Industry landscapes
Industry report

Funding and advertised pay are reported in USD; filed accounts retain their stated source currency and basis.

Exchange-rate basis

Indicative conversions use ECB reference rates dated 2026-09-14, applied consistently across all periods. They are not historical exchange rates. Indian rupees may use crore (1 crore = 10 million); other currencies use K, M and B. CSV downloads, source documents and quoted news headlines retain their original currencies.

THE BOSTON EDITION 2026

Boston’s
life sciences industry,
in focus.

The companies, capital and talent shaping life sciences in Boston. Find the leaders. Understand the segments. See where the activity is.

Snapshot: Funding in USD
Illustrated cover for Life Sciences Industry Landscape of Boston
US
COMPANIES · CAPITAL · TALENT

An industry ecosystem,
measured in context.

Life Sciences illustration
MEET THE COMPANIES

Explore Boston’s life sciences leaders

24 featured companies from the funding, hiring, revenue and team-size leaderboards.

Expand panel +
Life Sciences company highlights in Boston, snapshot 2 September 2026
Company
Intarciaintarcia.com$2.11B2
Ginkgo Bioworksginkgobioworks.com$813.02M1,218
Fog Pharmaceuticalsfogpharma.com$530.9M97
Paratek Pharmaparatekpharma.com$523.43M205
Genuity Sciencegenuitysci.com$515M140
Reify Healthreifyhealth.com$477.95M71
Scorpionscorpiontx.com$450M62
CELLINKcellink.com$388.79M65
Insuletinsulet.com12 roles2,600$1.06BFYFY2022 filing
TetraSciencetetrascience.com10 roles30
Paragonix Technologiesparagonixtechnologies.com9 roles73
SCIEXsciex.com9 roles2,778
Elektrofielektrofi.com7 roles62
InspireMDinspiremd.com7 roles66$8.98MFYFY2025 filing
OneStudyTeamonestudyteam.com6 roles309
Radius Healthradiuspharm.com6 roles291
Aktis Oncologyaktisoncology.com15
Ateaateapharma.com58$351.37MFYFY2021 filing
BICObico.com955
Beta Bionicsbetabionics.com92$100.25MFYFY2025 filing
Bone Biologicsbonebiologics.com2$1.07BFYFY2020 filing
ClinicalConnectionclinicalconnection.com
Concert AIconcertai.com1,000
PathAIpathai.com573
24 featured companies

Locked revenue figures are available in Radar; the eight company financial previews stay the same throughout this page. A dash means the figure is outside these featured lists. Revenue years vary by company; the figures are not a like-for-like revenue comparison. Compare annual accounts ↗

Company discovery

Recorded evidence only
THE KEY SIGNALS

Life Sciences industry KPIs in Boston

A few useful ratios bring the size of this ecosystem into perspective.

2 September 2026
Hiring participation9.6%

56 of 581 tracked companies have open roles.

Funding participation59.4%

345 of 581 tracked companies have a recorded round.

Top 3 funding share14.0%

Share of disclosed capital received by the three largest recorded recipients.

Median disclosed round$4.8M

Midpoint of 773 rounds with a disclosed amount.

Scale is concentrated. Opportunity is broader. The three largest funding recipients hold 14.0% of disclosed capital, while 40.6% of tracked companies have no recorded funding round.

Explore the segments →
CAPITAL & COMPANY FORMATION

How Boston life sciences has grown

Recorded company formation and disclosed funding across the complete annual series shown.

Expand panel +
2016 — 2025

Disclosed funding by year

Sum of recorded funding rounds · USD

Boston life sciences
$0$1.17B$2.33B$3.5B$4.67B2016: $957.96M20162017: $1.8B20172018: $1.44B20182019: $1.17B20192020: $1.73B20202021: $4.09B20212022: $1.99B20222023: $1.96B20232024: $2.69B20242025: $1.4B2025
View the numbers
Annual life sciences funding and company formation in Boston
YearFunding (USD)FoundedRaising
2016$957.96M3953
2017$1.8B2956
2018$1.44B3255
2019$1.17B3558
2020$1.73B4657
2021$4.09B5381
2022$1.99B3362
2023$1.96B1363
2024$2.69B1367
2025$1.4B654
WHERE CAPITAL SITS

Funding concentration

Share of all disclosed company funding.

  • Intarcia8.6%
  • Ginkgo Bioworks3.3%
  • Fog Pharmaceuticals2.2%
  • Other companies86.0%

Funding by stage

854 recorded rounds since 2016

NUMBER OF ROUNDS
Seed & Angel149 17.4%
Series A–B296 34.7%
Series C+ / PE68 8.0%
Grants, debt & other341 39.9%

Recent recorded rounds

Latest recorded rounds · USD
8 rounds

Swipe or scroll horizontally to browse.

