Recent years are incomplete: a company enters the record once it is covered, not when it is formed.
Disclosed funding per year
Rounds that state an amount
Best-funded companies in this field
Ranked by disclosed equity across 1,779 rounds.
| Company | HQ | Founded | Rounds | Disclosed |
|---|---|---|---|---|
| NU SkinManufacturer of anti-aging products | Provo, United States | 1984 | 2 | $751M |
| ViomeProvider of a machine learning based bioinformatics solutions | Los Alamos, United States | 2016 | 8 | $302M |
| MMUSAOnline e-commerce platform for fitness supplements | Carson City, United States | 1995 | 1 | $284M |
| YfoodProvider of ready-to-drink and powdered meal replacement products | Munich, Germany | 2017 | 3 | $256M |
| Bright LifeCareManufacturer of nutritional supplements and health and wellness products | Gurugram, India | 2011 | 12 | $229M |
| Kate FarmsProvider of plant-based nutrition drinks | Santa Barbara, United States | 2012 | 5 | $213M |
| NuritasDeveloper of natural active ingredients with scientifically proven health benefits | Dublin, Ireland | 2014 | 13 | $155M |
| ChromaDexDeveloper of nutritional ingredients for health and wellness | Irvine, United States | 1999 | 23 | $149M |
| ZoeProvider of gut health testing services and plant based supplements | New Castle, United States | 2017 | 16 | $133M |
| AG1Manufacturer of nutritional supplements | Carson City, United States | 2009 | 2 | $125M |
| BrightseedProvider of AI based platform to discover plant bio actives for human health | San Francisco, United States | 2018 | 3 | $120M |
| TerraViaProvider of algae-based food, nutrition, and specialty ingredients for various industries | San Francisco, United States | 2003 | 6 | $117M |
| CheckerspotBiotechnology company designs specialized fats and oils through precision fermentation using optimized microal | Alameda, United States | 2016 | 6 | $117M |
| OvivaProvider of an online nutritional consultation platform for patients | London, United Kingdom | 2014 | 7 | $114M |
| ALOHABrand of nutrition supplements | New York City, United States | 2012 | 7 | $113M |
- Seed700
- Series A285
- Post IPO190
- Grant (prize money)175
- Series B111
- Conventional Debt103
- Angel75
- Unattributed43
- PE33
- Series C29
- Unfunded4,004
- Not recorded1,437
- Deadpooled1,397
- Acquired436
- Funding Raised406
- Seed321
- Private242
- Public134
- Series A105
- Series B41
- Consumer Digital - US1,870
- Life Sciences - US1,396
- B2C E-Commerce1,367
- Online Pharmacies1,282
- Consumer Digital - Europe1,019
- Consumer Digital - India871
- HealthTech - US785
- Life Sciences - Europe652
- Food as Medicine624
- HealthTech - Europe525
- Life Sciences - India503
- HealthTech - India487
The record carries an amount for only some rounds, so the disclosed total is a floor, not a market size. Companies are included by their recorded sector classification, which is coarser than the condition itself.
What the businesses actually earn
Funding is what a company raised; this is what it earned. 371 companies in this field file annual accounts in India, giving real multi-year revenue, profit and margin — including the loss-making years.
Indian operations: filed accounts
371 legal entities with at least two filed years, from 1119 companies in this field based in India. 170 were profitable in their latest filed year; 205 grew revenue across the period. Figures in rupee crore, as filed.
