Industry landscapes
Industry report

Funding and advertised pay are reported in USD; filed accounts retain their stated source currency and basis.

Exchange-rate basis

Indicative conversions use ECB reference rates dated 2026-09-14, applied consistently across all periods. They are not historical exchange rates. Indian rupees may use crore (1 crore = 10 million); other currencies use K, M and B. CSV downloads, source documents and quoted news headlines retain their original currencies.

THE THE UNITED STATES EDITION 2026

the United States’s
ai drug discovery industry,
in focus.

The companies, capital and talent shaping ai drug discovery in the United States. Find the leaders. Understand the segments. See where the activity is.

Snapshot: Funding in USD
Illustrated cover for AI Drug Discovery Industry Landscape of the United States
US
COMPANIES · CAPITAL · TALENT

An industry ecosystem,
measured in context.

AI Drug Discovery illustration
MEET THE COMPANIES

Explore the United States’s ai drug discovery leaders

24 featured companies from the funding, hiring, revenue and team-size leaderboards.

Expand panel +
AI Drug Discovery company highlights in the United States, snapshot 1 September 2026
Company
XtalPixtalpi.com$1.32B27Financial figure available in RadarView in Radar
Eikoneikontx.com$1.16B331
Xairaxaira.com$1B
Earendilearendil.bio$787M
Generate Biomedicinesgeneratebiomedicines.com$693M7 roles75Financial figure available in RadarView in Radar
Recursion Pharmaceuticalsrecursion.com$676.01M9 roles400$74.68MFYFY2025 filing
Insitroinsitro.com$643.21M146
Nimbus Therapeuticsnimbustx.com$637M81
Genomic Healthgenomichealth.com10 roles2
SCIEXsciex.com10 roles2,778
Cytelcytel.com9 roles509
Signature Sciencesignaturescience.com9 roles235
Benchlingbenchling.com7 roles500
Olio Labsoliolabs.co5 roles
AbSciabsci.com256$2.8MFYFY2025 filing
Affymetrixaffymetrix.com721
Certaracertara.com827$418.84MFYFY2025 filing
Compendia Biosciencethermofisher.com75,000
CyteSisec.gov171
DNAnexusdnanexus.com143
Helixhelix.com265
In Silicoinsilico.com300
Metagenomimetagenomi.co11$25.21MFYFY2025 filing
Relay Therapeuticsrelaytx.com245$15.36MFYFY2025 filing
24 featured companies

Locked revenue figures are available in Radar; the eight company financial previews stay the same throughout this page. A dash means the figure is outside these featured lists. Revenue years vary by company; the figures are not a like-for-like revenue comparison. Compare annual accounts ↗

Company discovery

Recorded evidence only
THE KEY SIGNALS

AI Drug Discovery industry KPIs in the United States

A few useful ratios bring the size of this ecosystem into perspective.

1 September 2026
Hiring participation9.5%

80 of 841 tracked companies have open roles.

Funding participation55.6%

468 of 841 tracked companies have a recorded round.

Top 3 funding share13.3%

Share of disclosed capital received by the three largest recorded recipients.

Median disclosed round$2.27M

Midpoint of 994 rounds with a disclosed amount.

Scale is concentrated. Opportunity is broader. The three largest funding recipients hold 13.3% of disclosed capital, while 44.4% of tracked companies have no recorded funding round.

Explore the segments →
CAPITAL & COMPANY FORMATION

How the United States ai drug discovery has grown

Recorded company formation and disclosed funding across the complete annual series shown.

Expand panel +
2016 — 2025

Disclosed funding by year

Sum of recorded funding rounds · USD

the United States ai drug discovery
$0$1.4B$2.79B$4.19B$5.59B2016: $260.85M20162017: $865.94M20172018: $1.64B20182019: $1.23B20192020: $2.3B20202021: $4.9B20212022: $3.33B20222023: $2.37B20232024: $2.92B20242025: $3.25B2025
View the numbers
Annual ai drug discovery funding and company formation in the United States
YearFunding (USD)FoundedRaising
2016$260.85M4749
2017$865.94M5266
2018$1.64B4771
2019$1.23B4378
2020$2.3B6188
2021$4.9B5697
2022$3.33B4585
2023$2.37B5386
2024$2.92B2483
2025$3.25B1085
WHERE CAPITAL SITS

Funding concentration

Share of all disclosed company funding.