Series C04/2026
AcuityMD $80M

Backed by StepStone Group and Benchmark and others.

Series A03/2026
Poplar Therapeutics $45M

Backed by Janus Henderson Investors and RA Capital Management and others.

Seed03/2026
Outpost Bio $3.5M

Backed by Merantix Capital and Seedcamp and others.

Largest and notable recorded rounds

Each card is one recorded round
10 cards

Swipe or scroll horizontally to browse.

THE BUSINESS BEHIND THE ACTIVITY

Revenue, profitability & financial strength

Annual accounts for reporting companies linked to this landscape, on like-for-like currency and reporting bases.

Expand panel +
USD · millions · consolidated

Display conversions use the dated reference rates above. Where a verified rate is unavailable, figures retain their source currency. Each reporting cohort keeps its currency and accounting basis separate.

FY2025 · annual statements grouped by reported fiscal year; exact entity periods remain on preview rows · 12 reporting entities from 28 eligible matches.

Revenue in covered accounts$314.5m

Sum of reporting-entity revenue; not Boston market sales.

Net profit / loss$-1,225.9m

Combined result for the same cohort.

Aggregate net margin-389.8%

Combined net income ÷ combined revenue.

Median company revenue$14.4m

The middle covered reporting entity.

Profitable entities+8.3%

1 of 12 covered entities.

Top-five concentration+84.4%

Share of covered revenue from the five largest entities.

Annual account trend

Reported cohort totals by year; coverage is stated for every period.

Bar height shows revenue. Changes in coverage can affect totals.

Profitability has two perspectives

FY2025 · 12 reporting entities

Open the company accounts

Up to eight fixed company previews show financial amounts. Search and sort the wider company list, then continue in Radar.

12 reporting entities
Continue your financial research in Radar

Explore full company accounts and filings.

View financials in Radar ↗
BOSTON · INDUSTRY COHORTS

How does life sciences compare?

Each pair uses the same year, currency and reporting basis. Cohort overlap is disclosed.

IndustryCovered / eligibleRevenue totalMedian revenueNet profit / lossAggregate marginProfitable shareOverlap

Available-account cohorts are not estimates of whole industries. Overlapping entities can occur in more than one cohort; do not add cohort totals.

Coverage, calculations & financial sources

Filed annual accounts for exact designated national identifiers. Every aggregate and peer pair uses one fiscal year, source currency and reporting basis; periods, coverage and overlap are explicit; 2026 partials are excluded.

The same up to eight reporting entities remain open across years, filters and sorts. Other company figures are available in Radar.

Source currencies and accounting bases stay separate. Missing accounts are excluded rather than treated as zero. Exact reporting periods appear on company previews. Annual totals can change with coverage and do not measure growth of a fixed company cohort.

DIGITAL FOOTPRINT

Web traffic, app reach and release cadence

How the Boston companies on this page show up online: the sites people visit, the apps they install, and how often those apps ship.

Most-installed apps

12 of these companies (2.1%) publish at least one Android app — 38 apps in all, carrying 237.3K installs between them.

Installs are lifetime totals to date at the June 2026 store reading — a measure of reach, not of people using an app today.

App reach by segment

The busiest app inside each of this page’s own segments, with the quarterly release trend behind it (2023Q1–2025Q4).

SegmentAppsInstallsLeading appRelease trend
Life Sciences Platforms And Tools4178.2KFace2Gene 176.1K
Life Sciences Tech2176.1KProCTH Patient 27
Diabetes229.6KiLet App 20.2K
Nutraceuticals Tech2525.3KForm Health 17.7K
Disease Self Management2618.9KFood as Medicine 503
Fitness & Wellness Tech2418.8KInterstitial Cystitis (IC) 154
Assistive Tech3214Myomo 120
Orthopedics2144GateKeeper by Gate Science 24

A company can carry several segment tags, so these rows overlap and should not be added together. Trend lines are zero-based and share one quarter grid, so a flat line is a quiet segment, not a missing one.

Release cadence by quarter

New apps published, beside apps whose most recent update landed in that quarter — the second bar is how much of the shelf is still being maintained.

2023Q1: 12023Q1: 02023Q12023Q2: 12023Q2: 02023Q22024Q1: 12024Q1: 12024Q12024Q2: 22024Q2: 02024Q22024Q3: 32024Q3: 42024Q32024Q4: 122024Q4: 112024Q42025Q1: 102025Q1: 92025Q12025Q4: 12025Q4: 02025Q4

Darker bars are new releases, lighter bars apps updated. 37 of 38 apps carry a release date. The series ends at 2025Q4, the last quarter that closed before the June 2026 reading.

INSIDE THE INDUSTRY

The Boston life sciences market map

Explore the segments behind the headline numbers.

Expand panel +

Where companies are building

Rank segments by scale, hiring or disclosed funding.

