Industry landscapes
Industry report

Funding and advertised pay are reported in USD; filed accounts retain their stated source currency and basis.

Exchange-rate basis

Indicative conversions use ECB reference rates dated 2026-09-14, applied consistently across all periods. They are not historical exchange rates. Indian rupees may use crore (1 crore = 10 million); other currencies use K, M and B. CSV downloads, source documents and quoted news headlines retain their original currencies.

THE THE UNITED STATES EDITION 2026

the United States’s
age tech and longevity industry,
in focus.

The companies, capital and talent shaping age tech and longevity in the United States. Find the leaders. Understand the segments. See where the activity is.

Snapshot: Funding in USD
Illustrated cover for Age Tech and Longevity Industry Landscape of the United States
US
COMPANIES · CAPITAL · TALENT

An industry ecosystem,
measured in context.

Age Tech and Longevity illustration
MEET THE COMPANIES

Explore the United States’s age tech and longevity leaders

24 featured companies from the funding, hiring, revenue and team-size leaderboards.

Expand panel +
Age Tech and Longevity company highlights in the United States, snapshot 31 August 2026
Company
Human Interesthumaninterest.com$814.02M—577—
NU Skinnuskin.com$750.8M—1,900$1.49BFYFY2025 filing
Honorhonorcare.com$510M—1,902—
Guidelineguideline.com$344M—416—
Papapapa.com$256.81M—853—
Smartsmartretire.com$225.43M———
Vesta Healthcarevestahealthcare.com$198.04M—114—
A Place for Momaplaceformom.com$184.5M11 roles11—
Medical Guardianmedicalguardian.com—12 roles178—
Care.comcare.com—10 roles797—
SafelyYousafely-you.com—10 roles85—
Utah Retirement Systemsurs.org—10 roles2—
AARPaarp.org—9 roles2,362—
The Helper Beesthehelperbees.com—8 roles164—
IRA Financialirafinancial.com—7 roles——
Careforthcareforth.com——580—
Ekso Bionicseksobionics.com——59Financial figure available in RadarView in Radar
Find a Gravefindagrave.com————
Life Alertlifealert.com——304—
LifeVantagelifevantage.com——248$228.53MFYFY2025 filing
LogicMarklogicmark.com——27$11.43MFYFY2025 filing
One Skin Technologiesoneskin.co——17—
OurTime Datingourtime.com————
PCS Retirementpcsretirement.com——341—
24 featured companies

Locked revenue figures are available in Radar; the eight company financial previews stay the same throughout this page. A dash means the figure is outside these featured lists. Revenue years vary by company; the figures are not a like-for-like revenue comparison. Compare annual accounts ↗

Company discovery

Recorded evidence only

Explore the live startup set in Radar

No company example met every recorded classification, independence and public-profile gate in this snapshot. The live directory may have newer qualifying companies.

Explore classified startups in Radar ↗
THE KEY SIGNALS

Age Tech and Longevity industry KPIs in the United States

A few useful ratios bring the size of this ecosystem into perspective.

31 August 2026
Hiring participation5.5%

61 of 1,115 tracked companies have open roles.

Funding participation25.4%

283 of 1,115 tracked companies have a recorded round.

Top 3 funding share27.6%

Share of disclosed capital received by the three largest recorded recipients.

Median disclosed round$2.32M

Midpoint of 543 rounds with a disclosed amount.

Scale is concentrated. Opportunity is broader. The three largest funding recipients hold 27.6% of disclosed capital, while 74.6% of tracked companies have no recorded funding round.

Explore the segments →
CAPITAL & COMPANY FORMATION

How the United States age tech and longevity has grown

Recorded company formation and disclosed funding across the complete annual series shown.

Expand panel +
2016 — 2025

Disclosed funding by year

Sum of recorded funding rounds · USD

the United States age tech and longevity
$0$437.28M$874.56M$1.31B$1.75B2016: $158.96M20162017: $136.58M20172018: $1.01B20182019: $327.1M20192020: $585.21M20202021: $1.53B20212022: $957.44M20222023: $453.79M20232024: $651.64M20242025: $826.22M2025
View the numbers
Annual age tech and longevity funding and company formation in the United States
YearFunding (USD)FoundedRaising
2016$158.96M5736
2017$136.58M7540
2018$1.01B8235
2019$327.1M8842
2020$585.21M9755
2021$1.53B6555
2022$957.44M5350
2023$453.79M3850
2024$651.64M2436
2025$826.22M1143
WHERE CAPITAL SITS

Funding concentration

Share of all disclosed company funding.

  • Human Interest10.8%
  • NU Skin10.0%
  • Honor6.8%
  • Other companies72.4%

Funding by stage

609 recorded rounds since 2016

NUMBER OF ROUNDS
Seed & Angel233 38.3%
Series A–B174 28.6%
Series C+ / PE47 7.7%
Grants, debt & other155 25.5%

Recent recorded rounds

Latest recorded rounds · USD
8 rounds

Swipe or scroll horizontally to browse.

Series B04/2026
Wealth $65M

Backed by Titanium Ventures and PruVen Capital and others.

Series C02/2026
Sage Health $65M

Backed by Goldman Sachs and IVP and others.

Conventional Debt02/2026
Chptr —

Backed by .

Largest and notable recorded rounds

Each card is one recorded round
10 cards

Swipe or scroll horizontally to browse.

Series D10/2021
Papapapa.com$150M

Backed by TCG Ventures and SoftBank Vision Fund and others.

THE BUSINESS BEHIND THE ACTIVITY

Revenue, profitability & financial strength

Annual accounts for reporting companies linked to this landscape, on like-for-like currency and reporting bases.

