the United States’s
healthtech industry,
in focus.

Challenges in Drug Discovery

18.0% of this theme group

Researchers highlight difficulties in identifying effective compounds and translating findings into viable therapies.

Drug discovery (305) · Drug (169) · Pharmacogenomics (141) · Drug development (96)

Cancer epigenetics drug discovery and development: the challenge of hitting the mark

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations

Barriers to Telehealth Adoption

18.0% of this theme group

Studies point to accessibility, equity, and evaluation gaps that limit telemedicine’s reach.

Telemedicine (687) · Telehealth (648) · Health care (347) · Nursing (98)

Ensuring full participation of people with disabilities in an era of telehealth

Strategies for Evaluating Telehealth

Health System Integration Issues

13.6% of this theme group

Work examines fragmented administration, nursing, and informatics practices that hinder coordinated care.

Health administration (209) · Nursing research (154) · Health informatics (234) · Public health (215)

Is Europe putting theory into practice? A qualitative study of the level of self-management support in chronic care management approaches

Understanding integrated service delivery: a scoping review of models for noncommunicable disease and mental health interventions in low-and

Limits of Precision Medicine

13.6% of this theme group

Authors discuss obstacles in tailoring treatments to individual disease subtypes and patient genetics.

Precision medicine (602) · Personalized medicine (282) · Cancer (105) · Disease (121)

The growing role of precision and personalized medicine for cancer treatment

Precision Medicine: Disease Subtyping and Tailored Treatment

Digital Health Implementation Gaps

13.5% of this theme group

Papers note mismatches between digital tools and universal health coverage goals.

Digital health (431) · Health care (328) · Health informatics (149) · Informatics (73)

Technology and Universal Health Coverage: Examining the role of digital health

Digital Health and Health Systems of the Future

Pandemic‑Driven Telemedicine Strains

13.1% of this theme group

Research flags unequal access and rapid scaling challenges during COVID‑19.

Pandemic (570) · Coronavirus disease 2019 (384) · 2019-20 coronavirus outbreak (108) · Telemedicine (386)

Telemedicine and health access inequalities during the COVID-19 pandemic

Examining telehealth use among primary care patients, providers, and clinics during the COVID-19 pandemic

Medical Device Safety Concerns

10.3% of this theme group

Studies raise issues around standards, usability, and interoperability of wearable and implantable devices.

Medical device (152) · Wearable computer (47) · Health care (152) · Food and drug administration (36)

The Need to Apply Medical Device Informatics in Developing Standards for Safe Interoperable Medical Systems

Medical Device Usability Analyses

Caution on Remote Chronic Care

24.5% of this theme group

Evidence urges careful assessment of telehealth’s effectiveness and cost‑benefit for long‑term disease management.

Telemedicine (394) · Telehealth (307) · Medical emergency (63) · Health care (134)

Home telehealth for chronic disease management: A systematic review and an analysis of economic evaluations

Transition to telehealth

Governance and Informatics Risks

15.8% of this theme group

Authors caution about data governance, system integration, and staffing challenges in health informatics.

Health informatics (124) · Health administration (73) · Nursing research (49) · Health care (117)

A systematic approach to the planning, implementation, monitoring, and evaluation of integrated health services

INFORMATION SYSTEMS IN HEALTH MANAGEMENT: INNOVATIONS AND CHALLENGES IN THE DIGITAL ERA

COVID‑19 Telehealth Perception Issues

15.4% of this theme group

Surveys reveal patient and clinician concerns about quality and trust in pandemic‑era virtual care.

Pandemic (268) · Coronavirus disease 2019 (208) · Telemedicine (212) · Telehealth (177)

Patient Perception of Telehealth Services for Breast and Gynecologic Oncology Care during the COVID-19 Pandemic: A Single Center Survey-base

Community Mental Health Clinicians’ Perspectives on Telehealth During the COVID-19 Pandemic: Mixed Methods Study

Pharmacogenomics Validation Limits

14.4% of this theme group

Research highlights insufficient evidence and population diversity for routine pharmacogenomic testing.

Pharmacogenomics (86) · Drug discovery (91) · Drug (59) · Pharmacology (33)

Pharmacogenomic Testing and Depressive Symptom Remission: A Systematic Review and <scp>Meta‐Analysis</scp> of Prospective, Controlled Clinic

Warfarin Pharmacogenomics in Diverse Populations

Digital Mental‑Health Intervention Limits

11.4% of this theme group

Analyses point to mixed efficacy and ethical concerns in automated mental‑health solutions.