Enterprise tech454
Biopharmaceuticals182
Healthtech147
Enterprise software123
Medical devices111
Deep tech94
Consumer digital51
Saas51
Healthtech saas44
In vitro diagnostics35
Masschallenge batches34
Clinical trials tech26

Companies can sit in several segments. Counts and funding overlap.

SEGMENT TO EXPLORE

Enterprise tech

The largest measured segment in this report snapshot.

454companies
10.6%have hiring activity

48 companies hiring · $22.29B disclosed funding

Explore in Radar

How companies make money

Common revenue models; a company can use more than one.

Subscription251
Physical commerce240
E-commerce - product157
Fee-for-service84
Advertising14
Commission on transaction12
E-commerce - service8
Sponsorship2
THE COMPANIES IN MOTION

Who is listing, hiring leaders, launching and winning work

Recorded corporate activity linked to companies in this landscape.

Expand panel +
Recent corporate headlines 10 dated reports
IPO activityseaporttx.com ↗

Size: 11.8 million shares at $16.00 to $18.00 to raise $200.6 million – if priced at the $17.00 mid-point of its range Market Cap: $861.36 million Goldman Sachs, J.P. Morgan, Leerink Partners, Citigroup and Stifel are the joint book-runners.

Funding roundsacuitymd.com ↗

Boston-based AcuityMD a medtech intelligence platform that leverages AI and precise data to support commercial decision-making.

Mergers & acquisitionskeloniatx.com ↗

Eli Lilly has entered a definitive agreement to acquire Kelonia Therapeutics for up to $7 billion.

Mergers & acquisitionspraxismedicines.com ↗

Deerfield Management Company L.P. boosted its holdings in shares of Praxis Precision Medicines by 22.4% in the 3rd quarter.

Funding roundslifebiosciences.com ↗

Life Biosciences (Boston), a biotech focused on therapies to reverse cellular aging, announced an $80 million Series D round to fund a cellular rejuvenation platform.

Funding roundstranscodetherapeutics.com ↗

TransCode Therapeutics, Inc. (NASDAQ: RNAZ), a clinical stage company pioneering immuno-oncology and RNA for the treatment of high risk and advanced cancer, today announced that it has entered into an agreement with an institutional healthcare investor for financing of up to $20 million.

Mergers & acquisitionscentessa.com ↗

Eli Lilly and Co. has agreed to acquire Centessa Pharmaceuticals for $38.00 per share in cash plus a contingent value right (CVR) worth up to $9.00 per share, implying a total potential equity value of approximately $7.8 billion.

Funding roundsaprea.com ↗

Financing led by Soleus Capital with participation from Vestal Point Capital, Squadron Capital Management and additional new and existing investors DOYLESTOWN, Pa., March 30, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE ) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today announced that it has entered into a securities purchase agreement for an oversubscribed private placement financing that is expected to result in total gross proceeds of approximately $30 million to the Company before deducting placement agent fees and other private placement expenses (the “Offering”).

Funding roundsparatekpharma.com ↗

Private investment major Blackstone Inc is spearheading a $1.3bn private funding package to support the merger of Paratek Pharmaceuticals and Radius Health, according to a report by Bloomberg.

IPO activityaktisoncology.com ↗

Cancer drug developer Aktis Oncology went public in New York last month,

Full recorded event mix

Top 10 categories among 673 recorded events in the 24-month window.

Earnings
194
Leadership moves
117
Funding rounds
102
Mergers & acquisitions
73
IPO activity
56
Company announcements
39
Lawsuit
29
Asset acquisitions
14
Layoffs
13
Contracts
8
7 activity cards

Swipe or scroll horizontally to browse.

IPO pipeline

19 companies with recorded IPO activity

IPO · Nasdaq2 reports

IPO · NASDAQ16 reports

IPO · Nasdaq10 reports

Follow-on Offering · Nasdaq1 reports

SPAC · Nasdaq2 reports

Follow-on Offering · Nasdaq1 reports

Follow-on Offering5 reports

Centrexion ↗

IPO · Nasdaq2 reports

Leadership moves

46 tracked people moves

Valo Health ↗
Chris Anagnostopoulos, PhD

Appointment Chief Causal AI Officer

Dr. Sharon Mates

Appointment Board of Directors

Jeff Jonas

Resignation

Concert AI ↗
Missy Jerome

Appointment Chief People Officer

Insulet ↗
Mike Panos

Appointment EVP, chief commercial officer (CCO)

Insulet ↗
Cristal Downing

Appointment chief corporate affairs officer

Insulet ↗
Eric Benjamin

Promotion Chief Operating Officer (COO)

Nabla ↗
Laurie Soffiati

Appointment Country Director

Product launches

Products, platforms and features in the recorded window

PathAI ↗
AISight Dx

Digital Pathology Platform

AcuityMD ↗
AI tools

AI platform

Litigation

18 tracked suits

Company
Cerevel Therapeutics Holdings, Inc. investors v cerevel therapeutics, abbvie, bain capital

securities fraudClass Action · Ongoing

Company
Investors in Cerevel Therapeutics Holdings, Inc. v cerevel therapeutics

securities fraud / shareholder rights violationClass Action · Ongoing

Earnings pulse

Reported company results in the recorded window.