Expand panel +
USD · millions · consolidated

Display conversions use the dated reference rates above. Where a verified rate is unavailable, figures retain their source currency. Each reporting cohort keeps its currency and accounting basis separate.

FY2025 · company accounts; aggregate reporting threshold not met · 4 reporting entities from 9 eligible matches.

Revenue in covered accounts—

Sum of reporting-entity revenue; not the United States market sales.

Net profit / loss—

Combined result for the same cohort.

Aggregate net margin—

Combined net income ÷ combined revenue.

Median company revenue—

The middle covered reporting entity.

Profitable entities—

None of 4 covered entities.

Top-five concentration—

Share of covered revenue from the five largest entities.

Annual account trend

Reported cohort totals by year; coverage is stated for every period.

Bar height shows revenue. Changes in coverage can affect totals.

Profitability has two perspectives

FY2025 · 4 reporting entities

Open the company accounts

Up to eight fixed company previews show financial amounts. Search and sort the wider company list, then continue in Radar.

4 reporting entities
Continue your financial research in Radar

Explore full company accounts and filings.

View financials in Radar ↗
THE UNITED STATES · INDUSTRY COHORTS

How does age tech and longevity compare?

Each pair uses the same year, currency and reporting basis. Cohort overlap is disclosed.

IndustryCovered / eligibleRevenue totalMedian revenueNet profit / lossAggregate marginProfitable shareOverlap

Available-account cohorts are not estimates of whole industries. Overlapping entities can occur in more than one cohort; do not add cohort totals.

Coverage, calculations & financial sources

Filed annual accounts for exact designated national identifiers. Every aggregate and peer pair uses one fiscal year, source currency and reporting basis; periods, coverage and overlap are explicit; 2026 partials are excluded.

The same up to eight reporting entities remain open across years, filters and sorts. Other company figures are available in Radar.

Source currencies and accounting bases stay separate. Missing accounts are excluded rather than treated as zero. Exact reporting periods appear on company previews. Annual totals can change with coverage and do not measure growth of a fixed company cohort.

DIGITAL FOOTPRINT

Web traffic, app reach and release cadence

How the the United States companies on this page show up online: the sites people visit, the apps they install, and how often those apps ship.

Busiest websites

21 of the 1,115 companies on this page carry a measured traffic record (1.9%); these are the largest of those, by monthly visits. The median among them is 258,682 visits.

CompanyMonthly visitsAuthorityMobile
AARPaarp.org26,519,6288263.1%
Find a Gravefindagrave.com16,643,1337467.8%
Care.comcare.com4,806,7556379.9%
OurTime Datingourtime.com2,482,9955371.2%
Inspira Financialinspirafinancial.com2,043,8054666.7%
Boldinboldin.com1,014,8324117.9%
NU Skinnuskin.com897,3685163.1%
ForeverMissedforevermissed.com499,0644272.1%
GoGoGrandparentgogograndparent.com326,3974181.7%
Rementoremento.co285,3263872.2%

Visits and authority are third-party web estimates, not company-reported figures.

Most-installed apps

151 of these companies (13.5%) publish at least one Android app — 255 apps in all, carrying 25.3M installs between them.

Installs are lifetime totals to date at the June 2026 store reading — a measure of reach, not of people using an app today.

App reach by segment

The busiest app inside each of this page’s own segments, with the quarterly release trend behind it (2024Q1–2026Q2).

SegmentAppsInstallsLeading appRelease trend
Local Services4413.8MDr. Blood Pressure: Diabetes 7.8M
Healthcare Booking Platforms4013MCare.com: Hire Caregivers 2.5M
Assistive Tech708.4MPapa Pal: Find flexible work 246.7K
Hrtech96.1MAARP Now 5.5M
Foundations45.7MAARP SafeTrip™ 124.9K
Online Mom & Baby Care64.1MCare.com: Find Caregiver Jobs 1.5M
Matchmaking72.8MOurtime : Dating App for 50+ 1.8M
Investment Tech191.8MFinhabits: Invest My Money 987.3K

A company can carry several segment tags, so these rows overlap and should not be added together. Trend lines are zero-based and share one quarter grid, so a flat line is a quiet segment, not a missing one.

Release cadence by quarter

New apps published, beside apps whose most recent update landed in that quarter — the second bar is how much of the shelf is still being maintained.

2023Q2: 22023Q2: 22023Q22023Q3: 72023Q3: 112023Q32023Q4: 142023Q4: 32023Q42024Q1: 42024Q1: 32024Q12024Q2: 102024Q2: 62024Q22024Q3: 92024Q3: 122024Q32024Q4: 82024Q4: 22024Q42025Q1: 72025Q1: 52025Q12025Q2: 62025Q2: 92025Q22025Q3: 102025Q3: 272025Q32025Q4: 52025Q4: 242025Q42026Q1: 62026Q1: 482026Q1

Darker bars are new releases, lighter bars apps updated. 248 of 255 apps carry a release date. The series ends at 2026Q1, the last quarter that closed before the June 2026 reading.

INSIDE THE INDUSTRY

The the United States age tech and longevity market map

Explore the segments behind the headline numbers.

Expand panel +

Where companies are building

Rank segments by scale, hiring or disclosed funding.

Consumer digital802
Healthtech517
Enterprise tech448
B2c e-commerce242
Iot in healthcare202
Medical devices198
Fintech183
Enterprise software178
Loneliness economy176
Consumer internet of things171
Chronic disease management166
Saas162

Companies can sit in several segments. Counts and funding overlap.