  • XtalPi5.1%
  • Eikon4.4%
  • Xaira3.8%
  • Other companies86.7%

Funding by stage

1,081 recorded rounds since 2016

NUMBER OF ROUNDS
Seed & Angel236 21.8%
Series A–B304 28.1%
Series C+ / PE89 8.2%
Grants, debt & other452 41.8%

Recent recorded rounds

Latest recorded rounds · USD
8 rounds

Swipe or scroll horizontally to browse.

Seed05/2026
Blank Bio $7.2M

Backed by Define Ventures and Leonis Capital and others.

Grant (prize money)05/2026
LiteFold $23K

Backed by Mercatus.

Largest and notable recorded rounds

Each card is one recorded round
10 cards

Swipe or scroll horizontally to browse.

Series D04/2024
Xairaxaira.com$1B

Backed by Arch Venture Partners and Foresite Labs and others.

Series B01/2022
Eikoneikontx.com$517.8M

Backed by T. Rowe Price and CPP Investments and others.

Series C09/2020
XtalPixtalpi.com$318.8M

Backed by SoftBank Vision Fund and People's Insurance Company of China and others.

THE BUSINESS BEHIND THE ACTIVITY

Revenue, profitability & financial strength

Annual accounts for reporting companies linked to this landscape, on like-for-like currency and reporting bases.

Expand panel +
USD · millions · consolidated

Display conversions use the dated reference rates above. Where a verified rate is unavailable, figures retain their source currency. Each reporting cohort keeps its currency and accounting basis separate.

FY2025 · company accounts; aggregate reporting threshold not met · 9 reporting entities from 12 eligible matches.

Revenue in covered accounts

Sum of reporting-entity revenue; not the United States market sales.

Net profit / loss

Combined result for the same cohort.

Aggregate net margin

Combined net income ÷ combined revenue.

Median company revenue

The middle covered reporting entity.

Profitable entities

None of 9 covered entities.

Top-five concentration

Share of covered revenue from the five largest entities.

Annual account trend

Reported cohort totals by year; coverage is stated for every period.

Bar height shows revenue. Changes in coverage can affect totals.

Profitability has two perspectives

FY2025 · 9 reporting entities

Open the company accounts

Up to eight fixed company previews show financial amounts. Search and sort the wider company list, then continue in Radar.

9 reporting entities
Continue your financial research in Radar

Explore full company accounts and filings.

View financials in Radar ↗
THE UNITED STATES · INDUSTRY COHORTS

How does ai drug discovery compare?

Each pair uses the same year, currency and reporting basis. Cohort overlap is disclosed.

IndustryCovered / eligibleRevenue totalMedian revenueNet profit / lossAggregate marginProfitable shareOverlap

Available-account cohorts are not estimates of whole industries. Overlapping entities can occur in more than one cohort; do not add cohort totals.

Coverage, calculations & financial sources

Filed annual accounts for exact designated national identifiers. Every aggregate and peer pair uses one fiscal year, source currency and reporting basis; periods, coverage and overlap are explicit; 2026 partials are excluded.

The same up to eight reporting entities remain open across years, filters and sorts. Other company figures are available in Radar.

Source currencies and accounting bases stay separate. Missing accounts are excluded rather than treated as zero. Exact reporting periods appear on company previews. Annual totals can change with coverage and do not measure growth of a fixed company cohort.

INSIDE THE INDUSTRY

The the United States ai drug discovery market map

Explore the segments behind the headline numbers.

Expand panel +

Where companies are building

Rank segments by scale, hiring or disclosed funding.

Life sciences834
Enterprise tech802
Healthtech663
Enterprise software493
Deep tech475
Life sciences analytics201
Saas150
Healthtech saas141
Proteomics115
Artificial intelligence61
Native ai in life sciences60
Native ai in healthcare60

Companies can sit in several segments. Counts and funding overlap.

SEGMENT TO EXPLORE

Life sciences

The largest measured segment in this report snapshot.

834companies
9.6%have hiring activity

80 companies hiring · $26.13B disclosed funding

Explore in Radar

How companies make money

Common revenue models; a company can use more than one.

Subscription614
Physical commerce125
Fee-for-service112
E-commerce - product67
Commission on transaction27
Advertising16
E-commerce - service6
Licensing5
THE COMPANIES IN MOTION

Who is listing, hiring leaders, launching and winning work

Recorded corporate activity linked to companies in this landscape.

Expand panel +
Recent corporate headlines 10 dated reports
Funding roundsaurekabio.com ↗

Aureka Biotechnologies , a biotechnology company, has raised USD 35 million in a Series A+ round led by HongShan, with participation from Matrix Partners and BioTrack Capital. Existing backers, including 5Y Capital, Qiming Venture Partners, and NRL Capital, also joined the round.