31companies
209period observations
29.9%median reported growth

Median across 84 reported growth observations; companies may contribute multiple periods.

Mergers and acquisitions

Company-linked deal reports; status is preserved as recorded.

Acquirer → targetStatusDateValue / context
eli lillyKelonia ↗Completed2026-04-28$7.0B
lillyKelonia ↗Announced2026-04-20$7.0B
allspring global investmentsPraxis Medicines ↗Announced2026-04-12$496.0K
Woodline Partners LPPraxis Medicines ↗Announced2026-04-12$22.1M
Adage Capital Partners GP L.L.C.Praxis Medicines ↗Announced2026-04-12$83.0M
Deerfield Management Company L.P.Praxis Medicines ↗Announced2026-04-12$44.6M

A discussion or rumour is not a completed transaction. An unstated value is not zero.

PEOPLE & OPPORTUNITY

The talent market

827 postings in the preceding 12 months. The full 1,183-posting snapshot covers 65 employers.

Expand panel +

Most advertised job titles

Marketing Intern11
Scientific Business Analyst, Scientific Ai Boston10
Sr. Medical Science Liaison Cystic Fibrosis (Oh, Ky, Mi)9
Senior Product Marketing Manager9
Technical Product Marketing Manager Ii8
Corporate Development Summer Analyst8
0 internship postings

9 tracked postings mention remote work.

The seniority mix

728 postings specify a level.

unspecified
455
manager
365
senior
253
lead
76
intern
33
entry
1

Skills employers mention

Top skills across 1,183 tracked postings in the available jobs snapshot.

Javascript
25
Python
18
Excel
17
Typescript
15
React
8
Postgres
7
Salesforce
7
Structural
7
Aws
7
Gcp
7
ADVERTISED PAY$135.0K/ year

Median across 166 postings with pay data, expressed in USD.

Salary by seniority

manager$135.1K/ year78 postings
senior$137.5K/ year42 postings

Advertised posting medians do not describe all employees or roles.

THE PEOPLE BUILDING THE FIELD

Founders and leaders

490 founders and chief executives across 318 companies.

Expand panel +
12 profiles

Swipe or scroll horizontally to browse.

Education networks

163 profiles with education records.

Massachusetts Institute of Technology
47
Harvard University
45
Harvard Business School
16
Stanford University
14
Cornell University
9
University of Cambridge
8
University of Chicago
7
University of Pennsylvania
7

Prior employers

14 profiles with prior-work records.

McKinsey
5
Amazon
2
Boston Consulting Group
1
Google
1
Morgan Stanley
1
Bain
1
Microsoft
1
Apple
1

Profiles cover recorded founders and leaders; contact details remain in Radar.

NEWS INTELLIGENCE

How this industry appears in the news

7,288 articles in the measured 12-month window.

Expand panel +
7,288articles in the measured year
1,792articles in 2026Q1
85.9%positive tone in the latest complete year

News volume trends

Life Sciences coverage tagged Boston · articles per complete quarter

01,9013,8025,7037,6042021Q2: 2,1022021Q22021Q3: 2,1302021Q4: 1,7952022Q1: 2,2132022Q2: 2,0952022Q22022Q3: 2,0652022Q4: 2,2582023Q1: 2,1802023Q2: 2,8982023Q22023Q3: 2,0582023Q4: 2,6542024Q1: 2,6582024Q2: 2,7342024Q22024Q3: 2,1242024Q4: 2,0522025Q1: 6,6122025Q2: 1,5982025Q22025Q3: 1,5442025Q4: 2,4582026Q1: 1,7922026Q1
View quarterly article counts
QuarterArticles
2021Q22,102
2021Q32,130
2021Q41,795
2022Q12,213
2022Q22,095
2022Q32,065
2022Q42,258
2023Q12,180
2023Q22,898
2023Q32,058
2023Q42,654
2024Q12,658
2024Q22,734
2024Q32,124
2024Q42,052
2025Q16,612
2025Q21,598
2025Q31,544
2025Q42,458
2026Q11,792

Article volume measures coverage, not market sales.

Tone of coverage over time

2021
5,564 positive · 45 neutral · 942 negative
2022
7,554 positive · 92 neutral · 974 negative
2023
8,825 positive · 75 neutral · 887 negative
2024
8,438 positive · 87 neutral · 1,037 negative
2025
10,469 positive · 133 neutral · 1,591 negative

Leading coverage topics

Life Sciences coverage tagged Boston · ranked by full-period article count.