SEGMENT TO EXPLORE

Consumer digital

The largest measured segment in this report snapshot.

802companies
4.9%have hiring activity

39 companies hiring · $3.28B disclosed funding

Explore in Radar

How companies make money

Common revenue models; a company can use more than one.

Subscription738
Commission on transaction310
Fee-for-service192
E-commerce - product156
Advertising148
E-commerce - service124
Physical commerce104
Sponsorship13
THE COMPANIES IN MOTION

Who is listing, hiring leaders, launching and winning work

Recorded corporate activity linked to companies in this landscape.

Expand panel +
Recent corporate headlines 10 dated reports
Mergers & acquisitionscare.com ↗

Manhattan Beach-headquartered private equity firm Pacific Avenue Capital Partners announced that an affiliate has entered into an agreement to acquire Care.com, a digital marketplace for caregiving services, from IAC Inc.

Funding roundsgetelva.com ↗

The round was led by Lifeline Ventures, known for backing companies such as Oura, Supercell, and Wolt in their early stages. Additional investors include Tiny VC, Wave Ventures, and First Fellow Partners, alongside several angel investors, including Cal Henderson, the co-founder of Slack.

Funding roundschptr.com ↗

Chptr, a storytelling platform helping funeral homes share memorial stories with the communities they serve, has raised $3.25M in funding according to a recent SEC filing.

Mergers & acquisitionseksobionics.com ↗

Applied Digital plans to combine its cloud computing unit, Applied Digital Cloud, with EKSO.

Mergers & acquisitionslifevantage.com ↗

LifeVantage and LoveBiome: LifeVantage acquired LoveBiome to expand its gut health portfolio.

Mergers & acquisitionsseniorly.com ↗

CareScout has announced the acquisition of Seniorly (https://www.seniorly.com/).

Funding roundscarepool.us ↗

Carepool Innovation Inc., whose medical rideshare platform automates medical transportation, has landed significant new funding from Decathlon Capital Partners. The multi-million-dollar investment package will support the expansion of Carepool into new geographic markets.

Mergers & acquisitionstelomirpharma.com ↗

Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ('Telomir' or the 'Company'), a preclinical-stage biotechnology company developing therapies that target epigenetic drivers of cancer, aging, and age-related disease, today announced that it has executed a binding Letter of Intent (the 'LOI') to acquire TELI Pharmaceuticals, Inc.

Funding roundsgetduos.com ↗

DUOS, a leading AI-powered digital health platform for member activation and benefits execution, today announced a $130 million strategic growth equity investment led by FTV Capital, a sector-focused growth equity firm with deep expertise in healthcare technology and services. The investment round also includes participation from Forerunner Ventures, DUOS’ earliest institutional investor, bringing the company full circle as it enters the next phase of growth.

Mergers & acquisitionsguideline.com ↗

Last month, Gusto, a payroll and HR software company, announced that it agreed to acquire Guideline, a startup offering retirement plans to small and medium businesses.

Full recorded event mix

Top 10 categories among 220 recorded events in the 24-month window.

Funding rounds
52
Earnings
48
Leadership moves
47
Mergers & acquisitions
24
New products
17
Company announcements
15
Contracts
6
Capital infusions
4
Fundraising
3
Incorporation
1
7 activity cards

Swipe or scroll horizontally to browse.

Leadership moves

13 tracked people moves

LifeVantage ↗
Terrence Moorehead

Appointment President and Chief Executive Officer

LifeVantage ↗
Michael Beindorff

Appointment Interim Chief Executive Officer

LifeVantage ↗
Steve Fife

Retirement Previously Chief Executive Officer

NU Skin ↗
Chayce Clark

Appointment Chief Operating Officer

Chris Milone

Appointment Chief Marketing Officer

NU Skin ↗
James Thomas

Resignation Previously Chief Financial Officer

NU Skin ↗
Chelsea Lantz

Appointment interim Chief Financial Officer

Savvly ↗
Rob Evans

Appointment General Counsel

Product launches

Products, platforms and features in the recorded window

Guideline ↗
Data Insights Service

Analytics Service

Guideline ↗
KPI Forecast 2.0

Analytics Solution

NU Skin ↗
Prysm iO

Handheld wellness device

Honor ↗
HONOR Magic V6

AI‑native foldable smartphone

Honor ↗
HONOR AI Connect Platform

AI device ecosystem platform

Smart ↗
#2

Electric car

Contract wins

4 recorded customer wins

Honor ↗

Customer: nokiamobile

Smart ↗

Customer: tui groupAutomotive

Customer: cloverdale foodsfood processing

LogicMark ↗

Customer: Nevada Agency and Transfer CompanyCorporate Governance

Workforce actions

1 companies with reported reductions

Scale not stated rolesregulatory uncertainty

Regulatory events

1 recorded events

Endotronix ↗

approvedFDA

Litigation

1 tracked suits

Company
human interest v Brian Sterri, Brandon Sterri, guideline

corporate espionage and trade secret violationsCivil · Ongoing

Earnings pulse

Reported company results in the recorded window.

5companies
50period observations
-3.0%median reported growth

Median across 26 reported growth observations; companies may contribute multiple periods.

Mergers and acquisitions

Company-linked deal reports; status is preserved as recorded.

Acquirer → targetStatusDateValue / context
baker tilly→Vanilla ↗Announced2026-05-01Not stated in snapshot
pacific avenue capital partners→Care.com ↗Announced2026-04-01Not stated in snapshot
IAC Inc.→Care.com ↗Completed2026-04-01$500.0M
affiliate of Pacific Avenue Capital Partners→Care.com ↗Announced2026-03-02$320.0M
applied digital→Ekso Bionics ↗Announced2025-12-30Not stated in snapshot
LifeVantage→LoveBiomeCompleted2025-12-16Not stated in snapshot

A discussion or rumour is not a completed transaction. An unstated value is not zero.

