Best High Tech Companies in Maryland, United States
The 284 best High Tech companies in Maryland, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Novavax.
Our analysis of 306 High Tech companies
$95.7b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best High Tech companies in Maryland
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Novavax Developer of novel vaccines for the treatment of infectious diseases 83Product top 14%Patents top 17%Funding top 22%Innovation top 23% All 13 signals ▾Producttop 14% Patentstop 17% Fundingtop 22% Innovationtop 23% Partnerstop 26% Markettop 28% Moattop 29% Fin. healthtop 32% Globaltop 35% Growthtop 37% Newstop 40% Techtop 41% Talentbottom 48% Product: 4 distinct product lines · Company stage: Public Patents: 599 patents matched (strict assignee match) · 193 filings since 2022 vs 135 in 2017-21 rank vs industry peers · Fliar Intelligence Index 83/100 | $2.7B | 33 mo ago | 184 | John Jacobs President | DrupalApple iCloud MailMicrosoft 365+25 | 599 patents Patents concentrated in chemistry & materials | 2 launchs · 2 partnerships |
| 2 | Sirnaomics Developer of RNA based therapeutics for the treatment of cancer and fibrosis disease 80Patents top 14%Funding top 15%Innovation top 17%Growth top 28% All 9 signals ▾Patentstop 14% Fundingtop 15% Innovationtop 17% Growthtop 28% Moattop 35% Markettop 46% Talentbottom 49% Globalbottom 48% Newsbottom 21% Patents: 277 patents matched (strict assignee match) · 191 filings since 2022 vs 63 in 2017-21 Funding: Raised $267M across 14 rounds · 14 rounds over 19 yrs (0.7/yr) rank vs industry peers · Fliar Intelligence Index 80/100 | $267M | 9 mo ago | 88 | Patrick Lu President and CEO | — | 277 patents siRNA therapeutics and nanoparticle delivery systems for cancer and viral diseases | 1 launch |
| 3 | Xometry Provider of on-demand custom manufacturing platform for prototypes and production parts | $200M | 52 mo ago | 480 480 → 1,149 (+139%) | Laurence Zuriff Founder/CSO | PrismicTurbopackstyled-components+39 | 10 patents AI-driven prediction and optimization of manufacturing processes | — |
| 4 | ASG Security Developer of home security & automation solutions | $190M | 209 mo ago | 975 | Joe Nuccio President & CEO | — | — | — |
| 5 | SafeNet Cybersecurity solutions provider protecting applications, data, identities, and software | $139M | 194 mo ago | 488 | — | — | 145 patents Secure digital document handling, multi-user authentication, and data container protection. | — |
| 6 | Brivo Developer of AI and cloud-based integrated access control systems | $92M | 37 mo ago | 265 | — | WordPressSentryAtlassian Statuspage+43 | — | 1 award |
| 7 | TeraWulf Online sustainable mining platform for cryptocurrency | $86M | 44 mo ago | 8 | — | WebflowGSAPSwiper+18 | — | — |
| 8 | IonQ Provider of cloud and trapped ion technology-based universal quantum computers | $84M | 72 mo ago | 202 | Peter Chapman President/CEO | WebflowSalesforceAmazon Web Services+29 | 546 patents IonQ patents advance ion‑trap quantum hardware, control, and algorithmic optimization. | 2 launchs |
| 9 | Telcare Cellular technology and social networking to tackle diabetes | $67M | 139 mo ago | 26 | — | — | 16 patents Portable blood glucose meters with integrated data transmission and messaging functionality | — |
| 10 | Nuo Therapeutics Developer of regenerative products for wound care 53Growth top 11%Funding top 24%Talent top 45%Fin. health top 50% All 9 signals ▾Growthtop 11% Fundingtop 24% Talenttop 45% Fin. healthtop 50% Moatbottom 38% Globalbottom 37% Marketbottom 33% Techbottom 30% Newsbottom 21% Growth: Revenue +143% YoY · Fresh capital in last 24 mo Funding: Raised $64.6M across 18 rounds · 18 rounds over 16 yrs (1.1/yr) rank vs industry peers · Fliar Intelligence Index 53/100 | $65M | 10 mo ago | 10 10 → 19 (+90%) | David Jorden CEO & Director | — | — | — |