Covid 19 Vaccine Development And Efficacy Trials39,155 articles in the full recorded period
3,816 recent · 1,137 prior
Oncology And Targeted Therapy Advancements28,440 articles in the full recorded period
5,253 recent · 7,172 prior
Covid 19 Vaccination Campaigns And Rollout Strategies23,158 articles in the full recorded period
2,429 recent · 567 prior
Rare Disease Therapies And Orphan Drugs22,835 articles in the full recorded period
4,860 recent · 6,623 prior
Economy News: Inflation Rate Analysis22,793 articles in the full recorded period
5,403 recent · 4,499 prior
Gene Therapy And Crispr Technologies19,287 articles in the full recorded period
3,916 recent · 5,313 prior
Drug Pricing And Reimbursement Strategies19,105 articles in the full recorded period
6,323 recent · 4,596 prior
Vaccine Research And Production Methods14,227 articles in the full recorded period
1,534 recent · 1,914 prior
Macroeconomic Policy And Global Economics13,875 articles in the full recorded period
2,509 recent · 4,830 prior
Generic Drug Development And Market Trends13,278 articles in the full recorded period
3,980 recent · 3,287 prior

Recent and prior counts use the source comparison windows.

Topics gaining and losing attention

United States comparison coverage

KeywordRecentPriorChange
vaccine candidates3,157898252%
vaccine trials2,962904228%
vaccination campaigns2,752555396%
vaccine immunogenicity2,473668270%
mass vaccination sites2,021272643%
vaccination coverage1,516202650%
vaccine effectiveness study1,400251458%
angel investors1,344590128%
covid-19 vaccine development1,335238461%
pandemic vaccine stockpiling1,294242435%
investigational new vaccine4511,069-58%
cell-based therapies6191,059-42%
viral vector vaccines6841,048-35%
cancer biomarkers6701,040-36%
diagnostic biotechnology570948-40%

Event and signal lenses

United States comparison coverage

All complete annual cohorts shown
Rising

Regulatory Risk

290,712 classified articles

core inflation rate, inflation outlook, inflation breakdown

52.8% critical · 34.6% positive
Rising

Funding Momentum

102,225 classified articles

angel investors, vaccine candidates, vaccine trials

49.1% critical · 55.2% positive
Rising

Growth

175,378 classified articles

gdp acceleration, gdp growth rate, economic output growth

49.7% critical · 39.6% positive

Life Sciences coverage tagged Boston. Topic labels describe recorded classifications and can include broad context.

RESEARCH SIGNALS

What Life Sciences research is working on

6,260 papers in the recorded india scope.

Expand panel +
6,260papers
53,147worldwide comparison pool
6,260India-affiliated papers

Research orientation

Breakthrough
2,038
Promising
1,943
Descriptive
1,098
Problem-identifying
567
Cautionary
360
Comparative
175
Critical
79

Contribution mix

Empirical
3,753
Methods-led
1,242
Reviews
1,058
Position pieces
198
Theoretical
9

Tone counts: 5,526 positive · 456 neutral · 278 negative.

Common problems researchers identify
646 papers · 10.3% of this field
  • Agriculture59 papers
  • Antibiotic resistance53 papers
  • Biotechnology46 papers
  • Antimicrobial34 papers
  • Public health31 papers
  • Production28 papers
  • Population27 papers
  • Antibiotics24 papers

Landmark: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term prob

Cautions
360 papers · 5.8% of this field
  • Gene21 papers
  • Agriculture19 papers
  • Antibody15 papers
  • Mutation15 papers
  • In vivo14 papers
  • Population12 papers
  • Antibiotic resistance11 papers
  • Mitochondrion11 papers

Landmark: Genomic responses in mouse models poorly mimic human inflammatory diseases

Opportunities
3,981 papers · 63.6% of this field
  • Gene284 papers
  • In vivo224 papers
  • Antibody125 papers
  • Gene expression121 papers
  • Cell culture115 papers
  • Messenger RNA110 papers
  • Transcription103 papers
  • Cell101 papers

Landmark: U1 snRNP regulates cancer cell migration and invasion in vitro

Leading institutions

Harvard University
86,693
Howard Hughes Medical Institute
74,901
Cornell University
42,772
Stanford University
38,500
National Institutes of Health
35,881
Massachusetts Institute of Technology
33,017

Leading researchers

Daniel Merenstein
9,186
Colin Hill
8,812
Francisco Guarner
8,812
Gregor Reid
8,812
Glenn R. Gibson
8,812
Ahmad Almilaji
8,696
Kalina Szteyn
8,696
Evelyn Fein
8,696

Highly cited breakthrough-labelled papers

  • U1 snRNP regulates cancer cell migration and invasion in vitro7,224 citations
  • Comprehensive molecular profiling of lung adenocarcinoma5,754 citations
  • The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets4,863 citations
  • Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway4,674 citations
  • Circular RNAs are abundant, conserved, and associated with ALU repeats4,505 citations

Common problems researchers identify

632 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Challenges in Biomanufacturing TechnologiesCommon problems researchers identify · 01

Challenges in Biomanufacturing Technologies

116 papers

18.4% of this theme group

Researchers highlight technical hurdles in synthetic biology, enzymatic processes, and nanotech for biotech production.