Mergers & acquisitionscertara.com ↗

Certara Sells Unit to Veristat for $135 Million

IPO activityrecursion.com ↗

Recursion, based in Salt Lake City, prefers to call itself a “TechBio” company—… went public in 2021 with a $436.4 million raise...

Funding roundskimiatx.com ↗

Kimia has raised $7 million in a seed funding round led by Airtree Ventures, with backing from Blackbird Ventures and Skip Capital.

Funding roundsstipple.bio ↗

Cancer Stipple launches with $100M for novel oncology targets Stipple Bio Inc. raised $100 million in a series A financing to support progression of the company’s lead drug, STP-100, an antibody-drug conjugate that binds an undisclosed target, and the company’s Pointillist discovery platform. The round was co-led by RA Capital, a16z Bio+Health and Nextech Invest. Existing investors, including Emerson Collective Investments (managed by Yosemite), GV (Google Ventures), Lola Capital Partners, GordonMD Global Investments and others, also participated in the round.

IPO activitygeneratebiomedicines.com ↗

Generate Biomedicines had issued 25,000,000 shares in its public offering on February 27th. The total size of the offering was $400,000,000 based on an initial share price of $16.00.

IPO activityeikontx.com ↗

Eikon Therapeutics, which made its Nasdaq debut on Feb. 5 with a $381 million raise, designs assets by 'integrating AI capabilities and advanced automation' into its workflow to track how proteins move inside cells, according to its website.

Funding roundsunnaturalproducts.com ↗

Unnatural Products has now raised a total of $83.0M in total equity funding and is backed by argenx, Artis Ventures, Droia Ventures, First Spark Ventures, Merck Global Health Innovation Fund, and The Venture Collective.

IPO activityinsilico.com ↗

The AI-driven drug discovery company raised HK$2.28 billion (US$290 million) in the share sale.

Mergers & acquisitionsinsitro.com ↗

In addition, Israeli AI company, CombinAble.AI, was purchased by the AI therapeutics company Insitro in January as well.

Full recorded event mix

Top 10 categories among 505 recorded events in the 24-month window.

Leadership moves
99
Funding rounds
92
Earnings
87
Lawsuit
64
Mergers & acquisitions
38
IPO activity
36
New products
29
Contracts
26
Company announcements
15
Layoffs
10
7 activity cards

Swipe or scroll horizontally to browse.

Leadership moves

41 tracked people moves

Chris Gibson, Ph.D.

Departure Strategic Advisor

Valo Health ↗
Chris Anagnostopoulos, PhD

Appointment Chief Causal AI Officer

Certara ↗
Dr. Britta Wagenhuber

Appointment Head of Quantitative Systems Pharmacology (QSP) Consultancy

David R. Epstein

Appointment Member of the Board of Directors

Chris O’Brien

Appointment Chief Executive Officer

Tevogen ↗
Sadiq Khan

Appointment Interim Generics Leader

Tevogen ↗
Mittul Mehta

Appointment Interim Artificial Intelligence Leader

Tevogen ↗
William Keane

Appointment Interim Contract Research Leader

Product launches

Products, platforms and features in the recorded window

Seismic ↗
Digital Sales Room updates

Sales Enablement

Seismic ↗
Model Context Protocol (MCP) support

Interoperability

Certara ↗
TFL Studio

Platform

Certara ↗
Certara IQ

Platform

Contract wins

17 recorded customer wins

In Silico ↗

Customer: eli lillyPharmaceutical

In Silico ↗

Customer: Shanghai Pudong Development GroupBiotechnology

Gene Logic ↗

Customer: Daiichi Pharmaceuticals Co. Ltd. (Japan)

Customer: Berlex Biosciences Integration SystemBiotech

Affymetrix ↗

Customer: novartis pharmaceuticalsBiopharma / Genomics

Gene Logic ↗

Customer: Sumitomo PharmaceuticalsPharmaceuticals

Regulatory events

4 recorded events

CyteSi ↗

Developing regulatory frameworkSEC

CyteSi ↗

referral of evidence to SEC OIGSEC Office of Inspector General

CyteSi ↗

in final stages of investigationSEC Office of Inspector General

approvedauthorities

Litigation

43 tracked suits

Company
as you sow v sec

Shareholder proposal regulationRegulatory ·

Company
investor advocacy groups v sec

shareholder rights and corporate accountabilityRegulatory · Filed

Earnings pulse

Reported company results in the recorded window.