| Company | Revenue trend | Latest revenue | Net margin | Revenue CAGR |
|---|---|---|---|---|
| Tata Consumer Products Limited5 filed years · FY2021–FY2025 | ₹12,801.9 cr | +9.8% | +15.7% | |
| Divi'S Laboratories Limited5 filed years · FY2021–FY2025 | ₹9,360.0 cr | +23.4% | +8.3% | |
| Abbott Healthcare Private Limited5 filed years · FY2021–FY2025 | ₹8,685.8 cr | +12.7% | +9.4% | |
| Herbalife International India Private Limited5 filed years · FY2021–FY2025 | ₹8,275.0 cr | +12.6% | +26.1% | |
| Emcure Pharmaceuticals Limited5 filed years · FY2021–FY2025 | ₹4,381.9 cr | +7.2% | +9.0% | |
| Morepen Laboratories Limited5 filed years · FY2021–FY2025 | ₹1,811.6 cr | +6.5% | +13.0% | |
| Leeford Healthcare Limited5 filed years · FY2021–FY2025 | ₹1,718.1 cr | +14.0% | +12.8% | |
| Bright Lifecare Private Limited5 filed years · FY2021–FY2025 | ₹1,312.6 cr | +9.1% | +43.8% | |
| Zuventus Healthcare Limited5 filed years · FY2021–FY2025 | ₹1,085.0 cr | +12.4% | +7.5% | |
| Mahaan Milk Foods Limited5 filed years · FY2020–FY2024 | ₹590.2 cr | +2.6% | +14.2% | |
| Mosaic Wellness Private Limited5 filed years · FY2021–FY2025 | ₹571.4 cr | -2.1% | +165.6% | |
| Arjuna Natural Private Limited5 filed years · FY2021–FY2025 | ₹438.0 cr | +0.0% | +2.5% |
The same view, United States
Held back on this page. The coverage below is real and the companies are named; the figures open in Radar.
| Company | Revenue | Margin | Headcount | On file |
|---|---|---|---|---|
| GNCPittsburgh, United States · listed | •••• | ••• | •••• | ✓ |
| JeunesseUnited States | •••• | ••• | •••• | ✓ |
| herbalifeLos Angeles, United States | •••• | ••• | •••• | — |
| WWNew York City, United States · listed | •••• | ••• | •••• | ✓ |
| Renown Health ProductsBoca Raton, United States | •••• | ••• | •••• | — |
| Mead Johnson NutritionGlenview, United States | •••• | ••• | •••• | ✓ |
| Nestlé Health ScienceBridgewater, United States | •••• | ••• | •••• | ✓ |
| Zija InternationalLehi, United States | •••• | ••• | •••• | — |
| Bode ProScottsdale, United States | •••• | ••• | •••• | ✓ |
| unicity internationalBangalore, United States | •••• | ••• | •••• | ✓ |
| NU SkinProvo, United States · listed | •••• | ••• | •••• | ✓ |
| USANA Health SciencesSalt Lake City, United States · listed | •••• | ••• | •••• | ✓ |
Indian figures are statutory company accounts as filed, keyed to the registered legal entity rather than to a brand name — one brand can file under several entities, and a subsidiary of a foreign parent files here like any other domestic company. Net margin is profit after tax over revenue from operations. Loss-making years are shown as filed, not hidden.
What people install
291 apps name this subject in their title, with 46 million installs between them. It is the cheapest thing anyone builds around a health subject, and the quality spread shows it.
Apps released per year
By recorded release date
How they are rated
41 of 291 carry a rating
Most installed
Apps with more than 400 ratings, so a single review cannot place one here
| App | Installs | Rating | Ratings | Category | Released |
|---|---|---|---|---|---|
| iHerb: Vitamins & SupplementsiHerb | 35,759,681 | 4.7 | 729,518 | Shopping | 2013 |
| Nutrabay: Supplements StoreNutrabay | 3,044,722 | 5.0 | 26,846 | Health & Fitness | — |
| Supplementler.comSupplementler.com | 876,876 | 4.9 | 16,512 | Shopping | 2014 |
| Pigi Supplements: Whey ProteinAuthentic India | 868,863 | 3.8 | 10,023 | Health & Fitness | 2016 |
| Vitamin Pop: Fruit BubbleFunny Video Collections | 662,088 | 4.9 | 8,804 | Puzzle | 2026 |
| Vitamins, Minerals, NutrientsMedical Group Soft | 391,368 | 4.7 | 2,441 | Medical | 2015 |
| The Vitamin Shoppe - VShoppeThe Vitamin Shoppe, Inc | 375,707 | 4.4 | 5,710 | Shopping | 2017 |
| Vitaminler.comSupplementler.com | 320,262 | 4.9 | 4,937 | Shopping | 2016 |
| BulkSupplements.comBulkSupplements.com | 153,878 | 4.3 | 962 | Shopping | 2019 |
| Prove It - Supplement ReviewsProve It | 137,820 | 3.2 | 1,844 | Health & Fitness | 2025 |
| Vitamin and Minerals : GuideCreativeZones | 123,250 | 4.4 | 425 | Health & Fitness | 2017 |
| Vitamin - Fruits Deliveryvitamin app | 112,456 | 3.6 | 923 | Food & Drink | 2017 |
| SuppCo: Supplement ScannerSuppCo | 96,768 | 4.7 | 1,275 | Health & Fitness | 2024 |
| My Aetna SupplementalAdminco Inc | 62,427 | 4.4 | 574 | Health & Fitness | 2019 |
- Health & Fitness123 · 6M installs
- Shopping48 · 38M installs
- Food & Drink23 · 0M installs
- Education16 · 0M installs
- Medical15 · 0M installs
- Lifestyle12 · 0M installs
- Tools11 · 0M installs
- Productivity8 · 0M installs
A marketplace listing is not a medical device and an install is not a user. Most of these apps are trackers rather than regulated products, and only 41 of 291 carry enough ratings to mean anything — the long tail is near-identical clones of the same tracker.