PEOPLE & OPPORTUNITY

The talent market

1,049 postings in the preceding 12 months. The full 2,181-posting snapshot covers 117 employers.

Expand panel +

Most advertised job titles

Manager44
Dog Sitter30
Pet Sitter30
Graduate Consultant27
Healthcare Account Executive27
Caregiver / Home Care Aide26
0 internship postings

77 tracked postings mention remote work.

The seniority mix

589 postings specify a level.

unspecified
1,592
manager
348
senior
139
intern
46
entry
33
lead
23

Skills employers mention

Top skills across 2,181 tracked postings in the available jobs snapshot.

Lifting
52
Cna License
50
Excel
21
React
17
Crm
15
Aws
15
Memory Impairment
12
Word
11
Lpn
10
Sql
10
ADVERTISED PAY$52.0K/ year

Median across 199 postings with pay data, expressed in USD.

THE PEOPLE BUILDING THE FIELD

Founders and leaders

754 founders and chief executives across 563 companies.

Expand panel +
12 profiles

Swipe or scroll horizontally to browse.

Education networks

101 profiles with education records.

Harvard University
17
Stanford University
14
Harvard Business School
12
Massachusetts Institute of Technology
7
Columbia University
7
Cornell University
6
University of California (Berkeley)
5
University of Pennsylvania
4

Prior employers

28 profiles with prior-work records.

Microsoft
7
Intel
5
Google
3
Uber
3
McKinsey
2
Facebook
2
Apple
2
eBay
1

Profiles cover recorded founders and leaders; contact details remain in Radar.

RESEARCH SIGNALS

What Age Tech and Longevity research is working on

11,793 papers in the recorded india scope.

Expand panel +
11,793papers
51,685worldwide comparison pool
11,793India-affiliated papers

Research orientation

Promising
4,471
Breakthrough
2,768
Descriptive
2,374
Problem-identifying
912
Cautionary
670
Critical
407
Comparative
191

Contribution mix

Empirical
8,734
Reviews
1,607
Methods-led
897
Position pieces
371
Theoretical
184

Tone counts: 10,347 positive · 728 neutral · 718 negative.

Common problems researchers identify
1,319 papers · 11.2% of this field
  • Longevity633 papers
  • Senescence324 papers
  • Gerontology172 papers
  • Disease114 papers
  • Cell biology113 papers
  • Life expectancy111 papers
  • Demography84 papers
  • Telomere65 papers

Landmark: The Emerging Evidence of the Parkinson Pandemic

Cautions
670 papers · 5.7% of this field
  • Longevity231 papers
  • Senescence176 papers
  • Population49 papers
  • Cell biology44 papers
  • Fecundity40 papers
  • Internal medicine27 papers
  • Demography25 papers
  • Telomere22 papers

Landmark: Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation

Opportunities
7,239 papers · 61.4% of this field
  • Senescence3,430 papers
  • Longevity1,823 papers
  • Cell biology1,238 papers
  • Cancer research500 papers
  • Phenotype388 papers
  • Telomere365 papers
  • Cellular senescence304 papers
  • Transcriptome284 papers

Landmark: The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Leading institutions

Buck Institute for Research on Aging
35,667
Harvard University
30,754
Lawrence Berkeley National Laboratory
23,324
Mayo Clinic in Florida
22,731
Mayo Clinic
18,349
National Institute on Aging
15,512

Leading researchers

Judith Campisi
16,781
Jean‐Philippe Coppé
10,559
Tamar Tchkonia
7,443
Pierre‐Yves Desprez
6,516
James L. Kirkland
5,874
Ana Krtolica
5,379
Marco Demaria
4,204
Yi Zhu
4,050

Highly cited breakthrough-labelled papers

  • Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor4,030 citations
  • Cellular senescence mediates fibrotic pulmonary disease1,508 citations
  • A proteomic atlas of senescence-associated secretomes for aging biomarker development1,236 citations
  • Fat tissue, aging, and cellular senescence1,074 citations
  • Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity968 citations

Common problems researchers identify

1,221 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Immune System / DiseaseCommon problems researchers identify · 01

Immune System / Disease

219 papers

17.9% of this theme group

Immune system (34) · Disease (42) · Immunosenescence (20) · Neuroscience (21)

On the Immunological Theory of Aging

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

View research history
YearShare index
20223331.1
20233351.8
20243155.2
20253355.5
Senescence / Cellular SenescenceCommon problems researchers identify · 02

Senescence / Cellular Senescence

216 papers

17.7% of this theme group

Senescence (204) · Cellular senescence (43) · Cell biology (61) · Phenotype (17)

Assessing Cell and Organ Senescence Biomarkers

Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities

View research history
YearShare index
20221887.0
20232120.7
20241779.3
20251140.6
Gerontology / LongevityCommon problems researchers identify · 03

Gerontology / Longevity

186 papers

15.2% of this theme group

Gerontology (111) · Longevity (146) · Healthy aging (30) · Psychological intervention (27)

The Biology of Aging

Behavioral Aspects of Healthy Longevity

View research history
YearShare index
20221861.3
20231835.4
20242189.6
20251418.9
Longevity / Longevity RiskCommon problems researchers identify · 04

Longevity / Longevity Risk

162 papers

13.3% of this theme group

Longevity (148) · Longevity risk (9) · Ecology (12) · Evolutionary biology (13)