13companies
89period observations
10.7%median reported growth

Median across 50 reported growth observations; companies may contribute multiple periods.

Mergers and acquisitions

Company-linked deal reports; status is preserved as recorded.

Acquirer → targetStatusDateValue / context
veristatCertara ↗Announced2026-04-22$135.0M
SeismichighspotAnnounced2026-03-06Not stated in snapshot
ARK InvestRecursion Pharmaceuticals ↗Announced2026-02-27Not stated in snapshot
InsitroCombinAble.AICompleted2026-02-20Not stated in snapshot
highspotSeismic ↗Announced2026-02-17Not stated in snapshot
SSI Diagnostica Group of CopenhagenInDevR ↗Announced2026-02-06Not stated in snapshot

A discussion or rumour is not a completed transaction. An unstated value is not zero.

PEOPLE & OPPORTUNITY

The talent market

584 postings in the preceding 12 months. The full 885-posting snapshot covers 90 employers.

Expand panel +

Most advertised job titles

Direct Support Professional9
Principal Data Scientist, Medical Imaging9
Engineering Manager8
Principal Quantitative Clinical Pharmacologist Fsp8
Research Engineer8
Digital Strategist8
0 internship postings

16 tracked postings mention remote work.

The seniority mix

411 postings specify a level.

unspecified
474
manager
185
senior
131
lead
79
intern
12
entry
4

Skills employers mention

Top skills across 885 tracked postings in the available jobs snapshot.

Python
33
Machine Learning
17
Ai
17
Aws
16
Pytorch
13
Kubernetes
13
Figma
12
React
12
Azure
10
Sql
10
ADVERTISED PAY$112.5K/ year

Median across 69 postings with pay data, expressed in USD.

THE PEOPLE BUILDING THE FIELD

Founders and leaders

765 founders and chief executives across 493 companies.

Expand panel +
12 profiles

Swipe or scroll horizontally to browse.

Education networks

225 profiles with education records.

Stanford University
37
Massachusetts Institute of Technology
35
Harvard University
34
University of California (Berkeley)
26
Yale University
14
University of Cambridge
14
Duke University
10
Harvard Business School
9

Prior employers

19 profiles with prior-work records.

Google
4
McKinsey
3
Facebook
3
Amazon
3
Bain
2
Intel
2
Airbnb
1
Microsoft
1

Profiles cover recorded founders and leaders; contact details remain in Radar.

NEWS INTELLIGENCE

How this industry appears in the news

384,680 articles in the measured 12-month window.

Expand panel +
384,680articles in the measured year
106,616articles in 2026Q1
77.1%positive tone in the latest complete year

News volume trends

AI Drug Discovery coverage across United States · articles per complete quarter

052,073104,147156,220208,2942021Q2: 90,2452021Q22021Q3: 83,8862021Q4: 68,1212022Q1: 78,0882022Q2: 73,3772022Q22022Q3: 65,8412022Q4: 71,7752023Q1: 79,7792023Q2: 105,8792023Q22023Q3: 82,3472023Q4: 87,5072024Q1: 99,7302024Q2: 97,5742024Q22024Q3: 95,8912024Q4: 88,2162025Q1: 181,1252025Q2: 83,9402025Q22025Q3: 100,7912025Q4: 85,7752026Q1: 106,6162026Q1
View quarterly article counts
QuarterArticles
2021Q290,245
2021Q383,886
2021Q468,121
2022Q178,088
2022Q273,377
2022Q365,841
2022Q471,775
2023Q179,779
2023Q2105,879
2023Q382,347
2023Q487,507
2024Q199,730
2024Q297,574
2024Q395,891
2024Q488,216
2025Q1181,125
2025Q283,940
2025Q3100,791
2025Q485,775
2026Q1106,616

Article volume measures coverage, not market sales.

Tone of coverage over time

2021
195,315 positive · 3,595 neutral · 66,386 negative
2022
226,068 positive · 3,948 neutral · 58,766 negative
2023
279,033 positive · 4,695 neutral · 71,451 negative
2024
300,972 positive · 4,855 neutral · 75,208 negative
2025
347,869 positive · 5,418 neutral · 97,917 negative

Leading coverage topics

AI Drug Discovery coverage across United States · ranked by full-period article count.