| 11 | BrainScope Provider of AI-powered non-invasive medical devices for diagnosing and assessing brain injuries, including… | $62M | 33 mo ago | 38 38 → 34 (-11%) | Michael Singer Co-CEO | HubSpot CMS HubEnvoyBootstrap+15 | 165 patents Patents concentrated in health & consumer products | 1 job opening |
| 12 | Roboteam Developer of robotic platforms and command and control software solutions | $62M | 117 mo ago | 52 | — | WordPressMySQLPHP+21 | — | 2 launchs |
| 13 | Hillcrest Labs Provider of software and hardware for motion control applications | $61M | 114 mo ago | 44 | — | — | — | — |
| 14 | KEYW Corp Provider of the border and coastal security systems | $61M | 97 mo ago | 1,261 | — | — | 26 patents Configurable storage hardware, network optimization, virtualization platforms, and modular avionics equipment. | — |
| 15 | NovaSom Home sleep testing | $55M | 84 mo ago | 167 | John Spitznagel CEO | — | — | — |
| 16 | American Gene Developer of lentivirus therapies for the treatment of cancer and other chronic human diseases 55Funding top 24%Patents top 31%Moat top 35%Talent top 35% All 11 signals ▾Fundingtop 24% Patentstop 31% Moattop 35% Talenttop 35% Innovationtop 37% Growthtop 40% Producttop 40% Techtop 46% Marketbottom 36% Globalbottom 36% Newsbottom 22% Funding: Raised $52.8M across 10 rounds · 10 rounds over 13 yrs (0.8/yr) Patents: 228 patents matched (strict assignee match) · 90 filings since 2022 vs 138 in 2017-21 rank vs industry peers · Fliar Intelligence Index 55/100 | $53M | 7 mo ago | 31 | Jeff Galvin Chief Executive Officer | WordPressMySQLPHP+34 | 228 patents Non-integrating viral vectors for gene delivery and HIV immunotherapy, plus gamma‑delta T‑cell activation | — |
| 17 | Origin Wireless AI Developer of motion sensors | $42M | 32 mo ago | 38 38 → 57 (+50%) | Ray Liu Founder | WordPress Block EditorWordPressMySQL+28 | 170 patents Patents concentrated in electrical & electronics | 4 job openings · 1 launch · 1 award |
| 18 | Blue Pillar Industrial IoT connectivity platform for managing, monitoring, and controlling distributed equipment | $42M | 86 mo ago | 42 | — | — | 17 patents Monitoring, testing, and predictive analytics for emergency power supplies and industrial automation security. | — |
| 19 | Quantum Xchange Provider of secure communication solutions for cyber security | $40M | 65 mo ago | 15 | Eddy Zervigon CEO | WordPressMySQLSalesforce+23 | — | — |
| 20 | InventWood Developer of advanced wood material offering strength and fire resistance 55Growth top 28%Talent top 28%Patents top 31%Funding top 32% All 10 signals ▾Growthtop 28% Talenttop 28% Patentstop 31% Fundingtop 32% Innovationtop 35% Moattop 38% Techbottom 49% Globalbottom 31% Marketbottom 27% Newsbottom 18% Growth: Web rank 10,000,000 → 5,000,000 YoY · Fresh capital in last 24 mo Talent: 3 named leaders on record · 3 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 55/100 | $32M | 5 mo ago | 9 | Alex Lau Co-Founder and Executive Chair | WebflowGSAPSwiper+12 | 25 patents Engineered wood composites with enhanced strength, water stability, and vacuum insulation | — |
| 21 | Ultralytics Provider of a machine learning training and deployment platform | $30M | 9 mo ago | 11 | Glenn Jocher Founder & CEO | TurbopackNode.jsClerk+21 | — | 8 launchs |
| 22 | Xona Provider of secure access platform for operational technology and critical systems | $28M | 24 mo ago | 18 | Bill Moore Founder & CEO | WordPressMySQLPHP+29 | — | — |
| 23 | Link Labs Manufacturer of base stations for low-power networking | $20M | 26 mo ago | 55 55 → 38 (-31%) | — | HubSpot CMS HubLozad.jscore-js+20 | 93 patents Patents concentrated in electrical & electronics | — |
| 24 | Vorbeck Graphene-based materials science company delivering advanced solutions for defense and first responders | $19M | 143 mo ago | 34 34 → 37 (+9%) | — | Radix UITailwind CSSshadcn/ui+11 | — | — |
| 25 | Hi-G-Tek Solution to track and monitor assets | $19M | 187 mo ago | 2 | — | — | 31 patents Wireless, monitorable sealing and lock systems for containers and valve protection | — |