Full records
The complete tables behind the chapters above, including the rows that did not fit a ranking.
News coverage by country59 countries
| Country | Articles | Share | Relative attention | Companies | Research |
|---|---|---|---|---|---|
| United States of America | 19,818 | 14.12% | 0.53× | 2,874 | 9,025 |
| India | 2,369 | 1.69% | 0.26× | 1,119 | 273 |
| United Kingdom | 2,242 | 1.60% | 0.52× | 575 | 7,948 |
| Netherlands | 1,429 | 1.02% | 13.52× | 96 | 1,395 |
| China | 803 | 0.57% | 0.47× | 124 | 348 |
| Canada | 727 | 0.52% | 0.48× | 350 | — |
| Australia | 705 | 0.50% | 0.43× | 250 | 249 |
| Israel | 606 | 0.43% | 1.80× | — | — |
| Spain | 588 | 0.42% | 0.75× | 98 | 292 |
| France | 446 | 0.32% | 0.34× | 115 | 450 |
| Italy | 443 | 0.32% | 0.67× | 81 | 493 |
| Ukraine | 440 | 0.31% | 0.89× | — | — |
| Germany | 390 | 0.28% | 0.50× | 169 | 1,590 |
| Russia | 382 | 0.27% | 0.69× | — | — |
| Japan | 373 | 0.27% | 0.52× | 43 | 466 |
| Singapore | 306 | 0.22% | 0.51× | 84 | — |
| Turkey | 250 | 0.18% | 1.16× | 39 | — |
| Iran | 239 | 0.17% | 1.32× | — | — |
| Switzerland | 228 | 0.16% | 0.67× | 52 | 3,321 |
| Brazil | 213 | 0.15% | 0.39× | 99 | 229 |
| Belgium | 191 | 0.14% | below threshold | — | — |
| New Zealand | 186 | 0.13% | below threshold | 95 | — |
| Norway | 185 | 0.13% | below threshold | — | — |
| Ireland | 175 | 0.12% | below threshold | 40 | 293 |
| Colombia | 156 | 0.11% | below threshold | — | — |
| South Korea | 148 | 0.10% | below threshold | 85 | — |
| Mexico | 134 | 0.10% | below threshold | 45 | — |
| United Arab Emirates | 124 | 0.09% | below threshold | 43 | — |
| Nigeria | 109 | 0.08% | below threshold | — | — |
| Georgia | 107 | 0.08% | below threshold | — | — |
| Palestine | 96 | 0.07% | below threshold | — | — |
| Sweden | 88 | 0.06% | below threshold | 67 | — |
| Thailand | 86 | 0.06% | below threshold | — | — |
| Taiwan | 85 | 0.06% | below threshold | — | — |
| South Africa | 78 | 0.06% | below threshold | 74 | — |
| Republic of the Congo | 70 | 0.05% | below threshold | — | — |
| Austria | 70 | 0.05% | below threshold | — | — |
| Denmark | 66 | 0.05% | below threshold | — | — |
| Indonesia | 58 | 0.04% | below threshold | — | — |
| Pakistan | 55 | 0.04% | below threshold | — | — |
| Finland | 55 | 0.04% | below threshold | — | — |
| Greece | 54 | 0.04% | below threshold | — | — |
| Poland | 52 | 0.04% | below threshold | — | 233 |
| Egypt | 49 | 0.03% | below threshold | — | — |
| Argentina | 49 | 0.03% | below threshold | — | — |
| Ghana | 44 | 0.03% | below threshold | — | — |
| Vietnam | 44 | 0.03% | below threshold | — | — |
| Hungary | 42 | 0.03% | below threshold | — | — |
| Iceland | 41 | 0.03% | below threshold | — | — |
| Chile | 38 | 0.03% | below threshold | — | — |
| Lebanon | 37 | 0.03% | below threshold | — | — |
| Philippines | 36 | 0.03% | below threshold | — | — |
| Malaysia | 34 | 0.02% | below threshold | 72 | — |
| Syria | 34 | 0.02% | below threshold | — | — |
| Nepal | 31 | 0.02% | below threshold | — | — |
| Panama | 31 | 0.02% | below threshold | — | — |
| Afghanistan | 30 | 0.02% | below threshold | — | — |
| Sri Lanka | 29 | 0.02% | below threshold | — | — |