Covid 19 Vaccine Development And Efficacy Trials39,141 articles in the full recorded period
3,815 recent · 1,133 prior
Artificial Intelligence Advancements32,181 articles in the full recorded period
12,544 recent · 8,935 prior
Oncology And Targeted Therapy Advancements28,440 articles in the full recorded period
5,253 recent · 7,172 prior
Covid 19 Vaccination Campaigns And Rollout Strategies23,198 articles in the full recorded period
2,434 recent · 567 prior
Rare Disease Therapies And Orphan Drugs22,835 articles in the full recorded period
4,860 recent · 6,623 prior
Gene Therapy And Crispr Technologies19,287 articles in the full recorded period
3,916 recent · 5,313 prior
Drug Pricing And Reimbursement Strategies19,106 articles in the full recorded period
6,324 recent · 4,596 prior
New Product Launches And Innovations14,470 articles in the full recorded period
4,690 recent · 3,529 prior
Vaccine Research And Production Methods14,227 articles in the full recorded period
1,534 recent · 1,914 prior
Semiconductor Industry Updates13,538 articles in the full recorded period
5,147 recent · 3,401 prior

Recent and prior counts use the source comparison windows.

Topics gaining and losing attention

AI Drug Discovery coverage across United States

KeywordRecentPriorChange
vaccine candidates3,157897252%
vaccine trials2,962899229%
vaccination campaigns2,757554398%
vaccine immunogenicity2,471668270%
mass vaccination sites2,026272645%
cloud infrastructure1,65094375%
vaccination coverage1,516202650%
vaccine effectiveness study1,399251457%
angel investors1,344590128%
covid-19 vaccine development1,337238462%
class action securities litigation1191,072-89%
investigational new vaccine4511,068-58%
cell-based therapies6191,059-42%
viral vector vaccines6841,048-35%
cancer biomarkers6701,040-36%

Event and signal lenses

AI Drug Discovery coverage across United States

All complete annual cohorts shown
Rising

Regulatory Risk

363,044 classified articles

ai regulation compliance, responsible ai, vaccine candidates

54.7% critical · 38.7% positive
Rising

Funding Momentum

120,175 classified articles

angel investors, vaccine candidates, vaccine trials

50.8% critical · 55.8% positive
Rising

Growth

184,251 classified articles

earnings report, stock performance, quarterly results

42.7% critical · 47.6% positive

AI Drug Discovery coverage across United States. Topic labels describe recorded classifications and can include broad context.

RESEARCH SIGNALS

What AI Drug Discovery research is working on

13,110 papers in the recorded india scope.

Expand panel +
13,110papers
53,497worldwide comparison pool
13,110India-affiliated papers

Research orientation

Breakthrough
5,029
Promising
3,483
Descriptive
2,227
Problem-identifying
1,363
Cautionary
522
Comparative
266
Critical
220

Contribution mix

Empirical
5,056
Methods-led
4,473
Reviews
3,091
Position pieces
397
Theoretical
93

Tone counts: 12,011 positive · 703 neutral · 396 negative.

Common problems researchers identify
1,583 papers · 12.1% of this field
  • Disease294 papers
  • Immune system137 papers
  • Cancer117 papers
  • Clinical trial84 papers
  • Microbiome74 papers
  • Gene71 papers
  • Biomarker71 papers
  • Computational biology65 papers

Landmark: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

Cautions
522 papers · 4.0% of this field
  • Disease52 papers
  • Gene34 papers
  • Clinical trial33 papers
  • Cancer30 papers
  • Genome28 papers
  • MEDLINE26 papers
  • Immune system25 papers
  • Biomarker24 papers

Landmark: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Opportunities
8,512 papers · 64.9% of this field
  • Gene858 papers
  • Genome731 papers
  • Transcriptome694 papers
  • Disease633 papers
  • Immune system490 papers
  • Computational biology430 papers
  • Cancer385 papers
  • Biomarker297 papers

Landmark: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Leading institutions

Harvard University
423,548
Broad Institute
397,159
Howard Hughes Medical Institute
308,813
Dana-Farber Cancer Institute
202,075
Baylor College of Medicine
183,631
National Institutes of Health
173,167

Leading researchers

Koichiro Tamura
126,864
Glen Stecher
124,408
Michael I. Love
106,079
Wolfgang Huber
102,018
Simon Anders
97,164
Sudhir Kumar
87,769
Douglas Hanahan
65,683
Robert A. Weinberg
65,668

Highly cited breakthrough-labelled papers

  • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq297,164 citations
  • MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets45,127 citations
  • MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods40,217 citations
  • MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms37,942 citations
  • The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data29,447 citations

Common problems researchers identify

1,536 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Clinical Translation GapsCommon problems researchers identify · 01

Clinical Translation Gaps

280 papers

18.2% of this theme group

Researchers highlight challenges moving biomarkers and disease diagnostics from discovery to patient care.