The evolutionary ecology of senescence

On tree longevity

View research history
YearShare index
2022308.1
2023286.8
2024329.2
2025215.5
Reproduction / FecundityCommon problems researchers identify · 05

Reproduction / Fecundity

153 papers

12.5% of this theme group

Reproduction (25) · Fecundity (19) · Longevity (75) · Life history theory (10)

Life histories and the evolution of cooperative breeding in mammals

Insights from comparative analyses of aging in birds and mammals

View research history
YearShare index
2022248.2
2023224.7
2024235.1
2025238.7
Demography / Life ExpectancyCommon problems researchers identify · 06

Demography / Life Expectancy

145 papers

11.9% of this theme group

Demography (71) · Life expectancy (71) · Longevity (123) · Gerontology (44)

Measuring Recent Apparent Declines In Longevity: The Role Of Increasing Educational Attainment

Longer Lives, Sicker Lives? Increased Longevity and Extended Disability Among Mexican-Origin Elders

View research history
YearShare index
20222006.4
20231968.6
20242304.2
20251509.2
Longevity / Internal MedicineCommon problems researchers identify · 07

Longevity / Internal Medicine

140 papers

11.5% of this theme group

Longevity (72) · Internal medicine (11) · Caloric theory (6) · Insulin (5)

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in <i>C. elegans</i>

Sex Differences in Age Trajectories of Physiological Dysregulation: Inflammation, Metabolic Syndrome, and Allostatic Load

View research history
YearShare index
20223042.4
20233309.9
20243010.0
20251891.9

Cautions

638 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Longevity / FecundityCautions · 01

Longevity / Fecundity

168 papers

26.3% of this theme group

Longevity (74) · Fecundity (28) · Population (35) · Juvenile (12)

Cattle adapted to tropical and subtropical environments: genetic and reproductive considerations

Data from: Longevity of hymenopteran parasitoids in natural vs. agricultural habitats and implications for biological control

View research history
YearShare index
2022960.9
2023945.1
2024718.7
2025546.3
Senescence / Cell BiologyCautions · 02

Senescence / Cell Biology

106 papers

16.6% of this theme group

Senescence (65) · Cell biology (20) · Stem cell (10) · Progenitor cell (9)

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature

View research history
YearShare index
20222107.6
20232335.4
20242019.5
20251456.0
Longevity / GerontologyCautions · 03

Longevity / Gerontology

102 papers

16.0% of this theme group

Longevity (78) · Gerontology (20) · Life expectancy (14) · Demography (18)

Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases

Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Populatio

View research history
YearShare index
20222006.4
20231968.6
20242304.2
20251509.2
Senescence / Mesenchymal Stem CellCautions · 04

Senescence / Mesenchymal Stem Cell

84 papers

13.2% of this theme group

Senescence (78) · Mesenchymal stem cell (15) · Cancer research (18) · Cell biology (25)

Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

Senescence induces fundamental changes in the secretome of mesenchymal stromal cells (MSCs): implications for the therapeutic use of MSCs an

View research history
YearShare index
20221669.0
20232433.1
20241562.6
20251051.3
Longevity / Caenorhabditis ElegansCautions · 05

Longevity / Caenorhabditis Elegans

72 papers

11.3% of this theme group

Longevity (64) · Caenorhabditis elegans (12) · Drosophila melanogaster (9) · Genetics (8)

Uncoupling lifespan and healthspan in <i>Caenorhabditis elegans</i> longevity mutants

Metformin treatment of diverse <i>Caenorhabditis</i> species reveals the importance of genetic background in longevity and healthspan extens

View research history
YearShare index
20222173.1
20232451.8
20242115.3
20251369.5
Internal Medicine / Calorie RestrictionCautions · 06

Internal Medicine / Calorie Restriction

72 papers

11.3% of this theme group

Internal medicine (14) · Calorie restriction (8) · Endocrinology (10) · Caloric theory (6)

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling

View research history
YearShare index
20223267.9
20233524.0
20243220.3
20252011.0
Honey Bee / PesticideCautions · 07

Honey Bee / Pesticide

34 papers

5.3% of this theme group

Honey bee (8) · Pesticide (7) · Imidacloprid (6) · Brood (5)

Factors affecting the reproductive health of honey bee (Apis mellifera) drones—a review

Increase in longevity and amelioration of pesticide toxicity by natural levels of dietary phytochemicals in the honey bee, Apis mellifera

View research history
YearShare index
202213.2
202312.9
202412.6
202512.3

Opportunities

6,823 papers · 7 recurring themes
7 cards

Swipe or scroll horizontally to browse.

Senescence / AutophagyOpportunities · 01

Senescence / Autophagy

1,130 papers

18.8% of this theme group

Senescence (537) · Autophagy (101) · Internal medicine (108) · Oxidative stress (100)

Age-dependent effects of <i>Igf2bp2</i> on gene regulation, function, and aging of hematopoietic stem cells in mice

Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐

View research history
YearShare index
20223279.1
20233550.1
20243262.4
20252185.6
Senescence / Cell BiologyOpportunities · 02

Senescence / Cell Biology

1,109 papers

18.5% of this theme group

Senescence (1,008) · Cell biology (427) · Cellular senescence (189) · Phenotype (132)

Cellular Senescence and the Biology of Aging, Disease, and Frailty

Cellular senescence: from homeostasis to pathological implications and therapeutic strategies

View research history
YearShare index
20221887.0
20232120.7
20241779.3
20251140.6
Senescence / Cell BiologyOpportunities · 03