| 26 | Circonus Provider of a cloud-based data analytics platform for real-time IT monitoring and alerting | $17M | 55 mo ago | 21 | — | — | 11 patents Real-time metrics collection, time-series histogram generation, and data compression for monitoring systems. | — |
| 27 | Galen Robotics Provider of AI-based surgery planning and management tool | $16M | 35 mo ago | 28 | — | — | — | — |
| 28 | Edgybees Provider of AR and AI based real-time geo-tagging solution | $15M | 64 mo ago | 45 | Menashe Haskin Co-Founder | WordPressMySQLPHP+26 | — | — |
| 29 | Cytimmune Multifunctional and tumor-targeted cancer therapies | $15M | 65 mo ago | 1 | Lawrence Tamarkin Co-Founder | — | — | — |
| 30 | PlanetRisk Analysis of risk & opportunity for business | $14M | 104 mo ago | 127 | — | — | — | — |
| 31 | RightEye Provider of eye-tracking solution for general healthcare and wellness | $11M | 75 mo ago | 14 | — | WordPress Block EditorWordPressMySQL+33 | 34 patents Eye‑tracking based physiological and visual performance assessment and calibration platforms. | — |
| 32 | Materic Provider of diversified advanced materials 9Tech top 42%Funding bottom 46%Global bottom 29%Market bottom 15% All 4 signals ▾Techtop 42% Fundingbottom 46% Globalbottom 29% Marketbottom 15% Tech: 37 technologies across 5/8 capability areas · Cloud: Cloudflare Funding: Raised $9.2M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) rank vs industry peers · Fliar Intelligence Index 9/100 | $9M | 13 mo ago | 2 | — | WordPress Block EditorCart FunctionalityWooCommerce+34 | — | — |
| 33 | Machfu Provider of IIoT gateways and platform solutions | $7M | 61 mo ago | 14 | — | — | — | — |
| 34 | AMI Cardiac Monitoring Developer of cardiac health monitoring devices | $7M | 24 mo ago | 22 | Dot Glodek CEO | WebflowZohocore-js+11 | — | — |
| 35 | Everywhere Communications Provider of asset tracking solutions | $6M | 43 mo ago | 32 | Patrick Shay Founder & CEO | Connecting & Protecting people and assets globally | PageFlyCart FunctionalityShopify+23 | — | 1 launch |
| 36 | Attila Security Provider of security solutions for endpoints | $6M | 64 mo ago | 21 | Gregg Smith CEO | — | — | — |
| 37 | GeoCollaborate Provider of GIS software for accessing the GIS data | $4M | 25 mo ago | — | Dave Jones Founder & CEO | — | — | — |
| 38 | OmniSpeech AI-powered voice technology enhancing speech clarity and detecting audio deepfakes | $3M | 6 mo ago | 12 | — | — | 14 patents Advanced pitch detection algorithms for speech signal processing using PWVT and Teager energy | — |
| 39 | Brimrose Technology Manufacturer of CBRNE threat detection and monitoring systems | $3M | 16 mo ago | — | Ronald Rosemei Founder | — | 2 patents Automated image-based spatial monitoring and object detection for unattended sensing systems. | — |
| 40 | Clearstep Provider of AI-assisted chatbot for healthcare | $3M | 17 mo ago | 15 15 → 31 (+107%) | Adeel Malik CEO | WebflowVimeoAmazon Web Services+21 | — | — |
| 41 | EuQlid Provider of quantum sensing and imaging solutions for electronic systems | $3M | 7 mo ago | — | Sanjive Agarwala Co-Founder and CEO | — | — | — |
| 42 | AlarisPro Maintenance management solutions for airline operators | $3M | 37 mo ago | 10 | Tony Pucciarella Founder & CEO | Windows ServerYouTubeMicrosoft ASP.NET+10 | 2 patents UAV flight data recording and centralized fleet telematics management systems | — |
| 43 | HoloMD AI-powered platform focused on psychiatric care and remote therapeutic monitoring | $2M | 6 mo ago | — | Ali Allage Co-Founder & Chief Technology Officer | — | — | — |
| 44 | EpiWatch Digital remote health management tool for patients and physicians | $1M | 20 mo ago | 1 | Teresa Prego Chief Executive Officer | WordPressMySQLPHP+16 | — | 1 award |
| 45 | USI Manufacturer of fire & smoke alarm | $1M | 10 mo ago | 11 | — | Cart FunctionalityShopifycore-js+9 | — | — |