Clinical trial (35) · MEDLINE (27) · Biomarker (29) · Disease (54)

Evolving Paradigms in Chronic Limb-threatening Ischemia: A Systematic Review of Current and Emerging Diagnostic and Therapeutic Approaches

A Practical Roadmap for Clinical Translation of Metabolic Biomarkers: A Review

View research history
YearShare index
2022865.9
2023827.3
2024831.6
20251262.9
Cancer Immunotherapy BarriersCommon problems researchers identify · 02

Cancer Immunotherapy Barriers

269 papers

17.5% of this theme group

Papers flag obstacles in targeting tumor microenvironment and emerging immune checkpoints.

Cancer (102) · Tumor microenvironment (30) · Breast cancer (25) · Immunotherapy (28)

Metabolic reprogramming and cancer progression

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

View research history
YearShare index
20222422.1
20233082.5
20242613.2
20252334.4
Genomic Interpretation IssuesCommon problems researchers identify · 03

Genomic Interpretation Issues

262 papers

17.1% of this theme group

Authors discuss difficulties in variant classification, reporting, and functional annotation of genetic data.

Gene (54) · Genome (47) · Gene expression (14) · Genetic testing (22)

Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test result

Widespread Regulatory Turnover Across Human Segmental Duplications

View research history
YearShare index
20222572.7
20232646.5
20242427.6
20251985.2
Inflammation‑Driven Disease ComplexityCommon problems researchers identify · 04

Inflammation‑Driven Disease Complexity

262 papers

17.1% of this theme group

Works emphasize tangled roles of immune pathways in neuro‑degeneration and cardiovascular disorders.

Disease (84) · Inflammation (26) · Pathogenesis (23) · Immune system (42)

Parkinson’s disease: etiopathogenesis and treatment

Immunometabolic Pathways in Cardiovascular Disease: Inflammation and Metabolic Dysfunction Beyond Traditional Risk Factors

View research history
YearShare index
20223656.8
20233139.3
20243195.8
20253175.2
Computational‑Biology BottlenecksCommon problems researchers identify · 05

Computational‑Biology Bottlenecks

184 papers

12.0% of this theme group

Studies point to limits in modeling synthetic biology, extracellular vesicles, and regenerative processes.

Computational biology (45) · Synthetic biology (12) · Extracellular vesicles (12) · Regenerative medicine (10)

Clinical metagenomics

Epigenetics: Definition, Mechanisms and Clinical Perspective

View research history
YearShare index
20221002.0
20231033.6
20241279.7
2025938.0
Metabolic Disease MechanismsCommon problems researchers identify · 06

Metabolic Disease Mechanisms

173 papers

11.3% of this theme group

Researchers note unresolved links between obesity, insulin resistance, and inflammatory signaling.

Diabetes mellitus (45) · Disease (75) · Obesity (21) · Insulin resistance (14)

Inflammatory mechanisms linking obesity and metabolic disease

Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

View research history
YearShare index
20223247.1
20232770.6
20242817.3
20252753.4
Microbiome Knowledge GapsCommon problems researchers identify · 07

Microbiome Knowledge Gaps

106 papers

6.9% of this theme group

Papers reveal incomplete understanding of gut flora impacts on health and therapeutic modulation.

Microbiome (66) · Gut microbiome (17) · Human microbiome (14) · Gut flora (18)

Microbiota in health and diseases

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

View research history
YearShare index
2022176.9
2023161.2
2024201.7
2025230.8

Cautions

511 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Cancer Transcriptomics RisksCautions · 01

Cancer Transcriptomics Risks

98 papers

19.2% of this theme group

Authors caution against over‑interpreting tumor‑microenvironment transcript data without robust validation.

Cancer (26) · Breast cancer (16) · Transcriptome (10) · Tumor microenvironment (5)

[Strategic Combination Approaches in Cancer Immunotherapy].

Comparative analysis of potentially actionable genomic alterations in early-onset versus later-onset gastrointestinal cancers.

View research history
YearShare index
20222765.3
20233333.3
20242910.0
20252686.7
Clinical Trial Translation ConcernsCautions · 02

Clinical Trial Translation Concerns

94 papers

18.4% of this theme group

Works warn that promising compounds often fail to demonstrate efficacy in human disease settings.