| Venezuela | 29 | 0.02% | below threshold | — | — |
News subcategories in full40 labels
| Subcategory | Articles | Prior year | Recent year |
|---|---|---|---|
| supplements for cognitive function enhancement | 86,395 | 42,653 | 14,165 |
| herbal supplements and their uses | 84,220 | 41,160 | 14,355 |
| dietary supplements and nutraceuticals | 14,790 | 2,969 | 3,685 |
| protein shakes and supplements | 5,075 | 1,554 | 635 |
| nail health supplements and vitamins | 3,642 | 889 | 1,248 |
| sports nutrition and performance supplements | 3,604 | 1,001 | 1,298 |
| egg nutrition profiles (protein, vitamins) | 2,352 | 901 | 558 |
| probiotics and gut health supplements | 2,319 | 604 | 739 |
| regulations and safety of dietary supplements | 2,182 | 712 | 604 |
| hair growth supplements and vitamins | 2,106 | 584 | 727 |
| vitamin deficiency symptoms and solutions | 2,087 | 546 | 605 |
| vitamin d sources and supplementation | 2,055 | 504 | 553 |
| sports nutrition supplements and performance enhancement | 1,994 | 492 | 666 |
| antioxidant-rich superfood supplements | 1,839 | 516 | 534 |
| weight management supplements | 1,829 | 667 | 490 |
| vitamin c and immune system support | 1,763 | 479 | 479 |
| multivitamins for different age groups | 1,632 | 506 | 458 |
| plant-based protein supplements | 1,629 | 469 | 576 |
| calcium and bone health supplements | 1,514 | 413 | 446 |
| efficacy studies on popular supplements | 1,396 | 412 | 434 |
| vitamin b complex for energy metabolism | 1,362 | 392 | 391 |
| supplements for joint and muscle health | 1,305 | 334 | 514 |
| collagen supplements for skin health | 1,187 | 330 | 412 |
| interactions between medications and supplements | 1,079 | 361 | 307 |
| essential vitamins for daily health | 1,057 | 297 | 321 |
| fiber supplements and digestive health | 1,040 | 263 | 448 |
| prenatal vitamins and pregnancy nutrition | 972 | 217 | 251 |
| zinc supplements for immune function | 939 | 298 | 213 |
| children's vitamin requirements | 894 | 226 | 208 |
| iron supplements for anemia prevention | 862 | 271 | 233 |
| benefits of mineral supplements | 812 | 277 | 257 |
| micronutrient deficiencies and supplementation strategies | 792 | 232 | 192 |
| herbal and nutritional supplements for eye wellness | 759 | 204 | 143 |
| weight loss supplements review | 755 | 260 | 181 |
| electrolyte supplements for hydration | 754 | 289 | 193 |
| nutritional supplements for pets | 634 | 264 | 126 |
| vegetarian and vegan supplement options | 584 | 174 | 160 |
| dietary supplements for inflammation reduction | 584 | 172 | 153 |
| vitamin k and blood clotting functions | 557 | 272 | 101 |
| functional beverages (e.g., vitamins/probiotics added) | 502 | 218 | 122 |
Patent assignees in full25 names
| Assignee | Patents | Since 2020 |
|---|---|---|
| WISCONSIN ALUMNI RES FOUND | 436 | 14 |
| DSM IP ASSETS BV | 191 | 27 |
| OPKO IRELAND GLOBAL HOLDINGS LTD | 180 | 80 |
| LEO PHARMA AS | 127 | 6 |
| DELUCA HECTOR F | 95 | 0 |
| QUEST DIAGNOSTICS INVEST INC | 94 | 26 |
| CYTOCHROMA INC | 93 | 3 |
| CLAGETT-DAME MARGARET | 90 | 0 |
| PLUM LORI A | 87 | 0 |
| OPKO RENAL LLC | 75 | 23 |
| TEIJIN PHARMA LTD | 61 | 21 |
| BERG LLC | 58 | 11 |
| EIRGEN PHARMA LTD | 58 | 58 |
