12,968papers
53,351worldwide comparison pool
12,968India-affiliated papers
Research orientation
Contribution mix
Tone counts: 12,592 positive · 304 neutral · 72 negative.
Common problems researchers identify
1,070 papers · 8.3% of this field
- Tumor microenvironment492 papers
- Immunotherapy491 papers
- Immune system374 papers
- Cancer325 papers
- Cancer immunotherapy224 papers
- Cancer research174 papers
- Chimeric antigen receptor89 papers
- Clinical trial65 papers
Landmark: A framework for advancing our understanding of cancer-associated fibroblasts
Cautions
399 papers · 3.1% of this field
- Immunotherapy182 papers
- Immune system152 papers
- Tumor microenvironment147 papers
- Cancer research87 papers
- Cancer85 papers
- Cancer immunotherapy52 papers
- Chimeric antigen receptor27 papers
- T cell26 papers
Landmark: Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
Opportunities
10,200 papers · 78.7% of this field
- Tumor microenvironment4,695 papers
- Immune system3,658 papers
- Cancer research3,231 papers
- Immunotherapy3,201 papers
- Cancer1,615 papers
- Cancer immunotherapy1,319 papers
- Stromal cell614 papers
- Cytotoxic T cell598 papers
Landmark: Cancer immunotherapy using checkpoint blockade
Leading institutions
Dana-Farber Cancer Institute
53,191 The University of Texas MD Anderson Cancer Center
48,648 Memorial Sloan Kettering Cancer Center
41,938 Brigham and Women's Hospital
36,065 Leading researchers
Highly cited breakthrough-labelled papers
- Cancer immunotherapy using checkpoint blockade6,497 citations
- TIMER2.0 for analysis of tumor-infiltrating immune cells5,542 citations
- The future of immune checkpoint therapy4,710 citations
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor4,030 citations
- IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade3,763 citations
Common problems researchers identify
1,047 papers · 7 recurring themes
Common problems researchers identify · 01Tumor Microenvironment / Immune System
205 papers19.6% of this theme group
Tumor microenvironment (195) · Immune system (162) · Immunotherapy (121) · Cancer research (43)
Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy
The Suppressive Tumor Microenvironment: A Challenge in Cancer Immunotherapy
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Common problems researchers identify · 02Tumor Microenvironment / Cancer Research
196 papers18.7% of this theme group
Tumor microenvironment (185) · Cancer research (76) · Stromal cell (30) · Metastasis (28)
Therapeutic Targeting of the Tumor Microenvironment
Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy
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Common problems researchers identify · 03Immunotherapy / Cancer Immunotherapy
192 papers18.3% of this theme group
Immunotherapy (178) · Cancer immunotherapy (124) · Cancer (123) · Clinical trial (32)
Imaging of Cancer Immunotherapy: Current Approaches and Future Directions
Development of immune checkpoint therapy for cancer
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Common problems researchers identify · 04Cancer / Cancer Research
159 papers15.2% of this theme group
Cancer (62) · Cancer research (37) · Metastasis (18) · Cancer cell (14)
Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery Across Biological Barriers
Organotropism: new insights into molecular mechanisms of breast cancer metastasis
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Common problems researchers identify · 05Immune System / Cytotoxic T Cell
124 papers11.8% of this theme group
Immune system (73) · Cytotoxic T cell (14) · Immunotherapy (47) · Cancer research (28)
CTLs heterogeneity and plasticity: implications for cancer immunotherapy
Optimizing CD8+ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators
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Common problems researchers identify · 06Immunotherapy / Immune Checkpoint
89 papers8.5% of this theme group
Immunotherapy (77) · Immune checkpoint (29) · Immune system (46) · Pembrolizumab (9)
Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer
Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
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Common problems researchers identify · 07Chimeric Antigen Receptor / Cell Therapy
82 papers7.8% of this theme group
Chimeric antigen receptor (81) · Cell therapy (15) · Immunotherapy (55) · T cell (16)
CAR T cell immunotherapy for human cancer
Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
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Cautions
388 papers · 7 recurring themes
Cautions · 01Immunotherapy / Cancer
95 papers24.5% of this theme group
Immunotherapy (80) · Cancer (51) · Cancer immunotherapy (39) · Oncology (16)
Advances and challenges in immunotherapy in head and neck cancer
Harnessing nanoprodrugs to enhance cancer immunotherapy: overcoming barriers to precision treatment
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Cautions · 02T Cell / Cytotoxic T Cell
74 papers19.1% of this theme group
T cell (18) · Cytotoxic T cell (15) · Immune system (35) · Antigen (12)
Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery
Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti–PD-1 in head and neck cancer
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Cautions · 03Tumor Microenvironment / Immune System
74 papers19.1% of this theme group
Tumor microenvironment (59) · Immune system (53) · Immunotherapy (34) · Cancer research (24)
Plant-derived immunomodulators in cancer: Balancing immune activation and suppression within the tumor microenvironment
Towards the tumor microenvironment scoring methods for immune checkpoint inhibitor response
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Cautions · 04Tumor Microenvironment / Stromal Cell
52 papers13.4% of this theme group
Tumor microenvironment (39) · Stromal cell (10) · Cancer research (21) · Stroma (5)
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
Tumor microenvironment remodeling across thyroid cancer differentiation states revealed by spatial transcriptomics
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Cautions · 05Breast Cancer / Tumor Microenvironment
47 papers12.1% of this theme group
Breast cancer (8) · Tumor microenvironment (21) · Immune system (19) · Glioblastoma (5)
Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated pheno
Chronic compression drives macrophages toward a pathological pro-tumor state
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Cautions · 06Chimeric Antigen Receptor / Cell Therapy
25 papers6.4% of this theme group
Chimeric antigen receptor (24) · Cell therapy (5) · Immunotherapy (16) · Venetoclax (2)
Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures
CAR-T cells in solid tumors: Challenges and breakthroughs
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Cautions · 07Pembrolizumab / Nivolumab
21 papers5.4% of this theme group
Pembrolizumab (7) · Nivolumab (6) · Durvalumab (4) · Ipilimumab (4)
Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies
Cost-Effectiveness Analysis of Durvalumab in Limited-Stage Small Cell Lung Cancer in the United States
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Opportunities
9,894 papers · 7 recurring themes
Opportunities · 01Tumor Microenvironment / Immune System
1,106 papers18.4% of this theme group
Tumor microenvironment (987) · Immune system (851) · Cancer research (410) · Immunotherapy (324)
Immune targets in the tumor microenvironment treated by radiotherapy
Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy
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Opportunities · 02Tumor Microenvironment / Cancer Research
1,082 papers18.0% of this theme group
Tumor microenvironment (991) · Cancer research (525) · Cancer (234) · Stromal cell (110)
Tumor microenvironment complexity and therapeutic implications at a glance
Role of tumor microenvironment in cancer progression and therapeutic strategy
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Opportunities · 03Immune System / Immunotherapy
1,007 papers16.8% of this theme group
Immune system (501) · Immunotherapy (425) · Blockade (127) · Cancer research (374)
<scp>PD</scp>‐1 as a potential target in cancer therapy
Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade
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Opportunities · 04Cancer Research / Stromal Cell
939 papers15.7% of this theme group
Cancer research (348) · Stromal cell (146) · Metastasis (125) · Extracellular matrix (78)
A peek into cancer-associated fibroblasts: origins, functions and translational impact
Tumor–Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metast
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Opportunities · 05Immunotherapy / Cancer Immunotherapy
799 papers13.3% of this theme group
Immunotherapy (652) · Cancer immunotherapy (406) · Cancer (339) · Immune system (356)
Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors
Development of nano-immunotherapy for cancer treatment: achievements and scopes
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Opportunities · 06Cytotoxic T Cell / Chimeric Antigen Receptor
678 papers11.3% of this theme group
Cytotoxic T cell (235) · Chimeric antigen receptor (183) · T cell (210) · Immunotherapy (312)
CAR-NK cells: A promising cellular immunotherapy for cancer
Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System
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Opportunities · 07Nanocarriers / Photothermal Therapy
389 papers6.5% of this theme group
Nanocarriers (34) · Photothermal therapy (35) · Photodynamic therapy (33) · Immunotherapy (154)
Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
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How this field compares with the research baseline
Orientation shares compared with 25,000 papers in the reference sample.
Concerns receiving less research attention
Counts and shares refer to the stated research pool. A low count describes how much of that research is recorded here, not the absence of a real-world concern.
Institution and researcher rankings use citations to their covered work. Research scope: United States. This may be broader than the company geography.