Drug (17) · Drug discovery (8) · Clinical trial (15) · Disease (16)

The therapeutic potential of resveratrol: a review of clinical trials

Lipoprotein(a)-lowering therapies: a promising future

View research history
YearShare index
2022911.2
2023888.9
2024986.4
20251306.2
Epigenetic Marker UncertaintyCautions · 03

Epigenetic Marker Uncertainty

87 papers

17.0% of this theme group

Studies highlight variability and reproducibility issues in DNA methylation and protein‑structure biomarkers.

DNA methylation (7) · Antibody (6) · Protein structure (4) · Epigenetics (7)

Characterizing the Conformational Dynamics of an Intrinsically Disordered Localization Sequence

Epigenetic Markers of Response to Psychotherapy in Obsessive-Compulsive Disorder

View research history
YearShare index
2022444.9
2023467.7
2024361.0
2025324.1
Genome Editing Ethical LimitsCautions · 04

Genome Editing Ethical Limits

72 papers

14.1% of this theme group

Papers raise ethical and safety considerations surrounding large‑scale gene‑editing applications.

Gene (18) · Genetic testing (7) · Genome editing (6) · Genome (11)

Genomic Selection for Crop Improvement

Genomic selection in plant breeding: from theory to practice

View research history
YearShare index
20222420.5
20232512.7
20242228.9
20251728.0
Diabetes Therapeutic VariabilityCautions · 05

Diabetes Therapeutic Variability

71 papers

13.9% of this theme group

Researchers note inconsistent outcomes of novel diabetes interventions across patient sub‑populations.

Diabetes mellitus (12) · Type 2 diabetes (6) · Disease (15) · MEDLINE (11)

Dose-dependent effects of SGLT2 inhibitors on circadian blood pressure in hypertensive patients with diabetes: A systematic review and Bayes

Presenting non-insulin-based indices of insulin resistance relevant to pre-hypertension: A systematic review and meta-analysis

View research history
YearShare index
20223201.5
20232723.9
20242771.9
20252711.7
Sequencing Benchmark ChallengesCautions · 06

Sequencing Benchmark Challenges

59 papers

11.5% of this theme group

Works point out biases and performance gaps in current genomic and metagenomic analysis pipelines.

DNA sequencing (16) · Genome (18) · Computational biology (13) · Benchmark (6)

Characterizing and measuring bias in sequence data

Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software

View research history
YearShare index
20221389.5
20231365.3
20241669.5
20251346.5
Microbiome Study LimitationsCautions · 07

Microbiome Study Limitations

30 papers

5.9% of this theme group

Authors caution that long‑term antibiotic effects and cancer associations remain poorly quantified.

Microbiome (15) · Gut flora (8) · Gut microbiome (5) · Metagenomics (5)

Long-term impacts of antibiotic exposure on the human intestinal microbiota

Human Gut Microbiome and Risk for Colorectal Cancer

View research history
YearShare index
2022221.0
2023201.6
2024252.5
2025289.2

Opportunities

8,195 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Inflammation‑Targeted TherapiesOpportunities · 01

Inflammation‑Targeted Therapies

1,108 papers

18.5% of this theme group

Research explores novel anti‑inflammatory strategies for diabetes, cardiovascular disease, and related disorders.

Disease (325) · Inflammation (102) · Diabetes mellitus (53) · Immune system (108)

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics

View research history
YearShare index
20223678.0
20233167.0
20243229.4
20253203.8
Druggable Genome ExplorationOpportunities · 02

Druggable Genome Exploration

1,039 papers

17.3% of this theme group

Papers identify genomic regions and pathways ripe for new target validation and drug development.

Genome (394) · Gene (264) · Genomics (118) · Genome-wide association study (67)

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

The druggable genome and support for target identification and validation in drug development

View research history
YearShare index
20222539.2
20232616.9
20242403.6
20251960.3
Multi‑Omic Computational PlatformsOpportunities · 03

Multi‑Omic Computational Platforms

951 papers

15.8% of this theme group

Works develop integrative proteomics and bioinformatics pipelines to model complex biological interactions.

Proteomics (97) · Proteome (69) · Computational biology (104) · Workflow (58)

Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome \n

Large-scale multi-omic biosequence transformers for modeling protein–nucleic acid interactions

View research history
YearShare index
20221026.5
20231052.9
20241295.2
2025960.2
Antimicrobial Discovery InnovationsOpportunities · 04

Antimicrobial Discovery Innovations

887 papers

14.8% of this theme group

Studies present new peptide, phytochemical, and microfluidic approaches for next‑generation antibiotics.