Senescence / Cell Biology

944 papers

15.7% of this theme group

Senescence (831) · Cell biology (337) · Mesenchymal stem cell (60) · Inflammation (75)

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Cellular Senescence: Molecular Mechanisms, <i>In Vivo</i> Significance, and Redox Considerations

View research history
YearShare index
20221939.0
20232169.3
20241827.4
20251231.2
Longevity / GerontologyOpportunities · 04

Longevity / Gerontology

906 papers

15.1% of this theme group

Longevity (771) · Gerontology (121) · Demography (83) · Life expectancy (55)

The Search for Longevity and Healthy Aging Genes: Insights From Epidemiological Studies and Samples of Long-Lived Individuals

Multi-omic underpinnings of epigenetic aging and human longevity

View research history
YearShare index
20222006.4
20231968.6
20242304.2
20251509.2
Cancer Research / CancerOpportunities · 05

Cancer Research / Cancer

726 papers

12.1% of this theme group

Cancer research (388) · Cancer (170) · Senescence (480) · Tumor microenvironment (54)

Therapy-Induced Cellular Senescence: Potentiating Tumor Elimination or Driving Cancer Resistance and Recurrence?

The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced Inflammation

View research history
YearShare index
20222019.0
20232800.3
20241954.8
20251639.8
Caenorhabditis Elegans / LongevityOpportunities · 06

Caenorhabditis Elegans / Longevity

630 papers

10.5% of this theme group

Caenorhabditis elegans (182) · Longevity (504) · Drosophila melanogaster (90) · Drosophila (25)

Lysosomal signaling molecules regulate longevity in <i>Caenorhabditis elegans</i>

Genetics, Life Span, Health Span, and the Aging Process in Caenorhabditis elegans

View research history
YearShare index
202255.2
202350.2
202454.4
202558.7
Longevity / FecundityOpportunities · 07

Longevity / Fecundity

555 papers

9.2% of this theme group

Longevity (257) · Fecundity (46) · Honey bee (25) · Larva (24)

More on seed longevity phenotyping

Fluctuating thermal regimes extend longevity and maintain fecundity to increase shelf‐life of <i>Drosophila melanogaster</i> cultures

View research history
YearShare index
202274.6
202363.5
202458.8
202556.8

How this field compares with the research baseline

Orientation shares compared with 25,000 papers in the reference sample.

Research orientationThis fieldReference sample
Promising37.9%36.9%
Breakthrough23.5%26.5%
Descriptive20.1%17.6%
Problem-identifying7.7%9.7%
Cautionary5.7%4.6%
Critical3.5%0.9%
Comparative1.6%3.9%

Concerns receiving less research attention

Counts and shares refer to the stated research pool. A low count describes how much of that research is recorded here, not the absence of a real-world concern.

Concern / example paperPapersShareRaised as a problemWorldwide share
Privacy & surveillanceSenescence, NK cells, and cancer: navigating the crossroads of aging and disease400.36%5 (12.5%)0.29%
Labour & data workTransportation Equity, Health, and Aging: A Novel Approach to Healthy Longevity with Benefits Across the Life Span90.08%5 (55.6%)0.22%
Safety & misuseTranscriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse20.02%0 (0.0%)0.01%
Bias & fairnessThe False Promises of Working Longer10.01%1 (100.0%)0.03%
Concentration of compute powerDeep Brain Stimulation Battery Longevity: Comparison of Monopolar Versus Bipolar Stimulation Modes10.01%0 (0.0%)0.01%
Energy & datacenter footprint00.0%0 (%)0.0%
Water use00.0%0 (%)0.0%
Carbon & emissions of compute00.0%0 (%)0.0%
Hardware, e-waste & supply chain00.0%0 (%)0.0%

Institution and researcher rankings use citations to their covered work. Research scope: United States. This may be broader than the company geography.

DEMAND, SUPPLY & PLACE

Where demand signals run ahead of mapped supply — the United States

Compare demand signals in the United States’s newsflow with the age tech and longevity categories mapped to each signal.

Expand panel +
HOW TO READ THE GAP

Signal percentile − supply percentile = gap in percentile points. Positive gaps highlight questions to investigate. A high signal can reflect spending pressure or access friction, as well as potential demand.

The comparison is relative to the signal families on this page. A supply percentile of zero means the lowest relative reading, not zero companies. It is a prioritisation clue, not measured market size or unmet demand.

COMPARISON PERIOD2025-07-01 to 2026-07-01Against 2024-07-01 to 2025-07-01Explore the signals ↓

The opportunity, in one view

Signal and mapped-supply percentiles, their gap, and change in the signal’s article share.

Swipe horizontally to compare all columns →

8 the United States demand signals compared with mapped age tech and longevity supply
Signal familySignal percentileSupply percentileRelative gapGap (points)Signal share vs prior year
Mental health ↗Disease Burden78.666.7+11.9+63.1%
Ageing & elder care ↗Disease Burden28.616.7+11.9-43.4%
Air pollution ↗Environmental Driver21.416.7+4.7-18.3%
Diabetes, hypertension & cardiac burden ↗Disease Burden21.4100.0-78.6+21.4%
Cancer burden ↗Disease Burden35.7—No matching category—+2.5%
Infectious outbreaks ↗Disease Burden35.7—No matching category—+45.9%
Maternal & child health ↗Disease Burden92.9—No matching category—+110.1%
Layoffs & income shocks ↗Spending Pressure85.7—No matching category—+57.7%

Showing all 8 signals. Select a family for its history and mapped categories.