| HYBRIGENICS SA | 56 | 0 |
| SIEMENS HEALTHCARE DIAGNOSTICS INC | 53 | 7 |
| PROVENTIV THERAPEUTICS LLC | 49 | 3 |
| FAES FARMA SA | 47 | 29 |
| QINGDAO ZHENGDA HAIER PHARM CO | 43 | 0 |
| HOFFMANN LA ROCHE | 41 | 6 |
| SALK INST FOR BIOLOGICAL STUDI | 35 | 2 |
| EXTEND BIOSCIENCES INC | 33 | 11 |
| GALDERMA SA | 32 | 0 |
| DIASORIN S P A | 32 | 10 |
| CP PHARMACEUTICAL QINGDAO CO LTD | 30 | 25 |
| GRZYWACZ PAWEL | 28 | 0 |
Substances in the research record30 indexed
| Substance | Records | Before 2022 | 2022 onward |
|---|---|---|---|
| Vitamin D | 29,007 | 20,756 | 8,251 |
| 25-hydroxyvitamin D | 7,754 | 6,395 | 1,359 |
| Vitamins | 5,850 | 3,115 | 2,735 |
| Calcium | 2,999 | 2,251 | 748 |
| Biomarkers | 2,584 | 2,044 | 540 |
| Parathyroid Hormone | 2,154 | 1,718 | 436 |
| Receptors, Calcitriol | 1,946 | 1,374 | 572 |
| Cholecalciferol | 1,588 | 965 | 623 |
| Calcifediol | 1,010 | 527 | 483 |
| Calcium, Dietary | 998 | 820 | 178 |
| Bone Density Conservation Agents | 793 | 702 | 91 |
| Blood Glucose | 684 | 521 | 163 |
| VDR protein, human | 654 | 445 | 209 |
| Calcitriol | 617 | 425 | 192 |
| 1,25-dihydroxyvitamin D | 590 | 508 | 82 |
| Vitamin D-Binding Protein | 555 | 414 | 141 |
| C-Reactive Protein | 511 | 360 | 151 |
| Fibroblast Growth Factor-23 | 509 | 441 | 68 |
| Phosphates | 486 | 373 | 113 |
| Vitamin A | 449 | 294 | 155 |
| Cytokines | 448 | 315 | 133 |
| Fibroblast Growth Factors | 424 | 346 | 78 |
| Phosphorus | 399 | 303 | 96 |
| FGF23 protein, human | 387 | 342 | 45 |
| Insulin | 386 | 296 | 90 |
| Vitamin D3 24-Hydroxylase | 381 | 262 | 119 |
| Alkaline Phosphatase | 367 | 292 | 75 |
| 25-Hydroxyvitamin D3 1-alpha-Hydroxylase | 348 | 259 | 89 |
| Micronutrients | 341 | 230 | 111 |
| Diphosphonates | 319 | 279 | 40 |
Company locations30 cities
| City | Country | Companies |
|---|---|---|
| London | United Kingdom | 184 |
| Delhi | India | 169 |
| Mumbai | India | 156 |
| New York City | United States | 122 |
| Bengaluru | India | 114 |
| Los Angeles | United States | 92 |
| San Francisco | United States | 77 |
| Singapore | Singapore | 76 |
| Hyderabad | India | 66 |
| Toronto | Canada | 63 |
| Gurugram | India | 51 |
| Austin | United States | 50 |
| Miami | United States | 45 |
| Auckland | New Zealand | 44 |
| San Diego | United States | 42 |
| Vancouver | Canada | 39 |
| Ahmedabad | India | 39 |
| Sydney | Australia | 37 |
| Seoul | South Korea | 37 |
| Las Vegas | United States | 35 |
| Noida | India | 34 |
| Melbourne | Australia | 34 |
| Dubai | United Arab Emirates | 33 |
| Irvine | United States | 32 |
| Pune | India | 31 |
| Berlin | Germany | 29 |
| Chennai | India | 28 |
| Houston | United States | 27 |
| Hong Kong | China | 26 |
| Denver | United States | 25 |
Sources & methods
Every window, every corpus and every limit that shapes a figure above.
- What this report is
- One subject seen through five separate corpora. Nothing here is a clinical guideline, a diagnosis or a treatment recommendation. Where two corpora disagree, both are shown.
- Scope