Biochemical engineering (18) · Synthetic biology (12) · Biomanufacturing (8) · Nanotechnology (9)

Microbial Enzymes: Tools for Biotechnological Processes

Medical biofilms

View research history
YearShare index
202267.9
202370.3
202484.4
202567.1
Foodborne Pathogen and Mycotoxin RisksCommon problems researchers identify · 02

Foodborne Pathogen and Mycotoxin Risks

99 papers

15.7% of this theme group

Studies flag rising contamination threats and public‑health impacts from unsafe food and produce.

Public health (15) · Mycotoxin (8) · Disease (12) · Contamination (8)

The growing burden of foodborne outbreaks due to contaminated fresh produce: risks and opportunities

A review of Listeria monocytogenes: An update on outbreaks, virulence, dose-response, ecology, and risk assessments

View research history
YearShare index
2022301.0
2023265.8
2024276.2
2025304.0
Cancer‑Related Genetic and Epigenetic IssuesCommon problems researchers identify · 03

Cancer‑Related Genetic and Epigenetic Issues

98 papers

15.5% of this theme group

Papers discuss mutation detection, DNA methylation complexities, and metabolic profiling in oncology.

Mutation (7) · Cancer (9) · DNA methylation (5) · Gene (8)

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

View research history
YearShare index
2022974.1
20231199.2
2024866.8
2025797.1
Abiotic Stress in Modern AgricultureCommon problems researchers identify · 04

Abiotic Stress in Modern Agriculture

96 papers

15.2% of this theme group

Works point to difficulties in engineering crops for drought, salinity, and other non‑biotic stresses.

Agriculture (33) · Abiotic stress (10) · Abiotic component (12) · Biotechnology (20)

Genetic Engineering for Modern Agriculture: Challenges and Perspectives

Phytohormones and their metabolic engineering for abiotic stress tolerance in crop plants

View research history
YearShare index
20221472.5
20231503.8
20241656.9
20251839.0
Nutrient Deficiencies and Food‑Science GapsCommon problems researchers identify · 05

Nutrient Deficiencies and Food‑Science Gaps

93 papers

14.7% of this theme group

Research notes obstacles in biofortification, micronutrient production, and beneficial food fermentations.

Micronutrient (9) · Production (13) · Nutrient (10) · Food science (7)

Improving nutrition through biofortification: A review of evidence from HarvestPlus, 2003 through 2016

Food fermentations: Microorganisms with technological beneficial use

View research history
YearShare index
2022120.6
2023117.1
2024113.1
2025122.2
Escalating Antibiotic Resistance ConcernsCommon problems researchers identify · 06

Escalating Antibiotic Resistance Concerns

70 papers

11.1% of this theme group

Authors emphasize the growing threat of resistant bacteria and the need for new antimicrobial strategies.

Antibiotic resistance (49) · Antimicrobial (31) · Antibiotics (22) · Drug resistance (8)

An overview of the antimicrobial resistance mechanisms of bacteria

The global threat of antimicrobial resistance: science for intervention

View research history
YearShare index
2022886.3
2023838.0
2024911.9
2025963.5
Insecticide Resistance and Vector ManagementCommon problems researchers identify · 07

Insecticide Resistance and Vector Management

60 papers

9.5% of this theme group

Studies outline resistance mechanisms in pests and challenges for integrated control programs.

Resistance (14) · Insecticide resistance (5) · Vector (5) · Integrated pest management (5)

Insecticide Resistance in Mosquitoes: Impact, Mechanisms, and Research Directions

Innate Immunity in Plants: An Arms Race Between Pattern Recognition Receptors in Plants and Effectors in Microbial Pathogens

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YearShare index
20223.4
20233.1
20244.4
20254.3

Cautions

353 papers · 7 recurring themes
7 cards

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DNA Damage and Repair UncertaintiesCautions · 01

DNA Damage and Repair Uncertainties

87 papers

24.6% of this theme group

Researchers urge caution interpreting genomic instability and mutation data due to repair pathway complexities.