Where the signals are loudest

All 12 city readings for these demand families in the comparison geography. the United States is highlighted.

Mentions per 10,000 articles

Each city’s reading is a share of its own coverage.

Kentucky172.3

Maternal & child health · Mental health · Layoffs & income shocks

Delaware159.7

Maternal & child health · Ageing & elder care · Cancer burden

Indiana137.6

Maternal & child health · Mental health · Layoffs & income shocks

Maryland130.4

Maternal & child health · Mental health · Layoffs & income shocks

Connecticut124.9

Mental health · Maternal & child health · Ageing & elder care

South Carolina124.2

Maternal & child health · Layoffs & income shocks · Infectious outbreaks

Iowa121.1

Maternal & child health · Layoffs & income shocks · Mental health

Colorado120.9

Mental health · Maternal & child health · Air pollution

Wisconsin120.9

Maternal & child health · Mental health · Ageing & elder care

Louisiana120.9

Maternal & child health · Mental health · Layoffs & income shocks

Tennessee116.2

Layoffs & income shocks · Maternal & child health · Mental health

North Carolina114.7

Mental health · Maternal & child health · Layoffs & income shocks

Inside the leading signals

Open any signal for its quarterly history
DISEASE BURDENMental health+11.9percentile-point gap
THE OPERATING HYPOTHESIS

Mental-health pressure can pull counselling and tele-psychiatry demand where it surfaces.

14.86mentions per 10,000 articles+63.1%share change vs prior year

Mapped age tech and longevity categories

  • Loneliness Economy176

Companies can appear in multiple categories; these counts are not a unique-company total.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

05914192024Q3: 92024Q32024Q4: 102024Q42025Q1: 72025Q12025Q2: 92025Q22025Q3: 162025Q32025Q4: 122025Q42026Q1: 152026Q12026Q2: 122026Q2
View quarterly signal counts
Mental health in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q316879.9
2024Q4183210.33
2025Q119197.67
2025Q214649.19
2025Q3438416.09
2025Q4152112.6
2026Q1229315.88
2026Q293512.15

Where this signal concentrates in the comparison geography

Colorado42.7 / 10,000
Mississippi32.6 / 10,000
Connecticut29.9 / 10,000
DISEASE BURDENAgeing & elder care+11.9percentile-point gap
THE OPERATING HYPOTHESIS

An ageing base can shift demand toward geriatric, home and chronic care.

7.85mentions per 10,000 articles-43.4%share change vs prior year

Mapped age tech and longevity categories

  • Chronic Disease Management166

Companies can appear in multiple categories; these counts are not a unique-company total.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

051015202024Q3: 122024Q32024Q4: 172024Q42025Q1: 122025Q12025Q2: 132025Q22025Q3: 62025Q32025Q4: 82025Q42026Q1: 82026Q12026Q2: 82026Q2
View quarterly signal counts
Ageing & elder care in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q3209212.27
2024Q4302717.07
2025Q1316612.65
2025Q2222213.94
2025Q318016.61
2025Q410428.63
2026Q112948.96
2026Q26898.95

Where this signal concentrates in the comparison geography

Delaware24.3 / 10,000
Connecticut23.5 / 10,000
Indiana16.4 / 10,000
ENVIRONMENTAL DRIVERAir pollution+4.7percentile-point gap
THE OPERATING HYPOTHESIS

Sustained air-quality stress can pull respiratory and cardiac care demand with it.

6.47mentions per 10,000 articles-18.3%share change vs prior year

Mapped age tech and longevity categories

  • Chronic Disease Management166

Companies can appear in multiple categories; these counts are not a unique-company total.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

0369112024Q3: 62024Q32024Q4: 82024Q42025Q1: 72025Q12025Q2: 92025Q22025Q3: 52025Q32025Q4: 52025Q42026Q1: 72026Q12026Q2: 82026Q2
View quarterly signal counts
Air pollution in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q310756.31
2024Q414458.15
2025Q119067.62
2025Q215729.86
2025Q316265.97
2025Q46465.35
2026Q110767.45
2026Q26278.14

Where this signal concentrates in the comparison geography

Louisiana16.4 / 10,000
Delaware14.5 / 10,000
Colorado14.5 / 10,000
DISEASE BURDENDiabetes, hypertension & cardiac burden-78.6percentile-point gap
THE OPERATING HYPOTHESIS

Chronic cardiometabolic burden can turn into decades of management demand per patient.

4.5mentions per 10,000 articles+21.4%share change vs prior year

Mapped age tech and longevity categories

  • Medical Devices198
  • Chronic Disease Management166

Companies can appear in multiple categories; these counts are not a unique-company total.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

024682024Q3: 32024Q32024Q4: 32024Q42025Q1: 42025Q12025Q2: 42025Q22025Q3: 32025Q32025Q4: 62025Q42026Q1: 42026Q12026Q2: 52026Q2
View quarterly signal counts
Diabetes, hypertension & cardiac burden in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q35553.26
2024Q45393.04
2025Q110174.06
2025Q26934.35
2025Q39083.33
2025Q48056.67
2026Q16374.41
2026Q24135.36

Where this signal concentrates in the comparison geography

Connecticut11.1 / 10,000
Missouri8.4 / 10,000
Mississippi7.2 / 10,000
DISEASE BURDENCancer burden—supply not mapped
THE OPERATING HYPOTHESIS

Cancer burden can pull screening, diagnostics and oncology capacity demand.