- The evidence graph, the research chapter and the community chapter are scoped to vitamin D itself. The news, patent, company and app chapters are scoped to vitamins and supplements as a category, because those records rarely separate one nutrient from the shelf it sits on; where a figure covers the category it says so.
- The claim record
- 14,565 statements extracted from 9,397 research and news documents, each carrying a relation, a direction, a study design and a GRADE-style evidence strength. "High-strength" means high or very high. It describes the design behind a claim, not whether the claim is correct.
- Research
- Indexed research records carrying the subject heading, 2012–2025. Study design is as recorded on each record.
- News
- 140,355 articles matched by the news model's subcategory labels, May 2021–Apr 2026, from the Prism news corpus. Ingest does not stop cleanly, it tails off: weekly volume through May 2026 runs 720k, 750k, 446k then 348k, and June holds about a fifth of a normal month. The window therefore ends with the last month that is whole, and the final point on the monthly chart is drawn dashed because even it is still filling in.
- Patents
- Publications 2010–2024 whose title matches the subject terms. Publication lags filing by roughly eighteen months.
- Companies
- 8,596 companies from the Prism company record carrying the Nutritional Formula, Online Supplement Stores, Nutraceutical Ingredients, Personalized Nutrition, Nutrition Gummies, Women Health Supplements, Probiotic Functional Foods sector classification, joined to 1,779 funding rounds. Amounts are disclosed values only; the record's own total-funding field is unpopulated for all but a handful of these companies and is not used.
- Community voice
- 139,490 typed signals drawn from public patient and carer conversations through Prism social signals, each carrying what the message was doing (asking, recommending, reporting a side effect), a polarity and an aspect. Not a survey and not evidence: the people who post are not a sample of everyone with the condition. Wording is as written, lightly tidied; no individual, forum or platform is identified.
- What is being built
- Themes are keyword sets over each company's own description of itself, across the 8,326 companies that carry one. A company can sit in several themes, so the counts do not sum to the total.
- Filed accounts
- Statutory annual accounts as filed, keyed to the registered legal entity rather than to a brand: one brand can file under several entities. Figures in rupee crore. Net margin is profit after tax over revenue from operations. EBITDA is not derived here because it is meaningless for lenders and several of these entities are not manufacturers. The United States view is withheld on this page, not absent; its coverage counts are stated as they are.
- App marketplace
- 291 listings whose title names the condition, with install counts and ratings as published by the marketplace. An install is not a user and a listing is not a regulated device.
- What is not merged
- Terms that mean the same thing in different words are not merged in the claim record, so a subject's totals can be split across spellings. The explorer states the same limit.
1 country names in the news record could not be matched to the map and are excluded from it: antarctica.