DNA repair (7) · DNA polymerase (6) · DNA damage (7) · Mutation (9)

Examining the link between chromosomal instability and aneuploidy in human cells

Comparative analysis of microRNA expression in serum and plasma in patients screened for BRCA1 or BRCA2 mutations

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YearShare index
2022101.2
2023139.0
202491.9
202579.2
Immune Modulation Risks in TherapeuticsCautions · 02

Immune Modulation Risks in Therapeutics

64 papers

18.1% of this theme group

Papers caution about unintended immune effects when targeting antibodies or cellular subsets in vivo.

Antibody (9) · In vivo (8) · Peripheral blood mononuclear cell (4) · Immune system (5)

Selective B-cell subset depletion underlies increased infection risk in patients with MM treated with anti-BCMA vs anti-GPRC5D bsAbs

T cell responses towards PINK1 and ⍺-synuclein are elevated in prodromal Parkinson's disease - Fluorospot data

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YearShare index
2022543.7
2023602.0
2024448.8
2025441.1
Food Safety and Nanomaterial InteractionsCautions · 03

Food Safety and Nanomaterial Interactions

51 papers

14.4% of this theme group

Works warn of potential health and quality issues from nanomaterials in raw food ingredients.

Food safety (6) · Raw material (4) · Health benefits (4) · Sugar (3)

Caffeine (1, 3, 7‐trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters

Soybean susceptibility to manufactured nanomaterials with evidence for food quality and soil fertility interruption

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YearShare index
2022122.8
2023120.4
2024118.6
2025154.1
Livestock Nutrition and Emission Trade‑offsCautions · 04

Livestock Nutrition and Emission Trade‑offs

41 papers

11.6% of this theme group

Studies highlight uncertainties in additive use, animal performance, and greenhouse‑gas outcomes.

Dairy cattle (6) · Production (6) · Nutrient (6) · Beef cattle (5)

Impact of tannin-based additives on animal performance and enteric methane emissions in dairy and beef cattle: A meta-analysis

The effects of injectable trace mineral solutions on beef cattle performance and health during preconditioning and feedlot receiving: a syst

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YearShare index
2022126.8
2023122.4
2024118.5
2025129.2
Genomic Selection Accuracy LimitsCautions · 05

Genomic Selection Accuracy Limits

38 papers

10.8% of this theme group

Researchers note challenges in predicting traits and maintaining diversity using genomic breeding tools.

Gene (10) · Genomic selection (5) · Selection (6) · Trait (4)

Genomic Selection for Crop Improvement

Genomic selection in plant breeding: from theory to practice

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YearShare index
20222367.9
20232351.5
20242081.1
20251566.0
Integrated Pest Management Implementation IssuesCautions · 06

Integrated Pest Management Implementation Issues

37 papers

10.5% of this theme group

Papers point to practical and ecological concerns when deploying biological control and pesticide strategies.

PEST analysis (9) · Agriculture (7) · Pest control (3) · Integrated pest management (3)

The use of fungal entomopathogens as endophytes in biological control: a review

Insecticide Control of Vector-Borne Diseases: When Is Insecticide Resistance a Problem?

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YearShare index
20221443.5
20231484.3
20241642.9
20251827.1
Antibiotic Use and Resistance SpilloverCautions · 07

Antibiotic Use and Resistance Spillover

35 papers

9.9% of this theme group

Works caution that veterinary antibiotic practices can influence resistance patterns in human pathogens.

Antibiotic resistance (12) · Antibiotics (9) · Antimicrobial (6) · Bacteria (5)

Multidrug evolutionary strategies to reverse antibiotic resistance

Impact of Antibiotic Use in Adult Dairy Cows on Antimicrobial Resistance of Veterinary and Human Pathogens: A Comprehensive Review

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YearShare index
2022886.3
2023838.0
2024911.9
2025963.5

Opportunities

3,882 papers · 7 recurring themes
7 cards

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Probiotic and Postbiotic InnovationsOpportunities · 01

Probiotic and Postbiotic Innovations

759 papers

19.6% of this theme group

Research explores microbial products for improving human health, animal performance, and food safety.

Antimicrobial (64) · Fermentation (55) · Bacteria (52) · Antibiotic resistance (37)

Probiotics, their health benefits and applications for developing healthier foods: a review

Postbiotics: Multifunctional Microbial Products Transforming Animal Health and Performance

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YearShare index
20222406.7
20232240.7
20242316.1
20251955.8
Gene Regulation and Apoptosis TargetsOpportunities · 02

Gene Regulation and Apoptosis Targets

750 papers

19.3% of this theme group

Studies identify novel gene‑knockdown and pathway modulation approaches for disease therapy.

Apoptosis (37) · Downregulation and upregulation (57) · Gene knockdown (46) · Mutant (48)

PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development

Modulation of ossification and inflammatory pathways during dexamethasone-induced <i>in vitro</i> osteogenesis

View research history
YearShare index
2022364.0
2023394.7
2024257.4
2025261.8
Cell‑Based Immunotherapy AdvancesOpportunities · 03

Cell‑Based Immunotherapy Advances

513 papers

13.2% of this theme group

Papers present new antibody targets and microvesicle strategies to enhance T‑cell mediated treatments.