Antimicrobial (35) · Epitope (41) · Drug discovery (66) · Antibiotics (31)

Bioactive Phytochemicals in Experimental Models of Multiple Sclerosis: Mechanisms, Efficacy, and Translational Potential

Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function <i>in vitro</i>

View research history
YearShare index
2022172.7
2023170.1
2024187.2
2025238.5
Cancer Biomarker AdvancementOpportunities · 05

Cancer Biomarker Advancement

863 papers

14.4% of this theme group

Research advances microRNA and stochastic modeling tools to improve diagnosis and treatment prediction.

Cancer (250) · Breast cancer (94) · Immunotherapy (80) · Colorectal cancer (48)

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer

Advancing Cancer Research Through Stochastic Modeling: Insights into Tumor Growth, Evolution, and Treatment Response

View research history
YearShare index
20222471.1
20233143.1
20242665.0
20252400.0
CRISPR‑Based TherapeuticsOpportunities · 06

CRISPR‑Based Therapeutics

667 papers

11.1% of this theme group

Papers showcase multiplexed genome and RNA editing techniques for precise disease intervention.

CRISPR (114) · Genome editing (66) · Cas9 (43) · Gene (125)

Multiplex Genome Engineering Using CRISPR/Cas Systems

RNA editing with CRISPR-Cas13

View research history
YearShare index
202264.2
202365.9
202468.9
202571.3
Spatial Transcriptomics ExpansionOpportunities · 07

Spatial Transcriptomics Expansion

485 papers

8.1% of this theme group

Works leverage imaging and transcription factor analysis to map cellular states in disease contexts.

Transcriptome (345) · Transcription factor (65) · Gene (125) · Gene expression (46)

Reconstructing biologically coherent cellular profiles from imaging-based spatial transcriptomics

Transcriptomic Correlation Identifies Cell Model Representatives for <i>MYCN</i> -Amplified Pediatric Neuroblastoma, Downstream Impact of Mo

View research history
YearShare index
20222513.0
20232576.9
20242329.1
20251980.2

How this field compares with the research baseline

Orientation shares compared with 25,000 papers in the reference sample.

Research orientationThis fieldReference sample
Breakthrough38.4%26.6%
Promising26.6%36.7%
Descriptive17.0%17.9%
Problem-identifying10.4%9.7%
Cautionary4.0%4.3%
Comparative2.0%3.9%
Critical1.7%0.9%

Concerns receiving less research attention

Counts and shares refer to the stated research pool. A low count describes how much of that research is recorded here, not the absence of a real-world concern.

Concern / example paperPapersShareRaised as a problemWorldwide share
Privacy & surveillanceSARS-CoV-2 wastewater genomic surveillance: approaches, challenges, and opportunities390.32%2 (5.1%)0.28%
Bias & fairnessRNA-Based Biomarkers for Diagnostic Discrimination of Ischemic and Hemorrhagic Stroke: A Systematic Review40.03%1 (25.0%)0.04%
Safety & misuseLevels of Analysis in Evolutionary Genetics: Novel Genes and the Misuse of Homology20.02%1 (50.0%)0.01%
Energy & datacenter footprintMEGA12: Molecular Evolutionary Genetic Analysis Version 12 for Adaptive and Green Computing10.01%0 (0.0%)0.0%
Water use00.0%0 (%)0.0%
Carbon & emissions of compute00.0%0 (%)0.0%
Hardware, e-waste & supply chain00.0%0 (%)0.0%
Labour & data work00.0%0 (%)0.0%
Concentration of compute power00.0%0 (%)0.0%

Research orientation and citation rankings describe the covered collection. Its recorded publication dates do not support an overall publication-volume trend.

Institution and researcher rankings use citations to their covered work. Research scope: United States. This may be broader than the company geography.

GEOGRAPHIC FOOTPRINT

Where companies are based

Company counts, hiring and disclosed funding across the recorded hubs.

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8 cards

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UNDERSTAND THE LANDSCAPE

AI Drug Discovery in the United States: key questions

Clear definitions for making better comparisons.

What does this landscape measure?

It measures the tracked company ecosystem, recorded funding, hiring and other available evidence. It is not a market-size estimate.

Can segment counts be added together?

No. A company can belong to several segments, so segment counts and funding can overlap.

What does a missing figure mean?

A dash or unavailable panel means the current reviewed source snapshot does not support that figure.

Company ecosystem snapshot: 1 September 2026. Funding is recorded in USD; filed accounts retain their stated currency and reporting basis. Each section identifies its own coverage. The news and research behind these sections is explorable in Prism.

Canonical landscape ↗
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