| 46 | SenSanna Provider of end-to-end Surface Acoustic Wave sensing platform for IIoT | $500K | 31 mo ago | 9 | Jacqueline Hines Founder & Chairman & CEO | — | 36 patents Surface acoustic wave (SAW) sensors, tags, and low‑power remote monitoring solutions | — |
| 47 | Whisker Labs Provider of sensor hardware and software infrastructure 55Customers top 18%Growth top 26%Patents top 37%Moat top 38% All 10 signals ▾Customerstop 18% Growthtop 26% Patentstop 37% Moattop 38% Producttop 42% Innovationtop 43% Fundingtop 46% Techtop 50% Globalbottom 40% Marketbottom 37% Customers: Play-Store rating 4.74★ across 7,082 ratings (1 apps) · Review volume +37% in 6 mo Growth: Headcount 26 → 43 (+65%) across vintages · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 55/100 | $250K | 1 mo ago | 43 | — | WordPressApple iCloud MailMicrosoft 365+27 | 37 patents Early detection of electrical faults and power quality anomalies in wiring systems | — |
| 48 | JuneBrain Provider of a remote patient monitoring device for eye and brain diagnosis | $175K | 6 mo ago | 6 | Samantha Scott Founder & CEO | — | 6 patents Non-invasive EEG-based brain activity monitoring devices | — |
Top 12 High Tech companies in Maryland
#1
Public · Gaithersburg, Maryland · founded 2007 · 88 employees$267Mraised▾
Developer of RNA-based therapeutics for the treatment of cancer and fibrosis disease. The company has proprietary delivery technologies, a polypeptide nanoparticle RNAi platform and GalNAc RNAi platform, GalAhead, to develop drug candidate pipeline which include STP122G for cardiovascular disease treatment. It also, develops pipeline of drugs for cancers, skin conditions, fibrosis-related diseases, antiviral and cardiometabolic diseases, and medical aesthetics.
- Sep 2025Post IPO$17.7M
- Jul 2021Series E$105M
- Oct 2020Series D$105M
- Jul 2019Series C$25M
#2
Series A · College Park, Maryland · founded 2016 · 9 employees$31.8Mraised▾
Developer of advanced wood material offering strength and fire resistance. The company engineers a building material that is stronger and lighter than steel. This engineered wood has applications in construction and other industries. It provides a safer alternative to traditional materials due to its fire-resistant properties.
- Jan 2026Series A$15M
- Apr 2025Series A$15M
- Aug 2021Grant (prize money)$500K
- Jul 2018Grant (prize money)$1.1M
#3
Series B · Rockville, Maryland · founded 2008 · 31 employees$52.8Mraised▾
Developer of lentivirus therapies for the treatment of cancer and other chronic human diseases. The company has developed drugs using its delivery platform. The product pipeline includes a liver cancer therapeutic lentivirus and an AIDS therapeutic lentivirus, as well as Parkinson’s disease therapeutic lentivirus, and a familial dysautonomia therapeutic lentivirus.
- Nov 2025Series B$310K
- Apr 2022Series B$50M
- Nov 2015Series A$1.2M
- Sep 2015Grant (prize money)$232.2K
#4
Public · Gaithersburg, Maryland · founded 2001 · 10 employees$64.6Mraised▾
Developer of regenerative products for wound care. The company focuses on regenerative therapies to primarily address the areas of wound care, inflammation, and angiogenesis. Its proprietary technology Aurix is a biodynamic hematogel that is an auto platelet and plasma therapy system. It has been approved by the FDA for use in the management of wounds and ulcers of all types and severities.
- Jul 2025Post IPO$791.4K
- Sep 2024Post IPO$849.1K
- May 2024Post IPO$650.9K
- Dec 2023Post IPO$962.5K
#5
Series A · Frederick, Maryland · founded 2014 · 11 employees$30Mraised▾
Provider of a machine learning training and deployment platform. It is a global leader in vision AI, known for its pioneering YOLO models. With over hundred and fifteen GitHub stars, more than hundred million downloads, and five million monthly visitors, it delivers state-of-the-art computer vision solutions. Its advanced technology supports diverse industries including manufacturing, healthcare, transportation, agriculture, and retail by providing fast, accurate, and accessible AI tools.