7.52mentions per 10,000 articles+2.5%share change vs prior year

Mapped age tech and longevity categories

This signal has no matching category in the page’s age tech and longevity market map, so no supply percentile or gap is assigned.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

0369122024Q3: 62024Q32024Q4: 82024Q42025Q1: 62025Q12025Q2: 82025Q22025Q3: 62025Q32025Q4: 102025Q42026Q1: 72026Q12026Q2: 82026Q2
View quarterly signal counts
Cancer burden in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q310876.38
2024Q415518.75
2025Q116166.46
2025Q213068.19
2025Q316466.04
2025Q4123810.26
2026Q111147.72
2026Q26248.11

Where this signal concentrates in the comparison geography

Delaware15.3 / 10,000
Missouri14.4 / 10,000
Maryland12.9 / 10,000
DISEASE BURDENInfectious outbreaks—supply not mapped
THE OPERATING HYPOTHESIS

Outbreak pressure can pull testing, surveillance and rapid-care demand at short notice.

6.38mentions per 10,000 articles+45.9%share change vs prior year

Mapped age tech and longevity categories

This signal has no matching category in the page’s age tech and longevity market map, so no supply percentile or gap is assigned.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

0368112024Q3: 32024Q32024Q4: 42024Q42025Q1: 32025Q12025Q2: 52025Q22025Q3: 92025Q32025Q4: 32025Q42026Q1: 32026Q12026Q2: 42026Q2
View quarterly signal counts
Infectious outbreaks in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q36733.95
2024Q48004.51
2025Q19813.92
2025Q28605.4
2025Q326509.72
2025Q44653.85
2026Q14403.05
2026Q23684.78

Where this signal concentrates in the comparison geography

Kentucky19.4 / 10,000
South Carolina14.6 / 10,000
Louisiana14.3 / 10,000
DISEASE BURDENMaternal & child health—supply not mapped
THE OPERATING HYPOTHESIS

Maternal and child burden can pull immunisation, nutrition and pediatric care demand.

18.23mentions per 10,000 articles+110.1%share change vs prior year

Mapped age tech and longevity categories

This signal has no matching category in the page’s age tech and longevity market map, so no supply percentile or gap is assigned.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

081725342024Q3: 72024Q32024Q4: 72024Q42025Q1: 72025Q12025Q2: 112025Q22025Q3: 292025Q32025Q4: 92025Q42026Q1: 72026Q12026Q2: 112026Q2
View quarterly signal counts
Maternal & child health in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q313337.82
2024Q414147.97
2025Q119627.84
2025Q2186411.69
2025Q3800929.39
2025Q411689.68
2026Q111097.68
2026Q291911.94

Where this signal concentrates in the comparison geography

Delaware62.8 / 10,000
Kentucky61.4 / 10,000
South Carolina60.0 / 10,000
SPENDING PRESSURELayoffs & income shocks—supply not mapped
THE OPERATING HYPOTHESIS

Layoff cycles can pull discretionary spend back toward value offerings.

24.69mentions per 10,000 articles+57.7%share change vs prior year

Mapped age tech and longevity categories

This signal has no matching category in the page’s age tech and longevity market map, so no supply percentile or gap is assigned.

Quarterly share of the United States coverage

Mentions per 10,000 articles · zero baseline

091827362024Q3: 152024Q32024Q4: 142024Q42025Q1: 132025Q12025Q2: 192025Q22025Q3: 242025Q32025Q4: 312025Q42026Q1: 192026Q12026Q2: 242026Q2
View quarterly signal counts
Layoffs & income shocks in the United States coverage
QuarterMentionsPer 10,000 articles
2024Q3269215.79
2024Q4265714.98
2025Q1345713.81
2025Q2305519.17
2025Q3668724.54
2025Q4376131.16
2026Q1284319.69
2026Q2188524.49

Where this signal concentrates in the comparison geography

Tennessee44.9 / 10,000
Arkansas41.1 / 10,000
Iowa26.8 / 10,000
RESEARCH & CHANGING CONVERSATIONS

Related research and changing coverage

the United States age tech and longevity coverage

Expand panel +
RESEARCH CONTEXT · 2017

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Hypertension

7,315 citations in the snapshot

RESEARCH CONTEXT · 2019

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Circulation

6,114 citations in the snapshot

RESEARCH CONTEXT · 2019

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Circulation

4,494 citations in the snapshot

RESEARCH CONTEXT · 2019

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Circulation

4,422 citations in the snapshot

What is growing in this coverage

the United States coverage of this page's demand families

KeywordRecent articlesPrior articlesShare change
post-covid complications1,1031051194.7%
last-mile vaccine delivery14523677.0%
epidemic death tolls31353627.8%
snow rescue19936581.3%
disease outbreak deaths700152467.6%
contagion mortality rates22049453.3%

Share changes describe coverage in the stated comparison periods, not search demand or market size.

GEOGRAPHIC FOOTPRINT

Where companies are based

Company counts, hiring and disclosed funding across the recorded hubs.

Expand panel +
8 cards

Swipe or scroll horizontally to browse.

UNDERSTAND THE LANDSCAPE

Age Tech and Longevity in the United States: key questions

Clear definitions for making better comparisons.

What does this landscape measure?

It measures the tracked company ecosystem, recorded funding, hiring and other available evidence. It is not a market-size estimate.

Can segment counts be added together?

No. A company can belong to several segments, so segment counts and funding can overlap.

What does a missing figure mean?

A dash or unavailable panel means the current reviewed source snapshot does not support that figure.

Company ecosystem snapshot: 31 August 2026. Funding is recorded in USD; filed accounts retain their stated currency and reporting basis. Each section identifies its own coverage. The news and research behind these sections is explorable in Prism.

Canonical landscape ↗
Coming soon