Psychological intervention (118) · Digital health (104) · Mental health (62) · Intervention (56)

Digital Health Interventions to Enhance Prevention in Primary Care: Scoping Review

Digitization and its Discontents: The Promise and Limitations of Digital Mental Health Interventions

Precision Oncology Practical Hurdles

11.3% of this theme group

Papers discuss limited clinical impact and biomarker validation challenges in cancer precision therapies.

Precision medicine (127) · Personalized medicine (61) · Cancer (49) · Oncology (37)

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials

Mechanism-Centric Approaches for Biomarker Detection and Precision Therapeutics in Cancer

AI Integration Uncertainties

7.1% of this theme group

Authors warn of data bias, interpretability, and regulatory gaps when applying AI to personalized care.

Applications of artificial intelligence (19) · Health care (53) · Precision medicine (36) · Personalized medicine (28)

Leveraging Artificial Intelligence for Predictive Healthcare: A Data-Driven Approach to Early Diagnosis and Personalized Treatment

Advancements in the treatment of autoimmune diseases: Integrating artificial intelligence for personalized medicine

Expanding Telehealth for Seniors

18.5% of this theme group

Studies explore how virtual care can improve access and outcomes for older adults.

Telehealth (669) · Telemedicine (567) · Pandemic (136) · Coronavirus disease 2019 (120)

Urgent and non-emergent telehealth care for seniors: Findings from a multi-site impact study

Using inpatient telehealth for family engagement: A mixed methods study of perceptions from patients, families, and care team providers

Computational Drug Design Advances

16.2% of this theme group

Research showcases in‑silico methods accelerating target identification and molecule optimization.

Drug discovery (597) · Computational biology (310) · Chemical space (104) · Drug (199)

Assessing molecular docking tools: understanding drug discovery and design

Landscape of <i>In Silico</i> Tools for Modeling Covalent Modification of Proteins: A Review on Computational Covalent Drug Discovery

Integrated Digital Health Platforms

15.8% of this theme group

Works propose frameworks for cohesive digital interventions across public health and clinical settings.

Digital health (225) · Health informatics (198) · Health care (254) · Public health (106)

IDEAS (Integrate, Design, Assess, and Share): A Framework and Toolkit of Strategies for the Development of More Effective Digital Interventi

Integrated Digital Mental Health Care: A Vision for Addressing Population Mental Health Needs

Novel Therapeutic Molecule Exploration

15.7% of this theme group

Papers describe new drug candidates and mechanisms uncovered through advanced screening.

Drug discovery (269) · Drug (133) · Pharmacology (64) · In vivo (56)

Development and Characterization of Selective FAK Inhibitors and PROTACs with <i>In Vivo</i> Activity

A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

Precision Oncology for Breast Cancer

13.1% of this theme group

Research highlights rapid mutational profiling and model selection to guide personalized treatment.

Cancer (230) · Precision medicine (278) · Oncology (89) · Breast cancer (91)

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

Systems approach for congruence and selection of cancer models towards precision medicine

Broad Precision Medicine Applications

11.3% of this theme group

Studies demonstrate phenome‑wide analyses and molecular subtyping to refine disease management.

Precision medicine (299) · Personalized medicine (212) · Disease (137) · Health care (84)

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine

Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification

Wearable and Robotic Monitoring

9.4% of this theme group

Innovations focus on remote sensors and surgical robots for continuous patient observation.

Wearable computer (90) · Remote patient monitoring (52) · Surgical robot (38) · Robot (36)

Development of a remote therapeutic monitoring platform: applications for movement disorders

IoT-enabled health monitoring system for real time patient care: Design and evaluation

New York City

26.0% across the displayed hubs

131 companies hiring · $18.9B disclosed funding

San Francisco

22.2% across the displayed hubs

124 companies hiring · $25.9B disclosed funding

Los Angeles

10.3% across the displayed hubs

42 companies hiring · $3.8B disclosed funding

Boston

9.9% across the displayed hubs

56 companies hiring · $11.8B disclosed funding

San Diego

9.3% across the displayed hubs

42 companies hiring · $12.3B disclosed funding

Austin

8.3% across the displayed hubs

36 companies hiring · $3.9B disclosed funding

Chicago

7.9% across the displayed hubs

53 companies hiring · $3.7B disclosed funding

Atlanta

6.0% across the displayed hubs

26 companies hiring · $1.8B disclosed funding