Cell culture (77) · T cell (54) · Antigen (49) · Cell (62)

CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

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YearShare index
2022289.3
2023336.1
2024224.8
2025204.1
Epigenetic Editing and DNA Repair ToolsOpportunities · 04

Epigenetic Editing and DNA Repair Tools

497 papers

12.8% of this theme group

Research highlights emerging methods to correct methylation defects and manipulate replication processes.

DNA repair (65) · DNA damage (68) · DNA methylation (58) · DNA replication (34)

Convergent DNA methylation abnormalities at enhancers and bivalent promoters in human growth disorders

MacroH2A-Mediated Gene Repression through Nucleosome Compaction and Remodeling Inhibition

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YearShare index
2022224.2
2023281.6
2024196.5
2025158.4
Nanoparticle Imaging and Molecular ProbesOpportunities · 05

Nanoparticle Imaging and Molecular Probes

472 papers

12.2% of this theme group

Works develop activatable nanoprobes for real‑time fluorescence and magnetic resonance tracking in vivo.

In vivo (142) · Fluorescence (41) · Molecular imaging (28) · Nanotechnology (33)

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticl

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YearShare index
2022480.4
2023520.5
2024397.5
2025406.8
Genomic Breeding and Diversity ExpansionOpportunities · 06

Genomic Breeding and Diversity Expansion

453 papers

11.7% of this theme group

Studies showcase sequencing and selection techniques to broaden germplasm and accelerate crop improvement.

Germplasm (37) · Selection (42) · Genetic diversity (28) · Trait (28)

Genotyping‐by‐Sequencing for Plant Breeding and Genetics

Harvesting the Promising Fruits of Genomics: Applying Genome Sequencing Technologies to Crop Breeding

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YearShare index
202256.0
202351.4
202446.1
202553.1
RNA Modification and Regulatory NetworksOpportunities · 07

RNA Modification and Regulatory Networks

438 papers

11.3% of this theme group

Research investigates mRNA methylation and microRNA pathways for controlling gene expression in disease.

Messenger RNA (103) · microRNA (61) · Transcription (65) · RNA polymerase II (34)

m <sup>6</sup> A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

Microrna-Dependent Regulation of Dna Methyltransferase-1 and Tumor Suppressor Gene Expression by Interleukin-6 in Human Malignant Cholangioc

View research history
YearShare index
2022229.2
2023195.8
2024157.3
2025136.5

How this field compares with the research baseline

Orientation shares compared with 25,000 papers in the reference sample.

Research orientationThis fieldReference sample
Breakthrough32.6%26.7%
Promising31.0%37.0%
Descriptive17.5%17.4%
Problem-identifying9.1%9.6%
Cautionary5.8%4.4%
Comparative2.8%4.0%
Critical1.3%0.9%

Concerns receiving less research attention

Counts and shares refer to the stated research pool. A low count describes how much of that research is recorded here, not the absence of a real-world concern.

Concern / example paperPapersShareRaised as a problemWorldwide share
Privacy & surveillanceSARS-CoV-2 wastewater genomic surveillance: approaches, challenges, and opportunities180.3%2 (11.1%)0.21%
Hardware, e-waste & supply chainFate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste40.07%1 (25.0%)0.15%
Bias & fairnessNot All Allies Are Welcome: Partner Discrimination in Legume–Rhizobium Symbiosis30.05%1 (33.3%)0.03%
Safety & misusePublic perceptions and information sources on genetically modified organisms in Kenya10.02%1 (100.0%)0.01%
Energy & datacenter footprint00.0%0 (%)0.0%
Water use00.0%0 (%)0.0%
Carbon & emissions of compute00.0%0 (%)0.0%
Labour & data work00.0%0 (%)0.0%
Concentration of compute power00.0%0 (%)0.0%

Research orientation and citation rankings describe the covered collection. Its recorded publication dates do not support an overall publication-volume trend.

Institution and researcher rankings use citations to their covered work. Research scope: United States. This may be broader than the company geography.

UNDERSTAND THE LANDSCAPE

Life Sciences in Boston: key questions

Clear definitions for making better comparisons.

What does this landscape measure?

It measures the tracked company ecosystem, recorded funding, hiring and other available evidence. It is not a market-size estimate.

Can segment counts be added together?

No. A company can belong to several segments, so segment counts and funding can overlap.

What does a missing figure mean?

A dash or unavailable panel means the current reviewed source snapshot does not support that figure.

Company ecosystem snapshot: 2 September 2026. Funding is recorded in USD; filed accounts retain their stated currency and reporting basis. Each section identifies its own coverage. The news and research behind these sections is explorable in Prism.

Canonical landscape ↗
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