- Sep 2025Series A$30M
- 2024Seed—
#6
Public · Gaithersburg, Maryland · founded 1987 · 184 employees$2.7Braised▾
Developer of novel vaccines for the treatment of infectious diseases. Its pipeline includes a vaccine for respiratory syncytial virus infection, coronavirus, malaria, ebola, and seasonal quadrivalent vaccines for influenza. It uses recombinant nanoparticles and adjuvant technology.
- Sep 2023Post IPO$84.5M
- Jul 2020Grant (prize money)$1.6B
- Jun 2020Post IPO$200M
- Jun 2020Grant (prize money)$60M
#7
Seed · College Park, Maryland · founded 2009 · 12 employees$3.4Mraised▾
AI-powered voice technology enhancing speech clarity and detecting audio deepfakes. The company specializes in AI/ML algorithms to improve speech performance across various applications and devices. Their technology offers AI Noise Suppression for crystal-clear voice communication by removing background noise in real-time, suitable for VoIP calls, video conferencing, and gaming. They also provide AI Audio Deepfake Detection, identifying AI-generated voices to combat voice fraud and misinformation. Additionally, their AI Speech Biomarker Identification technology unlocks health and security insights from voice data, enabling non-invasive diagnostics and biometric authentication. The solutions are designed for seamless integration with DSPs, SoCs, and operating systems, offering low latency and low power consumption, ideal for wireless headsets and battery-powered devices. The company's focus is on delivering superior performance in speech extraction and deepfake detection through proprietary training and algorithm design.
- Nov 2025Seed$500K
- Dec 2014Grant (prize money)$225K
- 2014Grant (prize money)$135K
- Aug 2013Grant (prize money)$1.1M
#8
Seed · College Park, Maryland · founded 2022$3Mraised▾
Provider of quantum sensing and imaging solutions for electronic systems. The company develops instruments for inline metrology and process control. These instruments are designed for advanced semiconductor packages and batteries. The technology uses quantum defects in diamond combined with AI algorithms. It enables quantitative mapping of hidden electrical currents inside components. The aim is to enhance yields and decrease time to market.
- Nov 2025Seed$3M
#9
Acquired · Germantown, Maryland · founded 2014 · 43 employees$250Kraised▾
Provider of sensor hardware and software infrastructure. The platform enables energy data to be collected and consumed through its solutions. The solutions are provided for homeowners. It provides home intelligence technologies that detect and alert homeowners to electrical fire hazards across the home.
- Apr 2026Series C$6.6M
- Nov 2021Series C—
- Dec 2020Conventional Debt$4.7M
- Nov 2019Series B—
#10
Seed · Rockville, Maryland · founded 2024$1.6Mraised▾
AI-powered platform focused on psychiatric care and remote therapeutic monitoring. It combines clinical psychiatry expertise with AI to support clinicians through an empathetic AI agent. This agent conducts patient check-ins between visits, tracks mood, medication adherence, and treatment responses, while alerting staff to issues like deterioration.
- Nov 2025Seed$1.6M
#11
Funding Raised · Baltimore, Maryland · founded 2018 · 2 employees$9.2Mraised▾
Provider of diversified advanced materials. It researches and develops multiple products, such as silver nanowires, piezoelectric yarns, heat-reflecting face paints, flame retardant inks and coatings, encapsulated insecticides, cell culture bio papers, and electrospun nanofibers for air filtration. It has applications in the oil and gas, electronic, energy, textile, health, and industrial sectors.
- Apr 2025Grant (prize money)$9.2M
#12
Public · Owings Mills, Maryland · founded 1969 · 11 employees$1.1Mraised▾
Universal Security Instruments is a manufacturer of alarm systems. The products offered by the company are smoke & fire alarms, carbon monoxide alarm, combo smoke, and CO & gas alarm. It also offers alarm accessories, home safety, and security products.
- Aug 2025Post IPO$1M
- Mar 2014Post IPO$81.2K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of High Tech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Semiconductors in Maryland is moving
A read on the academic research around Semiconductors in Maryland — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 122 papers.
University of Maryland institutions lead Maryland's semiconductor research, focusing on integrated circuits, 3D IC technologies, and hardware security, with a cautiously optimistic tone (mean stance 0.48).
- University of Maryland, College Park115
- University of Maryland, Baltimore County4
- University of Maryland, Baltimore2
- University of Maryland Extension1
- Electronic circuit1→4
- Integrated circuit1→4
- CMOS2→3
- Integrated circuit2→3
- Integrated circuit5
- Optoelectronics5
- Power semiconductor device5
- Semiconductor device3
- Reliability (semiconductor)3
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.